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1 tributes to tissue morphogenesis is still an open question.
2 l space and astrophysical plasmas is a major open question.
3 nd current functional annotations remains an open question.
4 s involved in temporal processing remains an open question.
5 uch as transcription or DNA repair remain an open question.
6 heating that balances the losses is still an open question.
7 er this effect is scale-dependent remains an open question.
8 l activates the vestibular system remains an open question.
9 al like those of physical systems remains an open question.
10 n degrade complex agars remains therefore an open question.
11 ion to human immune function has remained an open question.
12 owledged, the mechanism of action remains an open question.
13  How cofactor activation proceeds remains an open question.
14 quate motor patterns in the brain remains an open question.
15 site signaling proteins remains an important open question.
16 d participate in hydrogen bonding remains an open question.
17 icroglial functions at synapses remain a key open question.
18 c increases in firearm prevalence remains an open question.
19 t of captive breeding on monarchs remains an open question.
20 hell structure and thermodynamics remains an open question.
21 n experience with moving objects is still an open question.
22 tion as drivers of cancer remains a critical open question.
23   Exactly what is learned and how remains an open question.
24 istinct or antagonistic behaviors remains an open question.
25 al polarity during regeneration is a crucial open question.
26 ies of the photo-active materials remains an open question.
27 lity varies across the brain is an important open question.
28 developing neural circuits of behavior is an open question.
29 ick required for error-prone synthesis is an open question.
30 triggers metabolon formation has remained an open question.
31 llite subsequently inserts into the NE is an open question.
32  up to this challenge is, for some, still an open question.
33 als to control emergency hematopoiesis is an open question.
34 ated in the same diagnostic group remains an open question.
35 istory of the chloroplast lineage remains an open question.
36           What determines p* is currently an open question.
37  a gapped topological spin liquid remains an open question.
38 observed social interactions has remained an open question.
39 to organs with specific 3D shapes remains an open question.
40 tion by influenza A viruses (IAVs) remain an open question.
41 he need for hyper-complex numbers remains an open question.
42 f rapid cell-to-cell signaling remains a key open question.
43 umor-prone environment to prevail remains an open question.
44 nship with cellular fate decision remains an open question.
45 tails of their formation mechanism remain an open question.
46 nd responses to these transitions remains an open question.
47 ocally regulate the CME machinery remains an open question.
48 inases outside the plant lineage, remains an open question.
49 function and disease development is still an open question.
50 hese cues to navigate to healthy reefs is an open question.
51  full extent of this contribution remains an open question.
52 regulate the activity of these enzymes is an open question.
53 w risk attitudes vary with wealth remains an open question.
54 ct of aging on monocyte functions remains an open question.
55 ed and directed to the cell front remains an open question.
56  proliferative TA state remains an important open question.
57 in establishing superconductivity remains an open question.
58 ys are more important than others remains an open question.
59 erns across different populations remains an open question.
60 ubcellular compartments, however, remains an open question.
61 s, differs between the two phases remains an open question.
62 ase diagram of the iron pnictides remains an open question.
63 is to ensure karyotype stability remained an open question.
64 of CO2 to formate and to methanol remains an open question.
65 terplay between these two factors remains an open question.
66 ctional changes during speciation remains an open question.
67 id interference with ongoing cognition is an open question.
68  metal-organic frameworks (MOFs) has been an open question.
69 chemoradiation in cancer patients remains an open question.
70 s folded on the length scale of a gene is an open question.
71 teins they encode, are functional remains an open question.
72 rajectory over the disease course remains an open question.
73 function of class A PBPs is therefore now an open question.
74 siological iron-sensing mechanism remains an open question.
75 e connections is a profound and far-reaching open question.
76 r in hydrogen bonding continues to remain an open question.
77 s of various sizes and geometries remains an open question.
78  restore healthy neurodevelopment remains an open question.
79  the effects of infection on HSCs remains an open question.
80 trophic interactions remains a long-standing open question.
81  cytokines perform similar roles is still an open question.
82  release would matter to a fungus remains an open question.
83 oral expression diversity is generated is an open question.
84 s broader relevance to cuprate physics is an open question.
85 ided with these optimal schedules remains an open question.
86 nvestigators with an emphasis on significant open questions.
87 wever the causes of such variation are still open questions.
88 EMI model may be used to study some of these open questions.
89 rgy funnel", the carotenoids still pose many open questions.
90 ension transmission at tAJs, and discuss key open questions.
91 AG2 loss contributes to tumorigenesis remain open questions.
92 esulting from cotranslational folding remain open questions.
93  and how it relates to the transcriptome are open questions.
94 new directions in these fields and remaining open questions.
