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2 via unprecedented Ph(3)P-I(2) mediated ring-opening of 1,3-dihydro-1H-benzimidazol-2-ones with secon
5 appears to proceed through concomitant ring opening of 2-aminobenzothiazole and S-arylation to give
6 of Ti imidos with nitriles and alkynes, ring opening of 2-imino-2H-azirines, or direct metalation of
9 H(2)(18)O to elucidate the mechanism of ring opening of 7(*+) and trapping of the resulting distonic
10 A rhodium(III)-catalyzed redox-neutral ring-opening of 7-azabenzonorbornadienes with aromatic ketoxi
11 at mediate neurotransmitter release requires opening of a 'closed' conformation of UNC-64/syntaxin.
12 report that the mechanically triggered ring-opening of a [4.2.0]bicyclooctene (BCOE) mechanophore se
13 eceptor (IP(3)R) allosterically triggers the opening of a Ca(2+)-conducting pore located ~100 angstro
14 y filter to enhance calcium permeability and opening of a canonical gate at the cytoplasmic end of th
15 TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the
16 g-lived loop conformation coincides with the opening of a cryptic pocket that accommodates thyroxine
18 ule dissection methods reveal that catalytic opening of a DHT motif harbouring a toehold triggers suc
21 n potassium channel and A1 receptor-mediated opening of a G-protein-coupled inwardly rectifying potas
22 intervention, such as queen clipping and the opening of a hive, causes strong interferences with impo
24 rmeability transition, as the consequence of opening of a mitochondrial permeability transition pore
25 famous Donora Zinc Works yet record both the opening of a nearby coal-fired power plant and amendment
26 e influenced by closing a port city; (2) the opening of a new port city in western China will attract
27 including the closure of a tourism city, the opening of a new port city in western China, and the inc
29 ermeable to osmolytes, proposedly due to the opening of a non-selective protein channel of unknown mo
32 ansition in human mitochondria refers to the opening of a nonspecific channel, known as the permeabil
35 covered electronic stabilization through the opening of a shell-closing gap at the top of the occupie
36 adical generated from Ti (III) mediated ring opening of a terminal epoxy ring tethered to a butenolid
40 Emerging methods for enantioselective ring opening of acceptor- or donor-only cyclopropanes are the
41 izable appendages has been developed by ring-opening of activated aziridines with 2-hydroxyphenyl acr
42 doles via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having subs
43 cellular membrane requires the simultaneous opening of activation and inactivation gates of the K(+)
46 (Br-PBTC), which selectively potentiates the opening of alpha4beta2*, alpha2beta2*, alpha2beta4*, and
48 lasticity; pubertal hormones may trigger the opening of an adolescent critical period for experience-
49 osphine oxide diastereomers accessed by ring-opening of an amino alcohol-derived cyclic sulfamidate.
50 probe recognized miR-196b as a result of the opening of an electrode hairpin probe on a polydopmine-g
51 and regio- and stereoselective nucleophilic opening of an epoxide were used as the main transformati
52 lly occupied during a time that predates the opening of an ice-free corridor (<=14,800 cal yr B.P.),
53 oincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conduct
54 annel, conduction is believed to result from opening of an intracellular constriction that prevents i
56 ion in the animal nervous system through the opening of an ion pore upon binding of neurotransmitters
58 n as an optical reporter, we showed that the opening of astrocyte CRAC channels stimulated vesicular
59 The reactions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoi
60 we disclose a bioinspired strain-driven ring opening of bicyclic methyleneaziridines to 2-amidopentad
65 resolutions: first, an atroposelective ring opening of Bringmann-type lactones produces a product wi
66 ond messenger NAADP and thereby promotes the opening of Ca(2+) -permeable two-pore channels (TPCs).
