ライフサイエンスコーパス: open conformation

1 ck, which prevents its adoption of an active open conformation.

2 tructural change into a state resembling the open conformation.

3 NavMs prokaryotic sodium channel in a fully open conformation.

4 ' the clamp loader-clamp complex in a stable open conformation.

5 THBs, which is lost when the pores assume an open conformation.

6 trate translocation by stabilizing an inward-open conformation.

7 d conformation or a transamidation-competent open conformation.

8 al alteration in the direction of an outward-open conformation.

9 11 form an extracellular gate in the inward-open conformation.

10 ) gradually shifts the equilibrium toward an open conformation.

11 e active closed conformation or the inactive open conformation.

12 LIX transforms cytosolic ALIX from closed to open conformation.

13 l-beta) to rapidly transition to an inactive open conformation.

14 ts of ionic locks that stabilize the outward-open conformation.

15 th a specific subset of TRiC subunits in the open conformation.

16 nantly exists in a fully extended, headpiece open conformation.

17 hat the transporter lies in an inward-facing open conformation.

18 ermediate preceding transition to the inward-open conformation.

19 m a closed, autoinhibited conformation to an open conformation.

20 ilibrium between the fully closed and a more open conformation.

21 tein syntaxin-1 switches from a closed to an open conformation.

22 omain, allowing the helicase to adopt a more open conformation.

23 terface with hydroxyls stabilize the channel open conformation.

24 of proliferating cell nuclear antigen in an open conformation.

25 und, the RyR pore adopts an extremely stable open conformation.

26 exhibiting a closed conformation, and one an open conformation.

27 a sodium- and chloride-bound outward-facing open conformation.

28 nd-binding alphaI domain in a high affinity, open conformation.

29 thought to render Syx1a in a constitutively open conformation.

30 a serine residue forces the channels into an open conformation.

31 sembled SNARE complex containing Syx1a in an open conformation.

32 in the active site, which still had the same open conformation.

33 n and closed states, but predominantly in an open conformation.

34 nsition from an inward-occluded to an inward-open conformation.

35 The V3 antibodies only bound to Env in its open conformation.

36 all NS1 constructs predominantly exist in an open conformation.

37 Ca(2+), the equilibrium shifts to favor the open conformation.

38 espective of strain differences can adopt an open conformation.

39 redoxin (Pdx), shows that P450cam adopts the open conformation.

40 3-GK interaction, causing PSD-95 to adopt an open conformation.

41 The channel adopts an open conformation.

42 ws the trimer to adopt either a closed or an open conformation.

43 here spontaneously adopt occluded and inward-open conformations.

44 ond time scale, switching between closed and open conformations.

45 and made only infrequent excursions to cleft-open conformations.

46 f the enzyme, oscillating between closed and open conformations.

47 omimicking SYD-2 (Y741E) primarily exists in open conformations.

48 ns dramatically increased the probability of open conformations.

49 terchanges between bent (auto-inhibited) and open conformations.

50 aptured in outward-open, occluded and inward-open conformations.

51 tural transitions that bridge the closed and open conformations.

52 nd conformation, but not when MET is in the "open" conformation.

53 rectly interacts with Sec24C, requiring its "open" conformation.

54 d the AMP-bound ADPGK structures are in the "open" conformation.

55 bodies, preferentially recognize Env in its "open" conformation.

56 r basis by which HHARI recruits E2 Ub in an 'open' conformation.

57 es, the inner pore-lining helices are in an 'open' conformation.

58 4PP-containing nucleotide pairs, forming an 'open' conformation.

59 inactive (bent-closed) and active (extended-open) conformations.

60 The open conformation (30%) is more susceptible to chymotryp

61 close enough to form a disulfide bond in an open conformation (6.9 A apart) because they are separat

62 d' conformation docked near the stalk to an 'open' conformation able to interact with membranes.

