ライフサイエンスコーパス: oligomerization

1 of K153Del-associated defects in PRPH2/ROM1 oligomerization.

2 , and a hub domain, which is responsible for oligomerization.

3 sights into the molecular origins of DNAJB6b oligomerization.

4 both of which are necessary for proper Gle1 oligomerization.

5 tochondrial outer membrane translocation and oligomerization.

6 s determines its subnuclear localization and oligomerization.

7 o the purified DR5 ectodomain and induce its oligomerization.

8 ss several subunits, that contribute to FliD oligomerization.

9 at impairs its phosphorylation and restricts oligomerization.

10 quence that balances folding, stability, and oligomerization.

11 riven by both genetic variation and receptor oligomerization.

12 olecular disulfide bonds that result in TFEB oligomerization.

13 ease domain activated through ligand-induced oligomerization.

14 n part determined by distinct modes of their oligomerization.

15 nnel Kv2.1, which undergoes disulfide bridge oligomerization.

16 t receptor predimerization to ligand-induced oligomerization.

17 omain of TRIM21, enhancing p62 stability and oligomerization.

18 structural compactness and thereby enhances oligomerization.

19 ders inflammasome assembly by blocking their oligomerization.

20 tion are observed to stem from this enhanced oligomerization.

21 interaction surface essential for high-order oligomerization.

22 require binding but also receptor-dependent oligomerization.

23 of ssDNA loops, an ability inhibited by A3G oligomerization.

24 otein folding intermediates and irreversible oligomerization.

25 form "networks," which increase the speed of oligomerization.

26 rus (VSV), we determined the importance of P oligomerization.

27 (mHTT) toxicity is caused by its aggregation/oligomerization.

28 trate that xanthine derivatives inhibit MLKL oligomerization.

29 blue-light inhibitors of CRYs) suppress homo-oligomerization.

30 (F349A), which selectively destabilizes Syt1 oligomerization.

31 ral genome, plays a major role via symmetric oligomerization.

32 raction with FBP and causing a disruption in oligomerization.

33 association nor accessory factors potentiate oligomerization.

34 nd the SAS-6 head domain and inhibit protein oligomerization.

35 tophagy by binding p62 and interference with oligomerization, a critical step of p62 function.

36 and USP28 in cells and show that modulating oligomerization affects substrate stabilization in accor

37 as a surprising positive correlation between oligomerization affinity and SERCA-binding.

38 al an evolutionary principle whereby protein oligomerization allows evolutionary change to accumulate

39 feine, a widely consumed drug that undergoes oligomerization and aggregation in aqueous solutions.

40 with the latter being inactive and prone to oligomerization and aggregation.

41 f OAS2 that enhance our understanding of the oligomerization and catalytic function of OAS enzymes.

42 osphomimetics of HDA15 partially disrupt its oligomerization and cause loss of enzymatic activity and

43 Here, we compared the impact of IP(6) on oligomerization and conformational equilibrium of the hi

44 ion, GA holds potential for preventing Abeta oligomerization and deposition in the brain.

45 tial pathogenic effects of Abeta-IAPP hetero-oligomerization and development of IAPP based therapies

46 Furthermore, mutations altering Ctp1 oligomerization and DNA bridging in vitro conferred cell

47 about the mechanisms and species involved in oligomerization and fibril formation.

48 We demonstrate that hIAPP promotes Abeta oligomerization and formation of small oligomer and larg

49 n has been shown to be important for protein oligomerization and formation of transmembrane pores, wh

50 st a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for pIgR binding a

51 aled striking conformational consequences of oligomerization and insight into the macromolecular stru

52 ults show the importance of high ATP in DnaA oligomerization and its dependence on the His136 residue

53 the mechanistic details surrounding receptor oligomerization and its potential dynamic regulation rem

54 d spines; and tau phosphorylation, cleavage, oligomerization and missorting.

55 ich disabled DRP1, preventing its high-order oligomerization and mitochondrial fragmentation function

56 l functions are also critically dependent on oligomerization and nucleation of transcriptional comple

57 dered regions can facilitate domain swapping oligomerization and other tightly regulated association

58 doplasmic reticulum stress-induced IRE1alpha oligomerization and phosphorylation, and inhibited endor

59 to inhibiting caspase cleavage to disrupting oligomerization and pore formation.

