ライフサイエンスコーパス: open probability

1 Ca diffusion, SERCA uptake activity, and RyR open probability.

2 s and rates inversely correlate with channel-open probability.

3 of sIPSCs and potentiation of single-channel open probability.

4 e significant changes in ATP sensitivity and open probability.

5 rotein kinase A results in increased channel open probability.

6 s with different single-channel kinetics and open probability.

7 70N, respectively), while increasing channel open probability.

8 than the GluN2A subunit, which has a higher open probability.

9 nce of ?160 pS and high, voltage-independent open probability.

10 RGS7(-/-)/RGS11(-/-) rod BCs have a very low open probability.

11 nse time course and increases single-channel open probability.

12 hannel environment, which change the channel open probability.

13 ed Na(+) self-inhibition and reduced channel open probability.

14 Ca(V)1.2, observed as an increase in channel open probability.

15 AC substantially reduces ENaC single channel open probability.

16 i, voltage and cAMP, exclusively control the open probability.

17 activated ENaC by increasing single-channel open probability.

18 s mediated by an allosteric reduction of the open probability.

19 y via its own receptor affecting the channel open probability.

20 it, likely reflecting an increase in channel open probability.

21 ed an ohmic behavior and a voltage-dependent open probability.

22 te dimerization and thereby increase channel open probability.

23 s open as well as an increase in the maximum open probability.

24 lyoxal increased and then decreased the RyR2 open probability.

25 nced calcium influx due to increased channel open probability.

26 and ryanodine receptor type 2 (RyR2) channel open probability.

27 KII and results in a decrease in the channel open probability.

28 drophilic pore of large conductance and high open probability.

29 ed TRPV3 single-channel conductance, but not open probability.

30 eceptors, and estimate the subunit-dependent open probability.

31 cts on single-channel conductance as well as open probability.

32 to endogenous protons, and decreased channel open probability.

33 nsferase increased InsP(3)R-3 single channel open probability.

34 e in the plasma membrane, and single-channel open probability.

35 ion at the selectivity filter and overall PD open probability.

36 observed Ca(2+) dependence of the channel's open probability.

37 n closed time, and thereby enhancing overall open probability.

38 sistent with an effect of bile acids on ENaC open probability.

39 ipid composition strongly increased the KcsA open probability.

40 ked ENaC palmitoylation also reduced channel open probability.

41 lowly, without appreciable change of channel opening probability.

42 g NMDA receptors also have a two-fold higher open probability (0.037) than exon 5-lacking receptors (

43 Ca(2)(+) channels in IHCs showed a low mean open probability (0.21 at -20 mV), but this increased si

44 ow that the receptor has a high constitutive open probability (~0.1), but is only weakly activated by

45 ficient mdx muscle: (1) increased MS channel open probability, (2) a shift of MS channel gating to la

46 emble alpha1 receptors in their high maximum open probability (99.1% cf. 98% for alpha1), but differ

47 at a decreased TRPV5 pore size and a reduced open probability accompany the plasmin-mediated reductio

48 pendence in the opposite direction, reducing open probability; acidification also reduced the number

49 -RyR) have increased calcium sensitivity and open probability, amplifying calcium transient at a cost

50 to the InsP3R and thereby increases channel open probability, an event associated with chemotherapy-

51 to three conductance levels with comparable open probabilities and displays modal behavior similar t

52 ver, these mutant channels have higher basal open probabilities and limited responses to the agonist

53 in induces a dose-dependent increase in both open probabilities and mean open times on KcsA in artifi

54 truncated form of TREK1 with a much reduced open probability and a proposed increased permeability t

55 he hKv7.4a channel by decreasing the channel open probability and altering activation kinetics.

56 ce had abolished vasopressin-stimulated ENaC open probability and apical membrane channel number.

57 nt mutation, D569N, that reduces the resting open probability and Ca(2+) permeability of the transduc

58 a and gamma subunits increases the channel's open probability and function.

59 ) -channels from Tric-a KO mice have a lower open probability and gate more frequently in subconducti

60 With a low intrinsic open probability and high propensity toward the inductio

61 tage-dependent changes in the single-channel open probability and is not species- or subunit-dependen

62 The channel has a low open probability and is tightly regulated, to avoid deco

63 profoundly affect SR Ca(2+) release even if open probability and mean OTs and CTs are identical.

