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1 at acutely synaptotoxic PrPSc appeared to be oligomeric.
2 used by soluble forms of PSMalpha3, possibly oligomeric.
5 uromodulatory action of picomolar amounts of oligomeric Abeta(42) (oAbeta(42)) on synaptic glutamater
6 enhances microglial migration in response to oligomeric Abeta(42) in Trem2(-/-) or R47H microglia bot
7 rdened with increasing levels of soluble and oligomeric Abeta, which are known to be the most toxic a
9 gerprints showed how the compositions of the oligomeric adducts had typically only minor differences
13 d inter-strand organization within a 150-kDa oligomeric aggregate of the 42-residue variant of the Al
14 ggregation kinetics and on the production of oligomeric aggregates and link these effects to the affi
16 scenario also promotes formation of soluble oligomeric aggregates capable of seeding de novo rPrP ag
19 ransfer technique we show that monomeric and oligomeric alpha-syn affect G4Qs and i-motifs in a diffe
21 nts carrying the SNCA triplication displayed oligomeric alphaSyn pathology and elevated alphaSyn extr
22 aberrantly elevated neuronal PLD1 is key for oligomeric amyloid driven synaptic dysfunction and under
24 brains.SIGNIFICANCE STATEMENT High levels of oligomeric amyloid-beta(42) (oAbeta(42)) induce synaptic
29 have studied the cellular uptake of soluble oligomeric and fibrillar forms of dGAE and examined the
30 line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that cou
33 on the functional advantages imparted by the oligomeric architecture found in many electron transfer
35 Rhodopsin (Rh) is the only GPCR whose native oligomeric arrangement was revealed by atomic force micr
39 complex from S.aureus exists as two distinct oligomeric assemblies: heterotetramer (YoeB-YefM2-YoeB)
50 have shown that Rep proteins have a dynamic oligomeric behavior where the nature of the DNA substrat
51 E) damage/PRC death by subretinally injected oligomeric beta-amyloid (OAbeta) and observed that ELVs
52 e proximity ligation assay (PLA) to identify oligomeric beta3-subunits, not just at the plasma membra
59 fusion protein assembles into a non-covalent oligomeric complex, exciting their GFP moiety with polar
60 ner mitochondrial membrane in a large hetero-oligomeric complex, whose abundance is regulated by prol
62 ically processed, folded, and assembled into oligomeric complexes and, for noncytosolic proteins, tra
63 idenaturing conditions, identifying distinct oligomeric complexes at the initial time points before t
64 ro and in cells (1,2), BRCA2 associates into oligomeric complexes besides also existing as monomers.
67 t U21 employs the novel mechanism of forming oligomeric complexes with class I MHC molecules that res
68 1 is expressed as a stable protein and forms oligomeric complexes with the nuclear-encoded Clp subuni
70 ep of TDP-43 self-assembly into intermediate oligomeric complexes, whereby these complexes may provid
73 The FtsH3 homolog is present in two hetero-oligomeric complexes: FtsH2/3, which is responsible for
74 that can be created by combining two chiral oligomeric components (e.g., proteins) in precise config
76 is complexes (CSCs) that are obligate hetero-oligomeric, comprising three non-interchangeable cellulo
77 Binding of DSS1 to RAD52 changes the RAD52 oligomeric conformation, modulates its DNA binding prope
78 stribution, oligomerization, and activity of oligomeric CPEB3, a critical player in the persistence o
79 ent with the hypothesis that obligate hetero-oligomeric CSCs evolved independently in mosses and seed
82 nes were screened for the presence of crown (oligomeric cyclic) procyanidins with 4, 5 or 6 (epi)cate
83 unique junctions between monomeric and homo-oligomeric de novo designed and ankyrin repeat proteins
84 aching can critically skew the estimation of oligomeric distributions, so that low abundance monomers
85 , which probed the charged axial surfaces of oligomeric DNA preferentially over the uncharged termini
86 network and "free" segments belonging to an oligomeric electrolyte hosted in the network pores, one
89 n-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signali
90 explain the characteristics of interfaces in oligomeric enzymes and their effects on catalytic activi
91 se that such sequential electron transfer in oligomeric enzymes serves as a regulatory mechanism to e
94 interaction between photosystems and higher oligomeric FCPs, comprising Lhcf8 as the main component.
