ライフサイエンスコーパス: oligomer

1 that the receptor may exist as a dimer or an oligomer.

2 at wraps around the C-terminal domain in the oligomer.

3 the essential functional unit of SMN is the oligomer.

4 at Cgamma on the repeating aeg units of PNA oligomer.

5 ding assays suggests that it functions as an oligomer.

6 inding appeared to disrupt this cell-surface oligomer.

7 orm of a protein within the cell is often an oligomer.

8 rder takes place during assembly of pre-pore oligomers.

9 red for determining the stoichiometry of the oligomers.

10 compared to previously analyzed beta-peptoid oligomers.

11 n-covalent dimers, trimers, and higher-order oligomers.

12 secondary structure evolution of individual oligomers.

13 nds via a concave hydrophobic surface in SAA oligomers.

14 njugated polymers as well as discrete living oligomers.

15 and dimer species with high-molecular-weight oligomers.

16 sure to Alzheimer's-related amyloid-beta1-42 oligomers.

17 gene expression, typically using Morpholino oligomers.

18 removes the damage in 24-32-nucleotide-long oligomers.

19 only into trimers but also into higher-order oligomers.

20 branched structures as well as prefibrillar oligomers.

21 development of tools targeting soluble Abeta oligomers.

22 e CaMKII-alpha hub and break it into smaller oligomers.

23 located on the core beta-sheets edges of the oligomers.

24 is not due the size exclusion of arrestin-1 oligomers.

25 ructure of the positive polaron in PTB7-type oligomers.

26 numab dramatically reduces the flux of Abeta oligomers.

27 n the E. coli protein, and form higher-order oligomers.

28 , disintegrating them into monomers or short oligomers.

29 are thought to be the most neurotoxic Abeta oligomers.

30 sary to prevent cellular toxicity from Abeta oligomers.

31 al terminals were exposed to alpha-synuclein oligomers.

32 hat could drive the formation of string-like oligomers.

33 trimers, hexamers, and high-molecular-weight oligomers.

34 omplexes are assembled in trimers and higher oligomers.

35 hat the protein has lost its ability to form oligomers.

36 weakly self-associated, acutely synaptotoxic oligomers.

37 y in vivo and in vitro that forms functional oligomers.

38 T) and four polybutylene terephthalate (PBT) oligomers.

39 e-function relationship of membrane-inserted oligomers.

40 green fluorescent protein to prepare protein oligomers.

41 duce a strong systematic bias toward smaller oligomers.

42 in cells and interacts with alpha-synuclein oligomers.

43 sponding structure of the first amyloid-beta oligomers.

44 ges, and bacterial DNA/RNA hybrid nucleotide oligomers.

45 ect the stability of ligand-independent EGFR oligomers.

46 trometry (IM-MS) to study soluble preamyloid oligomers.

47 nto a ring of treadmilling membrane-tethered oligomers.

48 tracts characterised grape seeds by catechin oligomers (36.0 +/- 0.3 mg/g) and mulberry seeds by ella

49 pathologic feature is driven by amyloid-beta oligomers (Abetaos) and propagates from neuron to neuron

50 Irrespective of whether chaperone oligomers act as reservoirs for active monomers or exhib

51 Thus, we conclude that Ca(2+)-sensitive Syt1 oligomers, acting as an exocytosis clamp, are critical f

52 , human serum albumin (HSA), inhibits alphaS oligomer (alphaS(n)) toxicity through a three-pronged me

53 which make it a likely contributor to early oligomer and fibril formation, and thus a potential crit

54 ts required for the formation of the ZAR(CC) oligomer and its activity.

55 Abeta oligomerization and formation of small oligomer and large aggregate heterocomplexes.

56 Structural elucidation of CRY-CRY homo-oligomers and a CRY-BIC heterodimer reveals how the acti

57 Using IL15-induced recombinant tau oligomers and a dot blot assay, we discovered a mAb (M20

58 protein alpha-synuclein (alpha-syn) to form oligomers and amyloid fibrils, and how such species prom

59 l triplet exciton was also determined in the oligomers and compared with polymer PTB7.

60 ncestral GTPases and co-assemble into hetero-oligomers and cytoskeletal filaments.

