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1 they are predicted to be cleaved by a prolyl oligopeptidase.
2 idase IV, dipeptidyl peptidase 9, and prolyl oligopeptidase.
3  than the analogous Y473F mutation of prolyl oligopeptidase.
4 , act separately from SPP as a novel stromal oligopeptidase.
5 ability of peptidase IImes to act also as an oligopeptidase.
6 acts and synthetic peptides, an enzyme named oligopeptidase 1 (OLP1) was found that catalyzes the cle
7 es dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in n
8 Escherichia coli encodes the metalloprotease oligopeptidase A (OpdA).
9                          We found that among oligopeptidases, a residue of the catalytic apparatus is
10 The group B streptococcal enzyme also showed oligopeptidase activity and degraded a variety of small
11 ial covalent reversible inhibitors of prolyl oligopeptidase activity.
12                    Additionally, with prolyl oligopeptidase and aminopeptidase B we identified two ne
13 opeptidase class of serine proteases, prolyl oligopeptidase and oligopeptidase B, showed that resonan
14  (TOPs) TOP1 (also referred to as organellar oligopeptidase) and TOP2 (also referred to as cytosolic
15 including DPP-4, DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase.
16 e cytosol, endopeptidases, especially thimet oligopeptidase, and aminopeptidases degrade many proteas
17 ase) and TOP2 (also referred to as cytosolic oligopeptidase) are essential components in plant respon
18                                              Oligopeptidase B (OPB) is a serine peptidase with dibasi
19 the activity of a T. cruzi serine peptidase, oligopeptidase B (OPB).
20 ity followed by mass spectrometry identified oligopeptidase B (OPB; Clan SC, family S9A) as the respo
21                                              Oligopeptidase B (OpdB) is a serine peptidase broadly di
22 QS-active peptidases identifies two enzymes, oligopeptidase B and metallocarboxypeptidase 1, that sig
23 or OPB and provide the first structure of an oligopeptidase B at high resolution.
24 85-residue peptide with high homology to the oligopeptidase B family in prokaryotes and eukaryotes.
25 work implicated the T.cruzi serine hydrolase oligopeptidase B in the generation of Ca2+-signaling act
26  of the QS signal, with peptidase release of oligopeptidase B mediated via an unconventional protein
27 n defect is associated with the inability of oligopeptidase B null mutant trypomastigotes to mobilize
28           Our data suggest that the T. cruzi oligopeptidase B participates in processing events in th
29                        Exogenous recombinant oligopeptidase B reconstitutes the oligopeptidase B-depe
30 id t-butoxycarbonyl-(D)Val-Leu-(L)boroArg to oligopeptidase B resulted in potent, slow binding inhibi
31 e we show that deletion of the gene encoding oligopeptidase B results in a marked defect in host cell
32                                 The T. cruzi oligopeptidase B was expressed as a fully active product
33  serine proteases, prolyl oligopeptidase and oligopeptidase B, showed that resonances corresponding t
34 he H652A and H652Q active center variants of oligopeptidase B, there are two resonances observed in t
35 evealed a novel enzyme, denominated T. cruzi oligopeptidase B, which is homologous to members of the
36 combinant oligopeptidase B reconstitutes the oligopeptidase B-dependent Ca2+ signaling activity in nu
37 yl endopeptidase and the bacterial peptidase oligopeptidase B.
38 de chain to form the oxyanion hole is prolyl oligopeptidase, but the Y44F mutation of cocE has a more
39 ies between the active centers of the prolyl oligopeptidase class of serine proteases and the pancrea
40 on NMR spectra for two members of the prolyl oligopeptidase class of serine proteases, prolyl oligope
41 e-substituted dirhodium catalyst to a prolyl oligopeptidase containing a genetically encoded L-4-azid
42 his study suggests that inhibition of prolyl oligopeptidase could help to ameliorate tau-dependent ne
43                                       Thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.
44 ls overexpressing mouse neurolysin or thimet oligopeptidase (EC 3.4.24.15), a closely related metallo
45 peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the
46 which is homologous to members of the prolyl oligopeptidase family of serine hydrolases, known to par
47  triad residues characteristic of the prolyl oligopeptidase family of serine proteinases (Ser-Asp-His
48 d sequence showed 66.4% identity to the PepF oligopeptidase from Lactococcus lactis, a member of the