63 a change of an active-site Omega-loop to an open conformation accommodates ceftazidime leading to en

64 he bi-lobed structure of GluN2 ATD adopts an open conformation accompanied by rearrangement of the Gl

65 CI shows a transition between "closed" and "open" conformations, accompanied by the striking rotatio

66 In addition, it identified an open conformation adopted late in splicing by a 3' splic

67 n shear force activation, the stem adopts an open conformation allowing the adhesion of VWF to platel

68 tal structure of XylE in a new inward-facing open conformation, allowing us to visualize the rocker-s

69 olution structure of TpbA in the ligand-free open conformation, along with an analysis of the structu

70 Hepcidin binds ferroportin in an outward-open conformation and completely occludes the iron efflu

71 ch reveals that HHARI binds this E2 Ub in an open conformation and explains the specificity of this c

72 e forms of tTG that constitutively assume an open conformation and induce apoptosis.

73 The two unliganded lobes present a canonical open conformation and interact via their respective C- a

74 s by XPB while AfBax1 maintains AfXPB in the open conformation and reduces its ATPase activity.

75 L1 mutations promote the open conformation and switch immune response from interf

76 beta subunit preferentially adopts the half-open conformation and that the transition to this confor

77 lexible, fluctuating between closed and more open conformations and sometimes sampling the fully open

78 most closed conformation, E2 adopts the most open conformation, and E3 adopts an intermediate conform

79 lamp loaders bind and stabilize clamps in an open conformation, and in the second stage, clamp loader

80 -binding site of SERT, stabilize the outward-open conformation, and inhibit serotonin transport.

81 ith the Arp2/3 complex, induced the standard open conformation, and two new masses appeared at positi

82 s that occur from the outward-open to inward-open conformations, and provide insight into the mechani

83 REV7 exists in active 'closed' and inactive 'open' conformations, and TRIP13 catalyses the inactivati

84 ransition between the inside and the outside open conformation are modified.

85 Structures obtained in closed and open conformations are reversibly interconvertible by ch

86 nce of any electron acceptors stabilizes the open conformation as the electrostatic repulsion due to

87 state that is different from the apo outward-open conformation as well as inward-facing conformations

88 s the change between outward-open and inward-open conformations as a unifying critical step in LeuT-t

89 todomain adopts extended-closed and extended-open conformations as well as a bent conformation.

90 Here we present a structure of this open conformation at 3.3 angstrom resolution using fiduc

91 despite the fact that FAK is in the active, open conformation at CAs, its kinase activity is dispens

92 Both subunits adopt an open conformation at rest, and only GBR1 closes on agoni

93 tart site and plays a role in maintaining an open conformation at that location.

94 conformation at the human NOS2 locus and an open conformation at the murine NOS2 locus.

95 concentrations, while in intermediate closed-open conformations (at pH ~6) the number and occupancy o

96 The PIC, in an open conformation, attaches to the 5' end of the mRNA an

97 ate mimetic (Ub-AMSN) bound, the E1 is in an open conformation before release of pyrophosphate.

98 tant immobilized in an outward (periplasmic)-open conformation bind to the flexible WT protein and st

99 d recently, showing the protein in an inward-open conformation bound to two Na(+) and a taurocholic a

100 ficient in Gq coupling do not stabilize this open conformation but instead favor two more occluded co

101 )-subunits in both enzymes are in the usual "open" conformation but appear to be occupied uniquely by

102 t, expression of WT FAK and FAK/Y180A/M183A (open conformation), but not FAK/Arg(454) (kinase-dead),

103 ains a pai-helical segment in the closed and open conformations, but becomes entirely alpha-helical u

104 rom a functionally "closed" State 1 to more "open" conformations, but the molecular mechanisms underl

105 Ca(2+) binding stimulates its open conformation by altering the structure of transmemb

106 The structure is locked in an outward-facing open conformation by an inhibitor.

107 Antidepressants lock SERT in an outward-open conformation by lodging in the central binding site

108 troscopy, we demonstrate that EHD2 adopts an open conformation by tilting the helical domains upon me

109 The results show that an open conformation can be readily detected in cells and t

110 Mutations expected to promote the open conformation caused enhanced activity in vitro and

111 tal form reveals that the locally closed and open conformations coexist as discrete ones at acidic pH

112 ses camphor mobility yet retains a partially open conformation compatible with the required proton re

113 and of the mutant Y93A stabilized 80% in the open conformation directly document two envelopes that d

114 he transition of the active site to the half-open conformation, driven by the intrinsic elasticity of

115 ly, we showed that ADAMTS13 circulates in an open conformation during the acute phase of immune-media

116 this receptor in transitions from closed to open conformations during entry.

