ライフサイエンスコーパス: opsonization

1 diated membrane permeabilization, and not by opsonization.

2 mediated complement activation as well as C3 opsonization.

3 he bacterium acquires FH to evade complement opsonization.

4 li replicated at a fast rate following serum opsonization.

5 omain for efficient viral neutralization and opsonization.

6 d their ability to stimulate T cells, as did opsonization.

7 neoformans via a process highly dependent on opsonization.

8 could be rescued by Fc receptor-dependent Ab opsonization.

9 needed to trigger complement activation and opsonization.

10 ailed to indicate a major effect of antibody opsonization.

11 nisms for the evasion of complement-mediated opsonization.

12 owth and presence of capsule are critical to opsonization.

13 human ascites in the presence and absence of opsonization.

14 lling was found not to be due to the rate of opsonization.

15 surface of nanoparticles in a process called opsonization.

16 hat mediates optimal complement fixation and opsonization.

17 ewhat different mechanisms for resistance to opsonization.

18 nce other aspects of Ab function, such as Ag opsonization.

19 se-affiliated C3b impaired C3 activation and opsonization.

20 lated well with the individual level of C3dg opsonization.

21 ence of opsonization than in the presence of opsonization.

22 To mimic IgG opsonization, a chimeric antibody-like molecule, contain

23 However, after opsonization, about seven times more bacteria were locat

24 nd is associated with its ability to promote opsonization, agglutination, and phagocytic ring formati

25 e that enhancement of Ag presentation by IgG opsonization allows innate-like MAIT cells to mount a fa

26 C1q opsonization also increased phagocytosis and efferocytos

27 Opsonization also increased the percentage of phagocytes

28 Our findings suggest that HIV-opsonization alters the activation and signaling pathway

29 Mannose-binding lectin (MBL) enhances opsonization and activates complement.

30 protects the body against infection through opsonization and activation of the complement system on

31 lets by macrophages correlated with antibody opsonization and antigen expression and was absent in pl

32 es preferentially bind via Fab, facilitating opsonization and bacterial killing.

33 an induce complement activation resulting in opsonization and binding of these complexes to complemen

34 We conclude that both complement opsonization and C5a-stimulated chemotaxis are required

35 t P. carinii-specific IgG partially mediates opsonization and clearance of P. carinii.

36 way and, as such, is essential for efficient opsonization and clearance of pathogens, altered self-st

37 d the role of surfactant protein A (SP-A) in opsonization and clearance of S. aureus.

38 f annexin A2 increased AP-mediated bacterial opsonization and clearance.

39 ecognition, in particular, the mechanisms of opsonization and complement activation, has been reporte

40 ns and evolved multiple mechanisms to escape opsonization and complement killing.

41 Therefore, we investigated the effects of opsonization and found that this increased the efficienc

42 sting that Rh05 protects infected cells from opsonization and IgG-dependent activation of host Fcgamm

43 tiates complement activation, leading to C3b opsonization and ingestion by phagocytic cells.

44 l sites to achieve optimal antibody-mediated opsonization and killing of S. pneumoniae.

45 ly attach to bacterial surfaces and initiate opsonization and killing.

46 mplement component C3 deposition, i.e., C3b (opsonization and lysis) or C3bi (opsonization only) frag

47 CP protects the bacteria from WTA-dependent opsonization and phage binding.

48 roup A streptococci is the ability to resist opsonization and phagocytic ingestion.

49 Strategies for avoidance of opsonization and phagocytic killing include elaboration

50 istance to different group A streptococci to opsonization and phagocytic killing.

51 complement-mediated bacterial lysis and (ii) opsonization and phagocytosis by human neutrophils.

52 e we demonstrate that evasion of Ab-mediated opsonization and phagocytosis by the highly virulent Sch

53 The reduced capacity of complement-mediated opsonization and phagocytosis in the complement-deficien

54 Furthermore, CRP enhanced opsonization and phagocytosis of apoptotic cells by macr

55 ement is at least in part due to C3-mediated opsonization and phagocytosis of P. aeruginosa.