61 e to discern the dissociated from the intact oligomers and detergent-bound complexes and correlate th

62 Both oligomers and fibrils seed the spread of Tau pathology,

63 cells with the dsRNA-analog poly(I:C), PGAM5 oligomers and high levels of PGAM5 were found in mitocho

64 Second, HSA remodels alphaS oligomers and high-MW fibrils into chimeric intermediate

65 sfold and assemble into a variety of soluble oligomers and insoluble aggregates, a process that is as

66 hat they can differentiate misfolded protein oligomers and insoluble aggregates, both in test tubes a

67 The toxicity of baboon oligomers and lack of significantly detectable toxicity

68 ded infectious prion nanoparticles including oligomers and microfilaments bound to lipid vesicles.

69 FSA's approach on the total sum of migrating oligomers and on toxicological threshold-of-concern.

70 (scFv) inhibited seeding by IL15-induced tau oligomers and pathological extracts from donors with AD

71 we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-beta (Abeta) fibrillizati

72 he synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids.

73 formation of extended liquid-like 2-butanol oligomers and promote dimeric H-bonded 2-butanol network

74 es are compared with those of related linear oligomers and the electronic structure is further evalua

75 developed to characterize membrane-inserted oligomers and the hereby obtained oligomerization states

76 ghly ordered structure of the single-layered oligomers and their likeness to the matrix layer of inta

77 We designed 20 oligomers and treated fibroblasts derived from five pati

78 erimentalists, including leaching of uncured oligomers and uncontrolled absorption of small compounds

79 ization, size-exclusion chromatography-based oligomer, and retrotranslocation assays, along with conf

80 ethod enables access to low molecular weight oligomers, and molecular weights between 1 and 30 kDa ca

81 removes the damage in 11-13-nucleotide-long oligomers, and the eukaryotic type, which removes the da

82 Thus, metastable oligomers antagonize their replacement by amyloid fibril

83 ogical threshold of concern (TTC) and sum of oligomers approaches were applied.

84 res predominate, but off-pathway beta-barrel oligomers are also predicted.

85 Off-pathway beta-barrel oligomers are also suggested to occur in coassembled bet

86 e of the amyloid beta (Abeta) peptide, whose oligomers are associated with Alzheimer's disease.

87 rface-induced dissociation (SID); (3) avidin oligomers are best described as heterogeneous ensembles

88 Amyloid-beta (Abeta) oligomers are implicated in Alzheimer disease (AD).

89 iposome membranes, suggesting that large BAX oligomers are not essential for the permeabilization.

90 nsistent with the hypothesis that preamyloid oligomers are the most toxic species produced during IAP

91 ariety of other PFAS, including monomers and oligomers, are emitted during the production, processing

92 the N-terminus of Abeta accommodated by the oligomers as an unstructured tail.

93 its structure that may contain cyclic esters oligomers as potential migrants.

94 Individual precise chain length oligomers as reference materials were obtained by a step

95 ent peptidoglycan internally to produce free oligomers as well as lipid-linked oligomers that can und

96 eveal that the proteasome can target soluble oligomers assembled from ubiquitin-modified proteins ind

97 olecular complexes, such as in toxic protein oligomers associated with amyloid diseases.

98 ies self-replication and generation of toxic oligomers associated with several neurodegenerative dise

99 hesis of eukaryotic glycans - branched sugar oligomers attached to cell-surface proteins and lipids -

100 the inability to generate a homogeneous BAX oligomer (BAX(O)) for analysis.

101 etween the m6A target and a biotinylated RNA oligomer bearing a single m6A enzymatically labelled wit

102 ind that under each vesicle, Synaptotagmin-1 oligomers bind and clamp a limited number of 'central' S

103 Photoisomerization of the oligomer-bound receptor causes a decrease in diffusion c

104 n vitro assays of the regions exposed in the oligomers but not in the fibrillar deposits.

105 lations of membrane-binding competent alphaS oligomers but possibly also by shielding the membrane in

106 Axin DIX (DAX) forms small single-stranded oligomers, but its self-association is stronger than tha

107 are thought to function as dimers or higher oligomers, but measuring membrane protein oligomerizatio

108 alized chiral building blocks into precursor oligomers by a trimer segment coupling strategy.