95 m-silicate-hydrates (C-S-H) still hosts many open questions.
96 ol of sulfur metabolism and discuss the main open questions.
97 tion accuracy can be achieved, are currently open questions.
98 e in healthy elderly humans remain important open questions.
99 ibility of hemispheric specialization remain open questions.
100 ty and individual musical preferences remain open questions.
101 ry areas to guide adaptive behaviour are key open questions.
102  and how ploidy reduction is achieved remain open questions.
103 ys are associated with skin disease remained open questions.
104  body axis during development, and highlight open questions.
105 tial strategies for addressing the remaining open questions.
106 and what their properties are, have remained open questions.
107  navigate during these migrations remains an open question [2].
108               This answers the long-standing open question about the existence of a finite correlatio
109 ht some of the recent advances and remaining open questions about how a mutation in a myofilament pro
110 models fulfill this need, but there are many open questions about how their connectivity gives rise t
111 al stimuli and simplified behaviors, leaving open questions about nervous system function in the cont
112 ons in optical lattices could help to answer open questions about the doped Hubbard Hamiltonian, and
113 hat is versus what isn't remembered, leaving open questions about the effect of dopamine replacement
114 tter ((3)CDOM*) reactivity, but there remain open questions about the reaction kinetics of (3)CDOM* w
115 te their apparent success, there remain many open questions about their intrinsic properties.
116 hrough both RIP and RAT, and discuss current open questions about these two signaling pathways.
117 er personal questions with known answers and open questions all requiring a "yes" or "no" thought usi
118                      However, to answer this open question, an in-depth analysis of this metabolic br
119  propagation across branch points remains an open question and is especially important for primary af
120                     Finally, we identify key open questions and challenges to comprehensively underst
121          We conclude the review by outlining open questions and directions for future research in the
122              Finally, we highlight important open questions and discuss the potential basic and appli
123                     Finally, we consider the open questions and future directions in this field.
124                     Finally, we identify the open questions and issues to be addressed in the near fu
125                     Finally, we will discuss open questions and possible future directions.
126 understand HK functions, clearing up several open questions and providing a new strategy for future w
127 es and ecosystem processes, and they explore open questions and research needs.
128                         Finally, we indicate open questions and suggest possible directions for futur
129  underlying cause of the failures remains an open question, and more effective CTPs are needed.
130 m fundamental principles to current utility, open questions, and future potential.
131                   We also highlight caveats, open questions, and key directions for future experiment
132 e analysis, and I will highlight challenges, open questions, and opportunities for methodology develo
133           We highlight basic concepts, major open questions, and translational research perspectives
134                                          Key open questions are (1) whether NLRP3 inflammasome activa
135 sGC stimulator vericiguat in HFrEF, the main open questions are the efficacy of the sacubitril/valsar
136                                          Key open questions are where does this additional load origi
137       However, its long-term fate remains an open question as its natural variability on centennial t
138                 However, it still remains an open question as to what kind of cellular communication
139 formation.SIGNIFICANCE STATEMENT There is an open question as to whether human amygdala function trac
140 t shape is crucial in these cases, there are open questions as to how shape is represented for object
141 cturing plant communities is nevertheless an open question because it is very difficult to isolate di
142 oxidation in the ferritin family is still an open question because of the differences in organization
143                        Here, we address this open question by combining topographically patterned sub
144 han currently known, and settle a heretofore open question by showing that a universal cluster state
145                             We highlight the open questions concerning localization, regulation, and
146  cross or respect this boundary, and present open questions concerning the development and plasticity
147 fect a given host species is still a largely open question, despite decades of research.
148 masome-like structures in plants has been an open question for many years.
149 s to postural stabilization still remains an open question for researchers.
150  of white matter connections has remained an open question for the past 250 years.
151 sms relate to rheological behavior are still open questions for fundamental understanding.
152 in uncertain environments, and we raise some open questions for future research.
153 mplications for clinical trials and identify open questions for future research.
154 ensing and cell death and explores important open questions for future studies in this area.
155 ts of existing assays and data, and identify open questions for future studies.
156 a, highlight conserved mechanisms, and raise open questions for the future.
157 s and disadvantages in various settings, the open questions for which novel methods are needed, and e
158                                It remains an open question how scalable and versatile such phenomena
159                                     It is an open question how these ground states governed by local
160                           However, there are open questions how plasma-generated RONS interact on a m
161                                It remains an open question, however, how the large number of connecti
162                                     It is an open question, however, whether connectomes differ acros
163                                     It is an open question, however, whether the hippocampus similarl
164 es the functional aspects of IDPs remains an open question, however.