117 gering Env to transition from a "closed" to "open" conformation during the early events of virus-cell

118 phorylation and agents that stabilize inward-open conformations (e.g., 5-HT, ibogaine) increased phos

119 An open conformation emerges from an ensemble of closed con

120 The more open conformation exhibits a second molecule of thiorida

121 Calcium binding to either domain favors an "open" conformation, exposing a large hydrophobic surface

122 post-chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP,

123 rmation of WT ADAMTS13 and suggested a more "open" conformation for GoF ADAMTS13.

124 of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyz

125 mation on Drosophila melanogaster Orai in an open conformation (Hou et al., 2018).

126 nt of transition to catalytically competent (open) conformation hypothesized from structural modeling

127 To test for the presence of an open conformation in intact cells, reporter cysteines we

128 contains a HEAT domain (SF3B1(HEAT)) with an open conformation in isolated SF3b(10), but a closed con

129 rom different strains primarily exists in an open conformation in solution and binds to cellular prot

130 been shown to induce cell death, assumes an open conformation in solution as assessed by an enhanced

131 tering analyses revealed that AnmK adopts an open conformation in solution in the absence of ligand a

132 modeling results show that apo-IRP1 is in an open conformation in solution, and the ensemble optimiza

133 nd molecular modeling suggest TerS adopts an open conformation in solution, characterized by dynamic

134 closed conformation in the ATP complex to an open conformation in the covalent ligase-AMP intermediat

135 a complete closed conformation to a complete open conformation in the presence of ADP.

136 sence of calcium, are compacted but adopt an open conformation in the presence of calcium, enabling a

137 reason for the catalyst to adopt the gauche-open conformation in the transition state.

138 cts with PRP5 and TAT-SF1, and maintains its open conformation in U2 snRNP, and that U2 snRNA forms a

139 say we show that these mutations restore the open conformation in vivo.

140 n stabilizes a novel energetically favorable open conformation in which changes at the intersubunit i

141 on the Nipah-N structure we modeled a PIV5-N open conformation in which the CTD rotates away from the

142 and that the free energy required to access open conformations in the glycine-bound LBD is largely r

143 ransfer, we identified functionally relevant open conformations in which the two MMP1 domains are wel

144 The apo form adopts a distinct open conformation, in which the smaller subdomain of SIR

145 partially open Env trimer than to the fully open conformation induced by CD4.

146 voltage-dependent transitions from closed to open conformation induced MEK-ERK1/2-dependent Tyr-447 p

147 formations, suggesting that NS1 can adopt an open conformation irrespective of E or G at the 71st pos

148 studies and MD simulations indicate that an open conformation is also stabilized by peptide ligand b

149 " conformations, and the extent to which the open conformation is favored directly correlates with th

150 We demonstrate that the HD-PTP open conformation is functionally competent for binding

151 The open conformation is induced by ATP hydrolysis and corre

152 Overall, an open conformation is required for tetraspanin-partner in

153 An open conformation is thus favored in solution with many

154 gh the betaE-catalytic site is in the usual "open" conformation, it is occupied by the unique combina

155 Spontaneous toggling of Prp5 into a stable, open conformation may be important for its release from

156 osed" conformation to a potentially active, "open" conformation mediated by Mats, a conserved Mps1-bi

157 Consistent with this more open conformation, neutralization potency of antibodies

158 This "open" conformation not only rationalizes the inactivity

159 Rather, the fully open conformation observed in the F1 X-ray structure is

160 oscopic current amplitude by stabilizing the open conformation of 7.1/KCNE1 channels.

