ライフサイエンスコーパス: omental

1 x (gastric submucosal = 2, subcutaneous = 3, omental = 4).

2 the IGF1 receptor initially increased tumor omental adhesion but decreased the growth of established

3 e relationship between metastatic burden and omental adipocyte content.

4 the role of SPARC in OvCa interactions with omental adipocytes and its role in OvCa colonization in

5 Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2

6 Human omental adipocytes display a range of biochemical proper

7 mployed multi-pronged approach using primary omental adipocytes from Sparc knockout mice, genetically

8 knockout mice, genetically engineered human omental adipocytes in 3D co-cultures with OvCa cells, as

9 We show here that primary human omental adipocytes promote homing, migration and invasio

10 d that endogenous oils from subcutaneous and omental adipocytes, and from healthy and unhealthy obese

11 hat LBSQ adipocytes, in contrast to UBSQ and omental adipocytes, store more FFA in women with greater

12 f cancer cells cocultured with primary human omental adipocytes.

13 Thus, the omental adipose bed represents a highly insulin-resistan

14 ressed genes (DEGs) between subcutaneous and omental adipose depots.

15 This work highlights the critical role that omental adipose inflammatory pathways might play in the

16 Omental adipose is a site of prodigious metastasis in bo

17 Omental adipose stromal cells (O-ASC) are a multipotent

18 7.5 pmol mg-1 h-1 [82.1-209], p < 0.05) when omental adipose stromal cells were treated with cortisol

19 significantly higher in subcutaneous than in omental adipose tissue (p=0.004).

20 An omental adipose tissue biopsy and blood sample were coll

21 Interestingly, in omental adipose tissue explants, glucose significantly i

22 Furthermore, in omental adipose tissue explants, insulin and glucose sig

23 mediators (i.e., leukotriene B4 and PGs) in omental adipose tissue from Ob patients.

24 and adiponectin (ADIPOQ) mRNA expression in omental adipose tissue in adult, pedigreed baboons (Papi

25 port, for the first time, elevated serum and omental adipose tissue levels of vaspin in overweight PC

26 the abundance of resistin (RETN) mRNA in the omental adipose tissue of baboons (L0D score 3.8).

27 enes were significantly downregulated in the omental adipose tissue of obese individuals with extreme

28 ng circulating vaspin, from subcutaneous and omental adipose tissue of PCOS women and matched control

29 n mRNA (P < 0.05), and protein (P < 0.05) in omental adipose tissue of PCOS women.

30 s of visceral adipose tissue was examined in omental adipose tissue of Stage IV PDAC patients and gon

31 -1 mRNA (P < 0.01) and protein (P < 0.05) in omental adipose tissue of women with PCOS (P < 0.01).

32 entin-1, including circulating omentin-1, in omental adipose tissue of women with PCOS and matched co

33 Omental adipose tissue shows higher oxidative phosphoryl

34 ion, likely because of the resistance of the omental adipose tissue to insulin suppression and the co

35 Human omental adipose tissue Treg cells also showed high ST2 e

36 Omental adipose tissue was obtained from 99 obese patien

37 Omental adipose tissue, a biologically active organ secr

38 tric surgery enhanced the OXPHOS capacity in omental adipose tissue, even under poor OXPHOS coupling

39 of the HOXB cluster was expressed highly in omental adipose tissue, indicating differential expressi

40 t exposure of glucocorticoid specifically to omental adipose tissue, suggesting that central obesity

41 es NK cell migration to EAC patient-derived, omental adipose tissue-conditioned media, but not toward

42 acity in paired explants of subcutaneous and omental adipose tissues.

43 four metabolically relevant tissues: liver, omental adipose, subcutaneous adipose, and stomach.

44 ive tissues liver, subcutaneous adipose, and omental adipose.

45 are associated more strongly with increased omental adiposity than with subcutaneous adiposity.

46 ed a bolus of [1-(14)C]palmitate followed by omental and abdominal subcutaneous fat biopsies to measu

47 fatty acid (FA) storage enzymes/proteins in omental and abdominal subcutaneous fat.

48 and the extravasation of lymphocytes to the omental and mesenteric adipose tissues is partly mediate

49 al expansion of Bc.DLFL1 lymphoma within the omental and mesenteric adipose tissues was coupled with

50 Omental and paravesical tumors were each present in six

51 s, PD specimens had the highest abundance of omental and parietal arteriolar C1q, C3d, terminal compl

52 Findings were validated in omental and parietal arterioles from independent pediatr

53 tion of mesenteric edema and the presence of omental and retroperitoneal edema.

