ライフサイエンスコーパス: optic nerve

1 peripheral blood, buccal swab, or uninvolved optic nerve.

2 le dye leakage from affected vessels and the optic nerve.

3 q11.2, optic nerve coloboma and dysplasia in optic nerve.

4 he translaminar pressure gradient across the optic nerve.

5 ort from the brain to the retina through the optic nerve.

6 y severe inflammation of the spinal cord and optic nerve.

7 ganglion cell neurons and their axons in the optic nerve.

8 superior colliculus and degeneration in the optic nerve.

9 ic gliomas relative to normal non-neoplastic optic nerve.

10 vival and inhibits astrocyte activity in the optic nerve.

11 urons of the retina and their axons form the optic nerve.

12 and predominantly affect the spinal cord and optic nerve.

13 generated centerline representations of the optic nerve.

14 cal neurons and in vivo in the injured adult optic nerve.

15 the vortex vein ampullae from the center of optic nerve.

16 in various cell types in both the retina and optic nerves.

17 3D DIR hypersignal was present in 17 (41.5%) optic nerves.

18 disease affecting the brain, spinal cord and optic nerves.

19 /knockout (KO) trans heterozygotes have thin optic nerves.

20 increased cup-to-disc ratio (n = 5 [4.9%]), optic nerve abnormalities (n = 2 [1.9%]), epiretinal mem

21 Optic nerves also showed progressive degeneration with e

22 on of structural changes at the level of the optic nerve and choroidal vascularization during acute I

23 nap frozen retinoblastomas which invaded the optic nerve and five which did not.

24 s were posteriorly located (mean distance to optic nerve and fovea = 2.0 +/- 2.2 mm and 1.6 +/- 1.5 m

25 miting membrane (ILM) was peeled between the optic nerve and fovea and stuffed into the optic disc pi

26 Moreover, immunostainings and dot blots of optic nerve and myelin showed that expression of Rtn4b i

27 s and a decrease in fractional anisotropy in optic nerve and optic tract in bilateral rats, while uni

28 llowing general anesthesia, OCT scans of the optic nerve and retina were acquired using an HRA+OCT Sp

29 Optic nerve and retinal abnormalities were the most freq

30 phy that involve progressive degeneration of optic nerve and retinal ganglion cells (RGC).

31 tage 3 when the vitreous was attached at the optic nerve and separated from the macula.

32 generative neutrophil promoted repair in the optic nerve and spinal cord, demonstrating its relevance

33 The optic nerve and the cells that give origin to its 1.2 mi

34 lary gap merge at a distance superior to the optic nerve and then follow a superonasal course anterio

35 istics including irreversible changes to the optic nerve and visual field loss caused by the death of

36 P latencies reflect the myelin status of the optic nerve and will provide a surrogate marker in futur

37 pace within the orbit, which impinges on the optic nerve and/or eye in affected individuals.

38 ninvasive therapeutic modality for the eyes, optic nerves and brain.

39 isease of the CNS that primarily affects the optic nerves and spinal cord.

40 beginning of regenerative axon growth in the optic nerve, and (2) the re-establishment of synaptic co

41 eate deformations or movements of the eye or optic nerve, and if such changes could be linked to SANS

42 diffuse invasion of the choroid, postlaminar optic nerve, and/or anterior chamber invasion received s

43 attachment (NCRNA) disease, characterized by optic nerve aplasia and total blindness.

44 Charts were reviewed for gestational age, optic nerve appearance, intraocular pressure (IOP), and

45 ked potential, best-corrected visual acuity, optic nerve appearance, visual fields, and global retina

46 The retina and optic nerve are among the metabolically most active stru

47 uggest that lesions occurring near or at the optic nerve are associated with a more severe degree of

48 drome, such as coloboma and dysplasia in the optic nerve, are reported here, contributing to the phen

49 ia for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvemen

50 athy (LHON) is a degenerative disease of the optic nerve associated with one of three mitochondrial D

51 Primary optic nerve atrophy resulting from death of retinal gang

52 ized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration,

53 gh prevalence of intellectual disability and optic nerve atrophy/hypoplasia.

54 from displacements of lens centers and globe-optic nerve attachments.

