ライフサイエンスコーパス: operate to

1 ory mechanisms of healthy tissue continue to operate to a degree in tumors.

2 ments, revealing that all the analyzed areas operate, to a greater or lesser extent, near the edge of

3 r are critically involved in tumorigenicity, operate to abnormally elevate biological output of a pro

4 Electrochemically active Fe is operated to accompany Mn, and zero-strain Ni is modulate

5 This possibly reflects selection operating to achieve a gene dose reduction while avoidin

6 ype, this is unlikely to be the sole pathway operating to achieve adaptation.

7 acillus subtilis but how the two proteins co-operate to activate gene expression is poorly-understood

8 into the mechanism by which AphA and AphB co-operate to activate the expression of tcpPH, we have pur

9 two yeast transcriptional regulators that co-operate to activate thioredoxin (TRX2) and thioredoxin r

10 m, multiple genetically separable mechanisms operate to adapt specific aspects of behavior [11-13].

11 ies show commonalities in how discrimination operates to affect health and wellbeing: how historical

12 Instead, the quinone pool primarily operates to aid ATP production.

13 ty implies that positive feedback mechanisms operate to allow commitment (i.e., the establishment of

14 ndent chromatin remodeling machines, that co-operate to assemble DNA and histone proteins into chroma

15 hypotheses about the types of processes that operate to assemble microbiomes over evolutionary time.

16 ally known as pattern-recognition receptors, operate to assess infectious and non-infectious threats

17 enoid valves), which are discretely computer-operated to automatically condition, calibrate and clean

18 Cellular defense systems operate to avoid molecular damage caused by ROS, but the

19 anglia support a basic attentional mechanism operating to bind input to output in the executive foreb

20 onize dE2F1-mediated activation, and they co-operate to block S phase progression in transgenic anima

21 ple integrated and often redundant responses operate to blunt the homeostatic threats generated by ex

22 icase domain (HD) and polymerase domain (PD) operate to bring together MHs and facilitate repair.

23 Thus, multiple genetic programs operate to calibrate dendritic coverage, to coordinate t

24 l cells and suggest that the two proteins co-operate to carry out specific as yet unknown tasks betwe

25 understood, but the intracellular mechanisms operating to change the direction of axon outgrowth rema

26 he notable plasticity by which the replisome operates to circumvent obstacles in its path and may exp

27 perception, determined by visual experience, operates to compensate for large genetic differences in

28 ns illuminate the substituent effects, which operate to confer this selectivity.

29 laque phenotype; determining which mechanism operates to constrain plaque size may be more informativ

30 ented for how domain II of the IRES and NS5A operate to control host and viral translation during HCV

31 gest that an innate structural mechanism may operate to control non-specific association of membrane-

32 er which protein thiol/disulfide couples may operate to control physiologically relevant processes.

33 This novel mechanism of chaperone action may operate to control the activity of other important signa

34 Regulatory mechanisms must therefore operate to control the overall amount of Ca2+ that enter

35 ns, we suggest that Rps3 and eIF3 closely co-operate to control translation termination and stop codo

36 Altogether, our results reveal how MukBEF operates to control chromosome folding and segregation i

37 A similar mechanism also operates to control expression of the genes in the Esche

38 es a similar 'clock-and-wavefront' mechanism operates to control somitogenesis; in all of them, somit

39 t promoters and the mechanisms by which TRF2 operates to control transcription remain elusive.

40 uses a mechanism that is distinct from that operating to control AU-rich mRNA stability in myeloid c

41 It is likely that this mechanism operates to couple O(2) supply and mitochondrial respira

42 nding sites or modification sites, which can operate to create an ultrasensitive dose response.

43 not the only way that this accessory protein operates to create a milieu conducive to robust virus gr

44 echnological landscape in which the field is operating to decode key questions regarding these dynami

45 We hypothesize that the SIS RNAi pathway operates to defend the genome during sexual development.

46 our data show that the SIS RNAi pathway also operates to defend the genome via squelching transposon

47 ) enabled an understanding of how the device operated to deliver a JITI (eg, the nature, type, and fr

48 lowed a full understanding of how the device operated to deliver a JITI.