54 anges occurred in body weight, fat pad mass (omental and retroperitoneal), food intake, serum insulin

55 Strikingly, in both omental and s.c. WAT from BMI-matched obese humans, expr

56 r cells preferentially lodge and grow within omental and splenoportal fat, which contain milky spots,

57 soforms (1 and 2) of 11 beta-HSD in cultured omental and subcutaneous adipose stromal cells from 16 p

58 Paired omental and subcutaneous adipose tissue samples were obt

59 Paired samples of human omental and subcutaneous preadipocytes from 12 individua

60 Mesenteric, omental, and retroperitoneal edema occur commonly in pat

61 pots studied with a rank order of perirenal, omental, and subcutaneous.

62 Omental arteries and plasma were collected from healthy

63 ssayed the differences in DNA methylation in omental arteries from normal pregnant and preeclamptic w

64 ine and bradykinin) in small resistance-size omental arteries obtained during surgery from women with

65 se expression was significantly increased in omental arteries of preeclamptic women and in VSMCs co-c

66 Omental arteries were evaluated for gene and protein exp

67 ignificantly less methylated in preeclamptic omental arteries, whereas TIMP and COL genes either were

68 We microdissected omental arterioles from tissue layers not directly expos

69 UA endothelial (UAendo), UA VSM, omental artery endothelium (OA endo), and OA VSM protein

70 nergetics and energy substrate preference by omental AT (OAT) and subcutaneous AT (SAT) from subjects

71 otein abundance is lower in subcutaneous and omental AT obtained from patients with T2DM compared wit

72 antigen-specific serum IgM, identifying the omental B cells as a source of IgM production in the SLP

73 Peritoneal or omental biopsies obtained from women diagnosed with stag

74 in high-grade serous ovarian cancer (HGSOC) omental biopsies reveals potential targets that could en

75 In Experiment 3, paired ILT and omental biopsies were collected intra-operatively during

76 ovaries and fallopian tubes, peritoneal and omental biopsies, and collection of peritoneal washings

77 laparotomy and at least an oophorectomy and omental biopsy) in each group of the study.

78 IL-1beta destabilizes adherens junctions in omental blood and lymphatic vessels, contributing to bot

79 ocytes escaping from naturally discontinuous omental blood vessels are collected by nearby lymphatic

80 irculating fibrin(ogen) leaking from gaps in omental blood vessels can trigger inflammasome-mediated

81 In humans, omental but not subcutaneous IL-6 mRNA expression correl

82 motes collagen production in human and mouse omental CAFs through arginase activity.

83 Three marker lesions-primary ovarian mass, omental cake, and peritoneal deposit-were outlined by a

84 baseline ADCs among primary ovarian cancer, omental cake, and peritoneal deposits indicate that diff

85 However, the omental cell-derived molecular determinants modulating i

86 tic indices were more than twofold higher in omental cells (serum-free medium: P < 0.05; TNF-alpha: P

87 nd CCAAT/enhancer-binding protein alpha than omental cells, as in primary preadipocytes, while hTERT

88 PAD4 pharmacologic inhibitor also decreased omental colonization.

89 Omental cyst and omental torsion both are uncommon but i

90 On CECT abdomen the findings of omental cysts and torsion of greater omentum with free f

91 Two large omental cysts were found in the pelvic cavity along with

92 stantially greater in preadipocytes from the omental depot than in those from the subcutaneous depot,

93 11c-expressing B cells nearly eliminated the omental Ehrlichia-specific plasmablasts and reduced anti

94 nd the capture of peritoneal contaminants by omental FALCs.

95 cent to the abdominal wall without overlying omental fat and central displacement of colon and were f

96 Conversely, ECMs isolated from omental fat and lung did not redirect testicular cells t

97 at biopsies (abdominal and femoral) and then omental fat biopsy during tubal ligation surgery.

98 ited mild inflammation in both perirenal and omental fat by increasing the expression of Tnfa (Tumor

99 s, with separate models run for each medium (omental fat in the operative cohort, serum in both cohor

100 se findings provide evidence for the role of omental fat in the pathogenesis, and potentially, the pr

101 igration of ovarian cancer spheroids towards omental fat is enhanced in the presence of malignant asc

102 ed significantly (P < 0.001) more weight and omental fat mass compared with OLETF-EX and LETO-SED.

