ライフサイエンスコーパス: oligopyrimidine

1 ding of RPS mRNA via cis-acting, 5'-terminal oligopyrimidines.

2 translation rate of mRNAs whose 5' terminal oligopyrimidine (5' TOP) motif regulates the synthesis o

3 t being transcripts containing a 5' terminal oligopyrimidine (5' TOP) motif.

4 own to affect the translation of 5' terminal oligopyrimidine (5' TOP) tract mRNA, which encodes the t

5 n machinery mRNAs that possess a 5'-terminal oligopyrimidine (5'-TOP) motif in their 5'-UTR, includin

6 ined down-regulation of a set of 5'-terminal oligopyrimidine (5'-TOP) transcripts encoding protein sy

7 dine tract characteristic of the 5'-terminal oligopyrimidine (5'TOP) class of genes.

8 The 5'terminal oligopyrimidine (5'TOP) motif is a cis-regulatory RNA el

9 h a subset of mRNAs that contain 5'-terminal oligopyrimidine (5'TOP) motifs known to control protein

10 ' untranslated regions comprised of terminal oligopyrimidine (5'TOP) tracts and that encode ribosomal

11 y rapamycin are highly enriched for terminal oligopyrimidine and for very short 5' and 3' untranslate

12 S5 transcript is a member of the 5' terminal oligopyrimidine class of RNAs, which is specifically con

13 ble in serum-containing medium than standard oligopyrimidine-derived ODNs or ODNs derived from dT and

14 extremely stable triplex with an oligopurine/oligopyrimidine DNA duplex with Delta T m +14.3 degrees

15 Mutation of the oligopyrimidine element showed that it is essential to o

16 tor receptor through an unannotated terminal oligopyrimidine motif in its 5' untranslated region.

17 stimulates translation of the TOP (terminal oligopyrimidine motif) and TOP-like mRNAs, polysome-prof

18 Terminal oligopyrimidine motif-containing mRNAs (TOPs) encode all

19 translation of transcripts with 5' terminal oligopyrimidine motifs.

20 hat ARF is a major suppressor of 5'-terminal oligopyrimidine mRNA translation.

21 nslation of a selective group of 5'-terminal oligopyrimidine mRNAs (encoding proteins involved in the

22 amycin inhibits translation of TOP (terminal oligopyrimidine) mRNAs by displacing eIF4E from their ca

23 activation, affect double-strand cleavage at oligopyrimidine-oligopurine tracts on DNA.

24 Furthermore, the oligopyrimidine ribo N3'-->P5' phosphoramidate formed an

25 ii) inhibited translation of non-5'-terminal oligopyrimidine ribosomal protein mRNAs and ribosomal RN

26 Mitotic 5'-terminal oligopyrimidine RNA translation was active and, unlike i

27 Short oligopyrimidine RNAs formed on the CTCCTC allele could b

28 roughly 45-nucleotide window overlapping an oligopyrimidine sequence having counterparts in the lyti

29 d selective triplex formation at oligopurine-oligopyrimidine sequences containing multiple isolated o

30 n the mRNA encoding PABP contains a terminal oligopyrimidine (TOP) element found in mRNAs, the transl

31 methylation, but not mRNAs with 5' terminal oligopyrimidine (TOP) elements.

32 Terminal oligopyrimidine (TOP) motifs are sequences at the 5' end

33 ificant enrichment of genes with 5' terminal oligopyrimidine (TOP) motifs, a gene class classically k

34 while reducing transcripts with 5' terminal oligopyrimidine (TOP) motifs, including those of ribosom

35 of transcripts with established 5' terminal oligopyrimidine (TOP) motifs, or, like Hsp90ab1 and Ybx1

36 f mTORC1 with a fundamental role in terminal oligopyrimidine (TOP) mRNA translation.

37 defined group of messengers called terminal oligopyrimidine (TOP) mRNAs which encode ribosomal prote

38 al protein mRNA overlapping with 5' terminal oligopyrimidine (TOP) mRNAs, and genes are dysregulated

39 This identified mRNAs with 5'-terminal oligopyrimidine (TOP) sequences as the largest single cl

40 ZNF9 interacts with the 5' UTRs of terminal oligopyrimidine (TOP) tract mRNAs encoding human ribosom

41 atively regulates translation of 5'-terminal oligopyrimidine (TOP)-containing mRNAs.

42 ranslated region (UTR) containing a tract of oligopyrimidines (TOP).

43 s mRNA, which does not contain a 5'-terminal oligopyrimidine tract (5'-TOP), was translated earlier,

44 cally regulate the expression of 5' terminal oligopyrimidine tract (5'TOP) mRNAs which encode protein

45 o ribosomal S6 protein phosphorylation and 5'oligopyrimidine tract (5'TOP)-encoded protein synthesis

46 luded or lay adjacent to the conserved 31-nt oligopyrimidine tract (referred to as the Y block), abol

47 regulation of mRNAs that contain a terminal oligopyrimidine tract (TOP) at their 5'ends, although th

48 In mammalian cells a 5'-terminal oligopyrimidine tract (TOP) is a conserved feature of th

49 protein and is known to regulate 5'-terminal oligopyrimidine tract (TOP) mRNA translation.

50 Class II consists of terminal oligopyrimidine tract (TOP) mRNAs that are regulated in

51 ferential translation of mRNAs containing an oligopyrimidine tract at the 5'-end of the message.

52 transcript demonstrates that it possesses an oligopyrimidine tract characteristic of the 5'-terminal

53 e), pathway and translation of a 5' terminal oligopyrimidine tract containing mRNA, Elongation factor

54 mechanisms that do not directly depend on 5' oligopyrimidine tract motifs (5'TOPs) found in mammalian

55 mal protein S6 and regulation of 5'-terminal oligopyrimidine tract mRNAs, is an important regulator o

56 the translation of mRNAs with a 5'-terminal oligopyrimidine tract such as eukaryotic elongation fact

57 , the translation of rpS8, an mRNA with a 5'-oligopyrimidine tract, did not coincide with rpS6 phosph

58 ranslation of mRNAs containing a 5'-terminal oligopyrimidine tract, our data suggest that transcripti

59 y the wild-type IRES is limited by its short oligopyrimidine tract.

60 A), the mRNA of which contains a 5' terminal oligopyrimidine tract.

61 the genome, and at sites of mTOR/5' terminal oligopyrimidine-tract translation regulation.

62 sis factors and contain hallmark 5'-terminal oligopyrimidine tracts (5'TOP).

63 specific subset of mRNAs bearing 5'-terminal oligopyrimidine tracts (5'TOPs) by the structurally rela

64 n, which regulates translation of mRNAs with oligopyrimidine tracts in the 5'-untranslated region.

65 for initiation of translation for mRNAs with oligopyrimidine tracts in their 5' untranslated region.