161 The crystal structure of the open conformation of a bacterial voltage-gated sodium ch

162 of the bilayer dictate the stability of the open conformation of a Kv pore module in the absence of

163 rmediate between the outward-open and inward-open conformation of ABC exporters.

164 onectin substrates suggest that the extended-open conformation of alpha5beta1 is adhesive and that th

165 Together, our findings show that the open conformation of AnmK facilitates binding of both th

166 eading to the transition from closed to semi-open conformation of apo Act.

167 The open conformation of apo EI allows phosphoryl transfer f

168 n promoted a standard (previously described) open conformation of Arp2/3 complex, with the N-terminal

169 s that EC1-EC2 interaction also supports the open conformation of CD81.

170 nts to activate canonical Wnt signaling, the open conformation of Dvl more effectively activates Jun

171 he pyrrole rings in the substrate, iii) more open conformation of enzyme active site to accommodate t

172 ding to pro-TGF-beta1 does not stabilize the open conformation of its headpiece.

173 Promoting an outward-open conformation of LeuT by mutation abolished the K(+)

174 state may reflect a physiologically relevant open conformation of MtrE.

175 AFa domains of rod PDE6, as well as a stable open conformation of Palphabeta catalytic dimer in diffe

176 o7 by the t-SNARE Sec9, which results in the open conformation of Sro7, also acts to inhibit vesicle

177 the interswitch region resulting in a fully open conformation of switch I.

178 of the ternary complex is biased toward the open conformation of syntaxin-1 compared with the binary

179 omplex are crucial in yeast to stabilize the open conformation of the 40 S subunit and are required f

180 of Mn(2+) and pro-TGF-beta1 to stabilize the open conformation of the alphaVbeta8 headpiece.

181 Progression from an open conformation of the apoenzyme to a nearly closed co

182 required for the maintenance of an extended-open conformation of the beta leg.

183 his is the first observation that reports an open conformation of the C-terminal helix in a chemokine

184 s that GoSlo-SR-5-6 works by stabilizing the open conformation of the channel and the activated state

185 action, it is strong enough to stabilize the open conformation of the channel and thus slow deactivat

186 extracellular facing monolayer stabilize the open conformation of the channel.

187 ure of tyrosine-GlcNAcylated RhoA reveals an open conformation of the effector loop distinct from rec

188 the MIM interaction, in concert with a more open conformation of the Ist1 core, resulted in stimulat

189 te inhibitor imatinib leads to an unexpected open conformation of the multidomain SH3-SH2-kinase c-Ab

190 The structure unexpectedly revealed a novel open conformation of the PRODH active site, which is int

191 r is detrimental to, cell survival, with the open conformation of the protein being responsible for i

192 e protein suggests that heparin enhances the open conformation of the RBD that binds ACE2.

193 y controlled conditions in order to keep the open conformation of the tTG.

194 The N196K residue appears to stabilize the open conformation of U2AF2 with an inter-RNA recognition

195 bly by a dynamic population shift toward the open conformation of U2AF65 to facilitate the recognitio

196 PK1 exhibits preferential binding toward the open conformation of vinculin, suggesting that the MAPK1

197 heta, reflecting their role in promoting the open conformation of Zap70.

198 GMF induced two distinct open conformations of Arp2/3 complex, which correlated w

199 This study determined that open conformations of Env with V3 exposed are present on

200 the Nbs stabilize several different outward-open conformations of LacY.

201 as Na(+) and cocaine that stabilize outward-open conformations of SERT decreased phosphorylation and

202 involves a transition between the closed and open conformations of the 30S ribosomal subunit and requ

203 Open conformations of the Cys domain are associated with

204 l interactions that stabilize the closed and open conformations of the ion conduction gate of the hum

205 ndings and homology models of the closed and open conformations of the Kv7.3 PM, we propose a structu

206 ynamic exchange between partially closed and open conformations of the SAM-II riboswitch in the absen

207 Tau adopts an open conformation on binding tubulin, in which the long-

208 static closed Get3*TA complex, Get3 samples open conformations on the submillisecond timescale upon

209 e refinement was used to generate closed and open conformations on which the alpha7 models were based

210 It is controversial, however, whether the open conformation only exists transiently in intact cell

211 ion of tissue transglutaminase enzyme in its open conformation (open-tTG) was developed and optimized

212 This domain of approximately 900 kb is in an open conformation over its length and is generally susce

213 e report the crystal structure of CD53 in an open conformation poised for partner interaction.