109 Here, we study the formation of fibrils and oligomers by exon 1 of huntingtin protein.

110 ation of disease-relevant small amyloid-beta oligomers by mass spectrometry and ion mobility spectrom

111 lly synthesize a larger repertoire of glycan oligomers by partitioning promiscuous enzymes across mul

112 the two polymers can form fully-bonded small oligomers by virtue of the number of binding sites in on

113 affected, showing that well-defined block co-oligomers can be achieved.

114 Monodisperse natural and synthetic oligomers can be obtained in low quantities by tedious,

115 esses, such as heat shock or acidosis, HSP27 oligomers can dissociate into dimers and monomers, which

116 ine-centered narrow domain where short actin oligomers can form and subsequently anneal to the pointe

117 oligosaccharides, such as a six-unit GlcNAc oligomer, can bind poliovirus but fail to enhance virion

118 unds of replication may have led to pools of oligomers composed mainly of RNA.

119 Our findings suggest Rca oligomers composed of Rca-alpha only are less effective

120 Trimers and higher-order oligomers composed of trimers are thought to be the most

121 the mitochondrial surface relative to mixed oligomers comprising native and GFP-tagged Drp1.

122 tric triblock amphiphiles (or high-chi block oligomers) comprising incompatible sugar-based (A) and h

123 izing Abeta variants with different critical oligomer concentrations, the interaction inhibits the au

124 place in the aqueous phase bias the grafted oligomer conformations that are adopted in the neighbori

125 indicated that in apples, only 5% of the PAC oligomers contain one or more A-type bonds, whereas in c

126 cranberries and peanut skins, 96% of the PAC oligomers contain one or more A-type bonds.

127 We use a series of fluorene oligomers containing a central benzothiadiazole(10) unit

128 onger and structurally heterogeneous heparin oligomers (decamers).

129 rge-transfer differences within the aromatic oligomers, depending on the helix handedness and on the

130 e drastically reduced GTP turnover restricts oligomer disassembly from the mitochondrial surface rela

131 TFEB oligomers display increased resistance to mTORC1-mediate

132 ate as oligomers, we found that most Abeta42 oligomers dissociate into their monomeric precursors wit

133 n in vivo and the inability to degrade Abeta oligomers due to a phagolysosome dysfunction.

134 fragments can be used to stabilize specific oligomers during amyloid fibril formation, facilitating

135 Peptoids, a sequence-defined family of oligomers, enable a peptidomimetic strategy, especially

136 As the oligomers fall apart after exiting the drift cell of the

137 Moreover, time-lapse analysis of Sup35 oligomer fibrillation on cells suggested that the amyloi

138 s to assess the therapeutic efficacy of this oligomer for those patients carrying the c.-32-13T > G m

139 enerate end-functionalized acetoxy ionizable oligomers for the structural deciphering of different co

140 These DNA/protein oligomers form "networks," which increase the speed of o

141 d relatively long (eicosasaccharide) heparin oligomers form 1:1 complexes with RBD, indicating the pr

142 esults indicate that ligand-independent EGFR oligomers form using interactions that are distinct from

143 revealed that the TTR segment inhibits Abeta oligomer formation and also promotes the formation of no

144 Here, we analyzed hetero-oligomer formation in human cells and in vitro using pur

145 Our results show that the effect of hetero-oligomer formation on the composition of the sHsp ensemb

146 gation/oligomerization, but the mechanism of oligomer formation remains unclear.

147 d by EGCG and inhibition of Abeta fibril and oligomer formation, as manifested by the recovery of the

148 o erythrocytes, likely by facilitating LukED oligomer formation.

149 very distinct from the elongated high-order oligomer formed by the pure protein.

150 the three-dimensional structure of an Abeta oligomer formed in a membrane mimicking environment, nam

151 cess, results which are distinct from beta2m oligomers formed at low pH.

152 ere, we report the formation of in vitro tau oligomers formed by an ionic liquid (IL15).

153 Preamyloid oligomers formed by baboon amylin, but not baboon amylin

154 he native sequence and thus better mimic the oligomers formed by full-length Abeta.