103 Expression of ST8SIA2 in omental fat of these individuals at baseline was signifi

104 Additionally, paired subcutaneous and omental fat samples were obtained during abdominal surge

105 Concentrations were higher in omental fat than in serum for all POPs.

106 t/activity of FA storage enzymes/proteins in omental fat was dramatically lower in those with more vi

107 The opposite pattern was seen in omental fat with the normal-fat meal and in all depots a

108 dominal wall mass, often involving subjacent omental fat, and may be the only site of recurrent disea

109 Adipose stromal cells from omental fat, but not subcutaneous fat, can generate acti

110 cells in the peritoneal fluid often colonize omental fat-associated lymphoid clusters but the mechani

111 including elevated glucose levels and excess omental fat.

112 he time representing the delay in collecting omental fat.

113 , and nine (75%) directly involved subjacent omental fat.

114 Similar changes were confirmed in omental fat.

115 ting motility, growth, and migration towards omental fat.

116 led that STAT4 overexpression induced normal omental fibroblasts and adipose- and bone marrow-derived

117 one patient, and bilateral pectoralis and an omental flap in one patient who required additional cove

118 2000, the authors successfully harvested 135 omental flaps (64 pedicled, 71 free transfer) for recons

119 ridement followed by closure using muscle or omental flaps.

120 s, intermediate in mesenteric, and lowest in omental hTERT-expressing strains, as in primary preadipo

121 ngle abdominal subcutaneous, mesenteric, and omental human preadipocytes by stably expressing human t

122 is characterized by numerous peritoneal and omental implants composed of glial tissue.

123 celerating factor composite thymokidneys and omental implants of thymic tissue.

124 orpuscles under the renal capsule and in the omental implants, and with evidence of few host lymphocy

125 itated engraftment of nonvascularized thymic omental implants.

126 agnosed with abdominal fat necrosis (primary omental infarct) on CT imaging between October 2014 and

127 that we encounter are epiploic appendagitis, omental infarction, mesenteric panniculitis, and encapsu

128 Idiopathic omental infarctions were detected in 13 patients on CT;

129 is the main diagnostic tool for diagnosis of omental infraction and differentiation between other cau

130 Omental infusion did not lower systemic free fatty acid

131 Omental insulin infusion was extracted at approximately

132 nd 17 miRNAs with differential expression in omental lesions compared to primary tumors.

133 17 to June 2018, patients with peritoneal or omental lesions identified by CT or MRI at the King Chul

134 d that EUS-FNA is feasible on peritoneal and omental lesions, however, EUS-FNA provided a limited amo

135 iRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug to

136 s with significantly increased expression in omental lesions, with concomitant decreased expression o

137 Omental lipolysis was also pulsatile, with about 10 puls

138 that local infusion of insulin did suppress omental lipolysis, but only at extremely high insulin co

139 liver regenerative response in the residual omental liver lobes (weight, protein content, incorporat

140 sulting in liver necrosis; the remaining two omental lobes (8% liver mass) are left intact.

141 BRG1 regulates IL-1beta production in omental macrophages by transcriptionally suppressing the

142 We found that omental macrophages fine-tune an unexpected developmenta

143 ived omentectomy to dissociate the role from omental macrophages.

144 Piezo1 expression was confirmed in omental masses from patients with stage III/IV HGSOC.

145 Thus, specialized omental mesothelial cells coordinate the recruitment and

146 , we evaluated the tumor stroma of 108 human omental metastases and determined that fibronectin was c

147 ding protein 4 (FABP4, also known as aP2) in omental metastases as compared to primary ovarian tumors

148 Here, we aim to understand how omental metastases differ from primary tumors and how th

149 s of primary EOC tumors and their respective omental metastases from 9 patients using miRNA Taqman qP

150 home to and proliferate in the omentum, yet omental metastases typically represent the largest tumor

151 primary ovarian carcinoma tumors, secondary omental metastases, and ascites cells isolated from sero

152 o model the net accumulation of experimental omental metastases, we show that MKK4-expressing implant

153 with fibrillar collagen in human and murine omental metastases.

154 mor burden and collagen remodeling in murine omental metastases.

155 Interestingly, metformin decreased omental metastasis at least partially by inhibiting MCP-

156 arian cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathw

157 promote expansion of regulatory T cells and omental metastasis through producing interleukin (IL)-10

158 Omental metastasis was decreased in mice with neutrophil

159 lity that blockade of NET formation prevents omental metastasis.

160 t SPARC suppresses multistep cascade in OvCa omental metastasis.

161 ominant pathway responsible for hematogenous omental metastasis.

162 epletion of ErbB3 in ovarian cancer impaired omental metastasis.

163 tes play distinct and complementary roles in omental metastatic colonization.

