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1 cessary to properly enter the capsid protein open reading frame.
2 cessing of a polyprotein encoded in a single open reading frame.
3 s operational when combined with an upstream open reading frame.
4 ate within the coding region of the opposite open reading frame.
5 s via introduction of a TC tag into the muNS open reading frame.
6 is translationally repressed by an upstream open reading frame.
7 ent translation elongation through the viral open reading frame.
8 ond and third in-frame AUG codons in the NS1 open reading frame.
9 mate-induced translation is dependent on Arc open reading frame.
10 e, and in the case of protein coding DNA, an open reading frame.
11 nal AUGs at positions 235 and 241 of the NS1 open reading frame.
12 O) that induces exon skipping to restore the open reading frame.
13 haracteristic gene models yet maintaining an open reading frame.
14 ntranslated regions (NTRs) flanking a single open reading frame.
15 specific activity of target sites within the open reading frame.
16 BpuR-binding site was mapped 5' of the sodA open reading frame.
17 tin is organized into domains in relation to open reading frames.
18 secondary structure motifs but no essential open reading frames.
19 erential translation and the use of multiple open reading frames.
20 gle RNA translation dynamics in frameshifted open reading frames.
21 acetyl-CoA carboxylase subunit D (accD)-like open reading frames.
22 enesis and thereby generate mutations in all open reading frames.
23 such as multi k-mer frequencies and relaxed open reading frames.
24 ange from 22.6-33.0 Kbp, consisting of 27-39 open reading frames.
25 e-encoding RNAs, and dynamic use of upstream open reading frames.
26 oligonucleotides (ASOs) that target upstream open reading frames.
27 sence of gene homologs to all 84 known HHV-7 open reading frames.
28 equences, including 2442 translated upstream open reading frames.
29 encoded by a 3,200-bp genome with only four open reading frames.
30 ribosomal entry sites (IRESs) preceding both open reading frames.
31 aves a clear three nucleotide periodicity in open reading frames.
32 d by GC-rich regions and the absence of long open reading frames.
33 ere confirmed as expressed genes with intact open reading frames.
34 control during the translation of suboptimal open reading frames.
35 particularly those with highly elongated neo open reading frames.
36 54 bp in length, and encodes a predicted 106 open reading frames.
37 ic and have a wide range of genome sizes and open reading frames.
38 uent studies utilized N-terminally truncated open reading frames.
39 infection and the expression of codon-biased open reading frames.
40 on (IGR), and the biosynthetic trpB and trpA open-reading frames.
42 P25K to long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p), which contains an
45 2 (Lso2; coiled-coil domain containing short open reading frame 124 [CCDC124] in mammals) was found t
46 detect two separate target sequences in the open reading frame 1ab (ORF1ab) region of the SARS-CoV-2
47 /ml for detecting two regions of the genome (open reading frame 1ab [ORF1ab] and nucleocapsid protein
49 ysis showed that amphoterin-induced gene and open reading frame 2 (Amigo2) was overexpressed in LV12
50 mammals), and recently, late-annotated short open reading frame 2 (Lso2; coiled-coil domain containin
53 eactive primer set targeting the overlapping open reading frame 2/3 (ORF2/3) nucleotide sequence of H
55 ins are essential for viral growth in vitro (open reading frame 32 [ORF32], ORF59, ORF81, ORF83, ORF9
56 at the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi's sarcoma-associ
57 (KSHV) alkaline exonuclease SOX, encoded by open reading frame 37 (ORF37), is a bifunctional early-l
59 f a rodent CoV were also observed at 8.9-kDa open reading frame 4a at the 3' end of the spike gene.
62 ntaneous, tetradecanoyl phorbol acetate-, or open reading frame 50 (ORF50)/replication transactivator
67 elevated expression of CXorf67 (chromosome X open reading frame 67), which frequently occurs in PFA e
69 ), including but not limited to chromosome 9 open reading frame 72 (C9orf72) repeat expansion carrier
70 85) of a pathogenic mutation in chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN) or mi
71 ncharacterized gene (C17orf99; chromosome 17 open reading frame 99), that is expressed in bone marrow
72 as a 10.3-kb genome that encodes a rare dual open reading frame, a feature uncharacteristic of classi
73 g site of Pfn2 or overexpression of the Pfn2 open reading frame alone in otherwise wild-type cells la
74 ts) translated from nonannotated Alternative Open reading frame (AltORFs) were discovered using custo
75 demonstrated the translation of alternative open-reading frames (altORFs) in addition to annotated p
76 levant to its expression, including a leader open reading frame and an RNA structure overlapping the
77 the Ugandan subtype F, but with different K1 open reading frame and KSHV whole-genome sequences and a
79 quence features: TRmIND by the length of the open reading frame and TRmD both by a approximately 60 n
80 proteins, two ribosomal RNAs, three putative open reading frames and 33 transfer RNAs of 19 amino aci
81 ble-stranded DNA genome coding for up to 250 open reading frames and a fully cytoplasmic replication.