49 mals, a relatively small number of receptors operate to detect signature molecules that herald infect

50 obins and leghemoglobin, proximal influences operate to determine fundamental dynamic and thermodynam

51 deling and nucleosome-depleted 'barriers' co-operate to determine the kinetics of nucleosome organiza

52 s are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflamma

53 Our results illustrate how VHL and PBRM1 co-operate to drive renal transformation and uncover replic

54 a functional network through which CIC::DUX4 operates to drive tumor progression and survival.

55 ase our understanding of the mechanisms that operate to effect extracellular proteostasis, as this is

56 framework of how modifiable behaviours could operate to either increase the risk of accelerated agein

57 onditions under which a CA1 microcircuit can operate to elicit theta-gamma PAC, and highlights the mo

58 sms of mRNA and ribosome association with ER operate to enable an mRNA transcriptome-wide function fo

59 ynthase gene dusB is low, unusual mechanisms operate to enable robust translation of fis.

60 hat are precisely manufactured, aligned, and operated to enable low detection limits.

61 Once in the growth cone, further controls operate to enhance the retention or rejection, as approp

62 p62 may therefore operate to enhance TRIM5alpha-mediated retroviral restri

63 d cells determine stomatal aperture and must operate to ensure an appropriate balance between CO2 upt

64 c loci in nematodes and vertebrates, and may operate to ensure coordinate expression of these functio

65 ablish or maintain multiple constraints that operate to ensure coordination of events leading to chia

66 ults, we postulate that different mechanisms operate to ensure efficient transcription by RNA polymer

67 roofreading' activities of RAD51 paralogs co-operate to ensure the enrichment of active, ATP-bound RA

68 control system of the endoplasmic reticulum operate to ensure the proper folding of nascent TCRalpha

69 of a complex feedback regulatory system that operates to ensure cholesterol homeostasis.

70 constraints imposed by an endogenous system operating to ensure that DNA acts in a cell-autonomous m

71 H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young

72 nd mCherry, reveal that different mechanisms operate to establish the excitation and emission maxima.

73 mplementation, possibly as incinerators were operating to EU-WID standards before the implementation

74 7 have fecal soiling, and 5 are too recently operated to evaluate.

75 ne possibility is that polar ejection forces operate to exert away-from-the-pole forces that could co

76 properties of the continents and the forces operating to exhume them over geologic time.

77 inct mechanisms flexibly and synergistically operate to facilitate perception and action.

78 se results suggest that hemispheric transfer operates to filter irrelevant information and efficientl

79 re key cis-regulatory elements, but how they operate to generate cell type-specific transcriptomes is

80 the Vegf-Dll4/Notch feedback system normally operates to generate heterogeneity between endothelial c

81 ggest that associative substitution pathways operate to get the hydrocarbon substrate into, and out o

82 also show that two complementary mechanisms operate to implement a bias when two sets of priors are

83 volution is that natural selection primarily operates to improve replication fidelity, with the ultim

84 ich most known Alzheimer's disease (AD) loci operate to increase AD risk remain unclear.

85 tational and population-level processes that operate to increase amounts of functionless DNA.

86 Multiple HSV genes can operate to increase virulence.

87 n intact ABA signaling pathway, and probably operates to increase ABA synthesis as part of a positive

88 ide sequence on either side of the linker co-operating to increase binding affinity.

89 e illustrates how pathogen detection systems operate to induce both membrane transport and signal tra

90 e Fas/CD95 cell death pathway which normally operates to induce apoptosis at the end of the terminal

91 Thus an auto-regulatory feedback mechanism operates to induce its own inhibitor SIRT3 by PGC-1beta.

92 t an independent-rapamycin-sensitive pathway operates to induce trophoblast motility, or that other,

93 s that the N- and C-termini of Kir6.2 may co-operate to influence channel closure by ATP.

94 subpopulation through which genetic variants operate to influence disease.

95 FoxOs operate to inhibit mTORC1 signaling and cell survival in

96 rolling entry of cells into S phase, pRB can operate to inhibit S phase completion.