155 Oligomers formed from mNBH could be reduced to mainly mo

156 Ab initio modeling of SANS shows that the oligomers formed from the BLG-retinol complex are smalle

157 herent acute synaptotoxicity, with preformed oligomers found in oM1000 appearing to be stable, tightl

158 Oligomers from the three series were quantified in PET t

159 h the time course of the levels of transient oligomers generated through secondary nucleation.

160 These findings indicate a specific role of oligomers generated through the catalytic action of fibr

161 ragment ion intensities of just two isomeric oligomer groups, GlcNAc(1)GlcN(3) and GlcNAc(2)GlcN(2),

162 s the ends of DIX oligomers, such that a DIX oligomer has at most four DAX binding sites.

163 co genotoxicity assessment of all identified oligomers has been performed and showed no genotoxicity

164 The dynamic and polydisperse nature of sHsp oligomers has made studying them challenging using tradi

165 The chaperone activity of HspB1-HspB6 hetero-oligomers, however, was modulated in a substrate-specifi

166 we confirmed the presence of alpha-synuclein oligomer in CD11b+ exosomes, which were able to induce a

167 cific activity towards alpha-syn fibrils and oligomers in comparison to monomers and recognized intra

168 nsight has been an increase in soluble Abeta oligomers in early AD that is causally linked to neurona

169 l effects of acutely applied synthetic Abeta oligomers in male and female mice heterozygous for eithe

170 olves the formation of different types of R1 oligomers in most studied species and R1-R2 octamers in

171 r tyrosine kinase (RTK) that forms activated oligomers in response to ligand.

172 ing a 1:2 complex that can form higher-order oligomers in solution, and we solved the crystal structu

173 vidence indicates that EGFR/ERBB1 also forms oligomers in the absence of ligand, but the structure an

174 It is challenging to preserve such oligomers in the gas phase where mass-selected structura

175 n amylin, like human amylin, forms low-order oligomers in the lag phase of amyloid formation.

176 ted arrestin-3 form trimers and higher-order oligomers in the presence of IP(6); we showed previously

177 ivity of the terminal alcohol to "unzip" the oligomers, in a controlled and iterative fashion, releas

178 e similarly obtained in preference to higher oligomers, in contrast to precedent reports.

179 n to interact with H2A/H2B and H3/H4 histone oligomers, individually, as well as simultaneously, sugg

180 enetic disruptions revealed that short Abeta oligomers induce acute wakefulness through Adrenergic re

181 down of PKCdelta expression with morpholinos oligomers inhibited TRPC1-based SOCs.

182 Handling these oligomers is complicated by the fact that they often exh

183 with a model in which the assembly of Abeta oligomers is driven by hydrogen bonding and hydrophobic

184 hot spots associated with gold nanoparticle oligomers is studied with continuous wave (CW) pump-prob

185 opy images showed the coexistence of compact oligomers, largely consistent with the AFM data, and lar

186 cleating both fibril types contain amorphous oligomers leading to branched structures as well as pref

187 and enables their characterization (both the oligomer length, and the number of incorporated sulfate

188 nhances or suppresses sleep as a function of oligomer length.

189 tween morphology and structure on the single oligomer level.

190 o biomechanical measurements found increased oligomer levels in aneurysm patients with altered aortic

191 While the Bok TMD oligomers locate preferentially to the endoplasmic retic

192 mer 1 which represents the first merocyanine oligomer longer than a dimer.

193 ow molecular weight and relative solubility, oligomers may be particularly pernicious seeds.

194 Our results suggest an oligomer-mediated toxicity mechanism for medin pathology

195 The production of these oligomers might be accompanied with monosaccharides.

196 sis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be s

197 ause ligand binding at internal sites of DNA oligomers modulates dynamics at the termini, the results

198 Before the formation of these soluble oligomers, monomeric species first adopt aggregation-com

199 TDP-43 oligomers mostly colocalized with intracellular Abeta in

200 of linear (alpha1)(2)(alpha2)(n-2)(beta)(n) oligomers (n > 1) while Hp 2-2 occurs in cyclic (alpha2)

201 Hp 2-2 occurs in cyclic (alpha2)(n)(beta)(n) oligomers (n > 2).

202 cerebroventricular injection of amyloid-beta oligomers (oAbeta), we analyzed cellular and behavioral

