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1 ies difference in interpulse interval may be oligogenic.
2 gous deleterious alleles, and (3) contribute oligogenic alleles by combining point mutations and exon
3 d modeling the genetic architecture of other oligogenic and multifactorial diseases.
4 h the disease, and to a new understanding of oligogenic and polygenic disease risk.
5 netic changes, somatic mutations, epistasis, oligogenic and polygenic hypotheses.
6 ndicate that magic traits can be based on an oligogenic architecture and can be maintained by selecti
7 table to genetic factors, consistent with an oligogenic architecture of EL estimated both from the ph
8 together, these lines of evidence support an oligogenic architecture underlying dispersal in Triboliu
9              Rheumatoid arthritis (RA) is an oligogenic autoimmune disease but, to date, linkage and
10 ne disease, showed significant linkage of an oligogenic autoimmune susceptibility locus, termed AIS1,
11                             Hypothesizing an oligogenic basis for HLHS, we tested 60 additional prior
12 e of familial and sporadic ALS, the proposed oligogenic basis for the disease, and how each new genet
13  combinations, limiting our ability to study oligogenic basis for these disorders.
14  in contrast to the previously characterized oligogenic basis of a pollinator shift in close relative
15 genic variant (P = 0.001) consistent with an oligogenic basis of amyotrophic lateral sclerosis.
16            These results illustrate that the oligogenic basis of CHD and significant heritability may
17  that at least 20% to 30% of DCM may have an oligogenic basis, meaning that multiple rare variants fr
18       Instead, resistance appears to have an oligogenic basis.
19 rung disease (HSCR) is a partially penetrant oligogenic birth defect that occurs when enteric nervous
20 ly robust methods; we extend this to examine oligogenic burden in the lysosomal storage pathway in PD
21                                              Oligogenic canine RPGRIP1-CRD illustrates the impact of
22 usal genes in HCM is, in part, because of an oligogenic cause, wherein the pathogenic variants do not
23       We posit that a subset of HCM might be oligogenic caused by multiple pathogenic variants that d
24 d that an affected individual can carry many oligogenic combinations, each contributing to the same p
25 genetic basis remains elusive, likely due to oligogenic complexity.
26       Viewing isolated GnRH deficiency as an oligogenic condition has implications for understanding
27 k factors with various levels of complexity: oligogenic copy number variants (CNVs), multigenic CNVs,
28                                    Moreover, oligogenic cosegregation was suggestive for complex inhe
29 success rate could at least be partly due to oligogenic defects - the accumulation of several rare he
30           We conclude that RPGRIP1-CRD is an oligogenic disease with at least three loci contributing
31 however, the precise genetic architecture of oligogenic diseases remains unknown.
32 ese methods for the dissection of late-onset oligogenic diseases.
33 ditory-visual synesthesia is likely to be an oligogenic disorder subject to multiple modes of inherit
34  with an interpretation of EOP as a complex, oligogenic disorder, with IL-1 genetic variation contrib
35  Bardet-Biedl syndrome (BBS), a pleiotropic, oligogenic disorder.
36                        A spectrum of complex oligogenic disorders called the ciliopathies have been c
37 ic and common polygenic diseases lie diverse oligogenic disorders involving mutations in more than on
38 ovel insights into incomplete penetrance and oligogenic effects underlying CHDs.
39 ply that human essential hypertension has an oligogenic element (a few genes may be involved in deter
40       If the genetic effects are mediated by oligogenic epistasis, as studies in the mouse suggest, i
41 congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the geneti
42 ssment of oligogenicity in ALS and show that oligogenic events involving known ALS risk genes are rel
43 se an hypothesis of a developmental phase of oligogenic expression that is followed by positive and n
44                        However, the study of oligogenic forms of T2D has illuminated distinct causal
45 ighted a new entity, that we suggest calling oligogenic forms of T2D, serving as a genetic link betwe
46 e effects, to predict polygenic (height) and oligogenic (fusiform rust resistance) traits in a struct
47 is associated with induction of the obligate oligogenic gene Olig2.
48 nificantly (P < 0.01) lower rate, suggesting oligogenic heterozygosity as a new potential mechanism i
49 ailed spermatogenesis strongly suggests that oligogenic heterozygosity could explain a significant pr
50             Additionally, multiple events of oligogenic heterozygosity were seen, affecting 23 of 339
51 logy revealed that controls were carriers of oligogenic heterozygous events at significantly (P < 0.0
52                             In line with the oligogenic hypothesis, we found significantly more combi
53 This supports the idea that CRC onset may be oligogenic in nature and may show molecular heterogeneit
54  families, and the disorder is thought to be oligogenic in origin.
55 that IBD comprises a heterogeneous family of oligogenic inflammatory disorders in which the specific
56 t a polygenic model with some evidence of an oligogenic influence (i.e., a handful of loci being resp
57                Elucidating the principles of oligogenic inheritance and mechanisms of genetic interac
58 uenced the age of symptom onset and supports oligogenic inheritance as relevant to disease pathogenes
59                                      Because oligogenic inheritance has been described for the relate
60                                              Oligogenic inheritance implies a role for several geneti
61                       This first evidence of oligogenic inheritance in failed spermatogenesis strongl
62                                   We studied oligogenic inheritance in Parkinson's (PD) by assessing
63 econd MKS gene, CEP290; p.R2210C, suggesting oligogenic inheritance in this disorder.