60 lesser extent, glycine-91) disrupted IFITM3 oligomerization and reduced its antiviral activity again

61 prebiotically abundant and capable of facile oligomerization and self-assembly.

62 21-mediated p62 ubiquitination abrogates p62 oligomerization and sequestration activity and negativel

63 rgy transfer (FRET) to quantify micropeptide oligomerization and SERCA-binding.

64 d speck-like protein containing a CARD (ASC) oligomerization and speck formation.

65 Mechanistically, Tn/STn antigens impair homo-oligomerization and stability of DR4 and DR5.

66 export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the

67 n linker in the full-length protein promotes oligomerization and thus may play a role in assembly of

68 aSyn by methylglyoxal (MGO) potentiates its oligomerization and toxicity, induces dopaminergic neuro

69 HlyA also promotes deubiquitination, oligomerization, and activation of the NLRP3 inflammasom

70 del whereby SUMO regulates the distribution, oligomerization, and activity of oligomeric CPEB3, a cri

71 n inform regarding protein sample purity and oligomerization, and additional tandem mass spectra can

72 tion with caspases, limiting its processing, oligomerization, and capacity to induce cell death.

73 rving protein ligand-substrate interactions, oligomerization, and conformational dynamics of OMPs in

74 d on 3-step processes featuring dehydration, oligomerization, and hydrogenation, the consolidated alc

75 ediates, whose structures, potentially toxic oligomerization, and interactions with cellular chaperon

76 pathways leading to symmetric higher-ordered oligomerization, and thereby affect crucial replication

77 ng surface of arrestin-3, induces arrestin-3 oligomerization, and this oligomer stabilizes the active

78 uding cancer cell invasion, while stable FAK oligomerization appears to be needed for optimal cancer

79 racellular distribution, co-localization and oligomerization, applying comprehensive live, single-cel

80 utant strains defective in metal sensing and oligomerization are attenuated for virulence in a mouse

81 s Y25, K28, and K29 that are involved in NS5 oligomerization are essential for localization and inter

82 Protein dimerization and oligomerization are essential to most cellular functions

83 The kinetics of these protein oligomerizations are difficult to quantify by traditiona

84 ULK1 phosphorylation inhibits Exo70 homo-oligomerization as well as its assembly to the exocyst c

85 ve CASQ2-p.R33Q variant were evaluated using oligomerization assays and their locations mapped to a r

86 nucleotide concentration, which allows DnaA oligomerization at the replication origin but the associ

87 complexes by drugs that prevent or block VWF oligomerization attenuate thrombus formation in a murine

88 sses with inhibition mechanisms involving R1 oligomerization belong to a clade separated from the two

89 Such oligomerization bested the conventional hybridization ch

90 within the C-terminal coiled-coil disrupted oligomerization, binding, and function of Coy1.

91 parent average number of molecules and their oligomerization (brightness) in each pixel from a series

92 he predicted coiled coils does not alter AAD oligomerization but does impair binding of the AADs to A

93 h a previously unknown fold has no impact on oligomerization, but N-terminal regions affect the dimer

94 ependent adoption of toxic conformations and oligomerization, but not filamentous aggregation.

95 are proposed to trigger CSPalpha aggregation/oligomerization, but the mechanism of oligomer formation

96 on, the consolidated alcohol dehydration and oligomerization (CADO) approach described here results i

97 used by nigericin or ATP, and subsequent ASC oligomerization caused by several inflammasome-activatin

98 eneck of MAC formation, after which rapid C9 oligomerization completes the pore.

99 gulated by multiple mechanisms which include oligomerization, conformational changes to aid substrate

100 zation, underscoring synergy among different oligomerization contact regions along the RAGE sequence.

