ライフサイエンスコーパス: open

1 tive state or is intrinsic in nature remains open.

2 le MPCs, regions around adipogenic genes are open.

3 DP, whereas the apo MCM2-5 interface remains open.

4 requencies during motor preparation for hand opening.

5 blue (585-660 nm) light beginning before eye-opening.

6 ligand binding site and culminating in pore opening.

7 Air-sea flux estimates indicate the GoM open (- 0.06 +/- 0.45 mol C m(-2) year(-1)) and coastal

8 healthcare and mortality data, to derive an open 2005-2013 cohort of adults (>=18 years of age) with

9 n and also - if economically convenient - to open a channel on the Lightning Network and transact "of

10 significant advantages for clinical use and open a new developmental path for a safe and effective v

11 understanding of non-volatile switching and open a new direction in precision defect engineering, do

12 Our findings may open a new gate toward therapeutics.

13 Our findings open a path towards exploration of higher-dimensional to

14 Recently, CRISPR-Cas technology has opened a new era of nucleic acid-based molecular diagnos

15 g deep architectures to structured data have opened a new paradigm for pharmaceutical research.

16 Microstimulation+imaging opened a unique possibility for investigating the connec

17 resembling those used by insect navigators, opening a new avenue for the investigation of the neural

18 bled the synthesis of nucleic acids, perhaps opening a way into the RNA world.

19 ends of 20S are coupled: binding one ATPase opens a gate locally, and also opens the opposite gate a

20 NMA very similar to NCA and NMC, this study opens a new space for cathode material development for n

21 This approach opens a powerful avenue for studying, at the single part

22 This opens a wide range of future applications including prot

23 h hospital's average annual volume for total open AAA repairs, and total open juxtarenal AAA repairs.

24 Is are a common cause of morbidity following open abdominal surgery.

25 5, 0.046, adjusted mean false discovery rate Open Access = 0.241 vs. closed access = 0.225).

26 higher false discovery rate, on average, for Open Access versus closed access journals (p = 0.320, 95

27 editable) and supporting tables are provided open access; they constitute a broadly applicable neuros

28 accurate predictions compared to benchmarked open-access and commercial tools, achieving accuracy clo

29 Importantly, it has been implemented in the open-access platform Fiji.

30 Importantly, we built an open-access web application allowing investigators to es

31 o the selectivity filter of KirBac1.1 in the open-activated state but that it may not directly enter

32 autoantibodies from iTTP patients induce an open ADAMTS13 conformation.

33 (2+) influx and permeability transition pore opening after ischemic injury to reduce ongoing patholog

34 provement of skill over LIM approaches, thus opening an avenue for environmental risk assessment rele

35 nsport of nephrin in R218Q knockin podocytes opens an avenue for developing targeted therapy for INF2

36 Our work opens an avenue to develop functional MOF channels for s

37 We present an interactive visualization and open analysis pipeline to facilitate use of our dataset

38 We identified that open and active chromatin at the major translocation clu

39 ltage-induced channel transition between the open and closed states measured on multichannel membrane

40 Cryo-EM structures in the open and closed states reveal a dynamic tunnel lining, w

41 ifferent residues to the channel pore in the open and closed states.

42 educe that quantum control problems both for open and closed systems are in general not algorithmical

43 se, the TCRA gene enhancer (Ealpha) is in an open and unmethylated chromatin structure well before ac

44 regulatory regions, which were specifically open and unmethylated in basal-like breast cancer.

45 species show an inverted pattern of stomatal opening and closing across the diel cycle, which conserv

46 are under axial strain in vivo and that the opening and closing of lymphatic valves leads to signifi

47 with decreased and increased Rac1 activities opening and closing, respectively, the silent synapse-me

48 and thermodynamically favorable after enzyme opening and pyrophosphate release, and it appears to lim

49 in different types of primary and secondary open angle glaucoma.