55 istered ST266 accumulated in rodent eyes and optic nerves, attenuated visual dysfunction, and prevent

56 le (-15 to +15 degrees relative to the fovea-optic nerve axis).

57 Remarkably, normal optic nerve axons also show temperature dependent effect

58 -1 has been shown to promote degeneration of optic nerve axons and apoptosis of retinal ganglion cell

59 Here we show two properties of optic nerve axons, accommodation and inward rectificatio

60 sociation with complete remyelination of the optic nerve but remained prolonged relative to controls.

61 lls in all areas of the brain, including the optic nerve, but not in other barrier-containing tissues

62 ntially involves small axons in the temporal optic nerve, but the reason is unclear.

63 educed survival of ganglion cellaxons in the optic nerve by 22%.

64 image into electrical data, like the eye and optic nerve chain, and then recognizes this electrical f

65 ) eyes did not have progressive glaucomatous optic nerve changes (followed untreated for an average o

66 52 (46.0%) eyes had progressive glaucomatous optic nerve changes and were classified as having pre-pe

67 the first time in patients with Dup22q11.2, optic nerve coloboma and dysplasia in optic nerve.

68 ptic neuritis, an inflammatory demyelinating optic nerve condition that occurs in MS and EAE.

69 for mtDNA maintenance to produce appropriate optic nerve connectivity and that SSBP1 mutations in dom

70 eration throughout the CNS, including in the optic nerve, corpus callosum, and the spinal cord.

71 ouse retinal ganglion cells (RGCs) following optic nerve crush (ONC), which severs their axons and le

72 By using optic nerve crush injury models, recent studies have rev

73 However, optic nerve crush injury-mediated retinal ganglion cell

74 ival in vivo in mice of both sexes following optic nerve crush injury.

75 Optic nerve crush rescued the circadian period of Myk/+

76 zed both chronic (bead occlusion) and acute (optic nerve crush, ONC) rat models to characterize disea

77 in models of experimental optic neuritis and optic nerve crush.

78 st RGC subtypes examined, they survive after optic nerve crush.

79 Ultimately, we found that optic-nerve crush pathologically upregulated activity in

80 The optic nerve cube 200x200 scan using the Cirrus SD OCT 40

81 Additionally, we found 5 novel loci for optic nerve cup area and 6 for disc area.

82 >= 21 mmHg with corneal edema, Haabs striae, optic nerve cupping or buphthalmos) requiring surgery wa

83 th (n = 13), retrobulbar hemorrhage (n = 7), optic nerve damage (n = 4), vascular occlusions (n = 2),

84 angle, raised intraocular pressure (IOP) and optic nerve damage leading to loss of sight.

85 intraocular pressure >21 mm Hg, glaucomatous optic nerve damage, and/or glaucomatous visual field los

86 sia, especially in patients with preexisting Optic Nerve damage.

87 In order to detect glaucomatous optic nerve damages early on and evaluate the severity o

88 Foveal hypoplasia, optic nerve decussation defects and anterior segment dys

89 visual pathways corresponding to the primary optic nerve defects.

90 coma, a disease characterized by progressive optic nerve degeneration, can be prevented through timel

91 RGCs manifests as characteristic cupping or optic nerve degeneration, resulting in visual field loss

92 lated glucose metabolism prior to detectable optic nerve degeneration.

93 noma (Dcc) receptor plays a critical role in optic nerve development.

94 o increase the signal strength and to assess optic nerve dimensions and nerve fiber layer (NFL) thick

95 Pathologic optic nerve DIR hypersignal was determined in four diffe

96 matous optic neuropathy (GON) and pathologic optic nerve DIR hypersignal, significantly increased IOP

97 rder, were nystagmus associated with retinal/optic nerve disease in 23 (32.4%), idiopathic or congeni

98 can be correlated with vision loss caused by optic nerve disease.

99 well as pathological changes in glaucoma and optic nerve disease.

100 non-neuronal cells is common in retinal and optic nerve disease.

101 improve diagnosis and therefore treatment of optic nerve diseases.

102 thalmic disorders such as glaucoma and other optic nerve diseases.

