ライフサイエンスコーパス: optimisation

1 generated, and transcriptomic prediction by optimisation.

2 matrix completion by using nonlinear convex optimisation.

3 and, like tapasin, works to enhance peptide optimisation.

4 rapy for pouchitis patients requires further optimisation.

5 ning the theoretical generality of Levy walk optimisation.

6 these systems lack the flexibility for easy optimisation.

7 s with only the width, allowing deep-network optimisation.

8 nducting oxide and thermo-electric materials optimisation.

9 gulation and could find applications in gene optimisation.

10 ity, oxidation and on-line analysis and self-optimisation.

11 they are particularly applicable to potency optimisation.

12 a more suitable one for ligand discovery and optimisation.

13 ew opportunities for drug discovery and lead optimisation.

14 s selected using an automated hyperparameter optimisation.

15 nd future work will consider multi-objective optimisation.

16 on discovery, mechanistic understanding, and optimisation.

17 nd toxicity, patient selection, and response optimisation.

18 erapy, Pleural Effusion assessment, and PEEP optimisation.

19 systems, with considerable scope for further optimisation.

20 ted on many possible ways for further breads optimisation.

21 lications thereby paving the way for further optimisation.

22 Serological markers require further optimisation.

23 ent, patients received 6 weeks of medication optimisation.

24 need (1802 [18.2%] of 9898 needed treatment optimisation, 1282 [13.0%] needed engagement in care, an

25 to allow time for myasthenic status and drug optimisation; (2) multidisciplinary liaison through the

26 m video recordings of bending tests, (ii) an optimisation algorithm for the characterisation of Young

27 The image optimisation algorithm minimises a cost function incorpo

28 ecular interaction networks, we developed an optimisation algorithm that integrates databases of know

29 ation of a two-joint planar robot arm and an optimisation algorithm was used to find the optimum matr

30 ction of signalling pathways, module-centric optimisation algorithms, whose aim is to identify sub-ne

31 An optimisation analysis of TB spending was conducted in Be

32 structures for targeting electronic property optimisation and a clear path towards increased synergy

33 cted farms during an outbreak using Bayesian optimisation and a simulation-based model of BT.

34 and short plasma exposures are required for optimisation and clinical translation of cold plasma tec

35 Further research is needed to inform dose optimisation and co-trimoxazole use in the context of ex

36 Optimisation and discovery of novel treatments for tuber

37 Here we report the optimisation and evaluation of an electrochemical biosen

38 ach brain and support the continued clinical optimisation and evaluation of Posiphen for MCI and Alzh

39 s them with respect to their use in antibody optimisation and highlights how they can be exploited fo

40 represent an attractive target for biomarker optimisation and immunotherapy design.

41 atic phenotype and constructs a platform for optimisation and improved maturation of HLC differentiat

42 revealed mechanisms involving tRNA sequence optimisation and post-translational protein modification

43 ting studies, and more use should be made of optimisation and probabilistic modelling approaches that

44 ogress, standardisation of research efforts, optimisation and training of an experienced and non-conf

45 Here, optimisation and utilisation of ambient laser desorption

46 n, Na, Ni, Pb, Sr and Zn were analysed after optimisation and validating the analytical method using

47 We report the optimisation and validation of a label-free, real-time c

48 This study describes the optimisation and validation of a very sensitive method f

49 This study describes an optimisation and validation process using liquid chromat

50 AFLP characteristics analyzed) identified in optimisation and verification experiments reached 7.51 a

51 of 322 participants during open-label ND0612 optimisation, and by 103 (80%) of 128 in the ND0612 grou

52 s of the clinical study (preliminary safety, optimisation, and feasibility vs preliminary efficacy vs

53 were found, a further computer-aided ligand optimisation approach led to the identification of a new

54 o be further impacted unless efforts towards optimisation are carried out.

55 d pressure, smoking cessation, and lifestyle optimisation are common to all stroke subtypes.

56 n model and data which persist despite model optimisation are used to flag up important questions con

57 Optimisations are described which appear to reduce the w

58 urgery, with symptoms remaining stable after optimisation as rated by clinicians and with patient rat

59 tive features will guide future nanoassembly optimisation, as well as the development of the new gene

60 With low OAT coverage among PWID, we did an optimisation assessment using current OAT procurement an

61 dy this shortfall, we present multi-response optimisation based on Response Surface Methodology (RSM)

62 Optimisation-based dynamic simulations were performed to

63 cell culture, and xenograft methods for lead optimisation before clinical trials are contemplated.

