ライフサイエンスコーパス: optimism

1 sely related past experiences or unrealistic optimism.

2 Despite this, there are reasons for optimism.

3 a subset of patients at risk is a cause for optimism.

4 r existence, rather than useful evidence for optimism.

5 among people with the highest versus lowest optimism.

6 potential HIV-1 cure have generated renewed optimism.

7 luate different approaches to adjustment for optimism.

8 can trypanosomiasis, giving rise to cautious optimism.

9 (95% CI, 0.94-0.98) indicating minimal over-optimism.

10 individuals who scored high and low on trait optimism.

11 ailure to code for errors that should reduce optimism.

12 estionnaire, measuring predisposition toward optimism.

13 approaches are providing grounds for renewed optimism.

14 ting characteristic curve (AUC) adjusted for optimism.

15 ultiple sclerosis has generated considerable optimism.

16 as new methodologies are cause for continued optimism.

17 enome-wide association, however, has revived optimism.

18 ts in healthy individuals, and is related to optimism.

19 illion people can be confronted with renewed optimism.

20 standing of likelihood of cure compared with optimism.

21 r cingulate cortex was correlated with trait optimism.

22 the rapid pace of research offers reason for optimism.

23 ourts to date in these cases gives cause for optimism.

24 disciplinary treatment team, and therapeutic optimism.

25 d immune tolerance provide further cause for optimism.

26 of the model was 0.664 after correction for optimism.

27 l trial results from 2018 provide reason for optimism.

28 Bootstrapping validation showed negligible optimism.

29 y the concordance index after correction for optimism.

30 vel approaches for which there is particular optimism.

31 Optimism, a potentially modifiable health asset, merits

32 ment at this conference brought about by the optimism about applying new sequencing techniques, genom

33 testosterone operates by inducing increased optimism about future price changes.

34 d a large, earlier body of data suggest that optimism about outcome from schizophrenia is justified.

35 This review will assess whether optimism about outcome from serious mental illness and o

36 The prevalent optimism about prognosis among surrogates in ICUs arises

37 These discoveries led to optimism about prophylactic HCV vaccines, and several st

38 Key tenets of the recovery model - optimism about recovery from schizophrenia, the importan

39 The findings offer cause for tempered optimism about the accuracy of strategic intelligence fo

40 of tumor immunology in the past decade, but optimism about the clinical application of currently ava

41 n the chimpanzee challenge model has allowed optimism about the development of at least a partly effe

42 ve attempted to identify the reasons why the optimism about the Patient Self-Determination Act has no

43 ("next-generation sequencing") have inspired optimism about the potential of human genomics for "prec

44 Our results suggest guarded optimism about the prospects of using genetic data in SW

45 However, any optimism about the resilience of these ecosystems is pre

46 May expresses optimism about the source, content, and consequences of

47 Concerns about safety are balanced by optimism about their potential role in delaying the prog

48 Optimism adjusted performance metrics were reported.

49 ed postoperative mortality for MaSBO with an optimism-adjusted Brier score of 0.114 and area under th

50 le model for 6-month mortality showed strong optimism-adjusted discrimination (concordance index, 0.7

51 out cross-validation) all generated unbiased optimism-adjusted estimates of the C statistic and had s

52 n, and leave-1-out cross-validation produced optimism-adjusted estimates of the C statistic that were

53 The optimism-adjusted Harrell C statistic for the combined s

54 associated with stressful life events, less optimism, ambivalence over expressing negative emotions,

55 This may also be influenced by personal optimism and a belief that patients are unable to predic

56 re were no significant relationships between optimism and biomarkers.

57 If associations between optimism and broader health outcomes are established, it

58 study, we evaluated the association between optimism and cause-specific mortality in women after con

59 t current research indicates causes for both optimism and concern depending upon the content of the t

60 sicians may possibly be explained by patient optimism and confidence; however, the discrepancies in r

61 Optimism and cynical hostility are independently associa

62 Effects of optimism and cynical hostility were independent.

63 linding), and normal human tendencies toward optimism and denial.

64 cation, smoking status, personality trait of optimism and evidence of mental health care/treatment.

65 hired and promoted, having higher degrees of optimism and extraversion, and less neuroticism.

66 imed to investigate associations of baseline optimism and gratitude with subsequent physical activity

67 ecific associations between higher levels of optimism and healthier behaviors, reduced risk of chroni

68 ovascular outcomes, the relationship between optimism and heart failure has not been examined.

69 Participants with low optimism and high anxiety had associations that were 3-4

70 ss and were characterized by lower levels of optimism and higher anxiety traits compared to the other

71 techniques, both of which heralded premature optimism and hubris, I urge open-minded skepticism.

72 fits of donation were associated with higher optimism and lower mental health; expected consequences

73 ences of donation were associated with lower optimism and lower physical and mental health.

74 g the .632 bootstrap method to correct model optimism and quantify calibration accuracy.

75 cancer on public health, there is cause for optimism and room for hope.