214 e predicted glycosidic position, whereas the open conformation possibly represents an unreactive stat

215 w-up study in 1 iTTP patient showed that the open conformation precedes a substantial drop in ADAMTS1

216 A maximum open conformation probability approaching 1.0 and maximu

217 er eliminates the barrier and stabilizes the open conformation relative to the closed.

218 residues Q122-E126 to adopt both closed and open conformations relative to the transmembrane domain.

219 Kinase inhibitors that stabilize an open conformation relieve this interference and reduce t

220 The observed relevance of open conformations resolves the debate about the roles o

221 her with a greater propensity to exist in an open conformation, resulting in increased OM permeabilit

222 vAb/1-226 captures the activation gate in an open conformation, revealing the open state of a BacNav

223 The structure, captured in an inside-open conformation, reveals the architecture of KCCs incl

224 ractions with the lipid tails to promote the open conformation, shifting the voltage dependence of ac

225 The structure is in a laterally open conformation showing that gating is independent of

226 Active Cdk12/CycK is arranged in an open conformation similar to that of Cdk9/CycT but diffe

227 ral azoles revealed binding of ligands to an open conformation similar to that of the ligand-free sta

228 ing H5N1-NS1(E71) and show that it adopts an open conformation similar to that of the minor group of

229 hibitory closed conformation to a permissive open conformation, speeding up actin polymerization.

230 ssociation of the filter gate with two novel open conformation stabilizers: an antidepressant and a p

231 demonstrates that SYD-2 largely exists in an open conformation state in ptp-3 mutants.

232 intermediate state (State 2), followed by an open conformation (State 3) that is susceptible to engag

233 formation (state 2) into the three-CD4-bound open conformation (state 3).

234 iate conformation (State 2) and then a more "open" conformation (State 3) that can be recognized by n

235 on and H6N6-NS1(Delta80-84/G71) also exhibit open conformations, suggesting that NS1 can adopt an ope

236 f the calmodulin insensitive mutant in a pre-open conformation suggests that channel opening may occu

237 able for internal electron transfer, and an "open" conformation suitable for intermolecular electron

238 The trimers in an open conformation swap domains with each other.

239 te lipid, the wild-type Merlin adopts a more open conformation than in solution, but Merlin(S518D) re

240 cing crystal structure, with a somewhat more open conformation than the crystal structure.

241 ps separate, among other changes, to form an open conformation that binds tightly to host receptors.

242 whereas addition of GAP converts DXPS to the open conformation that coincides with decarboxylation of

243 mary "closed" conformation that can adopt an open conformation that enables Poly-P binding.

244 rganization requires the protein to adopt an open conformation that exposes the surfaces engaging in

245 ver, at a finite rate, TG2 transitions to an open conformation that exposes the transamidase catalyti

246 acking of the V3 loop, and (iii) activate an open conformation that exposes V3 to the effects of V3 A

247 hitecture to clamp a switch I tyrosine in an open conformation that facilitates access of the arginin

248 -CoV-2 S and facilitates the adoption of the open conformation that is required for S to bind to the

249 the Sec61-translocon, and captures it in an open conformation that is translocation-incompetent.

250 nzyme is very flexible, allowing it to adopt open conformations that can bind nucleotide and closed o

251 pre-existing equilibrium between closed and open conformations that facilitates ligand binding to th

252 tramolecular pi-stacking interaction and an "open" conformation that cannot form the interaction.