101 cterized by dynamic HTHs that move around an oligomerization core, generating discrete binding crevic

102 d with pyridine-based aldehydes, and dynamic oligomerization could be achieved, leading to nitroaldol

103 An oligomerization-defective variant was used to reveal tha

104 High expression of oligomerization-deficient arrestin-1 resulted in rod dea

105 Here, we describe oligomerization-deficient Caspase-8(F122GL123G/F122GL123

106 of arrestin-1 self-association, we expressed oligomerization-deficient mutant in arrestin-1 knock-out

107 We show that the oligomerization-deficient mutant is capable of quenching

108 ognition of effectors by NLRs leading to the oligomerization-dependent activation of a plant resistos

109 ide, and sulfatide, via the C1q domain in an oligomerization-dependent fashion.

110 nactive state of DUOX1-DUOXA1, suggesting an oligomerization-dependent regulatory mechanism.

111 nate immune cells through nucleotide-binding oligomerization domain (NOD) 1 and/or NOD2 receptors.

112 advances on the roles of nucleotide-binding oligomerization domain (NOD)-like receptors and DEAD-box

113 The nucleotide-binding oligomerization domain (NOD)-like receptors belong to th

114 ways involving fungal nucleotide binding and oligomerization domain (NOD)-like receptors that were fo

115 sing cryoelectron microscopy, as well as the oligomerization domain (OD) of P at 1.4- angstrom resolu

116 stomatitis virus (VSV) P is dimeric with an oligomerization domain (OD) separating two largely disor

117 capping (Cap) domains of L interact with the oligomerization domain (P(OD)) and C-terminal domain (P(

118 Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular patt

119 -dioxygenase 1 (IDO1) through the nucleotide oligomerization domain 2 (NOD2) and epidermal growth fac

120 study identifies the role of the N-terminal oligomerization domain of angiopoietin-2 in vascular rem

121 cogenic activity is rescued by the synthetic oligomerization domain of FKBP, which confers conditiona

122 r molecule, IRF-3, HIF-1, nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin p

123 protein 1, IFNbeta-1, and nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin p

124 linker IDR, as well as the folded C-terminal oligomerization domain, while the folded N-terminal doma

125 The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agoni

126 Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause

127 ore effectively activates nucleotide-binding oligomerization domain-containing protein 2 (NOD2) in ma

128 ceptor (CCR) 2, CCR5, and nucleotide-binding oligomerization domain-containing protein 2 signaling an

129 ding Toll-like receptors, nucleotide-binding oligomerization domain-containing receptors, lymphocyte

130 res processing by the the nucleotide-binding oligomerization domain-like receptor family, pyrin domai

131 rived macrophages via the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3).

132 e innate immune molecule, nucleotide-binding oligomerization domain-like receptors (NLR) family CARD

133 mplate-binding domain separated by a central oligomerization domain.

134 Extracellular ligand oligomerization, domain-domain interactions, and binding

135 Nucleotide oligomerization domains 1 and 2 (NOD1/2) are PRRs that r

136 Conversely, the observed diversification of oligomerization domains may facilitate stable co-existen

137 ion of a series of mutations that impact the oligomerization domains of the Gle1A and Gle1B isoforms.

138 and imaging techniques, we have examined the oligomerization dynamics of the GFP-tagged mitochondrial

139 propose that MISR functions in higher-order oligomerization either directly, as an interaction inter

140 find that GFP-tagged Drp1 exhibits impaired oligomerization equilibria in solution that corresponds

141 We conclude that sHsp hetero-oligomerization exerts distinct regulatory effects depen

142 damage caused by light-induced Amyloid-beta oligomerization from Amyloid-beta expression alone.

143 us site in IFITM3, glycine-95, drive protein oligomerization from within a GxxxG motif.

144 pe, but is also affected by variations in Hp oligomerization, glycosylation, and proteolytic processi

145 Monitoring of protein oligomerization has benefited greatly from Forster Reson

146 od for controlling living macromolecular HCR oligomerization in a manner analogous to the controlled

147 indicates that the EZH2 TAD mediates protein oligomerization in a noncanonical PRC2 context and is en

148 ds we identify critical residues for DNAJB6b oligomerization in its C-terminal domain (CTD).

149 er oligomers, but measuring membrane protein oligomerization in lipid membranes is particularly chall

150 f the mitochondrial residence of BAX and its oligomerization in promoting membrane permeabilization a

151 ine the biological role of visual arrestin-1 oligomerization in rod photoreceptors, we expressed muta

152 s, and show that human CD11b-I induces LukGH oligomerization in solution.