103 and in the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT patients compared to

104 n the effect on the macula and RNFL near the optic nerve disk is investigated, there was significant

105 optic neuropathies are rare eye diseases of optic nerve dysfunction that present in various genetic

106 ing to disruptions of mtDNA and, eventually, optic nerve dysfunction.

107 ensual response is critical in assessing for optic nerve dysfunction.

108 intraretinal fluid, epiretinal membrane, or optic nerve edema.

109 o have an epiretinal membrane, and 1 eye had optic nerve edema.

110 unknown significance in PRPF31, and 1 showed optic nerve elevation in the setting of increased intrac

111 Optic nerve enhancement is a sign seen in different dise

112 No patients showed optic nerve enhancement on magnetic resonance imaging.

113 itis, vitritis, and optic disc edema without optic nerve enhancement should prompt serologic testing

114 predicted by the topographic organization of optic nerve fiber bundles in each subject's retina, succ

115 ons via ipsi- and contralaterally projecting optic nerve fibers.

116 Optic nerve findings included hypoplasia with the double

117 Optic nerve from EAE and optic chiasm from MS also showe

118 n (ICH) and obstructive sleep apnea (OSA) on optic nerve function in children with craniosynostosis (

119 es discovery of nerve fiber damage caused by optic nerve glioma.

120 terplay between physical properties of mouse optic nerve gliomas and the extracellular matrix.

121 Exclusions were no information on optic nerve grading; no 3MSE scores at the time of the e

122 First, to create an optic nerve growth curve from normal optic nerve sheath

123 An optic nerve growth curve was created by using ONSDs meas

124 changes in the retinal nerve fiber layer and optic nerve have demonstrated correlations with brain at

125 nerves on examination received SDOCT of the optic nerve head (24 radial scans).

126 ical coherence tomography (OCT) scans of the optic nerve head (OHN) were obtained from subjects with

127 The coordinates for the optic nerve head (ONH) and optic chiasm (OC) ends of the

128 -inner plexiform layer (GCIPL) thickness and optic nerve head (ONH) parameters using OCT.

129 that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of v

130 number, surface area, and distances from the optic nerve head (ONH) were computed.

131 with OCTA and OCT imaging of the macula and optic nerve head (ONH) were studied.

132 al coherence tomography (OCT) imaging of the optic nerve head and macula was conducted in patients an

133 o stabilize translaminar pressure across the optic nerve head and may provide a new avenue for glauco

134 n multivariate analysis, only initial VA and optic nerve head appearance at presentation were found t

135 sure (IOP), central corneal thickness (CCT), optic nerve head appearance, and mean deviation (MD) ass

136 VA and the appearance of the optic nerve head at presentation predict long-term outco

137 ghtened interest because of its influence on optic nerve head biomechanics.

138 usion (RNP) in quadrants intersecting at the optic nerve head by a masked independent reading center

139 iated with higher IOPs, thinner RNFLs, lower optic nerve head capillary densities, and greater decrea

140 medications or progressive visual field and optic nerve head changes despite maximal tolerated medic

141 r pressure (IOP), worsening visual field, or optic nerve head changes in whom primary trabeculectomy

142 sessment remains identifying the presence of optic nerve head cupping.

143 To investigate the prevalence of optic nerve head drusen (ONHD) in clinically normal subj

144 D Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD).

145 ears from LVPEI-GLEAMS underwent macular and optic nerve head imaging with spectral-domain OCT (SDOCT

146 y account for the peculiar appearance of the optic nerve head in PXG eyes.

147 ossible structural changes of the macula and optic nerve head in the free eyes of unilateral cured re

148 dients along anomalous communications in the optic nerve head induce migration of fluid into the adja

149 Optic nerve head morphology is affected by several retin

150 acula and a 6x6-mm OCTA scan centered on the optic nerve head obtained using a Topcon swept-source sy

151 Macular and optic nerve head optical coherence tomography (OCT) scan

152 Optic nerve head pallor of 1 or both nerves was present

153 en both eyes were open), and the presence of optic nerve head pallor.

154 We measured RNFL thickness and optic nerve head parameters using the Cirrus HD-OCT 4000

155 The following optic nerve head parameters were measured on serial vert

156 in video recordings of the blood flow in the optic nerve head region in eyes of healthy subjects.