253 This motion propagates through further opening conformations that allow binding of an Ub-loaded

254 mutant can be trapped in a prolonged 'burst opening' conformation that is proposed to be equipped wi

255 ed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His

256 In the widened channel in the open conformation, these same residues establish a const

257 ystal structure of the monomeric AlnB in the open conformation to 1.25-A resolution showed that the p

258 the 48S preinitiation complex (PIC) from an open conformation to a closed state with more tightly-bo

259 omotes syntaxin-1 switch from a closed to an open conformation to accelerate soluble N-ethylmaleimide

260 lamp is closed in solution but must adopt an open conformation to be assembled onto DNA by a clamp lo

261 idase site locks the protein in the extended/open conformation to disorganize/inactivate the GTP bind

262 onverts this fully closed conformation to an open conformation to initiate productive substrate bindi

263 selectively dissociates Env trimers with an open conformation to restrict HIV-1 replication.IMPORTAN

264 st a LacY mutant in an outward (periplasmic)-open conformation to stabilize this state of the WT prot

265 It transitions from closed to open conformations to expose its receptor-binding site a

266 MurJ alternates between inward- and outward-open conformations to flip lipid II, but how these confo

267 n mutations shifting the equilibrium towards open conformations to promote transfucosylation over hyd

268 ion has GTP binding/GTPase activity, and the open conformation transamidase activity.

269 nt mutant that stabilizes the protein in the open conformation trapped by these miniproteins.

270 the crystal structure of GLUT1 in an inward open conformation was reported.

271 lamp dynamics contribute to formation of the open conformation, we identified conditions that destabi

272 Lck mutants locked in the open conformation were more confined than Lck mutants in

273 full-length integrin adopts an extended and open conformation when bound to its physiological macrom

274 structures showed that RF1 and RF2 are in an open conformation when bound to the ribosome but are in

275 he GluN1 amino-terminal domain adopts a more open conformation when coassembled with GluN2A than with

276 ate that the well-studied P450cam adopts the open conformation when its redox partner, putidaredoxin

277 ound P450cam to shift from the closed to the open conformation when labeled on either the F or G heli

278 iation complex (PIC) is thought to assume an open conformation when scanning the mRNA leader, with AU

279 The TL remains in an inactive open conformation when the mismatched substrate is bound

280 MCT1 exhibits similar outward-open conformations when complexed with lactate or the in

281 mation observed in crystal structures and an open conformation where the PH domain moves away from th

282 t, the oxidized form of Rv2466c displays an "open" conformation, where tertiary structural changes in

283 toplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first

284 ructures of substrate-free Tps2PD reveal an "open" conformation whereby the cap and core domains sepa

285 r role of Pdx is to shift P450cam toward the open conformation, which enables the establishment of a

286 ons successfully transitioned into the fully open conformation, which is known to be the dominant bin

287 n-glycosylated 99-loop seems to favor a wide open conformation, which mostly increases the apparent a

288 These trimers had an "open" conformation, which is distinct from the "closed"

289 ining M2 is splayed open, reminiscent of the open conformation, while the intracellular-half is const

290 The apo-form of the protein has an open conformation with a disordered P-loop but a structu

291 We find that sTf binds Ti(IV) in an open conformation with both carbonate and citrate as syn

292 As the structures of Mg(2+) channels in an open conformation with bound Mg(2+) have not yet been so

293 The transporter is locked in an outward-open conformation with nortriptyline wedged between tran

294 t-catalytic structures reveal hPolbeta in an open conformation with PPi bound in the active site, the

295 be of the C-subunit, which is in a partially open conformation with the C-tail disordered.

296 hereas the CYP2B37 structure demonstrated an open conformation with three 4-CPI molecules, one within

297 nced Gq coupling more strongly stabilize an "open" conformation with an accessible transducer-binding

298 Strikingly, Vps45 holds Tlg2 in an open conformation, with its SNARE motif disengaged from

299 ex structure, the catalytic domain adopts an open conformation, with the K36M/I peptide snuggly posit

300 ultaneously ensuring that both SNAREs are in open conformations, with their SNARE motifs available fo