50 Here we show theoretically that the opening angle of the conical interface varies on a logar

51 ithin different types of glaucoma, including open-angle glaucoma (P = 0.36), chronic angle closure gl

52 Open-angle glaucoma patients may have increased odds of

53 he OMNI system in pseudophakic patients with open-angle glaucoma provides effective IOP reduction or

54 o radical chemistry, and acid-catalyzed ring-opening, as well as all other methods for the C-C bond c

55 Advances in cancer screening methods have opened avenues for incidental findings and cancer overdi

56 onstoichiometric MXenes reported to date and opens avenues for controlling physical properties of dif

57 accomplished at room temperature; hence this opens avenues for magnetooptical memory devices.

58 n isolates were manipulated and/or tested on open benches, including by procedures that could generat

59 s federal, state and local governments begin opening businesses and relaxing shelter-in-place orders

60 PKCdelta activity is obligatory for channel opening by PIP(2) , the probable activating ligand.

61 l mineral with a strong analogy to synthetic open-cell foams.

62 e analysis of combination studies remains an open challenge.

63 al sensing at the cellular level is still an open challenge.

64 Exposure to 10 or 25 uM ivabradine-an open channel blocker of HCNs-for 24 h resulted in a dose

65 genetic variants exhibiting allele-specific open chromatin (ASoC).

66 to identify genomic regions associated with open chromatin in Arabidopsis thaliana.

67 on combining the preferential methylation of open chromatin regions by DNA methyltransferases with lo

68 Mapping open chromatin regions has emerged as a widely used tool

69 We find that open chromatin regions in glutamatergic neurons are enri

70 he device performance by mainly limiting the open circuit voltage, interfacial layers are also crucia

71 The relation between open-circuit voltage, dark current, and noise current is

72 s that EC1-EC2 interaction also supports the open conformation of CD81.

73 the Sec61-translocon, and captures it in an open conformation that is translocation-incompetent.

74 MCT1 exhibits similar outward-open conformations when complexed with lactate or the in

75 omics field is now actively embracing public open data policies.

76 We anticipate that initiating an open dialogue focused on diversity and inclusion will pr

77 accept up to two electrons to form the cage-opened dianionic nido-C(2)B(10) cluster core.

78 eas the gill chambers of jawless vertebrates open directly into the environment, jawed vertebrates ev

79 500 and 750 mum from the scleral spur: angle opening distance (AOD), trabecular iris space area (TISA

80 articipants were attempting to generate hand opening either supported on a table or when lifting agai

81 rocess on a seven-point Likert scale or with open-ended questions.

82 Some 616 patients undergoing open esophageal cancer surgery between April 2, 2001 and

83 racing the reciprocally antipodal endocyclic open face H(ec) and B(1).

84 Eosin staining, and behavioral deficits with open field activity.

85 ampal parenchymal enhancement indicating BBB opening, followed by BBB closure within 24 h.

86 uced fit" mechanism in which the clamp first opens, followed by DNA binding, inducing opening of the

87 SONATA format is free and open for the community to use and build upon with the go

88 etermine the thermodynamics of the base pair opening for MN4.

89 It becomes accessible upon pocket opening for selective covalent attachment of electrophil

90 rbances, contusion of the eye and/or adnexa, open globes and open wounds of ocular adnexa, diplopia,

91 ication of N- and O-linked glycopeptides and open glycan searches.

92 54% in the laparoscopic group and 55% in the open group (between-group difference, 0.5 percentage poi

93 The polarimeter is released here as open hardware, with technical diagrams, a full parts lis

94 nts with congenital heart disease undergoing open-heart surgery, de novo variants were associated wit

95 Within the second phase of polymer growth, opened hGBP1 molecules can be incorporated in the growin

96 cieties is unique in animal life, it remains open how such a degree of prosociality is possible despi

97 lly invasive esophagectomy was equivalent to open in both propensity-score matched cohorts of patient

98 This review follows the pathways that were opened in neuroscience by major discoveries and set the

99 range of pressure for efficient and safe BBB opening is very narrow.

100 ich closes the channel when bound to ADP and opens it when bound to ATP.

101 volume for total open AAA repairs, and total open juxtarenal AAA repairs.

102 In an open label clinical trials, participants with ASD were a

103 ther small proportion of women included, the open label design, and its short duration.