203 e demonstrate an example where monomers (and oligomers) obtained from the hydrogenation process can b

204 of the F20Cha mutation to further stabilize oligomers of Abeta-derived peptides that contain more of

205 Soluble oligomers of aggregated tau accompany the accumulation o

206 This is of importance in those cases where oligomers of defined length are not easily obtained.

207 namic steady states from monomers to dimers, oligomers of dimers, and randomized polymer structures b

208 ity and FRET efficiency for homo- and hetero-oligomers of fluorescent protein-labeled forms of EGFR a

209 To better mimic oligomers of full length Abeta, we use an orthogonal pro

210 ermediates formed either spontaneously or by oligomers of gamma-tubulin.

211 Oligomers of pneumolysin form transmembrane channels in

212 Oligomers of RCD-1 were associated with the cell death r

213 We find no evidence for stable oligomers of RHBDL2 in giant plasma membrane vesicles of

214 Iodinated oligomers of several of the most popular conducting poly

215 The formation of oligomers of the amyloid-beta peptide plays a key role i

216 Soluble oligomers of the beta-amyloid peptide, Abeta, are though

217 Oligomers of the beta-amyloid peptide, Abeta, play a cen

218 a series of bis-functionalized beta-peptoid oligomers of the hexamer length.

219 Thin layers of diarylethene oligomers (oligo(DAE)) were deposited by electrochemical

220 as an intrinsic propensity to form low order oligomers on a supported lipid bilayer and that neither

221 pports enabled synthesis of sequence-defined oligomers on the gram-scale.

222 myotubes using phosphorodiamidate morpholino oligomer or locked nucleic acids (LNA)/2'-OMe mixmers wi

223 interaction of Fab and IgG1 in small soluble oligomers, or through the rapid coalescence of pre-exist

224 hts into the structure and assembly of Abeta oligomers, our laboratory has previously designed and sy

225 S solvation theory was used to calculate air-oligomer partition ratios, which were converted to estim

226 terizing the structure of toxic intermediate oligomers plays an essential role in better understandin

227 Formation of amyloid-beta (Abeta) oligomer pores in the membrane of neurons has been propo

228 e to reveal the structure of alpha-synuclein oligomers present at different stages of protein aggrega

229 within the limited subsets of short heparin oligomers produced either enzymatically or synthetically

230 ly associated with a narrow, specific glycan oligomer profile.

231 Many enzymes assemble into defined oligomers, providing a mechanism for cooperatively regul

232 A series of sequence-defined oligomers ranging from two to seven units was synthesize

233 us particles, as well as the structure of M1 oligomers reconstituted in vitro.

234 ysiological role of these ligand-independent oligomers remain unclear.

235 e structure of the LPL monomer, the inactive oligomer remained opaque.

236 f structural organization of alpha-synuclein oligomers reported in this study is critically important

237 ity of the amino- and carboxy-functionalized oligomers, respectively.

238 vealed that mouse BEX3 auto-associates in an oligomer rich in intrinsic disorder.

239 of computing partition ratios of SVOCs using oligomers selected on the basis of likely dust sources a

240 ts derived from five patients to identify an oligomer sequence that maximally increased enzyme activi

241 st Fourier transform, that yeast prion Sup35 oligomers showed higher structural uniformity and altere

242 between air and n-octanol as well as 8 other oligomers similar in chemical structure to common compon

243 for the formation of multilayered helical M1 oligomers similar to those observed in virions exposed t

244 Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, ar

245 rational design method for the discovery of oligomer-specific antibodies.

246 e use fluorescence microscopy to measure the oligomer stability and FRET efficiency for homo- and het

247 induces arrestin-3 oligomerization, and this oligomer stabilizes the active conformation of arrestin-

248 closest structural-similar 1st series cyclic oligomer standard as analytical reference.

249 Its oligomers start separating at fields of just 1 kV/cm (4

250 We show that the oligomer states are consistent with polymer micelles tha

251 To establish oligomer structure-membrane activity relationships, mole

252 dies reveal an equilibrium between low-order oligomer structures that differ significantly from previ

253 DAX caps the ends of DIX oligomers, such that a DIX oligomer has at most four DAX

254 Moreover, the IR spectra of individual oligomers suggest structural rearrangement that is neces

255 to both rigid amyloid fibrils and metastable oligomers termed AbetaO or protofibrils.