96 itions previously associated with a disputed oligomeric form exhibits secondary structure, dynamics,
97 coupled to reassociation into the functional oligomeric form leads to enhanced reactivity with locali
98 his study, we tested the hypothesis that the oligomeric form of amyloid-beta (oAbeta(42)), interactin
99 folded similarly in excised domains and this oligomeric form of apo fl TIA1, based on NMR chemical sh
104 lar Abeta, a neuropeptide largely present in oligomeric form, rise by orders of magnitude many years
107 r's disease (AD), and application of soluble oligomeric forms of Abeta produces AD-like impairments i
108 direct experimental evidence that it is the oligomeric forms of Abeta that are captured by DNAJB6 in
110 ination, we speculate that the monomeric and oligomeric forms of BRCA2 might be active for different
113 found that M204-scFv itself partitions into oligomeric forms that inhibit seeding differently, and c
114 en-like domain, and it occurs in three major oligomeric forms that self-assemble: trimers, hexamers,
119 ta (FLH), and Megathura crenulata (KLH), are oligomeric glycoproteins with complex dodecameric quater
120 rograde transport and binds to the conserved oligomeric Golgi (COG) complex and multiple retrograde G
121 ons between ATP7 paralogs with the conserved oligomeric Golgi (COG) complex, a Golgi apparatus vesicu
123 o establish that the proportions of distinct oligomeric HEXIM1 subpopulations define the apparent ano
126 ng the retromer sorting mechanism posit that oligomeric interactions between retromer and associated
128 n of serine at four sites mapping to crucial oligomeric interfaces in human alphaA- and alphaB-crysta
130 toward aggregation and the stabilization of oligomeric intermediates did not always correlate with a
134 ribute these differences to the existence of oligomeric intermediates, sampling various membrane-boun
135 nd dynamic network analyses showed that this oligomeric latch is conserved across DNA sliding clamps
136 luenza virus, matrix protein 1 (M1) forms an oligomeric layer critical for particle stability and pH-
137 junctions were examined over a wide range of oligomeric layer thickness (d) values from 4 to 60 nm.
143 alpha-toxin in their soluble, monomeric, and oligomeric membrane-inserted pore states in complex with
147 monomeric multifunctional enzyme L, and the oligomeric multimodular adapter P of Mononegavirales We
149 ive unit of procyanidins with an aDP of 6.8 (oligomeric native procyanidins) according to the phlorog
156 l data, we suggest structural models for the oligomeric pinhole (right-handed heptameric TMD2 bundle)
157 entrated on the fundamental understanding of oligomeric/polymeric and particulate species involved in
158 cated a close mutual association, the higher oligomeric pool is only weakly associated with the photo
159 ously reported the formation of two distinct oligomeric pools of IBV E in transfected and infected ce
163 1 and anti-osteocalcin antibodies, detecting oligomeric, prefibrillar structures or fibrillar species
165 howed that organic cultivation increased the oligomeric proanthocyanidin and anthocyanidin contents a
166 udies regarding composition and evolution of oligomeric proanthocyanidin-anthocyanin adducts in red w
169 lly processed coconut water, the increase in oligomeric procyanidins as A-type dimer and trimer may b
170 tannin oxidation on their self-association, oligomeric procyanidins were oxidized in a model solutio
171 ze and apparent modes of initiation, and the oligomeric products of some of these formed self-organiz
172 he membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perf
173 elles of the innate immune system consist of oligomeric protein complexes known as supramolecular org
174 an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecul
175 ANGPT2(443) is a naturally occurring, lower oligomeric protein isoform whose expression is increased
186 y self-assembles into microtubule-encircling oligomeric rings, which are proposed to function as coll
190 ase) proteolytic machinery consisting of two oligomeric segments, a barrel-shaped heterotetradecameri
193 ion of perylene core with several polyhedral oligomeric silsesquioxane (POSS) cages achieved spherica
195 of MXene and amine-functionalized polyhedral oligomeric silsesquioxane at the oil-water interface, we
196 prise a triphenylene core and six polyhedral oligomeric silsesquioxane cages grafted onto it through
197 tween the core and the peripheral polyhedral oligomeric silsesquioxane cages, and exhibits a relative
200 od to the data obtained from a heterogeneous oligomeric solution of human islet amyloid polypeptide.