64 g flour) on the quality of bread flour after optimisation by additions of alpha-amylase.

65 ng a peptide editor, TAPBPR improves peptide optimisation by promoting peptide-receptive MHC class I

66 At the same time such optimisation can also help refine model parametrisation

67 Further optimisation can be achieved by targeting policies at th

68 nimal blue-light exposure, and context-based optimisation can increase sensitivity and experimental t

69 Further optimisation can lead to a viable, safe and non-invasive

70 fications for fundamental aspects, while its optimisation clearly has an impact on technology (e.g.,

71 veal how variation in LL emerges from carbon optimisation constrained by both leaf structural traits

72 Using optimisation criteria based on minimisation of muscle st

73 investigated and optimised using univariate optimisation design.

74 Optimisation did not compromise the detection of other o

75 Non-responders after optimisation did not improve during the maintenance phas

76 uvant Lapatinib and/or Trastuzumab Treatment Optimisation) enrolled 455 women with invasive human epi

77 and validation of the program GOLD (Genetic Optimisation for Ligand Docking).

78 Issues relating to drug optimisation for neonatal prophylaxis and paediatric tre

79 pproach lays a foundation for future regimen optimisation for patient and societal benefits.

80 Optimisation for side-impacts would result in 6.3% (3.1-

81 tment, preparation of pellets, and LA-ICP-MS optimisation for the food sample matrix using leaf certi

82 The optimisation for the proposed PI-SSC is studied by using

83 res fitting of potentiometric data using the optimisation function of the Solver add-in of Microsoft

84 Genetically inspired optimisation has been used in a range of applications, f

85 s a wealth of papers dealing with extraction optimisation, identification and quantification of HTs.

86 As a result of the SBSE optimisation, improved detection limits and linear range

87 Synthesis and optimisation improvements are proposed.

88 trates the potential value of using Bayesian optimisation in developing cost-effective disease manage

89 r tumour recurrence is crucial for treatment optimisation in metastatic breast cancer.

90 ficiency of conventional 3D simulation-based optimisation in product development while exploiting rim

91 forts are needed to identify pharmacotherapy optimisation interventions that reduce inappropriate pre

92 but has a narrow therapeutic index and dose optimisation is challenging.

93 hat parasite-focused toolbox development and optimisation is critical.

94 In such optimisations, it is common to maximise the discounted u

95 uption resulting in automation and cognitive optimisation lack in MS.

96 provide a basis to regionally guide land-use optimisation, land management practices and regulatory a

97 After optimisation with a parallel global optimisation metaheuristic we obtained excellent agreeme

98 An optimisation method for the blade design of LVADs has be

99 Using non-linear optimisation methods, we examined how these optimum pack

100 We developed a linear optimisation model to estimate efficiency gains that cou

101 1, 0, +1 and +1.414) were used to design the optimisation model using central composite rotatable des

102 Gene weights are determined by the optimisation model, in a way that the resulting pathway

103 ised Artificial Neural Network predicted the optimisation objective at design points not explicitly s

104 poling penalty function inside the resulting optimisation objective function.

105 Optimisation of a dip-coating method enabled significant

106 Optimisation of a microwave-assisted methanolysis was pe

107 Detailed characterisation and optimisation of a new CDH/AuNP-based bioanode were perfo

108 et of model observables of interest, studied optimisation of a objective function, or have not dealt

109 This paper describes the optimisation of a screen-printing water-based carbon ink

110 le sugar glass MNs were fabricated following optimisation of a simple and novel low temperature vacuu

111 ttings with limited resources, investment in optimisation of adherence rather than implementation of

112 MBP-hFGF21 construct was further pursued for optimisation of affinity chromatography purification.

113 Optimisation of an analytical procedure for the separati

114 This study was focused on the optimisation of an extraction procedure based on a solid

115 ebral oxygen saturation monitoring to enable optimisation of anaesthesia depth and cerebral oxygen sa

116 In this study we evaluate the extraction optimisation of anthocyanins and total phenolics in D. h

117 quacy of experimental controls, insufficient optimisation of assay performance as well as lack of tra

118 ntered biological media and analytes hampers optimisation of biosensor performance for maximum sensit

119 c approach to the invention, development and optimisation of biotransformations utilising isolated en

120 ased on a combination of antiplatelet drugs, optimisation of blood pressure and LDL cholesterol value

121 Optimisation of breastfeeding practices could reduce hig

122 e potential to improve patient selection and optimisation of cardiovascular interventions across a ra

123 Optimisation of cellular activity and characterization o

124 This study focuses on the optimisation of cheese whey formulated media for the pro

125 tion of intensity-modulated radiotherapy and optimisation of chemotherapy strategies (induction, conc

126 nvironmental conditions and for experimental optimisation of complex combined experiments.