67 ation prompted an unprecedented delay in the opening of California's Dungeness crab fishery that inad
68 n the contrary, neurogranin synchronizes the opening of calmodulin's two lobes and promotes their act
69 complexes of CCAN and shows how the Y-shaped opening of CCAN accommodates Cenp-A(Nuc) to enable speci
74 romatin accessibility profiling showed quick opening of closed chromatin in naive T cells within 5 h
76 , ROS-induced oxidative stress regulates the opening of connexin channels in a system mediated by pho
78 ctive and challenging gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimeth
79 butadiene with ethylene, electrocyclic ring-opening of cyclobutene, electrocyclic ring-closing of Z-
80 and-directed beta-C-H arylation and the ring opening of cyclopropanecarboxamides is proposed based on
81 strated through the catalytic oxidative ring-opening of cyclopropanes for the synthesis of 1,3-fluoro
83 se is dynamically regulated by the transient opening of different types of voltage-gated calcium chan
85 ient low-cost method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH
87 ow oscillations were delivered at the airway opening of each model and distributed through the lungs
88 In teleost fish, gill slits arise through opening of endodermal pouches and connect the pharynx to
94 has implications for the question of whether opening of FNIII domains contributes to the stretching o
95 e of time, reactive fluid transport, and the opening of fractures as rock is exhumed and transformed
96 in the synthesis include the oxidative ring opening of furan and its use as a four-carbon synthon, S
97 junctional tensions of VECs to result in the opening of gaps before the initiation of leukocyte trans
98 e-electron laser to trace the ultrafast ring opening of gas-phase thiophenone molecules following ult
99 from the sonolysis of water, making the ring-opening of glucose energetically unfavorable and leaving
102 le germ cells of mice involves the transient opening of heterochromatin at megabase-size differential
104 acking to engender lateral branching and the opening of hydraulic cracks along the weak layers, even
107 activity of transcription factors allows for opening of inaccessible regulatory elements and has been
108 stores via activation of phospholipase C and opening of inositol trisphosphate (InsP3) receptors.
109 ains that sense membrane voltage and control opening of ion-selective pores, a mechanism that is cruc
110 llations could be initiated by the transient opening of IP(3) receptors facing either the cytosol or
111 ulation cascade (SDAC) strategy involving an opening of isatoic anhydride and annulation to benzimida
113 ble mechanism by which OprM is activated via opening of its periplasmic aperture through a concerted
114 oduction, [ATP](i) decreases to increase the openings of K(ATP) channels, which biases the electrical
117 ancing and uncertainty about the complete re-opening of laboratories and campuses, there is a pressin
118 structures in endothelial cells promote the opening of large-scale apertures, thereby breaching the
119 ted by entry of extracellular calcium due to opening of mechanosensitive ion channels and initiates a
120 rily through poration sites for fast ICWs or opening of mechanosensitive ion channels for slow ICWs,
121 ransfer catalysis: the enantioselective ring-opening of meso-aziridinium and episulfonium cations pro
123 ochondrial respiration and in preventing the opening of mitochondrial permeability transition pore in
124 emonstrated by mitochondrial depolarization, opening of mitochondrial transition pore, release of cyt
125 e last part of the review describes the ring opening of more reactive three-membered rings substitute
126 lso demonstrated that metformin inhibits the opening of mPTP and induces mitochondrial biogenesis.