164 the mouse genetic background does not alter omental milky spot number and size, nor does it affect o

165 is study, we report that, in addition to the omental milky spots and fat-associated lymphoid clusters

166 anatomically associated with lymph nodes and omental milky spots have site-specific properties that e

167 Omental milky spots readily concentrate intra-abdominal

168 Inhibition of the omental neutrophil response exacerbates septic progressi

169 NET formation in rendering the premetastatic omental niche conducive for implantation of ovarian canc

170 in abdominal subcutaneous (SC) compared with omental (Om) adipocytes.

171 We show that the lower adipogenesis of omental (Om) compared with abdominal subcutaneous (Abdsc

172 (ERAD) hyperactivation, as occurs in SC and omental (OM) preadipocytes in IR/T2D obesity.

173 No patient had omental or retroperitoneal edema alone.

174 ic edema occurred alone in 26 (38%) and with omental or retroperitoneal edema in 40 (58%) of the 69 p

175 Biocompatibility was demonstrated by either omental or subcutaneous xenotransplantation of liver sca

176 s lower than that for ovarian (P = .015) and omental (P = .006) sites.

177 In women, only omental palmitate storage rates were correlated (r = 0.5

178 Omental patch closure is appropriate therapy for patient

179 Omental patch closure was used in 49 patients and falcif

180 aches for repair include primary closure and omental patch closure.

181 Omental patch may be most useful in large perforations w

182 ease is typically treated surgically with an omental patch.

183 r cells to invade and proliferate into human omental pieces ex vivo and into the omentum of a mouse x

184 Omental plasmablasts elicited during Ehrlichia infection

185 Generation of the omental plasmablasts was route dependent, as they were d

186 Significance: Omental preadipocyte-mediated IGF1 signaling promotes ov

187 Omental preadipocytes are therefore more susceptible to

188 Here, we showed that omental preadipocytes enhance the tumor initiation capac

189 Together, this study shows that omental preadipocytes support ovarian cancer progression

190 Primary omental preadipocytes, in which telomeres were longest,

191 Discrete omental reservoirs of these RNases were evident in patie

192 e kidney disease prior to PD initiation, and omental RNase 3 reactive cells increased in patients und

193 Analysis of omental samples from patients with acute appendicitis co

194 The three-tier CRS system applied to omental samples from the validation cohort showed high r

195 Adnexal and omental sections were independently scored by three path

196 ct appears to be mediated by the presence of omental stem cells and their secretory products.

197 However, the omental stromal cell-derived molecular determinants that

198 Omental stromal cells facilitate ovarian cancer coloniza

199 reveal how omental stromal cells regulate neutrophil trafficking to

200 -cell RNA sequencing and spatial analysis of omental stromal cells revealed that the surface of FALCs

201 ls), extrahepatic sites of implantation (eg, omental, subcutaneous, or intramuscular), and induction

202 scle tumorlets diffusely stud peritoneal and omental surfaces in females, predominantly of reproducti

203 ated palmitate storage rates were greater in omental than abdominal subcutaneous fat in women (1.2 +/

204 han cortisol to cortisone) and was higher in omental than subcutaneous fat (cortisone to cortisol, me

205 Four of these baboons also received omental thymic tissue implants.

206 ndings of a cis-eQTL for RETN mRNA in baboon omental tissue and human lymphocytes lends support to th

207 Within the peritoneal cavity, omental tissue is a common site for metastatic disease a

208 ery uncommon however acute presentation with omental torsion and infarction is an unusual entity.

209 Omental cyst and omental torsion both are uncommon but important causes o

210 ysts in greater omentum leading to secondary omental torsion.

211 ion of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cance

212 and para-aortic lymphadenopathy, and a 4-cm omental tumor; in addition, both the uterus and rectosig

213 ur observations suggest that cancer cells in omental tumors express key miRNAs differently than prima

214 By contrast, omental tumors in germ-free, neomycin-treated mice or mi

215 f resident macrophages specific to Pten-null omental tumors in murine models, which were confirmed by

216 oped compared with TLSs in fallopian tube or omental tumors.

217 rived from neighbouring stromal cells in the omental tumour microenvironment, and that inhibiting the

218 In line with this, omental venules expressed higher levels of ICAM-1 and at

219 The second major complication was an omental vessel bleed after a TV cholecystectomy.

220 In conclusion, increases in omental WAT mitochondrial content between 20 and 40 week

221 pared with cells isolated from mesenteric or omental white fat.

222 in the composite engineered bladders with an omental wrap (56%, 1.58-fold, and 2.79-fold, respectivel

223 tion and implanted either with or without an omental wrap.

224 ulture to precondition grafts and the use of omental wrapping to promote vascularization.