104 rtension, we conducted a 6-week, randomized, open-label crossover trial comparing amiloride/hydrochlo

105 for 12 weeks (part A), followed by a 40-week open-label extension (part B), during which time all par

106 heir failing regimen for 8 days, followed by open-label fostemsavir plus optimized background therapy

107 sion that reported results of the phase III, open-label KATHERINE trial.

108 uring double-blind treatment, but during the open-label period, more rapid progression was noted amon

109 In this open-label phase 2 study (ClinicalTrials.gov identifier:

110 dence of MG infection in MSM enrolled in the open-label phase of the ANRS IPERGAY trial with on deman

111 In an open-label titration phase, increasing doses of apomorph

112 S Clinical Trials Group A5312 is a Phase 2A, open-label trial in which individuals with smear-positiv

113 In this randomised, open-label trial, DolPHIN-2, we recruited pregnant women

114 There was no masking in this open-label trial.

115 In AUGUSTUS (Open-Label, 2x2 Factorial, Randomized, Controlled Clinic

116 In this open-label, multicenter, noninferiority trial, we recrui

117 The prospective, randomised, open-label, non-inferiority NOBLE trial was done at 36 h

118 This multi-center, prospective, open-label, observational, single-arm trial of 1200 pati

119 This was an open-label, parallel-group, randomized, controlled trial

120 In this single-arm, open-label, phase 2 basket trial, we recruited patients

121 CLL14 is a multicentre, randomised, open-label, phase 3 trial done at 196 sites in 21 countr

122 In an update of the randomized, open-label, phase III European Mantle Cell Lymphoma (MCL

123 We did an open-label, pragmatic, adaptive, randomised controlled t

124 We did an open-label, randomised clinical trial at 57 centres in B

125 In this open-label, randomised controlled trial, adults (aged 16

126 DESIGN, SETTING, AND PARTICIPANTS: Open-label, randomized clinical trial conducted at 17 UK

127 In an open-label, randomized controlled trial (RCT), consecuti

128 We designed an open-label, randomized, multicenter, two-arm phase II tr

129 In this multicentre, open-label, single-arm, multicohort, phase 2 study (FIGH

130 In this multicentre, open-label, single-arm, phase 2 study (L-MIND), patients

131 In this open-label, single-arm, phase 3 trial, participants were

132 This open-label, single-arm, prospective cohort trial is the

133 Here we report an open, large-scale physiological survey of activity in th

134 iratory pressure to increase the fraction of open lung and reduce atelectrauma.

135 The fact that we have so many materials opens many exciting avenues but also create new challeng

136 usly only known from trilobites preserved in open-marine deposits.

137 is possible to tune the O(2) affinity at the open metal sites of MOFs for applications involving the

138 cyclopropanols, including base-mediated ring-opening, metal-catalyzed C-C insertions and eliminations

139 dentifies O-glycopeptides via an ion-indexed open modification search and localizes O-glycosites usin

140 ations, and the patch-clamped K(ATP) channel opened more frequently when glucose was high.

141 plus glibenclamide, an antagonist of K(ATP) opening (NaHS Glib), and Glib alone (Glib).

142 These observations open new and interesting questions on the function and r

143 e results obtained in this study potentially open new approaches to malaria diagnosis and surveillanc

144 on in the protein kinase superfamily and may open new avenues for targeting human FN3K in diabetic co

145 networks often suggest protein functions and open new avenues to characterize genes and proteins.