56 rum raised against recombinant Tp92 promotes opsonization and phagocytosis of T. pallidum by rabbit m

57 Bacteria can avoid complement-mediated opsonization and phagocytosis through acquiring FH to th

58 neutrophils to F. tularensis-infected lungs, opsonization and phagocytosis, evasion and inhibition of

59 ins of the innate immune system that promote opsonization and phagocytosis, galectin-3 has direct fun

60 ribute to GAS evasion of complement-mediated opsonization and phagocytosis.

61 st and has evolved many strategies to resist opsonization and phagocytosis.

62 beta3 IgG autoantibodies that cause platelet opsonization and phagocytosis.

63 s, the reaction mediated by hematin promotes opsonization and possible clearance of the youngest (hig

64 ier complexes, imparts stealth by preventing opsonization and removal by phagocytes and minimizes int

65 le fraction of the serum responsible for the opsonization and subsequent lytic killing of bacteria, w

66 eumococcus has developed strategies to evade opsonization and subsequent neutrophil-mediated killing.

67 Although capsule allows for evasion of opsonization and subsequent phagocytosis during invasive

68 ated lysis and decreased complement-mediated opsonization and suggest that amplification is used by t

69 articles nearly completely blocks complement opsonization and unwanted granulocyte/monocyte uptake.

70 anoworms in mice, rats, and dogs inhibits C3 opsonization and uptake by granulocytes.

71 ice correlates with less efficient bacterial opsonization and uptake by macrophages, and this reflect

72 earance mechanisms, in particular by evading opsonization and uptake by professional phagocytes.

73 ns a molecule that is able to replace C1q in opsonization and/or complement activation.

74 ins, developmental stages, DC subsets, serum opsonization, and exogenous DC stimuli involved in the s

75 IgM and high-titer IgG1 Abs, restored serum opsonization, and gave protection from mortality after S

76 Phagocytosis was augmented by IgG opsonization, and inhibited by TCR-blockade, suggesting

77 ent a link between biomolecule corona and C3 opsonization, and may determine individual complement re

78 m's main biological functions include lysis, opsonization, and recruitment of phagocytes.

79 ve C3b was converted to iC3b within 1 min of opsonization, and the ratio was stable over 1 h.

80 hagocytosis, was less affected by complement opsonization, and was less sensitive to microtubule and

81 rains strongly supports the use of merozoite opsonization as a correlate of immunity for field studie

82 lts are avidity dependent, the ELISA and the opsonization assay results were strongly correlated (r =

83 mes encapsulated in gel microdroplets, while opsonization assays failed to detect surface-exposed Tro

84 that it is not only important for decreased opsonization but also for invasion of endothelial cells

85 enic fungus Cryptococcus neoformans promotes opsonization but also inhibits polysaccharide release an

86 al activity of murine pDCs is independent of opsonization but appears to require the C-type lectin re

87 s were also synergistic with normal serum in opsonization but at a much lower level than fragments of

88 re not present in LVS, that allow evasion of opsonization by Ab, dampening the protective effects of

89 destruction of the Aspergillus hyphae needs opsonization by Abs and involves predominantly recogniti

90 Opsonization by Abs represents a critical component of t

91 on in some MM cells, thereby enhancing their opsonization by anti-MICA antibodies.

92 The results of this study indicate that opsonization by C3 does not necessarily lead to phagocyt

93 type 24 streptococci were fully resistant to opsonization by C3 only in the presence of plasma.

94 ds (CP5) strain, even though the kinetics of opsonization by C3b and iC3b was similar for both the CP

95 tory molecules that interfere with effective opsonization by complement and/or IgG.

96 ocytosis by human macrophages requires serum opsonization by complement.

97 bitor factor H, CFHR4 acts as an enhancer of opsonization by promoting complement activation.