153 Gaussian chains, or a partial unfolding with oligomerization in tetramers mediated by disulfide bridg

154 Encoding of CFC increases Abeta oligomerization in the hippocampus but not in the amygda

155 it to successfully characterize protein homo-oligomerization in the NE.

156 previously shown to be essential for protein oligomerization in vitro and for function in centriole a

157 r picture of how Ca(2+) binding triggers hCP oligomerization, increases protease stability, and enhan

158 Our results reveal a mechanism of oligomerization-induced Robo activation for axon guidanc

159 It couples to W34 across the oligomerization interface based on specific His/Trp ring

160 mutational analyses suggested that the ExoY oligomerization interface plays a crucial role in mediat

161 e functional unit, and suggests a reversible oligomerization interface.

162 We identify two oligomerization interfaces mediated by non-catalytic dom

163 We find that PGAM5 oligomerization into a dodecamer is not only essential f

164 ng that localization to the plasma membrane, oligomerization into a matrix layer, and generation of m

165 The resulting propene then undergoes oligomerization into six-carbon olefins before polymeriz

166 lar determinants required to mediate protein oligomerization, intramolecular conformational switch, a

167 /without substrates, apparently by promoting oligomerization involving binding to the C-terminal regi

168 Thus, inhibiting VDAC oligomerization is a potential therapeutic approach for

169 In-membrane oligomerization is decisive for the function (or dysfunc

170 The HD oligomerization is driven by an interdomain linker regio

171 rially reinforce each other, suggesting coat oligomerization is driven by the cumulative effects of m

172 Oligomerization is induced by an interaction of its ZM d

173 rapidly increase to ca. 1000 s(-1) after the oligomerization is initiated.

174 Gle1 oligomerization is necessary for many, but not all aspec

175 in the presence of P(DeltaOD) We conclude P oligomerization is not required for mRNA synthesis but e

176 Chaperone oligomerization is often a key aspect of their function.

177 mediates production, nickel-catalyzed olefin oligomerization is still a very dynamic topic, with many

178 Oligomerization is terminated upon upregulation of short

179 The driving force for Dvl2 oligomerization is the increased concentration of membra

180 The biological role of its oligomerization is unclear.

181 ch involves a preliminary stage of acetylene oligomerization, is shown to be kinetically less favorab

182 Beyond this distance, the oligomerization kinetics appears to be diffusion control

183 This newly identified Zn-induced oligomerization mechanism may be a part of a pathway dif

184 ter understand the distribution of different oligomerization mechanisms, we characterized the enzyme

185 Membrane protein oligomerization mediates a wide range of biological even

186 The mode of oligomerization might regulate the function of other sig

187 osolic regions) and compare the results with oligomerization modes of its four truncated fragments.

188 construction of metal/pH-switchable protein oligomerization motifs, and 3) generate a robust metal c

189 t bEBPs require nucleotides to stimulate the oligomerization necessary for function, our previous stu

190 eractions, we evaluated the possibility that oligomerization occurs at the expense of SERCA-binding.

191 of PsK domain of MLKL is a key step towards oligomerization of 4HB domain that causes cell death.

192 re, we study the earliest events involved in oligomerization of a minimalistic construct, htt(NT)Q(7)

193 We explored here the oligomerization of a structurally diverse set of prebiot

194 Changes in the oligomerization of AceR to enable interaction between RN

195 w that, although both expression and induced oligomerization of Amyloid-beta were detrimental to life

196 up to ~300 MPa causes irreversible covalent oligomerization of BLG.

197 Angle X-ray Scattering (SAXS) to investigate oligomerization of DnaA in solution.

198 Oligomerization of DNMT3A and DNMT3B permits both enzyme

199 d versatile reactivity of nickel enables the oligomerization of ethylene, propylene, and butenes into

200 lity of deliquescent minerals to mediate the oligomerization of glycine during iterative wet-dry cycl

201 nding the autoinhibition, lipid binding, and oligomerization of GSDMD by using overlapping interfaces

202 o patients, CLN4 mutations induced excessive oligomerization of hCSPalpha and premature lethality in

203 eins in the ER lumen induce dimerization and oligomerization of IRE1, triggering kinase trans-autopho

204 the c-Abl kinase by DNA damage triggers the oligomerization of IRE1alpha to catalyze RIDD.