64 D receptors are characterized by low channel open probability and prolonged deactivation time course

65 It also decreased TRPV1 current density and open probability and reduced the proportion of pancreati

66 ls causes adaptation, rapidly reducing their open probability and resetting their operating range.

67 CPVT-CaMs caused greater RyR2 single-channel open probability and showed enhanced binding affinity to

68 mal development, but exhibit reduced resting open probability and slowed onset of MET currents, consi

69 d reduced Ca(2+) sensitivity, single-channel open probability and tamoxifen sensitivity.

70 ing regions markedly affect both the channel-open probability and the activation of the channel by an

71 dogenous AA-dependent inhibition, increasing open probability and the fraction of functional channels

72 1/2B/2D receptors because agonist potencies, open probability and the glutamate deactivation time cou

73 We showed that [Mg(2+)]i affects both open probability and the number of functional channels,

74 ity was twofold smaller because of a smaller open probability and unitary conductance.

75 d that activation by POPG increases both the open probability and unitary conductance.

76 mino acid substitutions in ENaC that depress open probability and was precluded by proteolytic cleava

77 TP block, dramatically increased the channel open probability, and affected the interaction of Kir6.2

78 endently with respect to voltage-activation, open probability, and facilitation.

79 l domains of GluN2A subunits reduces channel open probability, and low-affinity voltage-dependent bin

80 ein expression, fewer active channels, lower open probability, and reduced effective activity.

81 t an H620Q mutant, shown to increase channel open probability, and the dual corrector/potentiator CFF

82 s revealed that FMRP loss reduced BK channel open probability, and this defect was compensated in dKO

83 y hyperpolarization and saturating cAMP, the open probability approaches unity.

84 ility approaching 1.0 and maximum functional open probability approaching 0.7 imply that, within the

85 ignificant "window current" at that voltage (open probability, approximately 1%), Ca(V)3.1 channels r

86 ignificant "window current" at that voltage (open probability, approximately 1%), which makes them a

87 ively, without appreciable change of channel-opening probability, as compared with GluA4 channel alon

88 in the range of 15 to 250 pS, with a larger open probability at 0 mV as compared with Cx43, which su

89 , stabilized by NS309, increases the channel open probability at a given Ca(2+) concentration.

90 ted by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca(2+) concen

91 0C channels exhibited a significantly higher open probability at diastolic Ca(2+) concentrations, ass

92 itutively open mutant BK channels, with high open probability at negative voltages, as well as a loss

93 1 pS (n = 17; symmetrical 150 mm K(+) ) with open probability being both voltage- and Ca(2+) -depende

94 he channel, nor is there a difference in the open probability between high and low [K(+)] as determin

95 ock-insensitive channels had lower intrinsic open probabilities but retained high sensitivity to zinc

96 ith end-stage heart failure, increased basal open probability but did not attenuate stimulatory respo

97 creases both alpha and alphabeta4 BK channel open probability, but only alpha BK develops acute toler

98 glycine potency by 2-fold, increases channel open probability by 6-fold, and reduces receptor sensiti

99 found that 4 mM NPA caused a 62% decrease in open probability by decreasing mean open time 2.5-fold a

100 increase in ryanodine receptor type 2 (RyR2) open probability by direct oxidation of the RyR2 protein

101 Rp29 may promote ENaC cleavage and increased open probability by directing ENaC to the Golgi via coat

102 enprodil decreased NMDA receptor equilibrium open probability by raising an energetic barrier to acti

103 Namely, 10 uM dantrolene reduced RyR channel open probability by ~50% in the presence of 3 mM free Mg

104 tching and subsequent ROS production on RyR2 open probability, Ca2+ sparks, and the myoplasmic calciu

105 egnenolone sulfate closely matched predicted open probability calculated assuming energetic additivit

106 y enhanced Na(+) self-inhibition and reduced open probability compared with wild type ENaCs.