256 otein: unmodified protein forms a structured oligomer that is suited for nucleocapsid assembly, and p

257 sforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer memb

258 ntified and characterized unexpected mannose oligomers that are alpha(1-2/3) linked.

259 propylene, and butenes into a wide range of oligomers that are highly sought-after in numerous field

260 spectrometry detection (SEC/MS) reveals the oligomers that are protected from lysis due to their tig

261 ansmembrane domain and can form higher-order oligomers that arrange MRAP2 monomers in a parallel orie

262 oduce free oligomers as well as lipid-linked oligomers that can undergo further elongation.

263 Soluble oligomers that form during this process typically contai

264 seases posit that the most toxic species are oligomers that form either along the pathway to forming

265 Cgamma-bimodal PNA oligomers that have two nucleobases per aeg unit are dem

266 is model indicated that mutant FHR5 can form oligomers that possess additional binding sites for C3b

267 P55 and GRASP65, self-interact to form trans-oligomers that tether adjacent Golgi membranes into stac

268 sion from a dormant cytoplasmic protein into oligomers that translocate to, and permeabilize, the pla

269 the synthesis of a series of linear perylene oligomers that undergo endothermic singlet fission and h

270 ocess further enabled information encoded in oligomers to be retrieved through selective hybridizatio

271 rationalized by the enhanced binding of FHR5 oligomers to C3b deposited on host cell surfaces.

272 ary nucleation rate, strong binding of Abeta oligomers to DNAJB6 inhibits the formation of amyloid nu

273 m overload, oxidative stress, and Abeta 1-42 oligomers toxicity.

274 catechol particles and colored water-soluble oligomers under conditions characteristic of viscous mul

275 l question of how intracellular Amyloid-beta oligomers underlie the pathologies of A.

276 aracterization of these trapped, off-pathway oligomers using X-ray crystallography and NMR, providing

277 detection of 0.9 pM for the short synthetic oligomer) using a much simpler and faster protocol (~1 h

278 s been applied for 2nd and 3rd series cyclic oligomers, using the closest structural-similar 1st seri

279 ssembly to enumerate the enzymatic causes of oligomer variability and show how to eliminate each caus

280 The most effective splice correcting oligomer was chosen to treat forced-myogenic cells, deri

281 he existence of a condensed and inactive LPL oligomer was proposed.

282 The separation of oligomers was observed to be significantly better in SGI

283 the lifespan deficit induced by Amyloid-beta oligomers was reduced with Li(+) treatment.

284 all mature amyloid fibrils must originate as oligomers, we found that most Abeta42 oligomers dissocia

285 The majority of oligomers were below the TTC (90 ug/person/day), but the

286 ratio and amount of soluble, fibrillar Abeta oligomers were elevated in Trem2-deficient brains.

287 Three oligomers were synthesized with monomer sequence precise

288 Neither variant formed large oligomers when activated in liposomes.

289 gnals from the various forms of Abeta (1-40) oligomers, whereas a mutational DNAJB6 variant in which

290 ce of Ca(2+) revealed that NS2 forms helical oligomers which, when aligned with the N-terminal domain

291 We propose that by binding to oligomers, which are hypothesized to be the earliest see

292 MR measurements supported formation of these oligomers, which can be bound by photoswitchable anion r

293 ucidate the first atomic structures of Abeta oligomers, which reveal how they form lipid-stabilized p

294 ht scattering identified nonfibrillar ~20-nm oligomers, while at high concentrations elongated fibers

295 Foldamers, which are oligomers with a strong tendency to adopt a specific con

296 ructural rearrangement that is necessary for oligomers with an antiparallel beta-sheet to propagate i

297 he van Leusen reaction, providing conjugated oligomers with backbones consisting of para-linked pheny

298 However, single-layered helical oligomers with biochemical and ultrastructural similarit

299 Our results show that oligomers with specific monomer sequences exhibit unexpe

300 yperfine coupling constants of the PTB7-type oligomers with the high-performance PTB7 polymer reveale