97 , indicating that a POSH-dependent mechanism operates to inhibit axon outgrowth in different types of

98 t is evident that three alternative pathways operate to introduce the PS module (including associated

99 , 5 patients are wet, and 8 are too recently operated to judge.

100 es include immune resistance mechanisms that operate to kill invading pathogens.

101 ct with self-antigens, tolerance checkpoints operate to limit but not completely prevent autoimmunity

102 ted by various signaling mechanisms that may operate to maintain appropriate levels of synaptic serot

103 ing that epigenetic mechanisms that normally operate to maintain centromere integrity are disrupted o

104 Thus, these motives and emotions do not operate to maintain certain states of the self, as some

105 omosomal fragments, selection pressures must operate to maintain high EGFR copy number over multiple

106 ses, suggesting that multiple mechanisms may operate to maintain local adaptation.

107 ecause of multiple layers of regulation that operate to maintain metabolic steady state and because o

108 present our understanding of mechanisms that operate to maintain proteostasis in extracellular body f

109 ic and non-cell-autonomous actions of CTLA-4 operate to maintain T cell tolerance to a self antigen.

110 response network of pathways, both of which operate to maintain the integrity of the genome.

111 w certain keystone members of the microbiota operate to maintain the stability and functional adaptab

112 ction on the transcriptional output may have operated to maintain a similar pattern of Endo16 express

113 he photosystem II (PSII) repair cycle, which operates to maintain photosynthetic activity in the ligh

114 The mechanism that operates to maintain this arrested state in GCs is curre

115 A network of mechanisms operates to maintain tolerance in the gut mucosa.

116 is not yet agreement on how these dams will operate to manage scarce water resources.

117 e "circuitry" connecting these factors could operate to match the expression of the lineage-committin

118 ptimal stomatal theory predicts that stomata operate to maximise photosynthesis (A(net) ) and minimis

119 ed DNA binding functions of Hop2 and Mnd1 co-operate to mediate synaptic complex assembly, whereas ss

120 otable reuse facilities must be designed and operated to minimize the presence of contaminants of eme

121 results indicate that an intact Xbp1 pathway operating to mitigate stress in the endoplasmic reticulu

122 , we hypothesized that a similar process may operate to modulate regulatory B cells (Breg).

123 complex network of inter-organ communication operates to modulate insulin secretion and regulate gluc

124 Our results point to a mechanism operating to modulate the domain or duration of signalin

125 t least two alternative transport mechanisms operate to move peptides into the cell.

126 Do transcribed enzymes operate to obtain N from SOM?

127 Operating to obtain a high specific energy, however, res

128 at incorporates resource-use plasticity that operates to optimize organism growth, underpinned by inv

129 velopment with morphogenetic mechanisms that operate to pattern an organ and the differentiation of i

130 much less is understood about how these can operate to pattern tissues in the context of the extensi

131 tion of neural identity are separable events operating to pattern the rostral end of the early chick

132 ly play important roles in checkpoints which operate to permit cell survival following many forms of

133 We propose that such a mechanism may operate to potentiate adaptive immune responses against

134 An automated pipetting robot is operated to prepare 264 mixtures of Ti(3)C(2)T(x) MXene,

135 Mechanisms that might operate to preserve the tight linkage of self-incompatib

136 malignant clones and that selection has been operating to preserve immunoglobulin structure.

137 DNA damage checkpoint pathways operate to prevent cell-cycle progression in response to

138 nts suggests that selective mechanism(s) may operate to prevent the appearance of these Abs during ac

139 uch needed insight into molecular mechanisms operating to prevent the loss of tolerance, particularly

140 wing the transition of some patients from an operating to procedure room or office-based setting.

141 idering how community effect signaling could operate to produce its observed effects, we construct an

142 s or the symptoms but at the mechanisms that operate to produce the symptoms.

143 laint of fatigue, other factors must also be operating to produce the full range of clinical symptoms

144 ion-coding striatal neuron, and show they co-operate to promote action selection in learning and comp

145 wo substrate-targeting sites in YopH that co-operate to promote epithelial cell detachment and bacter

146 ivity to early environmental influences that operate to promote social competency.