107 2-MARCKS complex, which is necessary for the open probability conformation of the channel and preserv

108 luded by proteolytic cleavage that increases open probability, consistent with an effect of bile acid

109 rameters, a reflection of ryanodine receptor open probability, consistent with the effect of IP3 sign

110 receptors activate in long episodes of high open probability, consisting of groups of openings in qu

111 to produce frequent firings, decreasing RyR open probability counter-intuitively promotes long-lasti

112 By comparison, RyR open probability declined more slowly, suggesting releas

113 channels are constitutively active and their open probability depends on the lipidic composition of t

114 eraction domain helix markedly reduced basal open probability despite intact binding of Ca(V)beta to

115 ctivation, reflecting an increase in channel open probability due to a loss of the inhibitory effect

116 .1 in giant liposomes, resulting in a higher open probability due to more frequent opening bursts.

117 In the context of channels that have a low open probability due to retention of an inhibitory tract

118 In the context of channels that have a low open probability due to retention of an inhibitory tract

119 showed that the mutant channels have higher open probability, due to a modification of gating, and n

120 ing the existence of an optimal range of RyR open probability favoring long-lasting sparks.

121 based on the subunit and match the reported open probabilities for the receptor.

122 this reduction we solve for the equilibrium open probability for calcium release in the model.

123 Kalpha macroscopic conductance or fractional open probability (FP(o)) as a function of voltage.

124 The gating characteristics, open probability, frequency, and current decrease, provi

125 of caveolin-1 significantly reduced channel open probability (from 0.05 +/- 0.01 to 0.005 +/- 0.001;

126 In this setting, decreasing RyR open probability further suppresses long-lasting sparks

127 to alpha(1C) stabilizes an increased channel open probability gating mode by a mechanism that require

128 arresting surface Ca(V)1.2 channels in a low open probability gating mode, rather than by interfering

129 and also by biasing the receptor toward low open probability gating modes.

130 recombinant receptors suggests that the high-open-probability gating mode of AMPA receptors containin

131 -actinin-1 binding, decreased single-channel open probability, gating charge movement, and its coupli

132 low open probability GluN2C- than the higher open probability GluN2A-subunit-containing receptors.

133 , being more effective in the inherently low open probability GluN2C- than the higher open probabilit

134 F mutation was highly active (single-channel open probability >0.3) in the absence of ATP and protein

135 or BAPTA caused smaller increases in resting open probability in Bth mutant OHCs than in wild-type co

136 ituted into lipid bilayers revealed enhanced open probability in cAF samples, providing a molecular b

137 spontaneous Ca(2+) release events, and RyR2 open probability in cAF, whereas protein kinase A inhibi

138 centrations of bupivacaine decreased channel open probability in GluN2 subunit- and pH-independent ma

139 enuated stimulatory effect on BK(Ca) channel open probability in inside-out membrane patches.

140 inated variation in ATP:ADP and KATP channel open probability in intact cells.

141 ternate kinetic behavior, consisting of high open probability in lower conductance states.

142 icit in Q1412X-CFTR suggest that the reduced open probability in Q1412X-CFTR is the result of a disru

143 Steady-state open probability in the presence of combinations of GABA

144 annel analysis showed that PKA decreased the open probability in wild-type but not S334A mutant chann

145 sly showed that PIP(2) increases the channel open probability, in this work we find that activation b

146 (2+)] = 25 muM, tauac = 0.082 ms, the IP(3)R open probability increased by approximately 20% and mean

147 found that after carbohydrate stimulus, ENaC open probability increased in split-open isolated collec

148 e activity in as little as 0.01% PIP(2), and open probability increases to approximately 0.4 at 1% PI

149 When activated, [Ca2+]i-sensitive RyR2 open probability increases, and the Ca2+ spark rate chan

150 +) binding site, both modulating the resting open probability independent of adaptation.

151 C456S) mutant channels have a higher channel open probability, induce more calcium influx, and enhanc

152 mics simulations show that the difference in open probability is caused by one long closed state in K

153 arks can occur when ryanodine receptor (RyR) open probability is either increased or decreased.