98 rthermore, plasmin-mediated inhibition of Ab opsonization by SchuS4 also inhibited Ab-mediated uptake

99 a were internalized, with no requirement for opsonization by serum, at a higher rate than smooth orga

100 the DeltatfpO mutant was more susceptible to opsonization by SP-A and by other pulmonary and circulat

101 ing inflammation through TNFR1 and thwarting opsonization by trapping IgG Fc domains, while the intac

102 fering with receptor-virus binding, by virus opsonization, by complement activation, and via FcgammaR

103 tibodies induce platelet clearance by simple opsonization, by inducing mild platelet activation, or b

104 Antigen opsonization can modulate the capture of antigen, its pr

105 Opsonization caused a statistically significant reductio

106 s bradykinin, and complement function (e.g., opsonization, chemotaxis) is impaired, despite elevation

107 oprF-deficient bacteria by neutrophils after opsonization compared with wild-type P. aeruginosa.

108 ral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellul

109 Classic antibody functions include opsonization, complement activation, and enhancement of

110 hagocyte THP-1 cells with different prey and opsonization conditions to compare the persistent associ

111 would cover 50.8% of the isolates, but cross-opsonization data are unknown for 38.5% of them.

112 Based on available cross-opsonization data, the 30-valent M-protein vaccine candi

113 s was affected by Ab subclass, presentation, opsonization density, Fc fucosylation, or mutation.

114 SP-A enhances phagocytosis via an opsonization-dependent mechanism and binds apoptotic PMN

115 h) and late (24-h) time points; however, PHS opsonization did not supplement this anticryptococcal ac

116 has been controversial, we report that iC3b opsonization does not significantly affect apoptotic cel

117 IgG opsonization drastically changed this interaction, induc

118 with O-ag specifically confers resistance to opsonization during host-mediated phagocytosis.

119 Likewise, IgG opsonization enhances antigen presentation to CD4(+) T l

120 Furthermore, opsonization enhances M-like-cell transcytosis of V. cho

121 itive bacterium known to require Ab-mediated opsonization for clearance.

122 omains within merozoite antigens targeted by opsonization generate strain-transcending immune respons

123 the complement inhibitor compstatin reduced opsonization >2-fold, and compstatin and a C5a receptor

124 gocytose P. marneffei even in the absence of opsonization, (ii) binding is divalent cation independen

125 P+ increased phagocytosis by 57% compared to opsonization in complement-inhibited serum.

126 was a strong predictive value of complement opsonization in dog and rat sera; nanoparticles with hig

127 Attenuated IgG opsonization in patients with CHB, which was correlated

128 ta indicate an important role for complement opsonization in promoting cell-mediated antitumor immune

129 effective inhibitor (IC(50) ~0.24 muM for C3 opsonization in sera), followed by SCR-1-2-3-4 (IC(50) ~

130 croorganisms by complement activation and/or opsonization in the absence of specific Ab.

131 ve expression of the M1 epitope and antibody opsonization in the kidney.

132 In this study, we examined opsonization in the presence or absence of monoclonal an

133 We explored the kinetics of iC3b opsonization in two models of murine cell apoptosis, gam

134 L-ficolin opsonization increased conidial uptake and enhanced kill

135 WGA-Fc opsonization increased fungal phagocytosis, as well augm

136 to the immunodominant antigen contributes to opsonization, increased phagocytosis, and killing of the

137 mens from PCV7-immunized children had median opsonization indices of 150 and < 20 for serotypes 6A an

138 llidum is cleared from sites of infection by opsonization, ingestion, and killing by macrophages.

139 C3 opsonization is known to enhance NK cell-mediated cytoly

140 e provided the first evidence that merozoite opsonization is predominantly strain transcending, and t

141 mediated mechanism(s), most likely bacterial opsonization, is of importance in localizing anaerobic r

142 In addition, ficolin-A opsonization led to a modulation of the proinflammatory

143 a was increased under low-pH conditions, and opsonization led to enhanced binding of conidia to A549

144 he highest between-subject variability in C3 opsonization levels, while rat and mouse sera showed the

145 ropose that epithelial nitration works as an opsonization-like system that promotes activation of the

146 mmalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damag

147 Aggregation, opsonization, lysis, and phagocytosis are mechanisms tri

148 layers increases circulation time by evading opsonization, macrophage phagocytosis, and reticuloendot

149 fferences in their ability to resist surface opsonization may contribute to the distinct virulence ph

150 Opsonization may trigger antimicrobial mechanisms such a

151 , interstitium and circulation) are similar: opsonization, membrane perturbation, triggering inflamma

152 from the circulation in a murine tumor cell opsonization model.