82 ature of indel mutations, which create novel open reading frames and a large quantity of mutagenic pe
83 lly been undertaken through the detection of open reading frames and other genomic motifs, supplement
85 roup of HERV-K elements, still retain intact open reading frames and the capacity to produce certain
86 e amino termini of these proteins to the NP1 open reading frame, and splice site mutations that preve
88 a phage genome as a network of paths: where open reading frames are favorable, and overlaps and gaps
90 ing to saturation of inserts adjacent to all open reading frames as well as conventional inactivation
91 may explain why, despite having lost the E6 open reading frame between 20 and 60 million years ago,
93 not have evolved by tandem duplication of an open reading frame, but rather originated by fusion betw
95 P24), angiopoietin 4 (ANGPT4), chromosome 11 open reading frame (C11orf30/EMSY), and exocyst complex
96 ubiquitin gene is a unique, highly conserved open reading frame composed solely of tandem repeats, ye
97 species carry a 7.5kb plasmid encoding eight open reading frames conventionally called plasmid glycop
98 ate a sgmRNA encoding a ribosomally occupied open reading frame (dORF) located downstream of the nucl
99 uding an immunogenic peptide derived from an open reading frame downstream of the melanoma stem cell
100 nsmembrane proteins endoregulin (ELN), dwarf open reading frame (DWORF), myoregulin (MLN), and anothe
101 A viruses, and as a likely consequence, most open reading frames encode multifunctional viral protein
102 highlights the functional activity of short open reading frame-encoded peptides and underscores thei
103 is of this envelope transcript revealed long open reading frames encoding putative surface and transm
104 nd DMD mutations that disrupt the dystrophin open reading frame extinguish luciferase expression.
105 lgarno (SD) sequences positioned upstream of open reading frames facilitate translation initiation.
106 vectors carrying the full-length dystrophin open-reading frame for transduction of human muscle deri
107 h excludes those lncRNA gene loci with small open reading frames from being regarded as protein-codin
108 sition of the repeat within or outside of an open reading frame has been used to focus research on di
109 citrus-CTV pathosystem, deletion of the p33 open reading frame in a CTV variant resulted in a signif
110 nserted increasing lengths of the dystrophin open reading frame in a foamy virus vector and quantifie
111 omolog repressed the translation of the main open reading frame in cis, independent of the sequence o
113 the function of MC021, we replaced the F13L open reading frame in vaccinia virus with an epitope-tag
114 Here, we sequenced the full gyrA and gyrB open reading frames in 240 multidrug-resistant and exten
115 tumors by functional, non-canonical upstream open reading frames in its 5' untranslated region, which
117 contained as many as around 10% of the total open reading frames in some genomes, substantially incre
118 alignments, we detected at least 175 de novo open reading frames in the focal species O. sativa subsp
119 le we did not find any intact capsid protein open reading frames in the integrated viral sequences, w
121 ubjects and sequenced the full gyrA and gyrB open reading frames in their respective sputum TB isolat
122 q allowed for the identification of upstream open reading frames in transcripts, which we predict to
123 genic mutations predicted to restore BRCA1/2 open reading frames, including two patients with multipl
125 e we individually express in human cells 204 open reading frames involved in the DNA damage response
126 th the hypothesis that mutation of the HBeAg open reading frame is an important factor driving CHB pa
128 serted downstream from the first ATG and the open reading frame is disrupted by a 1-bp insertion, exp
129 P1, a small NS protein encoded by the middle open reading frame, is required for the expression of th
130 rther analysis demonstrated that KSHV latent open reading frame K12 (ORFK12) gene (kaposin A)-mediate