157 The optic nerve head RNFL thicknesses were measured with spe

158 82 pairs of optic disc photographs and SDOCT optic nerve head scans from 927 eyes of 490 subjects wer

159 most of the identified genes are enriched in optic nerve head tissue.

160 measured at 768 points equidistant from the optic nerve head using spectral-domain OCT (Spectralis;

161 blood flow in vascular area surrounding the optic nerve head was measured in 8-week-old male mice ev

162 A fibrovascular tuft on the optic nerve head with induced traction on superior arcad

163 epithelium, outer part of the retina and the optic nerve head within 24-hours, in both groups of anim

164 ons from where ganglion cell axons enter the optic nerve head within a theta degrees wide sector, cen

165 OCT of the macula, optic nerve head, and peripapillary retina.

166 r, mpeg1+ cells congregate at and around the optic nerve head.

167 signaling and other immune responses in the optic nerve head.

168 or sclera, and posterior pole containing the optic nerve head.

169 vascularized and non-vascularized retina and optic nerve head.

170 OAG either through IOP or via changes to the optic nerve head; here we present evidence that some gen

171 simulations mirrored both visual fields and optic nerve histology from patients with LHON.

172 Optic nerve hypoplasia was recorded in 3 children and in

173 revealed unexpected damage to the retina and optic nerve in chemically burned eyes.

174 ning and pattern recognition, similar to the optic nerve in human eye.

175 Specifically, presence of DIR hypersignal in optic nerves in at least one optic nerve segment lowered

176 t long-segment severe axonal degeneration in optic nerves in patients with GON.

177 comatous neurodegeneration in the retina and optic nerve, including complement 1q, interleukin 6, and

178 In this study, we performed optic nerve injury in adult naked mole-rats, the longest

179 3CR1(+) and CCR2(+) monocytes infiltrate the optic nerve injury site and remain present for months.

180 death in RGCs, including in a mouse model of optic nerve injury, and show that the same pathway is ac

181 n-like pattern and are upregulated following optic nerve injury, but the presence of Nogo-A does not

182 Finally, in an animal model of optic nerve injury, we observed early glial activation a

183 sing three well-established rodent models of optic nerve injury.

184 of retinal ganglion cells in vivo following optic nerve injury.

185 hat could promote robust axon regrowth after optic nerve injury.

186 te pathway, enhanced axon regeneration after optic nerve injury.

187 tal ridge directly above the entrance of the optic nerve into the bony canal.

188 trans-scleral, extraocular, and postlaminar optic nerve invasion (1/38).

189 nvasion and 1.5 mm or greater of postlaminar optic nerve invasion have the poorest outcomes, supporti

190 an 3 mm choroidal and any prelaminar/laminar optic nerve invasion show no recurrence and may warrant

191 Of 178 patients without optic nerve involvement (tumor >1 disc diameter from opt

192 The pattern of optic nerve involvement is relatively unknown, but impor

193 Postlaminar optic nerve involvement was present in 53 patients; 42 h

194 VA, disease findings including RD outcomes, optic nerve involvement, and treatments were recorded.

195 oroidal concomitant with lamina or prelamina optic nerve involvement.

196 lary 3 mm or greater choroid and postlaminar optic nerve involvement; and 15 had focal (< 3 mm) choro

197 recombinant MHV strain is restricted to the optic nerve, is unable to translocate to the retina, and

198 ung mammalian eye does not require an intact optic nerve, its fine-tuning is disrupted by ONS.

199 become myelinated after passage through the optic nerve lamina region (ONLR), a transitional area co

200 Optic nerve length increased (0.80 +/- 0.74 mm, P < 0.00

201 The spaceflight-induced optic nerve lengthening and anterior movement of the ONH

202 Presence of an optic nerve lesion for this study was defined as history

203 However, although the repopulation of the optic nerve lesion site by astrocytes was significantly

204 the presence of asymptomatic and symptomatic optic nerve lesions in multiple sclerosis and could be u

205 phy detects retinal thinning associated with optic nerve lesions.