154 hannels are unique among VGICs because their open probability is increased by membrane hyperpolarizat

155 essed by extracellular [Au(CN)2](-) when the open probability is markedly reduced by introducing a se

156 98% for alpha1), but differ in that maximum open probability is reached when all five binding sites

157 he GluN2B subunit, which has a lower channel open probability, is on average more closed than the Glu

158 muM Ca(2+), Ln(3+) potently inhibited RyR's open probability (Kd Eu(3+) = 167 +/- 5 nM and Kd Sm(3+)

159 +) currents as a consequence of their higher open probabilities, leading to increased firing rates in

160 Ethanol also increased BK channel open probability measured in single-channel recordings f

161 ilized long openings characteristic of "high-open-probability" mode).

162 rotein, gamma-2, gating in the low- and high-open probability modes, respectively.

163 (-20 mmHg) caused a 19-fold increase in the open probability (NPo) of human TREK-1 channels.

164 BKCa channel normalized open probability (NPo) versus membrane potential (Vm) cu

165 Furthermore, the peak open probabilities of alpha1(D43C)beta2gamma2 and alpha1

166 ividual transport rates to quantify absolute open probabilities of EAAT2 anion channels from ratios o

167 Moreover, at negative potentials open probabilities of EAAT5 anion channels were much lar

168 d may provide a mechanism for modulating the open probabilities of the individual tetramers.

169 n of cysteamine that elicits an intracluster open probability of >0.9.

170 steroid alfaxalone had an estimated maximal open probability of 0.6 in oocytes and 0.01 in HEK cells

171 wild type) and reached a maximum one-channel open probability of about 45% at 100 mm glycine (compare

172 ate ENaC-mediated currents by increasing the open probability of active channels without recruiting a

173 pression of Ca(2+) release in ICC limits the open probability of Ano1 channels, reducing the excitabi

174 s were activated to similar extents (maximum open probability of approximately 0.8 at 0 mV) by 0.1-30

175 The open probability of BK channels is regulated by the intr

176 t activated alpha2M (alpha2M*) increased the open probability of BKCain an oscillatory pattern in hMS

177 f theophylline was due to an increase in the open probability of calcium-activated potassium channels

178 showed that mechanical stimulation increased open probability of carboxyfluorescein-permeable membran

179 ves as a CFTR potentiator that increases the open probability of CFTR channels.

180 pharmacologic strategies for modulating the open probability of channels obeying equilibrium versus

181 owed that PKC activation lowered the overall open probability of ClC-1 in the voltage range relevant

182 state is low (~1%), consistent with the low open probability of CLC-2 observed experimentally in the

183 ltage-dependent mechanisms that regulate the open probability of connexin channels.

184 bability on VG; 2), the voltage at which the open probability of each gate equals 0.5; 3), the gating

185 d A6 collecting duct cells revealed that the open probability of ENaC was sensitive to the sgk1 inhib

186 foundly decreased the maximum single-channel open probability of homomeric GlyRs (to 0.16; cf. 0.99 f

187 used to continuously monitor the number and open probability of InsP3R channels in the same excised

188 tagamma subunits (2-250 ng /mL) enhanced the open probability of Kv7.4 channels without changing unit

189 sis revealed up to 7-fold increased absolute open probability of L46P EAAT2 anion channels.

190 id (10 mum), a channel opener, increased the open probability of methionine-inhibited unitary current

191 tein phosphatase 2a inhibition increased the open probability of mitoK(ATP) channels through GSK3beta

192 ollowed by quiescence, leading to an overall open probability of only approximately 0.15 after 4 s un

193 2814 phosphorylation in CREM mice normalized open probability of RyR2 channels and SR Ca(2+) release,

194 Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum

195 timulation of cardiac myocytes increases the open probability of sarcolemmal voltage-sensitive Ca2+ c

196 east in part, by upregulating the levels and open probability of Shaker (Sh) potassium channels to su

197 ) spark frequency in atrial myocytes and the open probability of single RyR2 channels from JPH2 knock

198 important role in determining the intrinsic open probability of SK channels in the absence of Ca(2+)

199 itivity, activation rate, and single-channel open probability of SLO-2.

200 s, and we found that acidic pH increases the open probability of SspA.

201 odel indicates that the maximal steady-state open probability of the alpha4beta2delta receptor is ~0.