201 lations suggest this can be formulated as an oligomeric species comprising H-bonded amine-borane addu
204 Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales comparabl
205 ) may also act as a receptor for neurotoxic, oligomeric species of other proteins that are linked to
207 f a small molecule to reduce the toxicity of oligomeric species represents a potential therapeutic st
209 fluorescent tags, the sizes of the detected oligomeric species varied significantly depending on the
214 s to luminal calcium depletion, changing its oligomeric state and acting as a reductase to refill ER
215 nal calcium levels, dynamically changing its oligomeric state and enhancing its redox-dependent inter
216 site, provides a mechanism for coupling the oligomeric state and enzymatic activity of FICD to the e
217 e never been isolated and their composition, oligomeric state and functional properties have not been
218 or ergosterol in fungi may regulate the VDAC oligomeric state and may provide a potential target for
221 Hence, utilizing pressure-jump NMR, the oligomeric state can be studied at residue-specific reso
222 mounts of oligomers, which are also of lower oligomeric state compared to Abeta(1-42) oligomers.
223 TbGMPR by facilitating the transition of its oligomeric state depending on ligand nucleotide availabi
227 nsmembrane domain might directly control the oligomeric state of p24 and, thus, COP vesicle formation
231 tochondrial protein import by regulating the oligomeric state of the major protein import gate, the T
232 bridges DNA in a manner that depends on the oligomeric state of the protein, and truncated mutants d
233 e (CNBr) cleavage; (ii) determination of the oligomeric state of TMDs in bicelles; (iii) detection of
234 llergens to test the effects of affinity and oligomeric state on IgE binding and effector cell activa
236 and transition states, as well as the active oligomeric state or the "resistosome," have afforded a q
237 permeability transition pore (mPTP) but the oligomeric state required for channel formation is being
238 allowing measurement of the membrane protein oligomeric state within an intact lipid bilayer environm
239 t DDR2 ECD proteins in monomeric, dimeric or oligomeric state, and MC3T3-E1 cells expressing full-len
240 helicases is regulated by two factors: their oligomeric state, and the conformation of the flexible s
241 al tweezers assay, we explore the effects of oligomeric state, DNA geometry, and duplex stability on
242 highly frustrated regardless of the protein oligomeric state, overall topology, and enzymatic class.
243 l activation is linked to allergen affinity, oligomeric state, valency, and spacing of IgE-binding ep
244 phaHL micelle complexes are found to contain oligomeric state-proportional numbers of detergent molec
250 Our findings demonstrate that quantifying oligomeric states alone does not allow for a deep unders
251 bilayer, the connection between intermediate oligomeric states and lipid reorganization during pore f
252 We provide a review of TSPO monomeric and oligomeric states and their conformational flexibility,
255 of such putative assemblies and their exact oligomeric states is however complicated by a high level
257 s of known sizes and was used to uncover the oligomeric states of the epidermal growth factor recepto
263 exes by using the CCS, molecular weight, and oligomeric states to mine the Protein Data Bank (PDB) fo
266 ds that change protein conformation, mediate oligomeric states, and facilitate downstream coupling of
267 doxins are known to switch between different oligomeric states, depending on redox state, pH, posttra
268 ngs indicate that mtSSBs can adopt different oligomeric states, ranging from stable tetramers to stab
269 re of sparsely populated [Formula: see text] oligomeric states, yet still eventually forms fibrils.
274 f tau imaging agent for the detection of tau oligomeric strains and differential diagnosis of the tau
275 oroplast glutamyl peptidase (CGEP) is a homo-oligomeric stromal Ser-type (S9D) peptidase with both ex
276 er oligomers in cell membranes and show that oligomeric structure becomes more complex as receptor ex
277 In conclusion, the results predict a hetero-oligomeric structure for the T. cruzi MCU complex, with
278 thiourea derivative-rapidly destabilizes the oligomeric structure, whereas AMD3100, another well-char
280 ate the reported cytotoxicity to the peptide oligomeric structures and their interactions with membra
281 This fact, together with recent growth of oligomeric structures in the Protein Data Bank (PDB), de
284 rdered interface present in free monomers or oligomeric subunits may be a general, functional feature
285 ike an assembly line for monomeric and small oligomeric subunits of Abeta to increase their aggregati
287 ctive excitation of a pai-conjugated diblock oligomeric system featuring tetrathiophene (T(4)) and te
288 perone activity released monomeric and small oligomeric Tau species, which induced the aggregation of
290 uppression did not protect against exogenous oligomeric tau-induced impairment of long-term synaptic
294 the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates eith
295 ystallographically solved structures of homo-oligomeric transmembrane proteins (HoTPs) and find that
297 MHC molecules that result in sorting of the oligomeric U21/class I MHC complexes to Golgi--derived q
298 ngsta (WO(3) ) also promote the formation of oligomeric vanadia (V(2) O(5) ) sites, showing that prom
299 gressive addition of vanadia to TiO(2) forms oligomeric vanadia structures and reveals a proportional