153 al pathway of complement (CP) can mediate C3 opsonization of Ags responsible for the costimulation an

154 Preferential opsonization of amastigotes with mannose-binding protein

155 phis, was apparently not affected by surface opsonization of amastigotes, was not mediated by interle

156 diated bacteriolysis and complement-mediated opsonization of an isogenic set of organisms containing

157 inhibition experiments, beta(2)GPI prevented opsonization of apoptotic cardiomyocytes by maternal ant

158 omatin fragmentation, could stop binding and opsonization of apoptotic cells by autoantibodies, and i

159 Complement-mediated opsonization of bacteria by C3 binding is an important c

160 Opsonization of bacteria by complement proteins is an im

161 on that has been hypothesized to involve the opsonization of bacteria released from host cells.

162 Furthermore, AprA inhibited opsonization of bacteria with C3b and the formation of t

163 Opsonization of bacteria with immune serum prior to intr

164 We show that opsonization of bacteria with serum IgA induced cross-ta

165 However, opsonization of C. gattii with complement components was

166 In contrast, opsonization of C. neoformans by IgG3 does not require t

167 plement-sufficient autologous plasma for the opsonization of C. neoformans.

168 Opsonization of C. parapsilosis by serum factors was not

169 manner, and phagocytosis was not enhanced by opsonization of Candida in serum.

170 Complement-mediated opsonization of CP+ increased phagocytosis by 57% compar

171 The importance of complement-mediated opsonization of CP+ was tested by neutrophil phagocytosi

172 toire of I-Ab(DeltaIEC) vs control mice, but opsonization of cultured C rodentium by SIgA isolated fr

173 Complement-mediated opsonization of encapsulated Staphylococcus aureus (CP+)

174 activation due to CD55 absence may result in opsonization of erythrocytes, possibly leading to clinic

175 decreased the association of F. novicida and opsonization of F. novicida with lung collectin surfacta

176 oma with neutrophils and putatively involved opsonization of fibrils by the antibody, leading to cell

177 al unknown serum factor(s) may contribute to opsonization of GBS directly or via a novel mechanism of

178 reperfused stroke, complement activation and opsonization of hippocampal synapses directed ongoing mi

179 reperfused stroke, complement activation and opsonization of hippocampal synapses resulted in synapti

180 rvations provide the first evidence that IgG opsonization of HIV is associated with a decreased CTL-s

181 In this study, we investigated whether the opsonization of HIV with complement (C-HIV) or a mixture

182 vo data, therefore, indicate that complement opsonization of HIV-1 strengthens DC-mediated antiviral

183 In contrast, opsonization of Hp with immunoglobulin G (IgG) induced r

184 Optimal platelet activation required opsonization of hyphae with fresh or heat-inactivated wh

185 ons to determine the mechanism through which opsonization of IAV with collectins protects neutrophils

186 Opsonization of IEs by cytophilic antibodies that recogn

187 enza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and

188 Opsonization of K1-positive strains, but not K1-negative

189 Opsonization of L. pneumophila in vitro with anti-L. pne

190 tant roles in innate lung defense, enhancing opsonization of microbes and limiting lung inflammatory

191 We demonstrate that IgG opsonization of myelin debris is required for its effect

192 us system (CNS) pathology may facilitate the opsonization of myelin debris, allowing repair to procee

193 anism in MS central nervous system (CNS) for opsonization of myelin membrane CNP, mediated via the C3

194 ynamics of protein adsorption and complement opsonization of nanomedicines.