146 a broad-spectrum antiviral aptamer, and they open new possibilities for accelerating RT maturation an

147 The knowledge gained in this study would open new possibilities for the design and synthesis of m

148 Reduced Ca(V) 1.3 activity might open new ways to understand symptoms of Best vitelliform

149 These and other advances have opened new avenues for the medicinal chemistry of PS-ASO

150 2) grown on graphite or MoS(2) substrate has opened new opportunities to explore these ultrathin magn

151 e recognition of lysine-containing peptides, opening new perspectives in the field of peptide sensing

152 ation episignatures and, most significantly, opens new avenues for accurate diagnosis and clinical as

153 eir importance in regulation of excitability opens new avenues for improved therapy for muscle channe

154 indexing into frameworks of memory function opens new avenues of study and even therapies for hippoc

155 he fidelity of translation initiation by OCM opens new avenues to understand alternative translation

156 This work opens new opportunities for high-quality SCHPFs with lar

157 the ability to tune the anomalous phase, and opens new opportunities for superconducting spintronics,

158 lts establish the potential utility of PS to open novel effective delivery strategies for inhaled dru

159 Collectively, our results open novel research avenues in deadly tumors.

160 Uncovering this link might open novel ways of treatment and prevention to improve p

161 es" and past population dynamics, they leave open numerous questions regarding the biological charact

162 re divided into two groups of isomers, named open (O-) and closed (C-), based on the ring conformatio

163 g-related GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) severe/life-threatening

164 , Al, Fe, Ti) far exceed global riverine and open ocean mean values and highlight the importance of s

165 via unprecedented Ph(3)P-I(2) mediated ring-opening of 1,3-dihydro-1H-benzimidazol-2-ones with secon

166 of Ti imidos with nitriles and alkynes, ring opening of 2-imino-2H-azirines, or direct metalation of

167 Brief exposure to ATP induces the opening of a nonselective cation channel; while repeated

168 covered electronic stabilization through the opening of a shell-closing gap at the top of the occupie

169 e binding of transcription factors and local opening of chromatin.

170 A nucleophilic retro-Claisen ring-opening of donor-acceptor cyclobutenes, formed with high

171 compromised host-symbiont state and (ii) the opening of niche space for potential pathogens during th

172 Opening of stomata in plants with crassulacean acid meta

173 Rate-determining opening of the chelate by an ancillary ligand followed b

174 f structural changes which terminate with an opening of the complex into two separate domains, one of

175 nt laryngeal nerve following the progressive opening of the esophageal prosthesis.

176 ivation mechanism, which proceeds through an opening of the intracellular region allosterically elici

177 rst opens, followed by DNA binding, inducing opening of the loader to release autoinhibition.

178 sformation between these two phases involves opening of the P(3) ring at the base of the P(4)Se(3) mo

179 Release from chromatin involves opening of the ring at the Smc3-Scc1 interface in a reac

180 e (ATP) analogs, which is expected to induce opening of the sliding clamp.

181 PTP (permeability transition pore) and that opening of this pore leads to necroptosis, a regulated f

182 rst examples of selective and regiodivergent opening of unsymmetrical phenonium ions with chloride io

183 twist and pinch motions were observed in an open ORC conformation revealing a hinge at the ORC5.ORC3

184 32 556] EVR versus $31 442 [$24 669-$40 419] open; P<0.001), driven by a lower rate of in-hospital co

185 ospital complications (6.6% EVR versus 38.0% open; P<0.001).

186 This study uses Medicare Open Payments data to characterize trends in the prevale

187 ber 2018 after implementation of the federal Open Payments transparency program in 2013.

188 le mutants, in correlation with the stomatal opening phenotype.

189 and 4-guanidino-benzimidazoles to target the opened pocket, including a dihydro-imidazoquinazoline wi

190 r, dioxolane (DOL), is known to undergo ring-opening polymerization inside electrochemical cells to f

191 tatus, including out-of-season controls, and open populations.

192 rt a model in which TARK1 regulates stomatal opening postelicitation.

193 superficial part of the canal forms from an open primary canal that closes and then reopens.

194 showed that mechanical stimulation increased open probability of carboxyfluorescein-permeable membran

195 Here, we solve this open problem, presenting a comprehensive theory of five

196 roject data across single-cell atlases is an open problem.

197 nally, the structure of the anticipated ring-opening product, dibenzosuberenone, bearing a beta-amino

198 Here, we address this open question by combining topographically patterned sub

199 An open question in aggressive cancers such as melanoma is

200 tributes to tissue morphogenesis is still an open question.