127 ) S confers embryonic cardiac protection via opening of myocardial K(ATP) channels and not via increa
129 rk data to develop models for predicting the opening of new shipping lines and for forecasting trade
130 compromised host-symbiont state and (ii) the opening of niche space for potential pathogens during th
131 back-propagating action potential due to the opening of NMDA receptors and voltage dependent calcium
132 nt for maintaining the normal probability of opening of NMDARs and for keeping NMDARs localized in sy
134 bifunctional enzyme that catalyzes the ring opening of oxepin-CoA and converts it to 3-oxo-5,6-dehyd
137 from the endoplasmic reticulum, followed by opening of plasma-membrane calcium-release activated cal
139 sults reveal that the rate constant for ring opening of radical cations derived from 1'-methyl-3',4'-
141 vely-charged Glu did not induce constitutive opening of Slo2.1 or Slo2.2, suggesting that ion permeat
142 ds to LL HC hyperpolarization because of the opening of small-conductance Ca(2+)-activated potassium
143 increased micropore volume results from the opening of some of the small (sodalite) cages, otherwise
145 dily synthesized through a nucleophilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the a
147 sis, short-term exposure to UVA inhibits the opening of stomata, and this requires a reduction in the
148 including the activation of Rubisco and the opening of stomata, whereas transitions from high to low
150 -carbon bond dissociation and the structural opening of the 1,3-cyclohexadiene ring by the direct mea
151 f this process involves a base-mediated ring opening of the 3-aroylbenzofurans and subsequent Michael
152 eds via a Lewis acid catalyzed SN2-type ring-opening of the activated aziridine followed by a concomi
153 cillin-binding protein (PBP)2a, resulting in opening of the active site, whereby the beta-lactam anti
157 d to their isolation and divergence; (1) the opening of the Atlantic Ocean, (2) the breakup of Gondwa
158 substep, our simulations show no significant opening of the ATP-bound beta subunit; instead, we obser
159 ons are a result of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the
161 M treatment benefits can be achieved through opening of the BBB before intraarterial infusion of beva
163 nt a model that is based on a time-dependent opening of the BBB for nanoparticles, followed by a rapi
165 ylimidazolium iodide (1a) catalyzes the ring opening of the bicyclic amidine system of DBU (1,8-diaza
167 dicate that, upon lipopolysaccharide-induced opening of the blood-brain barrier, SLE anti-BC abs are
168 Construction of the five Cu(I) sites at the opening of the bundle lags behind the main core, and the
171 chable following the reversible ring closure/opening of the central dithienylethene via irradiation w
172 o the channel periphery and remotely control opening of the central pore, has eluded such analysis.
173 tion of KCNE1 with KCNQ1 dramatically delays opening of the channel but the mechanisms by which this
177 Activation of the P2X7 receptor leads to opening of the characteristic dye-permeable membrane por
179 cific genes correlated with ploidy-dependent opening of the chromatin as well as, in a subset of test
180 thyltransferase SETD1 as a key factor in the opening of the chromatin on inflammatory gene promoters
181 f structural changes which terminate with an opening of the complex into two separate domains, one of
182 driven by Arf1 in live cells and found that opening of the complex is prerequisite for oligomerizati
184 al dynamics involving twisting and clamshell opening of the complex, whereas VCBC-CUL5 maintains a mo
186 lidines and oxazolidines via S(N)2-type ring-opening of the corresponding activated aziridines and ep
187 situ ring-expansion (via intramolecular ring-opening of the corresponding aziridinium intermediates w
188 etween imbibition of the mature dry seed and opening of the cotyledons, the final stage of seedling e
189 our model, the former is responsible for the opening of the critical period, while the latter limits
191 lin-4(1H)-one, followed by nucleophilic ring opening of the cyclopropyl ring to form desired tetrahyd
195 ing Death Receptor 5, involves a scissorlike opening of the disulfide-linked transmembrane (TM) dimer
197 active sound control system fitted onto the opening of the domestic window that attenuates the incid
198 n by changing climatic conditions and by the opening of the Drake Passage and associated intensificat
202 MIDA boronate (24) comprise two steps: ring opening of the epoxide to a carbocation intermediate fol
203 ation can be explained by Lewis acid induced opening of the epoxy bridge with transfer of one alkyl g
206 mational shifts in the barrel domain lead to opening of the exit pore and rearrangement at the latera