202 atically affects CaM's ability to reduce the open probability of the cardiac ryanodine receptor (RyR2

203 this difference is related to changes in the open probability of the CFTR channel during exercise, re

204 Trypsin, which increases open probability of the channel by proteolytic cleavage,

205 ng to shorter mean close-time and hence high open probability of the channel in comparison to IP3R in

206 d that the GORK S722E mutation increases the open probability of the channel in the absence, but not

207 Thus, the open probability of the channel must be close to unity.

208 -alpha that is crucial for activation of the open probability of the channel, but not membrane expres

209 Oxidation of RyR2s was found to increase the open probability of the channel, whereas CaMKII can be a

210 s to the amino-terminal domain determine the open probability of the channel.

211 and are themselves sufficient to affect the open probability of the channel.

212 face thiol disulfide formation increases the open probability of the heme pocket and allows nitrite b

213 lation; and 3) phosphorylation increases the open probability of the heme pocket, which increases lig

214 alcium concentration, which sets the resting open probability of the mechanosensitive channels.

215 esent in the immature cochlea, the increased open probability of the mechanotransducer channels cause

216 Depolarization did not increase the resting open probability of the MET current of Tmc1(Bth/Bth) OHC

217 ations within the GluN2D pre-M1 region alter open probability of the NMDA receptor.

218 t-exposure test response correlates with the open probability of the preceding desensitizing response

219 ved shut conformations, thereby reducing the open probability of the receptor with no change in the m

220 to a total absence of one and increased the open probability of the remaining two thermoresponsive C

221 drophobic barrier within the pore, and a low open probability of the selectivity filter (SF) gate.

222 at the synapse, despite the high equilibrium open probability of these mutant channels.

223 dition, protonation conditions determine the open probability of TMEM16A without changing its calcium

224 optical fluctuation analysis to estimate the opening probability of individual voltage-gated calcium

225 capsaicin (CAP) responses, thus reducing the opening probability of the channel by stabilizing its cl

226 orter and thereby possibly in regulating the opening probability of the inner gate.

227 e mean channel conductance, but not the peak open probability, of recombinant GluA2-containing AMPARs

228 racterizing 1), the steepness of each gate's open probability on VG; 2), the voltage at which the ope

229 ned by comparing steady-state single-channel open probability or macroscopic peak responses elicited

230 deactivation, an increase in single channel open probability, or a reduction in C-type inactivation.

231 A) receptor potency, mean channel open-time, open probability, or single-channel current.

232 SCCaFTs displayed widely variable open probabilities (P(o)) and stepwise transitions among

233 reflect intrinsic differences in equilibrium open probabilities (P(o)).

234 d by its toxicity, native cysteines, and low open probability (P (o)).

235 Additionally, mitoBK(Ca) displays a high open probability (P(o) ) and voltage half-activation (V(

236 binding domains (NBDs), albeit with reduced open probability (P(o) ).

237 expression but found a ~95% reduction in the open probability (P(o) ).

238 ation, H(2)O(2) significantly increased ENaC open probability (P(o)) and single-channel current ampli

239 Another mutation, K1250A, known to increase open probability (P(o)) of DeltaF508 CFTR channels, exac

240 Single-channel open probability (P(o)) of neuronal SLO-2 is ~50% lower

241 ed [(3)H]ryanodine binding and increased the open probability (P(o)) of single RyR2 channels reconsti

242 enhance receptor function by increasing the open probability (P(o)) of the ion channel.

243 revealed InsP(3)-independent gating and high open probability (P(o)) under optimal cytoplasmic Ca(2+)

244 a dramatic decrease in the receptor-channel open probability (P(o)).

245 ecreases ENaC activity via affecting channel open probability (P(o)).

246 a(2+)]i, suggesting Ca(2+) regulation of MCU open probability (P(O)); (iii) in the heart, two feature

247 The resting open probability (P(open)) of MET channels determines th

248 Ensemble averages of the open probability (p(open)) of single K(ATP) channels ove

249 ly activated by GABA that has a maximal peak open probability (P(Open,peak)) of 0.4, taurine (maximal

250 ction effects, with the gain of constitutive open probability paralleling disease severity.