49 structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revea
50   This mutant lacks the Dictyostelium prolyl oligopeptidase gene (dpoA).
51 more, the expression of secreted trypanosome oligopeptidases generates a paracrine signal that accele
52 FAP relative to its closest homologs, prolyl oligopeptidase (half-maximal inhibitory concentration, ~
53 hough conformational heterogeneity of prolyl oligopeptidase has been demonstrated in solution, it is
54                                              Oligopeptidases impose a size limitation on their substr
55             Here, we assessed whether prolyl oligopeptidase inhibition could protect against tau-medi
56  II-(1-7) or bradykinin(1-5), and the prolyl oligopeptidase inhibitor Fmoc-Ala-Pyr-CN (IC(50) = 50 nm
57 -KO mice were treated with S-17092, a prolyl-oligopeptidase inhibitor that inhibits the formation of
58 s, we have reported covalent bicyclic prolyl oligopeptidase inhibitors that were highly selective for
59                                       Prolyl oligopeptidase is a serine protease that is associated w
60                                       Thimet oligopeptidase mutated so that neurolysin residues are a
61                                          The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first
62                            The 80 kDa prolyl oligopeptidase of Trypanosoma cruzi (TcPOP) has been ide
63 tems in Arabidopsis thaliana, the organellar oligopeptidase, OOP (At5g65620).
64 P3 is induced in wild-type cells by a prolyl oligopeptidase (POase) inhibitor.
65 ur own interest in the development of prolyl oligopeptidase (POP) and fibroblast activation protein a
66              Serine peptidases of the prolyl oligopeptidase (POP) family are of substantial therapeut
67                                       Prolyl oligopeptidase (POP) is a large 80 kDa protease, which c
68                                       Prolyl oligopeptidase (POP) is widely distributed in mammals, w
69  processing enzyme is a member of the prolyl oligopeptidase (POP) subfamily of proteases (EC 3.4.21.2
70 es, each containing a gene encoding a prolyl oligopeptidase (POP).
71 tides, similar to the closely related prolyl oligopeptidase (POP).
72                                       Prolyl oligopeptidase (PREP) accelerates the aggregation of alp
73 otent compounds with selectivity over prolyl oligopeptidase (PREP) by up to 3 orders of magnitude.
74                                       Prolyl oligopeptidase (PREP) can accelerate the aSyn aggregatio
75 vel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise selective, potent modulat
76 exert toxic effects on neurons, while prolyl oligopeptidase (PREP) has been shown to interact with aS
77                                       Prolyl oligopeptidase (PREP) is a widely distributed serine pro
78  shares exopeptidase specificity, and prolyl oligopeptidase (PREP), with which it shares endopeptidas
79 idases (DPPs) DPPIV, DPP9, DPPII, and prolyl oligopeptidase (PREP).
80              The intracellular enzyme prolyl oligopeptidase probably degrades tasidotin to P5.
81 expression of leucine aminopeptidase, thymet oligopeptidase, puromycin-sensitive aminopeptidase, and
82 His-495/Asn-496, and Arg-498/Thr-499; thimet oligopeptidase residues listed first) in their substrate
83                         Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on
84 n neurolysin switch hydrolysis to the thimet oligopeptidase site.
85                         Therefore, cytosolic oligopeptidases such as TPPII normalize rates of intrace
86 that proteases, such as the trypanopains and oligopeptidases that are released by trypanosomes, could
87 er one of the two sites is mutated in thimet oligopeptidase, then the enzyme cleaves almost equally a
88 rolylprolinal (BCPP), an inhibitor of prolyl oligopeptidase, there was a 30-fold increase in the IC(5
89 bitor of the cytosolic endopeptidase, thimet oligopeptidase (TOP) (EC ), whose physiological function
90                                       Thimet oligopeptidase (TOP) is a zinc metallopeptidase that met
91               One such endopeptidase, thimet oligopeptidase (TOP), which was recently shown to degrad
92 igest matched the protein sequence of thimet oligopeptidase (TOP).
93 degraded by the metalloendopeptidase, thimet oligopeptidase (TOP).
94                  Arabidopsis thaliana thimet oligopeptidases TOP1 and TOP2 are required for plant def
95               Previous studies of the thimet oligopeptidases TOP1 and TOP2 placed them in the salicyl
96                   We demonstrate that thimet oligopeptidases (TOPs) constitute a class of SA-binding
97 iously shown in Arabidopsis thaliana, thimet oligopeptidases (TOPs) TOP1 (also referred to as organel
98                         We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can com
99 ent aggregation, and we found that different oligopeptidases use different strategies to achieve such
100 e ITC-ERM approach to another enzyme (prolyl oligopeptidase), we unexpectedly discovered non-Michaeli
101 y deletion of the gene that codes for prolyl oligopeptidase, which also regulates inositol metabolism
102 quences of a T. denticola surface-associated oligopeptidase with BANA-hydrolyzing activity, we identi
103            We show that inhibition of prolyl oligopeptidase with the inhibitor KYP-2047 reduced tau a

 
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