207 mulations, providing sufficient evidence for opening of the expansion cohort (n=41), which was recrui
209 t of the chromophores became more polar with opening of the external gates as the protein transitione
211 M) biosynthetic pathway, the Baeyer-Villiger opening of the fourth ring of premithramycin B (PMB), cr
212 f conformational changes in the T3SS trigger opening of the gate through interactions between FlhB/Sc
213 pyruvate dehydrogenase (PDH), which mediates opening of the gateway from glycolysis to the tricarboxy
216 that the dominant and repetitive mode of DNA opening of the helicase can be used to allow efficient D
217 attern at the site of modification, a slight opening of the hm(5)rC-G pair compared to the unmodified
218 30 seconds of reperfusion immediately after opening of the infarct-related artery and before stent i
220 e often generated from [1.1.1]propellane via opening of the internal C-C bond through the addition of
221 ment of a noncanonical toggle switch and the opening of the intracellular crevice for G protein coupl
223 Comparison of MD trajectories show that opening of the intracellular gate causes a structural ch
225 ivation mechanism, which proceeds through an opening of the intracellular region allosterically elici
227 ne product was nonfluorescent; however, upon opening of the lactone ring by the formation of the ethy
229 um ylide to metal-free azirinium ylide, ring-opening of the latter to give a 1,5-diazahexa-1,3,5-trie
231 plasmic domains that subsequently drives the opening of the luminal gate, and thereclosing of luminal
232 opment of the modern industrial port and the opening of the Malamocco-Marghera channel in the late 19
233 sonication leads to the mechanochemical ring opening of the MeO-gDCC and the subsequent elimination o
234 s induces Ca(2+) overload and ultimately the opening of the mitochondrial permeability transition por
235 leading to mitochondrial Ca(2+) overload and opening of the mitochondrial permeability transition por
236 /apoptosis, associated with the pathological opening of the mitochondrial permeability transition por
240 stically, HETEs activated the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the
241 ed small-molecule inhibitors of CypD prevent opening of the mPTP in hepatocytes and the resulting eff
243 in-protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cT
244 ins that travel from the larger to the small opening of the nanopore than for those that travel in th
246 oincide with the continental breakup and the opening of the North Atlantic Ocean over a period from 6
248 sociated with the no-reflow phenomenon after opening of the occluded vessels in patients with coronar
249 for colorimetric sensing of fluoride by ring-opening of the otherwise photochromic benzo-/naphthopyra
250 sformation between these two phases involves opening of the P(3) ring at the base of the P(4)Se(3) mo
254 to maintain low matrix [Ca(2+)] and prevent opening of the permeability transition pore and cell dea
256 age-sensing domains (VSDs) that regulate the opening of the pore domain and ensuing permeation of sod
259 yo-electron microscopy structures reveal the opening of the RagB lid and thus provide direct evidence
261 ese results reconcile competing ideas on the opening of the rift system by highlighting differences i
263 the inability for transport arises from slow opening of the SBP or the selectivity provided by the tr
264 lation enables further modification and ring opening of the single-ring aromatics vanillate and 3-O-m
269 ation of azetidines is achieved without ring opening of the strained saturated heterocycle by conduct
272 to the polymer, as well as in the subsequent opening of the sulfamate ring once it has been installed
274 tric current to intestinal cells resulted in opening of the tight junctions in vitro and a consequent
277 aled through either of two discrete actions: opening of the vaginal plates to allow copulation, or ex
279 them small enough to extravasate through the openings of the bone's sinusoidal capillaries and thus l
281 Ca(2+) efflux from mitochondria during brief openings of the mitochondrial permeability transition po
287 PTP (permeability transition pore) and that opening of this pore leads to necroptosis, a regulated f
291 ein 2, triggering the transient and specific opening of tumor tight junctions allowing for infiltrati
294 rst examples of selective and regiodivergent opening of unsymmetrical phenonium ions with chloride io
296 ility through inhibition of K(ATP) channels, opening of voltage-dependent calcium channels, increased
298 action potential (AP) waveform controls the opening of voltage-gated calcium channels and contribute
300 osis in alpha-cells is tightly linked to the opening of voltage-gated P/Q-type Ca(2+) channels, the a