205 relevance of TNFR1 clustering for signaling, oligomerization of ligand-free and ligand-activated TNFR

206 A novel method for controlling the oligomerization of metastable DNA hairpins using the hyb

207 Scaffolding protein also catalyzes oligomerization of monomeric portal protein into dodecam

208 The resulting oligomerization of mutant CSPalpha causes its mislocaliz

209 This allows oligomerization of mutant CSPalpha via ectopic binding o

210 pharmacological iron chelation mitigates the oligomerization of mutant CSPalpha, accompanied by parti

211 In addition, oligomerization of OAS isozymes, potentially OAS1 and OA

212 Interfering with the oligomerization of P may represent a general strategy to

213 ely used driving force for membrane-mediated oligomerization of proteins in general.

214 obe intermediate states during unfolding and oligomerization of proteins remains a major challenge.

215 The oligomerization of PrP in mM1000 could be substantially

216 Collectively, these findings support that oligomerization of PrPSc into small multimeric assemblie

217 Ligand-dependent oligomerization of receptor tyrosine kinases (RTKs) resu

218 , and 2,5-dialkylpyiridines were produced by oligomerization of short-chain aldehydes in the presence

219 TING and support a model in which high-order oligomerization of STING and TBK1, induced by cGAMP, lea

220 hboring TatB molecule and to thereby mediate oligomerization of TatB within the TatBC receptor comple

221 Albicin induces oligomerization of the complex in solution, suggesting t

222 Centriole assembly requires oligomerization of the essential protein spindle assembl

223 polypropylene copolymers (PP-Tann) retarded oligomerization of the linseed oil.

224 compensate for the entropic loss due to the oligomerization of the monomers.

225 Oligomerization of the oxidized linseed oil was assessed

226 ollowing infection or injury begins with the oligomerization of the upstream inflammasome-forming sen

227 play central roles in the proper folding and oligomerization of these proteins.

228 Higher-ordered oligomerization of this protein forms hexagonally patter

229 Since oligomerization of thylakoid curvature protein (CURT1A)

230 the formation of protein filaments to drive oligomerization of TIR effector domains and rapid NAD(+)

231 correlation spectroscopy for the analysis of oligomerization of transmembrane proteins in cell-derive

232 We find that oligomerization of VSV P is not required for any step of

233 ncluding their formation by cyclizations and oligomerizations of aldehydes and creatinine under usual

234 Collectively, PACs with a higher degree of oligomerization offer a robust bioadhesion between the h

235 unbinding component likely results from Zur oligomerization on chromosome involving inter-protein sa

236 ubules, with a closed conformation favouring oligomerization on microtubules.

237 and multiple interfaces align to promote FAK oligomerization on the membrane.

238 gomers in vivo However, the impact of hetero-oligomerization on their structure and chaperone mechani

239 helicases are inefficient and require either oligomerization or assistance from other partner protein

240 hese mutations either impair UGDH stability, oligomerization, or enzymatic activity.

241 he cell, which then are secreted and undergo oligomerization outside the cell.

242 embly dynamics, persistent Drp1 higher-order oligomerization over membranes is sufficient for mitocho

243 Deliquescent mixtures can foster yields of oligomerization over ten-fold higher than non-deliquesce

244 We establish a pH-dependent oligomerization pathway forming tetrameric DEC-205 using

245 lates the kinetics of the transient branched oligomerization pathway that precedes nucleation, result

246 urthermore, we suggest the relevance of this oligomerization pathway within a cellular setting, where

247 profilin-htt(ex1) complexes, the productive oligomerization pathway, leading to the formation of hel

248 re, we provide basic characterization of the oligomerization patterns of full-length RAGE (including

249 nd irreversible coupling of antigens onto an oligomerization platform.

250 g of structural changes occurring during the oligomerization process.