195 Opsonization of O-antigen-deficient LVS in serum lacking

196 Opsonization of OmpA(+) E. coli either with adult or cor

197 Opsonization of organisms by complement did not compensa

198 vivo and in vitro approaches to ask whether opsonization of particles with IgG enhances intracellula

199 ke immune complex, pentraxin aggregation and opsonization of pathogen result in Fc receptor and macro

200 a circulating immune factor responsible for opsonization of pathogens and directly activating comple

201 ions present in most human sera promotes the opsonization of PC-expressing strains of A. actinomycete

202 plement activation by PF4/heparin complexes, opsonization of PF4/heparin to B cells via CD21, and the

203 ethylene glycol [PEG]-Cp40) on hemolysis and opsonization of PNH erythrocytes in an established in vi

204 ivation effectively prevent hemolysis and C3 opsonization of PNH erythrocytes, and are excellent, and

205 We have previously shown that opsonization of retroviruses acts as an endogenous adjuv

206 Opsonization of Salmonella with O:4-specific IgA, IgG1,

207 Opsonization of Schu S4 with either fresh serum or purif

208 Opsonization of Schu S4 with either human serum or purif

209 lycoproteins F and G, we are able to monitor opsonization of single RSV particles using fluorescence

210 atural antibodies play a critical role in C3 opsonization of SPIO nanoworms and a range of clinically

211 Complement-mediated opsonization of Staphylococcus aureus bearing the domina

212 Kinetics of opsonization of Streptococcus pneumoniae by C3 fragments

213 We previously demonstrated that opsonization of superparamagnetic iron oxide (SPIO) nano

214 The effect of Galgp is not due to opsonization of the bacteria, but required its interacti

215 cal complement cascade via C1q to promote C3 opsonization of the bacterium and phagocytosis via CR3 a

216 luble anti-erythrocyte IgG resulted in rapid opsonization of the bound erythrocytes, followed by thei

217 hronic malaria, complement activation by and opsonization of the DV may serve a useful function in di

218 k to the patient, will result in the in situ opsonization of the membranes by anti-Gal, thereby impro

219 IgG opsonization of the model microbe Escherichia coli with

220 -associated C2a cleaved C3, resulting in C3b opsonization of the mycobacteria and recognition by macr

221 Opsonization of the organism by Pneumocystis-specific an

222 CRP opsonization of the R36a strain of S. pneumoniae increas

223 igated whether either complement or antibody opsonization of the virulent prototypical type A strain

224 Opsonization of the wild-type strain inhibited phagocyto

225 eat-labile factors in normal human serum for opsonization of the yeast.

226 to VAR2CSA-expressing IEs, and (iii) greater opsonization of these IEs by human monocytic cells than

227 Complement-mediated opsonization of these organisms was assessed by determin

228 trong strain-transcending component, and the opsonization of transgenic parasites deficient for MSP3,

229 d to compare the mechanisms of resistance to opsonization of type 18 and type 24 streptococci and to

230 DBL5epsilon domains significantly diminished opsonization of VAR2CSA-expressing IEs by human monocyte

231 the host complement system, which results in opsonization of virus by inactivated complement fragment

232 e tetherin expression increased the antibody opsonization of vpu-deficient HIV-infected cells.

233 actions with phagocytes in vitro and in vivo Opsonization of Y. pestis with polyclonal antiserum mode

234 Opsonization of zymosan by CRP is mediated through Fcgam

235 ngs and peripheral organs by potentiating C3 opsonization on bacterial surfaces, through the increase

236 The dependency of C3 opsonization on immunoglobulin binding is almost univers

237 To determine the effect of antibody opsonization on the ability of Brucella to establish its

238 Therefore we analyzed the effect of IgG opsonization on the antigen-presenting capacity of DCs b

239 nregulation of activated complement factor 3 opsonization on the pathogen surface, accompanied by red

240 Here, we examine the effects of Ab opsonization on Y. pestis interactions with phagocytes i

241 Deposition of complement factors (opsonization) on nanoparticles may promote clearance fro

242 lated organisms were completely resistant to opsonization only in the presence of fibrinogen.

243 i.e., C3b (opsonization and lysis) or C3bi (opsonization only) fragment deposition, is central to th

244 es (IC) bound to primate E CR1, either via C opsonization or by means of bispecific mAb complexes, ca

245 llation, an effect that could be reversed by opsonization or coinstillation of TGF-beta1 neutralizing

246 f production of toxic oxygen metabolites and opsonization or engulfment of the microbes, but depended

247 onsidered benign or beneficial by minimizing opsonization or inflammation.

248 ighly regulated protein complex resulting in opsonization or membrane lysis.