127 e new tools for the downstream, preclinical, optimisation of compounds.

128 entail new biology-driven approaches, since optimisation of conventional treatments has in many case

129 These results may facilitate the optimisation of delivery systems for lipophilic bioactiv

130 ogrammer was responsible for programming and optimisation of device settings.

131 global monitoring systems and can inform the optimisation of diagnosis and treatment where P vivax ha

132 Optimisation of effectiveness and coverage of interventi

133 mbles human anatomy, as well as the need for optimisation of electrodes and parameters for a human-si

134 the surface functionality, allowing for the optimisation of electrostatic diamond seeding densities.

135 arch should focus on the rationalisation and optimisation of existing programmes, with particular att

136 learning has important implications for the optimisation of experimental breeding programmes in the

137 The optimisation of experimental conditions was performed.

138 on of brain perfusion (flow), as well as the optimisation of extraction oxygen mechanisms (misery per

139 increased and provides the basis for further optimisation of FFS as simple, convenient and sustained

140 propriate (focusing on limb preservation and optimisation of function).

141 behaviour is environmentally forced through optimisation of gain, provides an integrated approach to

142 rted if complications were prevented through optimisation of general health status and if complicatio

143 but management of vascular risk factors and optimisation of glycaemic control could have therapeutic

144 esulted in guidelines worldwide recommending optimisation of glycosylated haemoglobin, but no trial r

145 as a simple and reliable maturity index for optimisation of harvest time.

146 f HBc particles in bacteria is demanding and optimisation of HBc particle yield from E. coli is requi

147 ETATION: Housing-level policy related to the optimisation of healthy density in cities might be a pot

148 dictive capability for use in the design and optimisation of high efficiency lasers in the infrared.

149 Here we show the design and optimisation of hybrid DNA-RNA CRISPR and tracr molecule

150 rom the trade-off limit - to quantify the co-optimisation of hydraulic efficiency and safety.

151 This study describes the optimisation of in vitro tissue culture-induced variatio

152 In complex social species, the optimisation of individuals' network position has import

153 For some device architectures, optimisation of its growth on silicon nitride is essenti

154 retical model and provide a step towards the optimisation of laser-mediated gene delivery into mammal

155 an efficient and systematic approach to the optimisation of lipase-catalysed biological processes.

156 One constraint is optimisation of national biosafety processes to support

157 A continuous expansion and optimisation of national transfusion services and implem

158 In this study, optimisation of natural colorant non-conventional extrac

159 easingly important role in the discovery and optimisation of novel, potent and selective protein kina

160 me a crucial step for the efficiency and the optimisation of numerous molecular biology techniques su

161 ication procurement is needed, combined with optimisation of OAT dosing.

162 e Surface Methodology (RSM) was utilised for optimisation of parameters affecting immobilisation of F

163 ed confirmation of physiological effects and optimisation of parameters in healthy humans prior to tr

164 However such methods require optimisation of parameters in order to control the risk

165 efficiency of copper was obtained after the optimisation of parameters such as extraction and disper

166 and survival for treatments is important for optimisation of patient management.

167 e is shown to emerge as a consequence of the optimisation of photosynthetic traits.

168 ponse to UVB therapy, and for individualised optimisation of phototherapy regimes to improve clinical

169 Thus, optimisation of population iodine intake is an important

170 The overall optimisation of preparation conditions was an UT of 14.6

171 Further optimisation of present standard chemoradiation is neede

172 during food processing could facilitate the optimisation of production, increase the desirability of

173 cause of cost and manufacturing constraints, optimisation of protection against all poliovirus types

174 Possible ISSD applications include optimisation of protein expression, improvement of the p

175 hodology (RSM) was used for modelisation and optimisation of protein extraction parameters in order t

176 Optimisation of protein extraction yield from pinto bean

177 Recent developments in the design of tags, optimisation of purification conditions, experimental de

178 Examples are presented for the modelling and optimisation of representative imaging of neural cells u

179 carcity of human material for study requires optimisation of research strategies and co-ordination of

180 ation on individual mRNAs, as well as global optimisation of ribosome availability.