201 hat is versus what isn't remembered, leaving open questions about the effect of dopamine replacement

202 resulting from alcohol use are evident, some open questions regarding alcohol use and its consequence

203 To help address several open questions regarding the history of these movements,

204 nvestigators with an emphasis on significant open questions.

205 t dsRNA1 dsRNA is 1,683 bp in length with an open reading frame (ORF) that encodes 539 amino acids (m

206 riants that contained mutations in the viral open reading frame 5 (ORF5) protein.

207 elevated expression of CXorf67 (chromosome X open reading frame 67), which frequently occurs in PFA e

208 uding an immunogenic peptide derived from an open reading frame downstream of the melanoma stem cell

209 to dicistronic viruses but contain a single open reading frame, thus likely representing a recent ex

210 b plasmid DNA encoding the 3.9 kb human NPC1 open reading frame, under the influence of a 1.5 kb plat

211 lyses have revealed abundant expressed short open reading frames (ORFs) in bacteria.

212 forms of HIV-RNA transcripts with competent open reading frames (ORFs), and can be found in the peri

213 iling, identification of actively translated open reading frames (ORFs), to the quantification of tra

214 ing to saturation of inserts adjacent to all open reading frames as well as conventional inactivation

215 lgarno (SD) sequences positioned upstream of open reading frames facilitate translation initiation.

216 Two open reading frames predicted from the genomic islands c

217 We identified 220 OR open reading frames, 20 of which are full length, intact

218 annotation pipelines generally ignore small open reading frames, which are those most likely to enco

219 128 adopts a unique binding mode with a more open receptor conformation at the extracellular face.

220 atients who were consecutively scheduled for open reduction and internal fixation of their fracture b

221 rence in disease-related spending on EVR and open repair patients 5 years after surgery.

222 The laser based on valley edge states may open routes to the practical use of topological protecti

223 We find that open science has a more connected, collaborative structu

224 ng climate, air quality, and human health in open seas and coast lines.

225 In this work, we have used open-shell dispersion-corrected DFT calculations, quasi-

226 The reactions afford the synthesis of two open-shell nanographenes (1a and 1b) exhibiting differen

227 heterocyclopentanediyl isomer represents an open-shell singlet biradical with interesting photochemi

228 Our code is released open source and freely available to the scientific commu

229 ipyrad is a free and open source program written in Python.

230 lotype path traversal algorithm (Gretel) are open source, MIT licensed and freely available online at

231 19 facilitated the development of automated, open-source algorithms for the early detection of sepsis

232 P3D is open-source and implemented in C++.

233 OTTO is an open-source automated liquid handler that can be fabrica

234 he models were implemented into the free and open-source OPERA application to enable screening of new

235 Our open-source platform, CPMG (Composite Peptide Macrocycle

236 ds, we developed BrainIAK (brainiak.org), an open-source Python software package that seamlessly inte

237 Here, we present Tensorpac, an open-source Python toolbox dedicated to PAC analysis of

238 Detailed scripts in the open-source R language are freely available on GitHub, t

239 U-PASS is an open-source R Shiny application.

240 SciPy is an open-source scientific computing library for the Python

241 While several open-source software suites provide subdiffraction local

242 We have produced open-source tools and a public data set consisting of tu

243 in commercial software to integrate free and open-source/external scripts and tools, tailoring the wo

244 After bonding open spring palatal expanders for 3-day, 5-day, 7-day, a

245 at agonist-bound receptors transition to the open state via two conformations, an "unconstrained pre-

246 te structures, an intermediate state, and an open state, each embedded in a phosphatidylcholine bilay

247 Here, utilizing K(V)7.1's unique two open states, we report a two-stage E-M coupling mechanis

248 erature promotes guard cell expansion, which opens stomatal pores to facilitate leaf cooling.

249 ncorporated in the growing polymer where the opened structure is stabilized, similar to a surfactant

250 (2013-2018) treated with curative intent by open surgery were studied.

251 of lung injury relies on two principles: 1) open the lung to minimize the presence of heterogeneity-

252 s to tune the T1 value of the phantoms which open the way to elaborated phantoms of other tissues in

253 ecific integrin make-ups is possible and may open the way to more precise treatment, but more efforts

254 ed and tracked clinical outcome, potentially opening the door to treatment optimization.