249 that IC bound to Raji cell CR2, either via C opsonization or through the use of an anti-CR2 mAb, are

250 their decreased susceptibility to lysis and opsonization, organisms with 4 copies of the Cap b locus

251 of the innate immune system involved in the opsonization, phagocytosis, and destruction of microorga

252 Complement-mediated opsonization, phagocytosis, and immune stimulation are c

253 ptamer enabled us to commandeer the C3-based opsonization-phagocytosis pathway to selectively transpo

254 The resultant opsonization plus subsequent lysis may be important rout

255 Pathogen opsonization positions Fcs to activate pro-inflammatory

256 blood and reduced sensitivity to complement opsonization, providing additional evidence of strain-de

257 Phagocytosis facilitated by serum opsonization required the presence of Ig for effective a

258 Highly correlated opsonization responses were observed across the 15 paras

259 In mice challenged with free R36a, CRP opsonization resulted in higher secondary and memory IgG

260 Specific antibody opsonization significantly enhances the level of phagocy

261 important anti-infection roles of complement opsonization, site-targeted inhibition of MAC should be

262 ce" is regulated by time-dependent bacterial opsonization, stochastic platelet binding, and capture o

263 Serum opsonization studies showed that both were resistant to

264 tance of maintaining a functional complement opsonization system to fight infections, a critical comp

265 assay and for opsonic antibodies by in vitro opsonization tests and indirect bactericidal tests.

266 alized bacteria was higher in the absence of opsonization than in the presence of opsonization.

267 infection of endothelium and macrophages by opsonization that inhibited phagosomal escape and result

268 Furthermore, because the ability of iC3b opsonization to enhance phagocytosis of apoptotic cells

269 ed complement activation with subsequent C3b opsonization upon incubation with normal human serum.

270 rdiocytes but that clearance is inhibited by opsonization via maternal autoantibodies, resulting in a

271 Opsonization was also shown to manifest an increase in i

272 Furthermore, opsonization was serotype transparent.

273 Employing passive antibody transfer and opsonization, we demonstrate with this study that immuni

274 antibodies, measured as avidity and in vitro opsonization, were comparable between elderly and young

275 ing platelet glycoprotein GPIb and bacterial opsonization with activated complement C3, influences bl

276 ti-BcfA antibody-mediated clearance and that opsonization with anti-BcfA serum enhances phagocytosis

277 omplement and by Fc receptors after specific opsonization with antibodies.

278 ivation, it has been speculated that ongoing opsonization with C3 fragments leads to recognition and

279 HU S4 DeltafevR to induce cell death despite opsonization with C3.

280 ement receptors after relatively nonspecific opsonization with complement and by Fc receptors after s

281 sogenic mutants lacking protein H to inhibit opsonization with complement C3b and binding of C4BP.

282 Opsonization with either complement proteins or antibody

283 Following opsonization with fresh serum, Hp triggers a modest resp

284 a was significantly increased upon bacterial opsonization with Gal-9 (p < 0.05), an effect abrogated

285 Opsonization with heat-inactivated immune serum reduced

286 A previous study showed that opsonization with human immune serum could either promot

287 Opsonization with human serum played only a modest role

288 inomycetemcomitans, mainly in the absence of opsonization with human serum.

289 flow cytometry-based analysis, we found that opsonization with IgG accelerates antigen degradation wi

290 However, the opsonization with IgG was no better than no treatment or

291 ophages with gamma interferon (IFN-gamma) or opsonization with immunoglobulin G (IgG) isolated from a

292 th strains was significantly increased after opsonization with nonimmune C5-depleted serum.

293 revious studies demonstrated that, following opsonization with normal human serum (NHS), phagocytes b

294 es via complement receptor 1 (CR1) either by opsonization with normal human serum as a complement sou

295 Opsonization with pooled human serum (PHS) increased bin

296 one marrow macrophages (BMM) was enhanced by opsonization with SAP or CRP.

297 Furthermore, opsonization with serum engages other pathways in the cy

298 Similarly, opsonization with the postimmunization sera failed to en

299 These effects of opsonization with whole plasma could not be duplicated b

300 showed results similar to those for antibody opsonization, with C. neoformans localized to endosomes