251 t activation, Ca(2+)-dependent inactivation, open probability), permeation (ion selectivity, affinity

252 en and close times, and the resulting IP(3)R open probability PO.

253 ctance (g) and a approximately 13-fold lower open probability (Po ), were found with the R117H mutati

254 FTR, but found a approximately 13-fold lower open probability (Po ).

255 ulin on the channel, thus increasing channel open probability (PO) and Ca(2+)-dependent inactivation.

256 ngle channel conductance, maximal achievable open probability (Po) and the [Ca2+] required for activa

257 m indicate an approximately fourfold greater open probability (PO) for CaV2.1.

258 roduct of the number of channels (N) and the open probability (Po) of a channel).

259 hannels were incorporated into bilayers, the open probability (Po) of channels from Tric-a KO mice wa

260 K201 (>/=5 microM) increased the open probability (Po) of very active ("high-activity") R

261 hyl)-2'-deoxy-ATP (P-dATP), can increase the open probability (Po) to approximately 0.7, implying tha

262 bin1, and displayed increased single channel open probability (Po).

263 due less hydrophobic (L596A/G/W/Q/K) reduces open probability [Po; loss-of-function (LOF)], likely du

264 e presence of PIP2, although with only a low open-probability profile.

265 ticulum (SR) Ca load is high, increasing RyR open probability promotes long-lasting sparks by potenti

266 Rat, but not human, T-tubule LTCCs had open probability similar to crest LTCCs, but exhibited a

267 urface regions and simultaneously boosts its open probability so that Ca(V) 1.2 is mostly active when

268 e structure affects both zinc inhibition and open probability, supporting the general model in which

269 Because of differences in open probability, synaptic triheteromeric receptors outn

270 ure of the dynamic changes in single-channel open probability that account for changes in macroscopic

271 and made careful measurements of the maximum open probability the channel can attain at different tem

272 ree models of RyR gating that have identical open probabilities: the commonly used two-state Markov g

273 of the tetramer or allosteric regulation of open probability through voltage-dependent subunit activ

274 We subsequently assayed for increased open probability time and membrane expression, both of w

275 TIP peptide increased open probability time in H441 cells overexpressing wild

276 With sparse Ca(2+) channels and low opening probability, triggering of fusion for each vesic

277 Slo2 potassium channels have a very low open probability under normal physiological conditions,

278 ctivator of TRPM8 channels, because absolute open probability values measured with fully activated vo

279 Kbeta4 subunit alleviated reduced BK channel open probability via increasing BK channel open frequenc

280 The increase in overall steady-state open probability was accompanied by a reduction in activ

281 Second, open probability was augmented because the frequency and

282 -native crest of the sarcolemma, where their open probability was dramatically increased (0.034+/-0.0

283 High open probability was linked to enhance calcium-calmoduli

284 ductance calcium-activated K(+) (BK) channel open probability was reduced by loss of fragile X mental

285 rrelation between intracellular pH and Panx1 open probability was shown in oocytes.

286 Estimated open probabilities were calculated and analyzed using gl

287 yH-101-sensitive CFTR conductances, and CFTR open probabilities were reduced by 80% in GFP-positive c

288 odine receptor expression and single-channel open probability were increased.

289 Single channel conductance and open probability were reduced for R43C and V168M, respec

290 tor channel type-2), and RyR2 single-channel open-probability were significantly increased in POAF.

291 ted in RyR2 channels that had relatively low open probability, whereas the fast block was unaffected

292 nnels occasionally switched from low to high open probability, which perhaps reflects occasional bind

293 ed agonist potency, and/or increased channel open probability, while the GluN2D(Ser573Phe), (Ser1271P

294 id sequence identity, they exhibit different open probabilities with ca. 90% in KcvNTS and 40% in Kcv

295 om WT mice, multiple channels gate with high open probability with a more than six-fold increase in a

296 ge-dependent gating, which increases channel open probability with depolarization.

297 ce that the location of Ca channels with low open probability within nanometers of the release sites

298 4C mutation dramatically reduced the maximum open probability without altering channel conductance.

299 e cell currents by decreasing single channel open probability without loss of surface receptors.

300 that protons regulate TMEM16A by tuning its open probability without modifying the single channel cu