181 power and digestion time) were used for the optimisation of sample digestion.

182 ained by the commonly used SPME methodology, optimisation of SBSE achieved better results for volatil

183 Simultaneous optimisation of several conflicting characteristics pose

184 he utility of novel treatment strategies and optimisation of short-term antithrombotic treatment stra

185 a systematic approach to the development and optimisation of singleplex and multiplex ddPCR assays fo

186 uence with respect to the identification and optimisation of sites accessible to antisense oligonucle

187 entally measured dispersion coefficients and optimisation of some model parameters, such as the bandw

188 Further optimisation of specific androgen-progestin regimens and

189 ual recalibration may be fundamental for the optimisation of speech comprehension, recalibration prob

190 nt trial data, and explore opportunities for optimisation of STEMI outcomes with a pharmacoinvasive a

191 demonstrates that important information for optimisation of such complex bioformulations, including

192 Optimisation of surgery for patients with localised dise

193 ) to assess the modalities that best balance optimisation of survival with the lowest adverse effects

194 genetic algorithm (GA) for the simultaneous optimisation of SVM parameters and pre-processing (GENOP

195 Optimisation of systemic risk factors by patients' prima

196 Amperometric optimisation of the assay resulted in limits of detectio

197 One of the methods was chosen for optimisation of the duration of incubation.

198 Optimisation of the experimental parameters was performe

199 This is the first photonic simulation and optimisation of the extensive growth of entanglement in

200 random walk for the prognostic modelling and optimisation of the growth of hESC colonies.

201 After optimisation of the homogenisation procedure, stable emu

202 n participants who completed the study after optimisation of the infectivity assay, had both a pre-tr

203 Optimisation of the laser microdissection technique was

204 Optimisation of the method considered kinetic studies to

205 For optimisation of the method, recovery tests with differen

206 Optimisation of the methods enabled the chromatographic

207 r a fibre channel hinges on the simultaneous optimisation of the modulation format and code rate, bas

208 tigate the Quantizer problem, defined as the optimisation of the moment of inertia of Voronoi cells,

209 and the observations were used to guide the optimisation of the process.

210 nhancement of detection was achieved through optimisation of the properties of the redox-tagged pepti

211 different concentration ratios, therefore an optimisation of the ratio is important to produce a solu

212 However, optimisation of the regimen could potentially prolong tr

213 ose to be active or inactive according to an optimisation of the relative energetic and reproductive

214 m in a DM fibre laser, which involves manual optimisation of the relative length of fibres with oppos

215 Optimisation of the stationary phase nature, particle si

216 onditions, allowing for facile tailoring and optimisation of the structure and properties.

217 A task-specific optimisation of the system is implemented, and the perfo

218 lementary surface and bulk analysis allowing optimisation of the therapeutic effect of such formulati

219 r:ethanol:methanol ratios promoted the joint optimisation of the total phenolic and isoflavone conten

220 , our work opens up new perspectives for the optimisation of their properties.

221 the cell of different mtDNA states, and the optimisation of therapeutic control of mtDNA populations

222 reliable lifetime prediction and performance optimisation of these alloys.

223 We propose that the origin and optimisation of this differentiation program represents

224 Future optimisation of this technology may enable novel assays

225 the pathways to be generated, through to the optimisation of those pathways so that more efficient co

226 ical classifications, revealing evolutionary optimisation of translation responses to be strongly inf

227 As part of the Optimisation of Treatment and Management of Schizophreni

228 Optimisation of treatment requires systematic rotation t

229 We herein describe the characterisation and optimisation of two competitive enzyme-linked immunosorb

230 outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hy

231 sing 20 parameter combinations enabled rapid optimisation over a large parameter space.

232 The optimisation parameters studied were: the carrier flow r

233 After an optimisation period, during which calcium and active vit

234 maintenance period, which followed a 1-year optimisation period.

235 ing crop primary productivity (e.g. nutrient optimisation, pH management, irrigation); (b) reducing s

236 After the medication optimisation phase and between Jan 6, 2014, and Aug 11,

237 ht and laboratory values over time (MTD with optimisation phase).

238 point of approximately 17 ng/ml with further optimisation possible.