255 catalytic activities found in metazoan CCDs, opening the possibility of modifying their activity thro

256 one coupled to an appropriate optical setup, opening the way to simple and inexpensive point-of-care

257 ic photochemistry in aqueous medium but also opens the door for nanoengineered, solar-based methods t

258 of bioinspired systems such as pollen paper opens the door to a wide range of sustainable, eco-frien

259 ng one ATPase opens a gate locally, and also opens the opposite gate allosterically.

260 hotodetachment spectroscopy of radioisotopes opens the path for future EA measurements of other radio

261 in whole bacterial cells for the first time, opens the path for future investigations of the biologic

262 or scope 3 emissions of utilities, and being open to extend utilities' role beyond water and wastewat

263 The strained phosphorus-oxygen heterocycles open to the corresponding heterodiene structure at eleva

264 The transformation is performed in an open-to-air flask as it shows negligible sensitivity tow

265 simulations and FRET experiments showed that open-to-closed transitions in the structure of the headp

266 re we present an instrument that combines an open-top, single-objective light sheet fluorescence micr

267 y effects is becoming vital now that FUS-BBB opening treatments have entered clinical trials.

268 ion triggers a complete rearrangement of the open, trough-like ID structure through the ubiquitin of

269 Here, we revisit the effects of open unc-64/syntaxin by generating knockin (KI) worms.

270 13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin suggested a specific function of UN

271 sted a specific function of UNC-13/Munc13 in opening UNC-64/ syntaxin.

272 that Rad4, when tethered to DNA, could also open undamaged DNA, suggesting a 'kinetic gating' mechan

273 These data from dead minds open up an untapped and highly diverse subject pool.

274 he emergence of superconductivity in TBG and open up avenues towards engineering quantum phases in mo

275 The techniques demonstrated here open up the possibilities to study quantum entanglement

276 Our findings open up this class of materials for voltage-controlled f

277 icates that the expansion of C(4) vegetation opened up new niche opportunities, probably alleviating

278 ripotent stem cells into beta-like cells has opened up new opportunities for T2D disease modeling.

279 can now be obtained in a matter of seconds, opening up the possibility of high-throughput screening

280 measurements in the proximal lumbar plexus, opening up the possibility of studying a broad spectrum

281 bits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically

282 librium between In(I), In metal, and In(III) opens up additional flexibility in precursor selection.

283 oorthogonal catalysis and physical hydrogels opens up new opportunities to administer and modulate th

284 ctions, some of which are parasite-specific, opens up new therapeutic possibilities.

285 The identification of POP opens up numerous avenues for continued scientific explo

286 of exciton polaritons (interacting photons) opens up possibilities for future studies of quantum flu

287 f elk did show a tendency to minimize use of open vegetation at specific times of the day, overall we

288 in fine tuning the granulocytic production, opening venues for clinical intervention that require en

289 by lesion discrimination relied on efficient opening versus diffusion.

290 yzes different reactions (styrene oxide ring-opening, vesidryl synthesis, Friedel-Crafts alkylation,

291 Cut-open vessels, uncertainties in maximum air volume estima

292 The average opening was 95% of the targeted FUS volume, which corres

293 The hinge domains of cohesin adopt an "open washer" conformation and dock onto the STAG1 subuni

294 pretreatment that were poorly removed in the open-water wetland.

295 hromatin regions around osteogenic genes are open, whereas in immobile MPCs, regions around adipogeni

296 uitable substrates for enantioselective ring opening with CsF and a chiral bis-urea catalyst.

297 bility within the territory, with grassland, open woodland and dense thicket being favoured habitats

298 Grassland and open woodland habitat types were used throughout the yea

299 to determine ideal habitat ratios (grassland:open woodland:low shrubland of 1.00:6.10:0.09 ha) to ass

300 on of the eye and/or adnexa, open globes and open wounds of ocular adnexa, diplopia, superficial corn