64 elevant for the many human diseases in which oligogenic inheritance is emerging as a mechanism for he
65                                              Oligogenic inheritance makes the etiology of development
66          Together, the data suggest that the oligogenic inheritance of rare Mendelian variants may be
67                                 Here we show oligogenic inheritance of S-HSCR, the 3p21 and 19q12 loc
68  model provides a platform for understanding oligogenic inheritance that results in clinically releva
69                         Isolated HSCR has an oligogenic inheritance with RET as the major disease-cau
70         These studies are consistent with an oligogenic inheritance, in which synergistic interaction
71 ith tooth agenesis in 2 families, suggesting oligogenic inheritance.
72  genetic basis of phenotypic variability and oligogenic inheritance.
73 ways identified 29 patients with evidence of oligogenic inheritance.
74 whole genome de novo assembly also supported oligogenic inheritance; implicating 13 genes involved in
75 g digenic interactions, the simplest form of oligogenic interactions, using high-throughput sequencin
76 of tract microstructure was determined using oligogenic linkage analysis of this large multigeneratio
77                                   Sequential Oligogenic Linkage Analysis Routines (SOLAR) software wa
78 plemented in the computer package Sequential Oligogenic Linkage Analysis Routines (SOLAR, San Antonio
79 inear Mixed Model) and SOLAR-MGA (Sequential Oligogenic Linkage Analysis Routines -Major Gene Analysi
80  variance component models in the Sequential Oligogenic Linkage Analysis Routines software program.
81 , and the serine-glycine ratio in Sequential Oligogenic Linkage Analysis Routines while accounting fo
82 ve been implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package.
83        METHODS AND We used SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate herita
84 onent model implemented in SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate linkag
85 ts methods, implemented in SOLAR (Sequential Oligogenic Linkage Analysis Routines), to estimate herit
86 types was calculated using SOLAR (Sequential Oligogenic Linkage Analysis Routines).
87                             Using Sequential Oligogenic Linkage Analysis Routines, the genetic correl
88 s analysis, as implemented in the Sequential Oligogenic Linkage Analysis Routines, was used to estima
89 es using pedigree information and Sequential Oligogenic Linkage Analysis Routines.
90 (25-75%)/FVC were performed using Sequential Oligogenic Linkage Analysis Routines.
91 ng the power to detect multiple QTLs through oligogenic linkage analysis.
92 sing Bayesian Markov chain Monte Carlo joint oligogenic linkage and association analysis, we detected
93 hy, which we speculate to be consistent with oligogenic mechanisms resulting in pleiotropic outcomes.
94 ecessive trait, recent data have unmasked an oligogenic mode of disease transmission, in which mutati
95 sively in the bilateral cases, suggesting an oligogenic mode of inheritance.
96               Our linkage results support an oligogenic model for IGE, with strong evidence for a loc
97 ting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts.
98         We present evidence in support of an oligogenic model where two or more ultrarare mutations o
99 tifactorial mode of inheritance alone, or an oligogenic model with some evidence of a recessive compo
100 t disease that fits most accurately into the oligogenic, multifactorial class of genetic diseases.
101 new targets for broad-spectrum therapies for oligogenic or polygenic forms of human IRDs.
102 dies, suggest that most POI cases are likely oligogenic or polygenic in nature, which has important i
103 herein multiple genetic variants contribute (oligogenic or polygenic inheritance).
104 g and cardiac conduction suggests a possible oligogenic origin for the ectopies originating from Purk
105 pens up new avenues for the investigation of oligogenic patterns in apparently Mendelian disorders.
106 regating in these families, suggests complex oligogenic patterns of inheritance for ARMD.
107           Further, we identify signatures of oligogenic-positive selection in multiple populations at
108  be a relatively powerful design for mapping oligogenic QTL.
109 eme sibpairs (ESP) methods to detect complex oligogenic quantitative trait loci (QTL) are investigate
110 ttention is now appropriately focused on the oligogenic, quantitative aspects of reproduction.
111  be useful for development of cultivars with oligogenic resistance that are expected to provide broad
112 se results indicate that PI 567324 possesses oligogenic resistance to the soybean aphid.
113 pe association suggest potentially additive, oligogenic risk mechanisms for sudden death in this coho
114 spite several studies suggesting a potential oligogenic risk model in amyotrophic lateral sclerosis (
115 slate our findings back to human AD, we used oligogenic risk scores based on gene clusters with share
116 l as the contribution of apoE and sex, in an oligogenic segregation analysis of 75 families (742 indi
117                                 We performed oligogenic simultaneous segregation and linkage analyses
118 isk for hypertension is due to multiple (ie, oligogenic) susceptibility loci.
119  that suggest categorizing genes involved in oligogenic T2D.
120 ay be less than 100, suggesting LOAD is more oligogenic than polygenic.
121  of genes significantly decreased from small oligogenic to large multigenic CNVs (r = -0.88, p = 8.78
122 hods allow multipoint linkage analysis under oligogenic trait models in pedigrees of arbitrary size;
123 her as a simple Mendelian recessive or as an oligogenic trait, since mutations at two loci are someti
124  accuracy increase was only observed for the oligogenic trait.
125                                       We use oligogenic-trait segregation analysis to estimate the nu
126 sess the ability of predicting polygenic and oligogenic traits controlled by different levels of domi
127          Species that differ in monogenic or oligogenic traits that affect ecological performance and
128 Analysis Workshop; this data set had several oligogenic traits, generated by use of a 1,497-member pe
129 h are crucial first steps toward deciphering oligogenic underpinnings of CHDs, including hypoplastic
130  confounded by its genetic heterogeneity and oligogenic underpinnings.
131 , we looked for strong, potentially mono- or oligogenic variants for ischemic stroke, and second, we
132      Potato resistance to S. endobioticum is oligogenic with one major and several minor resistance l
133                      Inheritance seems to be oligogenic, with genotype at BAAT modifying penetrance i

 
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