131 d find that the feature relationship between open reading frame length and guanine-cytosine (GC) cont
132 deletion of uridines to generate functional open reading frames, many of which encode components of
133 he expression of identified and unidentified open reading frames needed to deal with and overcome the
137 use sgRNA-mediated CRISPR/Cas9 to target the open reading frame of a gene in the genome and analyze t
138 onfirmed by GFP accumulation from the second open reading frame of a polycistronic messenger RNA, whi
141 ransmembrane protease, serine 2) gene to the open reading frame of ERG, encoding an ETS family transc
142 ating a library of fragments derived from an open reading frame of interest and enriching for the int
144 in the 5' untranslated region or within the open reading frame of the toxin hamper its translation b
146 otated protein-coding genes, including small open reading frames of less than 100 codons, and the tra
147 l segments combined in which the overlapping open reading frames of matrix 1 (M1)/M2 for the modified
149 1 (M1)/M2 for the modified M segment and the open reading frames of nonstructural protein 1 (NS1)/nuc
150 peptides not only from precursors encoded in open-reading frames of mRNA transcripts but also cryptic
153 results in bicistronic transcripts with two open reading frames, of which only the first, MOCS1A, is
154 luding the repressive effect of the upstream open reading frames on gene expression and the mutationa
155 d a form of B. burgdorferi in which the ospA open reading frame, on lp54, was replaced with the ospC
156 er from SARS-CoV only in containing an extra open reading frame (ORF) (named ORFX), between ORF6 and
159 r antibiotic resistance encoded in the first open reading frame (ORF) and accumulation of the reporte
160 reast cancer cells, targeted E-cadherin mRNA open reading frame (ORF) and suppressed E-cadherin prote
162 e assessment across pan-cancer fusion genes, open reading frame (ORF) assignment, and retention searc
163 efect in translation of the chloroplast psbJ open reading frame (ORF) but has no effect on psbA expre
164 tic' and harbour an additional uninterrupted open reading frame (ORF) covering almost the entire leng
165 ing genes relied on assumptions, such as one open reading frame (ORF) encodes one protein and minimal
166 e RNA genomes of 2.2 to 4.4 kb with a single open reading frame (ORF) encoding an RNA-dependent RNA p
168 Turnip crinkle virus (TCV) coat protein (CP) open reading frame (ORF) has been found to promote inter
169 ctions during virus replication, although an open reading frame (ORF) is retained among an unknown pe
173 yvirus, family Potyviridae) contains a large open reading frame (ORF) of 3,494 codons translatable as
175 is the introduction of a frameshift into the open reading frame (ORF) of the target gene which trunca
176 esponse is quite broad: the median number of open reading frame (ORF) products recognized was nine pe
177 t dsRNA1 dsRNA is 1,683 bp in length with an open reading frame (ORF) that encodes 539 amino acids (m
178 rate that the last 36 nucleotides of the NSs open reading frame (ORF) were needed to ensure the effic
179 Additionally, 594 GENCODE lncRNAs acquire an open reading frame (ORF) when their structure is extende
180 f the frameshift site or by truncating the X open reading frame (ORF), had little effect on the infec
181 functional domains/sites or shifting of the open reading frame (ORF), leading to a variety of human
182 of a conserved 260-triplet-long overlapping open reading frame (ORF), which we call POLGARF (POLG Al
185 ome by assessing the ability of nearly every open reading frame (ORF; approximately 5,300 ORFs) to in
186 enome size of 4248 bp and only four putative open reading frames (ORF), vB_RpoMi-Mini becomes the sma
187 ochorism and to the presence of the atypical open reading frames (ORFans) F-orf and M-orf, respective
188 y quantify the expression of canonical viral open reading frames (ORFs) and to identify 23 unannotate
190 nts, the determinants of ribosome flux along open reading frames (ORFs) are not fully understood.
