ライフサイエンスコーパス: optic vesicle

1 rm and the underlying neuroepithelium of the optic vesicle.

2 entrolaterally and then rostrally toward the optic vesicle.

3 and induction of Bmp7 gene expression in the optic vesicle.

4 ed in neural differentiation in the immature optic vesicle.

5 retina (NR) arise from a common origin, the optic vesicle.

6 rain by the evagination and formation of the optic vesicle.

7 plate, and specified mitotic patterns in the optic vesicle.

8 of Pax6 is biallelic in the lens placode and optic vesicle.

9 but also involve the cells of the posterior optic vesicle.

10 of a putative downstream gene, Msx2, in the optic vesicle.

11 l identity in the dorsal, prospective nasal, optic vesicle.

12 eye field and later in the lens placode and optic vesicle.

13 g plays a significant role in patterning the optic vesicle.

14 eural retina and pigmented epithelium in the optic vesicle.

15 ich is expressed in the prospective temporal optic vesicle.

16 , nor does it affect axial patterning of the optic vesicle.

17 t during the period of lens induction by the optic vesicle.

18 region and BMP4 is ventrally expanded in the optic vesicle.

19 r initial morphogenesis and outgrowth of the optic vesicle.

20 ldh1a2 (Raldh2) expressed transiently in the optic vesicles.

21 stricted to the ventral diencephalon and the optic vesicles.

22 lization and growth of the telencephalic and optic vesicles.

23 will give rise to the ventral forebrain and optic vesicles.

24 ntributing to the bilateral expansion of the optic vesicles.

25 cephalon and in defective evagination of the optic vesicles.

26 ses occur much earlier than the formation of optic vesicles.

27 A Notch ligand, Delta2, is expressed in the optic vesicle adjacent to the PLE, and inhibition of its

28 e present a model of the partitioning of the optic vesicle along its proximo-distal axis.

29 d transcripts are expressed in lens placode, optic vesicle and CNS, and only weakly in corneal and co

30 y diminished accumulation of ECM between the optic vesicle and ectoderm and reduced levels of transcr

31 r with restricted expression in the anterior optic vesicle and in the telencephalic neuroepithelium o

32 fication of temporal identity in the ventral optic vesicle and is sufficient to induce temporal chara

33 pigment epithelial (RPE) compartment during optic vesicle and optic cup development.

34 requirements for functional Pax6 in both the optic vesicle and surface epithelia in order to mediate

35 n order to study the interaction between the optic vesicle and the prospective lens epithelium during

36 e the extracellular matrix (ECM) between the optic vesicle and the surface ectoderm prevents the pros

37 feration and adhesion to the ECM between the optic vesicle and the surface ectoderm was sufficient to

38 of prospective dorsal cells within the early optic vesicle and their spatial relationship to early do

39 29 was increased 2.3-fold by removal of the optic vesicle and was reduced by 50% when chCNTF was ove

40 hat Bmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme a

41 nscription factors expressed in the anterior optic vesicle and/or optic cup, respectively, did not af

42 rgement of the presumptive telencephalon and optic vesicles and an expansion of the post-gastrula exp

43 Lhx2(-/-) optic vesicles and lens ectoderm upregulate Pax2, Fgf15

44 which is expressed in the prospective nasal optic vesicle, and Foxd1, which is expressed in the pros

45 ens ectoderm, nor does a lens form, when the optic vesicle anlage is removed at late neural plate sta

46 The distal and ventral portion of the optic vesicle are fated to become the retina and optic n

47 ndicating that other factors produced by the optic vesicle are involved.

48 This may explain why Pax6(-/-) optic vesicles are inefficient at inducing a lens placod

49 Also, proximo-distal specification of the optic vesicle (as assayed by the elimination of Pax6(-/-

50 wild-type and Pax6(-/-) cells occurs in the optic vesicle at E9.5 and is most likely a result of dif

51 ow that Xenopus sprouty2 is expressed in the optic vesicle at late neurula stage and knockdown of Spr

52 embryos, but Raldh2 is also expressed in the optic vesicle at this stage suggesting that both genes m

53 alic-optic-hypothalamic field, such that the optic vesicle became mispositioned and appeared to arise

54 Consequently, the evaginating optic vesicles become partitioned into prospective nasal

55 During early formation of the eye, the optic vesicle becomes partitioned into a proximal domain

56 id not affect the initial development of the optic vesicle but did arrest subsequent neuroretina spec

57 for the patterning and specification of the optic vesicle, but due to a lack of genetic models, its

58 , the ciliary epithelium is derived from the optic vesicle, but the molecular signals that control mo

59 Shp2 instead controls the patterning of the optic vesicle by regulating the retinal progenitor facto

60 found that removal of the anterior or dorsal optic vesicle caused loss of the area centralis, which i

61 Addition of FGF to the optic vesicles caused the presumptive pigmented epitheli

62 During later evagination, optic vesicle cells shorten, drawing their apical surfac

63 formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality.