239 ign statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase product

240 rent theories of LL that are based on carbon optimisation principles are challenging to quantitativel

241 Haplotyping is currently addressed as an optimisation problem aiming at solutions that minimise,

242 f target regimes is a multi-parameter global optimisation problem.

243 Optimisation problems typically involve finding the grou

244 An optimisation procedure (accounting for the subdistrict m

245 The optimisation procedure was done in two steps: using a tw

246 As response variables in the optimisation process include main individual polyphenols

247 ronment, thus likely resulting from a neural optimisation process rather than a pre-programmed mechan

248 the base material, as this will speed up the optimisation process.

249 A pre-requisite to medicinal chemistry optimisation programmes required to improve the drug-lik

250 Aggregated optimisation results suggest that 35 860 (32%) of 111 52

251 on the sampling (the linear bias) constrains optimisation results to a subspace of optimal solutions

252 A surrogate model was required to allow the optimisation routine to conduct an efficient search; a m

253 ical model of detection and use a stochastic optimisation routine to identify which arrangement of su

254 s spurred the development of statistical and optimisation routines for parameter inference.

255 analogues were enrolled into a 2-month dose-optimisation run-in period.

256 We improve the optimisation scheme underlying Oscope and provide a well

257 Compounds were isolated after a solvent optimisation selection based on solute distribution in a

258 l analyses based on product yield across the optimisation set allow an insight into the important asp

259 Despite therapeutic optimisation, she died of respiratory insufficiency.

260 est GC content in the aGPCR family and codon optimisation significantly increased its expression.

261 ameter of 3 mm was then targeted by a second optimisation stage, which found the corresponding forwar

262 Through several optimisation steps a suitable method was achieved showin

263 ostulate that sex-specific primordial energy optimisation strategies exist, which developed to help c

264 ical environment; and aid with the design of optimisation strategies for controlled drug release.

265 To demonstrate the existence of these energy optimisation strategies, we recruited 88 healthy adults

266 mide provide a framework for further regimen optimisation strategies.

267 segment external elastic lamina-based stent optimisation strategy was safe and resulted in similar m

268 ube bi-directional ASA with a 'matrix-based' optimisation strategy, speeding up the whole process in

269 and form a template for future immunotherapy optimisation studies across cancer types and indications

270 Optimisation studies were carried out for amount of micr

271 The optimisation suggested that extraction with 84.5% methan

272 We establish a heuristic optimisation technique for the design of the metamateria

273 We then use convex optimisation techniques in order to find approximations

274 lass pathway activity inference method using optimisation techniques is reported.

275 transport investigation unveil high level of optimisation that achieves high-brightness white in a th

276 f suboptimal peptides is followed by peptide optimisation that depends on temporary ER retention.

277 This study presents the optimisation through an experimental design then the val

278 Antibiotic optimisation through therapeutic drug monitoring (TDM) i

279 selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approa

280 finite element model was formulated for rim optimisation to address the computational inefficiency o

281 lele system, along with significant upstream optimisation to define the specific test conditions.

282 provides opportunities and scope for product optimisation to improve their nutritive value.

283 pecially abrasive peeling might need further optimisation to make them gentler and minimise bioactive

284 This provides scope for product optimisation, to improve the nutritive value of commerci

285 CDR loops conformation and VH/VL orientation optimisation upon antibody sequence change.

286 from polyphosphate and by thorough reaction optimisation using design of experiments, the amine conc

287 An optimisation using L-BFGS-B algorithm with upper/lower b

288 ents, providing a platform for their further optimisation using medicinal chemistry.

289 To enable experimental optimisation using the Fisher Information Matrix it effi

290 Hydraulic efficiency-safety optimisation was accompanied by higher APf and vessel-to

291 An additional optimisation was achieved by reducing the grind size of

292 untry variation in vaccine coverage, and the optimisation was based on a single outcome measure, ther

293 t concentration detected (1 muM) without any optimisation was comparable with that of a BIAcore SPR s

294 Optimisation was completed on 15 isolates of Escherichia

295 Dose optimisation was investigated using a modified toxicity

296 Optimisation was performed to highlight differentially e

297 After optimisation with a parallel global optimisation metaheu

298 Our method allows for fast optimisation with reduced memory requirements: the numbe

299 Following optimisation, work-loop contractions were performed that

300 This SAW-driven electroluminescence, without optimisation, yields photon antibunching with g((2))(0)