206 robust thresholds for identifying unilateral optic nerve lesions.

207 Optic nerve location constitutes the main aspect in the

208 NA (mRNA) fivefold but does not recapitulate optic nerve loss; however, SE(del)/knockout (KO) trans h

209 In the optic nerve, MBV also prevented IOP-induced decreases in

210 We examined the optic nerves microscopically during active disease and r

211 r gene associated with foveal hypoplasia and optic nerve misrouting without pigmentation defects.

212 y, knockout of the Ahr gene in mouse impairs optic nerve myelin sheath formation and results in oculo

213 cluded macular involvement (31/38), complete optic nerve obscuration (27/38), and RD (28/38).

214 nt, 15% (4/27; 95% CI, 1%-28%) with complete optic nerve obscuration, and 14% (4/28; 95% CI, 1%-27%)

215 ded clinical features (intraocular pressure, optic nerve obscuration, macular involvement, tumor seed

216 ucleation and biopsied the frontal lobes and optic nerves of a macaque experimentally infected with v

217 .5 +/- 21.6 mum; p < 0.001) in comparison to optic nerves of glaucoma patients without DIR hypersigna

218 uced expression of NDUFS4 protein within the optic nerves of Vglut2-Cre;ndufs4(loxP/loxP) mice.

219 In this study, we found that, in injured optic nerves, oligodendrocyte precursor cells (OPCs) und

220 Participants with normal optic nerves on examination received SDOCT of the optic

221 in vivo neuroprotection of injured RGCs and optic nerve (ON) by AAV-mediated CRISPR/Cas9 inhibition

222 Optic neuropathies are a group of optic nerve (ON) diseases caused by various insults incl

223 Retinal ganglion cell axons forming the optic nerve (ON) emerge unmyelinated from the eye and be

224 ocyte rolling and adhesion in veins near the optic nerve (ON) head at 9 hours after ON injury.

225 Optic nerve (ON) invasion is an important high-risk feat

226 ession changes within specific cell types in optic nerve (ON) may suggest new treatment targets for v

227 urately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal model

228 reporters, manifested a retinopathy and thin optic nerves (ON).

229 clusion of large retinal arteries around the optic nerve or macula with severe vision loss.

230 e children with systemic neurologic disease, optic nerve or retinal disease (even if unilateral) or a

231 glaucomatous change in the appearance of the optic nerve or retinal nerve fiber layer occurring befor

232 cellular matrix remodeling in other, related optic nerve pathological states, we found decreased expr

233 was not related to ischemic or demyelinating optic nerve pathology but was associated with increased

234 alance, inflammation, dysmorphic retinal and optic nerve pathology, and severe visual impairment.

235 /P361R) mice exhibit progressive retinal and optic nerve pathology.

236 We characterize optic nerve photographs of 67,040 UK Biobank participant

237 than 0.6 in either eye based on stereoscopic optic nerve photographs.

238 The optic nerve, present in 2 of the eyes, demonstrated atro

239 In the optic nerve, pro-inflammatory markers were upregulated w

240 ecific and sex-specific investigation of the optic nerve provides targets for the development of ther

241 d in RGC development, promotes long-distance optic nerve regeneration in adult rats of both sexes.

242 Similarly, optic nerve regeneration was completely unaffected, alth

243 CRMP2(T/A) in GSK3(S/A) RGCs further boosted optic nerve regeneration, with axons reaching the optic

244 hosphorylation of CRMP2 in RGCs and improved optic nerve regeneration.

245 ges slightly, but significantly, compromised optic nerve regeneration.

246 he prevalent requirement of active CRMP2 for optic nerve regeneration.

247 oftware in inner and outer annuli around the optic nerve region in addition to peripapillary superfic

248 Venous congestion and edema within the optic nerve related to high IOP may contribute to the DI

249 inal ganglion cells (RGCs) and the resulting optic nerve remains unclear.

250 consider not only the informativeness of the optic nerve responses, but also the amount of informatio

251 e as much information as possible, given the optic nerve's limited capacity.