165                              Assessing these open questions ideally involves recording across the who
166                     Until now, it remains an open question if skyrmions can also exist in the absence
167                                           An open question in aggressive cancers such as melanoma is
168 he three-body problem is arguably the oldest open question in astrophysics and has resisted a general
169 uclear explosions of white dwarf stars-is an open question in astrophysics.
170 thers are confined geographically remains an open question in ecology and biogeography.
171 g in its vicinity is therefore still a major open question in ice physics.
172 on and organization remains an important and open question in non-equilibrium statistical mechanics.
173 s (Gram-negative or diderm) is a fundamental open question in the evolution of Bacteria.
174 ater specialists, for example, to help solve open questions in aquatic ecology.
175 e nature of the neutrino is one of the major open questions in experimental nuclear and particle phys
176  paper are directly applicable to many other open questions in granular and soft matter systems, such
177      This commentary focuses on two related, open questions in Hulleman & Olivers' (H&O's) proposal:
178                                  A number of open questions in human evolutionary genetics would beco
179 hosen by online vote, with priority given to open questions in important areas that are specific enou
180 sociality evolved and in which groups remain open questions in mammalian evolution, largely due to th
181             We review progress and highlight open questions in neuroaesthetics.
182   This review focuses on recent advances and open questions in our understanding of the complex role
183 ll also point out some of the most important open questions in the field and emerging evidence sugges
184                              We also discuss open questions in the field concerning the stability of
185                             We highlight the open questions in the field of cardiovascular calcificat
186                         We end by discussing open questions in the field of synaptic autophagy.
187 have attempted to identify the most pressing open questions in the field.
188 enomenon, emerging management strategies and open questions in the field.
189 d roles during CNS development and discusses open questions in the field.
190 rnal metabolism in cyanobacteria and present open questions in the field.
191 ly, this review discusses the challenges and open questions in the rapidly expanding field of immunom
192 these three elements, we review examples and open questions in the research on symbiosis.
193                                 There remain open questions in the signaling networks, the ultimate r
194                     Throughout, we highlight open questions in the study of graph learning that will
195 n for tissue-specific pathology and identify open questions in this area of host-Toxoplasma interacti
196 ology can help shed light on the plethora of open questions in this field are highlighted.
197 ry collaboration to identify and address key open questions in this research field.
198                                              Open questions, in addition to those shown in the Graphi
199                     However, a long-standing open question is how astrocytes regulate neural circuits
200                                    A central open question is how collective filament dynamics emerge
201                                A fundamental open question is how local variability in preferred SF i
202 are well known as the Hippo kinases, a major open question is how these kinases are regulated by upst
203                                           An open question is how to maximize the modularity of their
204                                 An important open question is to what extent epigenetic factors contr
205                                           An open question is to what extent variation in the mitocho
206                                 An important open question is what characterizes the representational
207                                           An open question is whether and how emergent properties may
208                                           An open question is whether ERAPs edit peptides to this opt
209                                           An open question is whether fear-related brain areas respon
210                                           An open question is whether neural entrainment also occurs
211                                           An open question is whether proteins might function as tran
212                            A fundamental and open question is whether range adaptation is behaviorall
213                                           An open question is whether remodelers are distinctly respo
214                      A fundamental remaining open question is whether the laws of quantum mechanics a
215                                           An open question is: Does incorporating asymmetric branchin
216 gnitude of THE in magnetic multilayers is an open question, it is imperative to develop comprehensive
217 mortality has been rarely tested, leaving an open question of how much the findings from humans imply
218        Thus occlusion is linked with another open question of microvascular function: how are red blo
219 fractions of heritable variation, leaving an open question of whether accurate complex trait predicti
220           Here, we address the long-standing open question of whether every pure bipartite entangled
221    Our analysis of the key uncertainties and open questions of and beyond the inventory shows that, a
222 loregulators, and we briefly discuss current open questions of how metalloregulators function in bact
223 ies have been conducted to address important open questions on OFR chemistry and to guide experimenta
224        For example, there remain fundamental open questions on the phase diagram of the Hubbard model
225 s of tuning cytoskeletal mechanics remain an open question, one that we discuss herein.
226 ow future research might solve the remaining open questions presently under discussion.
227            Together, this review explores an open question regarding features of global transcription
228 al experimental evidence for a long-standing open question regarding the pathophysiological potential
229 resulting from alcohol use are evident, some open questions regarding alcohol use and its consequence
230                      However, there are many open questions regarding how the method might have such
231 despread use over four decades, there remain open questions regarding its fundamental limitations.