251 Massive SRSF7 binding to these sites and its oligomerization promote the assembly of large nuclear bo

252 separate domains and highlight the enhanced oligomerization properties of full-length RAGE.

253 stability of the dimeric SecYEG complex and oligomerization properties of SecA were strongly comprom

254 e examine non-Coulombic ionic effects on the oligomerization properties of sliding clamps.

255 Here we show that C2B domain-dependent oligomerization provides the molecular basis for the Syt

256 mistry of the duplex formed in the templated oligomerization reaction to give exclusively the antipar

257 However, for oligomerization reactions using copper-catalyzed azide a

258 Thus, oligomerization reduces the cytotoxicity of arrestin-1 m

259 Thus, oligomerization reduces the cytotoxicity of high levels

260 and protein-membrane interactions to protein oligomerization remain poorly understood.

261 Moreover, the unique oligomerization/SERCA-binding profile of DWORF is in har

262 alization can promote transmembrane receptor oligomerization, shield proteins from enzymatic degradat

263 Spy&Go, combined with simple oligomerization, should have broad application for explo

264 , our study demonstrates that disrupting LDH oligomerization state by targeting their tetramerization

265 in-membrane oligomers and correlating their oligomerization state with membrane pore formation.

266 of which reflects a more dynamic native Drp1 oligomerization state.

267 imited red-shifting, and a non-ideal dimeric oligomerization state.

268 RAM with lipid membranes is dependent on its oligomerization state.

269 allosterically regulate kinase activity and oligomerization state.

270 erent chemotypes differentially regulate its oligomerization state.

271 ny cases, it is unclear whether the obtained oligomerization states are functionally relevant or are

272 uced by DNA binding, and suggest that higher oligomerization states are important for the gene regula

273 brane proteins are able to utilize different oligomerization states to achieve particular activities,

274 e-inserted oligomers and the hereby obtained oligomerization states were intuitively related to the f

275 involved in nucleic-acid binding and protein oligomerization, such as a C(2) H(2) -zinc finger (ZF),

276 Calcium-dependent HrpZ1 oligomerization targets ATG4b-mediated cleavage of ATG8

277 Our results confirm known oligomerization tendencies of separate domains and highl

278 e complex in solution, suggesting that it is oligomerization that leads to stabilization on SPR surfa

279 th partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell.

280 d nearby stem II three-way junction nucleate oligomerization through cooperative binding of two Rev m

281 photoreceptors undergo photoresponsive homo-oligomerization to become physiologically active, and BI

282 HP1 is proposed to use oligomerization to compact chromatin into phase-separate

283 e metal-dependent exopeptidases that rely on oligomerization to diversify their functional roles.

284 pecific regulatory events that promote Dam1c oligomerization to ensure accurate segregation.

285 We propose that Cdk1 activity promotes Dam1c oligomerization to ensure that kinetochore-microtubule a

286 lasma membrane, has been observed to undergo oligomerization to form clusters.

287 comprehensive analysis of Ca(2+) binding and oligomerization to hCP without modifying the protein in

288 onal changes from soluble to pore forms, and oligomerization to produce the active pore.

289 tically alters the outcome of metal-directed oligomerization to yield a new trimeric architecture, (T

290 r the major role of the C2 and TM domains in oligomerization, underscoring synergy among different ol

291 ling a form of monomeric hMLKL necessary for oligomerization upon phosphorylation as compared to apo

292 nown to play an important regulatory role in oligomerization, was severely inhibited by serine epimer

293 he domains responsible for RNase activity or oligomerization, were required for MCPIP1-mediated viral

294 es of N (N(Delta30)) is required to impair N oligomerization, whereas the presence of a full-length C

295 to 0.54/mum(2) Wnt3a also leads to increased oligomerization which raises the weighted mean size of D

296 on involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at endoplasm

297 reveals structural transitions required for oligomerization, which include the lateral movement of a

298 rmits quantitative assessment of cytoplasmic oligomerization, while stepwise photobleaching and singl

299 n themselves, understanding the mechanism of oligomerization will further our understanding of how ch

300 ecome soluble under harsh conditions through oligomerization with DNA.