252 In chickens with optic nerve section (ONS), FD myopia still occurs, sugge

253 hypersignal in optic nerves in at least one optic nerve segment lowered RNFL thickness on average by

254 NFL) thickness and pathologic hypersignal in optic nerve segments on 3D double inversion recovery (DI

255 Measurement of optic nerve sheath diameter (ONSD) by point-of-care ultr

256 eate an optic nerve growth curve from normal optic nerve sheath diameter (ONSD) values measured by us

257 coefficient between point of care and expert optic nerve sheath diameter after enrollment of 50 subje

258 ur objective was to evaluate the accuracy of optic nerve sheath diameter as a noninvasive screening t

259 While optic nerve sheath diameter demonstrated a modest, stati

260 Optic nerve sheath diameter greater than 0.72 demonstrat

261 The highest axial measurement of optic nerve sheath diameter in either eye is the most pr

262 Optic nerve ultrasonography (optic nerve sheath diameter sonography) has been propose

263 eristic curve of the highest expert-measured optic nerve sheath diameter to detect intracranial press

264 ed to set test cutoffs for ultrasound of the optic nerve sheath diameter.

265 The optimal cutoff for optic nerve sheath dilatation on ultrasonography was 5.0

266 Ultrasound measurements of the optic nerve sheath in axial and coronal views either ave

267 Dilation of the optic nerve sheath on axial ultrasound of the eye has be

268 ish induced signs of nephropathy and reduced optic nerve size, the latter phenotype complemented by W

269 Optic nerve slices were modeled as grids containing axon

270 abnormalities (seven of 37; 19%), prominent optic nerve subarachnoid spaces (20 of 36; 56%), and enh

271 n younger than older subjects, may be due to optic nerve tethering in adduction.

272 rve involvement (tumor >1 disc diameter from optic nerve), the mean (SD) largest basal diameter was 1

273 nasal displacement of vessels, and superior optic nerve thinning with inferior VF defects, suggest P

274 cedure obtained sufficient macaque brain and optic nerve tissues to detect PrP.

275 to visualize the neural image carried by the optic nerve to the brain.

276 Partial optic nerve transection (pONT) is an established model o

277 ircuit whereby afferent light signals in the optic nerve ultimately drive iris-sphincter-muscle contr

278 Optic nerve ultrasonography (optic nerve sheath diameter

279 Optic nerve ultrasonography can help diagnose increased

280 hood ratio, and negative likelihood ratio of optic nerve ultrasonography in patients with traumatic b

281 The index test was the highest remote-expert optic nerve ultrasound for the admission.

282 tic nerve ultrasound was performed daily and optic nerve ultrasound measured at the point-of-care as

283 We also evaluated the ability of optic nerve ultrasound to predict a therapeutic intensit

284 Optic nerve ultrasound was performed daily and optic ner

285 ith macular sparing (7/7; 95% CI, 47%-100%), optic nerve visibility (10/10; 95% CI, 63%-100%), and le

286 Presence of macular sparing, optic nerve visibility, less than 1 quadrant of RD, or a

287 cess, New York, USA), and HH-OCT macular and optic nerve volume scans at 0 degrees (Bioptigen, Inc.,

288 distribution ultimately renders the donating optic nerve vulnerable to further metabolic stress, whic

289 n distance of a vortex vein ampulla from the optic nerve was 14.2+/-1.1 mm (range, 10.3-17.7 mm).

290 16 mm or a height greater than 8 mm when the optic nerve was involved.

291 espread demyelination of the spinal cord and optic nerves, we also show that thinly remyelinated axon

292 infiltrate, and atrophic changes within the optic nerve were consistently present.

293 l ganglion cell layer and axon number in the optic nerve were markedly reduced.

294 head (ONH) and optic chiasm (OC) ends of the optic nerve were recorded along with the entire centerli

295 Careful examination of the optic nerve will assist in differentiating from NTG.

296 y eliminated microglia in murine retinae and optic nerves with high efficiency.

297 the integration of an artificial retina and optic nerves with various synaptic behaviors.

298 let within the orbitary cavity, close to the optic nerve, with no signs of penetrating ocular wound.

299 which there is complete demyelination of the optic nerve, with subsequent remyelination.

300 ge by 17.54 mum (p = 0.005) in comparison to optic nerves without DIR hypersignal.