64 was expressed in distinct regions within the optic vesicle, ciliary body, and lens, with patterns tha

65 The optic vesicle comprises a pool of bi-potential progenito

66 is a morphogenetic event initiated after the optic vesicle contacts the overlying surface/pre-lens ec

67 These optic vesicle-containing brain organoids (OVB-organoids)

68 Expression studies and optic vesicle culture experiments also suggest a role fo

69 that Hes1 is expressed in the forming lens, optic vesicle, cup, and pigmented epithelium and is nece

70 Retinal organoids (optic vesicles) derived from pluripotent stem cells have

71 During embryogenesis, optic vesicles develop from the diencephalon via a multi

72 mbryos, we demonstrate expression of BMP4 in optic vesicle, developing retina and lens, pituitary reg

73 both intra- and extra-cellular regulation of optic vesicle development and patterning.

74 The arrested optic vesicle development has led to the assumption that

75 we will point out some important aspects of optic vesicle development that have not yet received eno

76 several regulatory genes essential for early optic vesicle development, including Pax6, Otx2, Mitf, P

77 esenting an overview of current knowledge of optic vesicle development, we will address conceptual an

78 he absense of surface ectoderm, cells of the optic vesicles display both neural and pigmented retinal

79 specific deletion of Fgfr1 and Fgfr2 in the optic vesicle disrupts ERK signaling, which results in o

80 ric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye development th

81 atterning of the proximal/distal axis of the optic vesicle during the early phases of eye development

82 from the failure in the invagination of the optic vesicle during the fetal period and it can be asso

83 s and move randomly, leading to insufficient optic vesicle elongation and consequently a cyclopia phe

84 ted; cells move in a pinwheel pattern during optic vesicle elongation and retinal precursors involute

85 ization, and collective cell motion promotes optic vesicle elongation during normal development.

86 During eye development, optic vesicles evaginate laterally from the neural tube

87 Optic vesicle evagination persists for longer than expec

88 ard6gammab and Laminin1 severely compromises optic vesicle evagination.

89 m the extraocular non-neural ectoderm during optic vesicle evagination.

90 ecific gene expression was examined in chick optic vesicle explant cultures or in the presumptive neu

91 In optic vesicles explant cultures, RPE-specific gene expre

92 The surface ectoderm expresses FGFs and the optic vesicles express FGF receptors.

93 ession of FGF9 in the proximal region of the optic vesicle extends neural differentiation into the pr

94 n of Chd7 in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain

95 t mice, progenitor cells at the dorso-distal optic vesicle fail to differentiate appropriately, causi

96 nt cells showed that Pax6 is required in the optic vesicle for maintenance of contact with the overly

97 Once the optic vesicles form, rax expression is restricted to the

98 ormation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages

99 Optic vesicle formation, transformation into an optic cu

100 Optic vesicles formed but lacked the optic cups.

101 The cultured optic vesicles formed eye cups that contained a lens ves

102 Optic vesicles from embryonic day 1.5 chick were culture

103 he anterior neural plate, evagination of the optic vesicles from the ventral forebrain, and the cellu

104 hogenesis, the simple neuroepithelium of the optic vesicle gives rise to four basic tissues in the ve

105 Mutant optic vesicles had reduced proliferation, coupled with p

106 several paracrine factors in patterning the optic vesicle have been studied extensively, little is k

107 Substituting the optic vesicle in explant cultures with BMP4-carrying bea

108 d by exogenous BMP4 protein applied into the optic vesicle in explant cultures.

109 w that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with

110 uggesting that the initial patterning of the optic vesicle into proximal and distal territories is di

111 Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neura

112 ivin-like signal, pattern the domains of the optic vesicle into RPE and neural retina.

113 ues provided by FGF organize the bipotential optic vesicle into specific neural retina and pigmented

114 n eye organogenesis is the transition of the optic vesicle into the optic cup.

115 ng of the bipotential retinal primordia (the optic vesicles) into neural retina and retinal pigmented

116 increased apoptosis, and a delay in ventral optic vesicle invagination leading to the formation of s

117 y expressed in the presumptive retina during optic vesicle invagination.

118 l growth and the acquisition of shape during optic vesicle invagination.

119 The optic vesicle is a multipotential primordium of the reti

120 we can conclude that FGF signaling from the optic vesicle is not required for lens induction.

121 During vertebrate eye development, the optic vesicle is partitioned into a domain at its distal

122 g analyses demonstrate that the dorsolateral optic vesicle is the earliest region to express dorsal s

123 rity, especially dorsal specification in the optic vesicle, is poorly understood at a molecular and c

124 factor-coated beads close to the base of the optic vesicle leads to a rapid downregulation of MITF an

125 lls (iPSCs) derived from blood could produce optic vesicle-like structures (OVs) with the capacity to

126 ural plate stages; (3) interactions with the optic vesicle maintain Xlens1 expression in the lens pla

127 The expression domain of the proximal optic vesicle marker pax2a is expanded in blowout at the

128 nded in blowout at the expense of the distal optic vesicle marker pax6, suggesting that the initial p

129 he periocular mesenchyme in Lmx1b morphants, optic vesicle morphogenesis is largely restored.