147 ediated effects and a viral superantigen are operating to promote the dramatic expansion and persiste

148 re emerging as key players in processes that operate to protect neurons and other brain cells by neut

149 We speculate that this switch operates to protect insulin-and the beta-cell-from prote

150 gical and chemical characteristics have been operated to prove the existence of beta sheets piezoelec

151 oylation as a possible mechanism that may be operating to rapidly regulate synaptic efficacy.

152 at both nuclear import and export mechanisms operate to regulate cellular localization of an HMG box

153 th positive and negative feedback loops that operate to regulate different aspects of flower formatio

154 Here we discuss those mechanisms that operate to regulate effector immune responses.

155 site for Pbx-Prep/Meis (PM) heterodimers co-operate to regulate enhancer activity in r4.

156 Different mechanisms operate to regulate histone protein levels, and inductio

157 e signaling pathways in which RIPK4 and IRF6 operate to regulate keratinocyte differentiation are poo

158 ate the mechanisms by which Mdm2 and Mdmx co-operate to regulate p53 level and activity.

159 studies suggests that KSR1 and DCAF1 may co-operate to regulate schwannomas formation.

160 here that distinct regulatory miRNA networks operate to regulate Th2 cells in house dust mite-allergi

161 ts of the reciprocal control mechanisms that operate to regulate the activities of the two phyA signa

162 gnaling induced LGP2 expression wherein LGP2 operated to regulate death-receptor signaling and impart

163 strict access of the PPyT, and posit that it operates to regulate a subset of the heterogenous struct

164 Furthermore, this mechanism normally operates to regulate GSH biosynthesis in the cell, as GS

165 We find that ADO operates to regulate the stability of its substrates rap

166 gesting the existence of parallel mechanisms operating to regulate SERT at serotonergic synapses.

167 'Purifying selection' mechanisms operate to remove such dysfunctional mtDNAs.

168 Pyroptosis operates to remove the replication niche of intracellula

169 chronic photoinhibition, a PSII repair cycle operates to replace damaged PSII subunits with newly syn

170 st that several distinct signalling pathways operate to repress FPB1 and PCK1 transcription in the pr

171 has revealed that two regulatory regions co-operate to repress PAD1 expression, this being alleviate

172 data indicate that a negative feedback loop operates to repress transcription of the iscRSUA-hscBA-f

173 ents cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood.

174 e showed that JAZ5 and JAZ10 specifically co-operate to restrict COR cytotoxicity and pathogen growth

175 ld requirement for Alx4 in a genetic program operating to restrict polarizing activity and Shh expres

176 proteins suggests that a distinct mechanism operates to retain resident plasma membrane proteins in

177 lly driven, and that a selection pressure is operating to retain type II NAD(P)H dehydrogenases in th

178 e roots use a "tipping point" mechanism that operates to reverse the asymmetric auxin flow at the mid

179 apture and suggests non-image forming vision operates to sample local regions of the visual field to

180 tissue sites and how tissue-related factors operate to shape immune cell fate and function.

181 iche segregation and environmental filtering operate to shape the assemblage of the avian community i

182 ntly infected host, different mechanisms can operate to silence antiviral T cell responses; CD8 T cel

183 otor proteins kinesin-3 and dynein, which co-operate to support bi-directional motion of early endoso

184 zones (LGP), but the mechanisms by which it operates to sustain skeletal growth are not fully clear.

185 secretion (TTS) systems, which independently operate to target proteins to extracellular sites.

186 The inhibitory loop then operates to terminate outgrowth signals in the order obs

187 pressure UV light with and without TiO2 was operated to test the elimination efficiencies for 56 mic

188 t ES attached in the recirculation loop were operated to test whether the ES could control NH3 toxici

189 ing a plasma treatment process intentionally operated to treat these compounds slowly to allow for by

190 , different points in a drinking water plant operated to treat this source water, and in the associat

191 We propose that KIRs on memory T cells operate to uncouple effector functions by modifying the

192 The three cultures operate, to varying degrees, across all of science.

193 t operational time frames when the plant was operating to when it was shut down, the plant was found