192 ns conserved (core) and variable (accessory) open reading frames (ORFs) grouped at fixed regions in t
193 me of Bam35, nearly half of the 32 annotated open reading frames (ORFs) have no homologs in databases
194 rganized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRN
196 ave been identified with unusually divergent open reading frames (ORFs) in the conserved region of rp
199 ure, 68 substitutions that were localized in open reading frames (ORFs) likely associated with host c
202 ding the first detection of products from 27 open reading frames (ORFs) previously designated "predic
203 nting a novel strategy to generate candidate Open Reading Frames (ORFs) resulting from Cytidine to Ur
204 iversity leading to the formation of altered open reading frames (ORFs) that appear to be under relax
205 tic tools, we first identified 315 potential open reading frames (ORFs) within the genome, including
206 forms of HIV-RNA transcripts with competent open reading frames (ORFs), and can be found in the peri
208 es for re-evaluating the coding potential of open reading frames (ORFs), including many short ORFs th
210 ome sequence containing 128 unique predicted open reading frames (ORFs), many of which were most clos
211 sor encoding distinct repeat epitopes in two open reading frames (ORFs), one translated from the 5' c
213 iling, identification of actively translated open reading frames (ORFs), to the quantification of tra
214 quantify translation at the level of single open reading frames (ORFs), using information from Ribo-
215 r double-stranded DNA (dsDNA) genome with 31 open reading frames (ORFs), whose predicted gene product
222 idae, which bidirectionally encode two major open reading frames (ORFs): Rep and capsid protein (CP)
223 e library (616 overlapping peptides spanning open reading frames [ORFs] 1-3) was used in interferon-g
225 sm analysis, FX548 contained no mutations in open reading frames other than hgbA We conclude that by
227 iptome analysis revealed that an unannotated open reading frame (Percc1) flanks the regulatory sequen
230 ing a premature stop codon in the 33277 fimB open reading frame relative to the 381 fimB allele.
232 on enhancing factor (PTEF) relieves upstream open reading frame repression and thereby facilitates VA
233 vel of PTEF, and the alleviation of upstream open reading frame repression requires the proteolytic p
234 xis (PrEP), we performed KSHV typing with K1 open reading frame Sanger and KSHV whole-genome sequenci
236 idence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mamm
239 ous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked b
240 hese elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the i
241 ed deletions at coding sequence of the ORF8 (open reading frame), spike, and ORF7a proteins, specific
242 One-by-one disruption of each of LINC00261's open reading frames suggests that the RNA, rather than t
244 oter region was found to contain an upstream open reading frame that is required for Pi-responsive ex
245 that Tug1 contains an evolutionary conserved open reading frame that when overexpressed produces a st
246 transcript variant lacking a small upstream open reading frame that would otherwise inhibit translat
250 long RTC4 transcript contains small upstream open reading frames that prevent translation of the down
251 f P3 fused to Pretty Interesting Potyviridae open reading frame), the two PD-localized potyviral prot
252 circular genome of 107,063 bp containing 97 open reading frames, the majority of which share sequenc
253 on our mutant analysis, we revised the rec27 open reading frame: the new start codon is in the previo
254 to dicistronic viruses but contain a single open reading frame, thus likely representing a recent ex
256 rons, CGG RAN acts as an inhibitory upstream open reading frame to suppress basal FMRP production.
257 Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has unde
258 nd initiation codon selection by 5' upstream open reading frames, translation initiation factors, and
261 b plasmid DNA encoding the 3.9 kb human NPC1 open reading frame, under the influence of a 1.5 kb plat
262 10-nucleotide sequence preceding an upstream open reading frame (uORF) and downstream GFP drives a br
264 ntrolled by a single cis-regulatory upstream open reading frame (uORF) in the 5' untranslated regions
265 sttranscriptionally regulated by an upstream open reading frame (uORF) located in its 5' untranslated
266 n this work, we demonstrate that an upstream open reading frame (uORF) present in the 5' untranslated
267 enterovirus genomes also harbour an upstream open reading frame (uORF) that is subject to strong puri
269 characterize a complex landscape of upstream open reading frames (uORFs) across 5'-untranslated regio
274 observed thousands of AUG-initiated upstream open reading frames (uORFs) that are a major contributor
275 ASOs that bind to mRNA sequences in upstream open reading frames (uORFs) to specifically increase the
276 translation events, including 1,329 upstream open reading frames (uORFs) within the 5' untranslated r
277 sion of Kozak sequence composition, upstream open reading frames (uORFs), and secondary structure.
278 sense-mediated decay (NMD) targets, upstream open reading frames (uORFs), canonical ORFs shorter than
280 ry 5' leader sequence with multiple upstream Open Reading Frames (uORFs), thereby activating stress-r
284 gions of an antigen or antigens, alternative open reading frame usage, and translation of RNA splicin
287 n the CD4+ T-cell response to specific HSV-1 open reading frames was greater between MZ twins than be
290 annotation pipelines generally ignore small open reading frames, which are those most likely to enco
291 d multiple microproteins encoded in upstream open reading frames, which form stable complexes with th
292 pathogenic functions of the plasmid-encoded open reading frames, which may motivate further investig
296 nalysis of the i-leader revealed a potential open reading frame within the leader sequence and the te
300 o far uncharacterized mitochondrial protein (open reading frame YDR381C-A) as an important assembly f