130 ) mouse embryos, eye field specification and optic vesicle morphogenesis occur, but development arres

131 ensive cell movements occur during zebrafish optic vesicle morphogenesis, however the location of pro

132 ombination of conditional Porcn depletion in optic vesicle neuroectoderm, lens, and neural crest-deri

133 The results suggest that: (1) the optic vesicle neuroepithelium requires a temporally spec

134 In Lhx2-/- embryos specification of the optic vesicle occurs; however, development of the eye ar

135 at neural plate stage; instead, the smaller optic vesicle of tcf7l1a mutants shows delayed neurogene

136 ent, respectively, was also decreased in the optic vesicles of Frs2alpha(2F/2F) mice.

137 pment of the neural tube, urogenital system, optic vesicle, optic cup and optic tract.

138 nterodorsal hypothalamus in a portion of the optic vesicle or retina.

139 Using optic vesicle organoids to model the onset of the EF, we

140 rs invariably in the telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, o

141 at canonical Wnt signaling in the developing optic vesicle (OV) and OC plays a crucial role in determ

142 normally requires Pax6 function in both the optic vesicle (OV) and the lens epithelium, or only in t

143 se, Mitf is expressed early and uniformly in optic vesicle (OV) cells as they evaginate from the deve

144 s of a pseudostratified neuroepithelium, the optic vesicle (OV), in which cells acquire neural retina

145 n the mouse ventral forebrain and developing optic vesicles overlapped that previously reported for S

146 selectively increased in early hiPSC-derived optic vesicles (OVs) when compared to isogenic cultures

147 During embryogenesis, optic vesicles (OVs), the eye primordium attached to the

148 Our data indicate that Lhx2 is required for optic vesicle patterning and lens formation in part by r

149 We previously showed that during optic vesicle patterning, the Lim-homeodomain transcript

150 ntain or initiate the expression patterns of optic-vesicle-patterning and lens-inducing determinants.

151 bsequent stages, loss of Lhx2 did not affect optic vesicle position but caused arrest of optic cup fo

152 lens development including formation of the optic vesicle, primary lens fibers, and proliferating an

153 such that, when Yap and Taz are both absent, optic vesicle progenitor cells completely lose their abi

154 Taz, overexpression of either protein within optic vesicle progenitors leads to ectopic pigmentation

155 ead activity is necessary and sufficient for optic vesicle progenitors to adopt RPE identity in zebra

156 per movement of retinal progenitors into the optic vesicle, rather than an effect on progenitor cell

157 titutively nuclear Vax2 protein in the chick optic vesicle results in constitutive repression of Pax6

158 oids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive

159 s strong expression of the gene in the head, optic vesicles, spinal cord and branchial arches with we

160 eye morphogenesis is arrested at a primitive optic vesicle stage in homozygous Pax6 mutant mouse embr

161 We lineage-labeled RPCs at the optic vesicle stage.

162 al distribution of rods is determined by the optic vesicle stage.

163 At optic vesicle stages of development, this treatment resu

164 During early optic vesicle stages, an appropriate mitotic tree is req

165 se that the ciliary body may be specified at optic vesicle stages, at the same developmental stage wh

166 Next, we determine that the optic vesicle territory of mouse embryos displays elevat

167 rmally expressed in the distal region of the optic vesicle that is destined to become the neural reti

168 the pre-lens ectoderm resulted in persistent optic vesicles that initiated neural retinal differentia

169 t, ablation of the lens placode gave rise to optic vesicles that underwent invagination and formed th

170 example, develops from neuroectoderm via the optic vesicle, the corneal epithelium is descended from

171 The most ventral structure arising from the optic vesicle, the optic stalk, is missing and is replac

172 isrupts development of the telencephalic and optic vesicles, the pharyngeal endoderm and the first br

173 ositioning of retinal progenitors within the optic vesicle through suppressing Ras/Raf/MAPK signaling

174 from the pre-lens ectoderm that induces the optic vesicle to form an optic cup.

175 lts we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by

176 the temporal requirements for Shh during the optic vesicle to optic cup transition and after early op

177 s multiple stages, from the formation of the optic vesicle to the differentiation of the neuroretina.

178 eir origin in the lens-averted domain of the optic vesicle to their destination in the ciliary margin

179 We have used explant cultures of chick optic vesicles to study the regulation of retinal pigmen

180 s, we found that neurogenesis in Pax6 mutant optic vesicles was not arrested, but instead accelerated

181 Using explant cultures of mouse optic vesicles, we demonstrate that bipotentiality of th

182 unction not only in the lens but also in the optic vesicle, where it plays a hitherto unknown role in

183 e mutual interaction of the ectoderm and the optic vesicle, whereas after lentectomy the lens is rege

184 dependence on the later inducing tissue, the optic vesicle, which contacts lens ectoderm at this stag

185 day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible s

186 onds to Pax6, a key patterning factor in the optic vesicle, while FGF signaling regulates Xath5 expre

187 dorsal-specific transcription factors in the optic vesicle; yet the events leading to initiation of d