232                                 We summarize open questions regarding PRS usability, ancestry bias an
233                    The current knowledge and open questions regarding the cardiovascular effects asso
234                      To help address several open questions regarding the history of these movements,
235                               There are many open questions regarding the hydration of solvent-expose
236 t sites during this process, there are still open questions regarding the involvement of other mechan
237 at the same time also points toward specific open questions regarding the minimal genome of JCVI-syn3
238                     Throughout, we highlight open questions regarding the physical principles for DNA
239 use of both its technological importance and open questions regarding the physics of energy transfer
240   This work might provide a method to answer open questions regarding the regulation of the proteosta
241                               A crucial, yet open, question regards how babies deal with stimuli expe
242 ts and interpenetration are highlighted, and open questions related to state-of-the-art computational
243     Finally, we discuss major challenges and open questions related to the application of SERS for un
244                                   We discuss open questions related to the use of spatially targeted
245   Despite extensive studies, there are still open questions relating to membrane phase behavior, part
246                                However, many open questions remain about appropriate implementation o
247 n is rapidly growing in popularity, but many open questions remain about its properties.
248                                              Open questions remain regarding how force propels coordi
249                                     However, open questions remain regarding long-term outcomes and t
250                                     However, open questions remain regarding the key mechanistic step
251                             However, several open questions remain regarding the molecular machinery
252 focused on striatal-based feedback learning, open questions remain regarding the role of hippocampal-
253 nd optoelectronic performance; however, many open questions remain unanswered.
254 domonas, and Stentor coeruleus Although many open questions remain, elucidating how cells repair them
255                                         Many open questions remain, however, about the spatial and te
256 doping and spin polarization, for which many open questions remain.
257                                           An open question remains whether myelination also contribut
258 arbon nanotubes (CNTs) has been an important open question since the first reports of the strong modu
259                             We also identify open questions, such as what causes species resilience a
260 te decades of research, there are still many open questions surrounding the mechanisms by which enzym
261 stability against thermal fluctuations is an open question that must be answered before skyrmion-base
262 or function of CFRI in cardiomyocytes remain open questions that are discussed herein.
263          Finally, we consider some currently open questions that are yet unresolved.
264 s of current research approaches and outline open questions that can help guide future transdisciplin
265 gh efficiency photocatalysts followed by six open questions that may need to be resolved by forming a
266 erogeneity during skin wound healing, and on open questions that must be addressed to clinically tran
267 error-driven supervised learning, as well as open questions that must be addressed to unify our under
268  emerged from these modeling studies and the open questions that need to be answered by future resear
269                        This review indicates open questions that require further research and propose
270                                  We point to open questions that require resolution and call upon the
271 mmunity and are highlighted here, along with open questions that require serious attention for full u
272 ate key discoveries, and discuss some of the open questions that will drive future studies aimed at u
273                            We also highlight open questions, theoretical puzzles and problems shared
274 aries and/or defects emerges as an important open question to address, with recent advances in fabric
275 red more than sixty years ago, it remains an open question to explain its ubiquity.
276 and non-thermal bioeffects and it remains an open question to what degree does temperature impact the
277 cadC during cell state transitions, it is an open question to what extent such harmful AP-sites may a
278 ontexts and conclude with a consideration of open questions to be addressed in the future.
279 asets, but there are still several critical, open questions to be addressed.
280 bserved tonic signaling heterogeneity remain open questions today.
281 tracting key concepts and highlighting major open questions toward a more complete understanding of P
282 an insight for experts in an effort to bring open questions under a new light.
283 of personal questions with known answers and open questions using linear support vector machine (SVM)
284                     Herein, we address these open questions using single-turnover electrophysiology,
285 ids, which is only increasing, it remains an open question what geometry of the electrodes is optimal
286 r despite long-running debate, it remains an open question whether a reliance on social learning can
287 s across the tree of life, but it remains an open question whether amphibian chemical defense phenoty
288                                     It is an open question whether design methods tailored to build D
289                           It thus remains an open question whether height loci exhibit signals of pol
290                 In particular, it remains an open question whether metacognitive judgments are based
291                       However, it remains an open question whether network-based strategies should be
292                       Finally, it remains an open question whether the primary visual cortex of highe
293                      However, it is still an open question whether the single-atom sites possess simi
294                                 Yet it is an open question whether there is any fundamental differenc
295                                     It is an open question whether turbulent mixing across density su
296 have been studied extensively, it remains an open question why microvessels need to be so narrow.
297                             Addressing these open questions will be critical for future translational
298 mechanical rhythm over a lifetime remains an open question with significant implications to human hea
299                           Answering the many open questions with regard to the role of DCs in immune
300                         However, there is an open question within the atom probe community as to the

 
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