76 ngs in the literature related to unrealistic optimism and self-beliefs, it does not appear to influen

77 f features of positive mental health such as optimism and self-confidence; a return to one's usual, n

78 Optimism and speculation require a counterweight.

79 After adjusting for physical health, optimism, and demographics, donors' SWL was significantl

80 echanisms of reward and motivation (hedonia, optimism, and learned helpfulness), fear responsiveness

81 Optimism, anxiety, and personality traits fell into the

82 interview and completing a survey assessing optimism, anxiety, personality traits, and sociodemograp

83 However, grounds for optimism are provided by progress in implementation of t

84 Positive psychological constructs, such as optimism, are associated with beneficial health outcomes

85 These results give some cause for optimism as to the possibility for patients to adapt to

86 Work to date on animal optimism, as an indicator of positive affect, has genera

87 tive framework, to directly assess how trait optimism, as classically measured using self-report ques

88 Additionally, there was optimism associated with the diagnostic and prognostic u

89 ydroxy-L-phenylalanine; L-DOPA) increases an optimism bias.

90 nitoring emotional salience in mediating the optimism bias.

91 mined how the brain generates this pervasive optimism bias.

92 crimination after accounting for performance optimism (Bootstrapped area under the curve: 0.90; 95% C

93 Post-ACS optimism, but not gratitude, was prospectively and indep

94 dispose to type 2 diabetes was launched with optimism, but progress has been slower than was hoped.

95 away from this Series with a great sense of optimism, but with specific recommendations that are bas

96 in this study displaying a form of parental optimism by allocating greater resources at birth to mal

97 eterminate has the potential for unrealistic optimism by both physicians and families.

98 been demonstrated in randomized trials that optimism can be learned.

99 Whether interventions that target optimism can successfully increase optimism or improve c

100 Reason for optimism comes from a recent study of mutant flies with

101 euroticism to more disengagement coping; and optimism, conscientiousness, and agreeableness to less d

102 A general sense of optimism continues to exist that there will be further p

103 th in the ages provided and in the degree of optimism conveyed.

104 ST-elevations-had excellent discrimination (optimism corrected C-Statistic, 0.88) and calibration (H

105 in the MHP diet was best predicted at ~28% (optimism-corrected adjusted R2 = 0.279) by wGRS1 and age

106 2 and baseline energy intake explained ~29% (optimism-corrected adjusted R2 = 0.287) of BMI decrease

107 -terminal pro-brain natriuretic peptide, the optimism-corrected area under curve of the ARIC HF risk

108 PSA, and age as predictors, which reached an optimism-corrected area under the ROC curve (AUC) of 0.8

109 the SORT improved discrimination (bootstrap optimism-corrected AUROC = 0.92, 95% CI: 0.90-0.94) and

110 d showed good discriminatory ability with an optimism-corrected C statistic of 70.1%.

111 del including only these 4 predictors had an optimism-corrected C-index of 0.74 (95% CI, 0.69-0.80) a

112 lization showed good discrimination, with an optimism-corrected C-index of 0.79.

113 odels demonstrated excellent discrimination (optimism-corrected c-indices of 0.81) and outstanding ca

114 ariables (c-statistic = 0.84 [0.82 to 0.86]; optimism-corrected c-statistic = 0.83; pFEV1 = 3.4 x 10(

115 discriminate well when applied to new data (optimism-corrected c-statistic = 0.84).

116 romised [I], and procedure type [T]) with an optimism-corrected C-statistic of 0.704 (95% confidence

117 es) showed moderate discriminatory capacity (optimism-corrected c-statistic value 0.729).

118 Model performance was assessed using optimism-corrected C-statistics and calibration plots, a

119 The optimism-corrected R(2) of the model was 0.71, which was

120 How people maintain unrealistic optimism, despite frequently encountering information th

121 powering outcomes were identified: increased optimism, emotional well-being, social well-being, being

122 ry model refers to subjective experiences of optimism, empowerment and interpersonal support, and to

123 une responses, has been replaced by cautious optimism engendered by the RV144 trial outcome, the isol

124 ental treatments to the clinic, momentum and optimism exist for the translation of candidate experime

125 Meta-analyses link optimism, extraversion, conscientiousness, and openness

126 Our findings provide optimism for a bright future of fair and collaborative a

127 paleoenvironmental and genetic data provide optimism for a fuller understanding of the initial colon

128 ansmission is encouraging and has stimulated optimism for achieving a dramatic change in the trajecto

129 rse influenza strains has spurred the recent optimism for creating universal influenza vaccines.

130 pically severe disease, but there is current optimism for curative gene transfer strategies to induce

131 or treatments for this devastating disorder, optimism for developing RTT treatments derives from a un

132 ation and stem-cell therapy suggest cautious optimism for finding an effective treatment in the not-t

133 These advances provide optimism for improvements in the diagnosis, staging, and

134 Optimism for the concordance index and calibration slope

135 These exciting recent results provide optimism for the development of mAbs that bind novel tar

136 uencing in the clinic has sparked tremendous optimism for the future of rare disease diagnosis, and t

137 e pathogenesis, there is reason for cautious optimism for the future.

138 nucleic acid technologies, have given great optimism for the impact of 'genomic medicine'.

139 optimized treatment strategies provide much optimism for the treatment of more heart failure patient

140 scovery in this system, as well as providing optimism for the usefulness of inferences from mRNA expr

141 asis of ear morphogenesis offers grounds for optimism for translational research toward intervention

142 Newer pharmacological approaches provide optimism for treatment for this common problem.

143 r to question many of the foundations of the optimism GWAS prompted.

144 ociodemographic factors, each SD increase in optimism had an odds ratio of 0.74 (95% confidence inter

145 Although higher optimism has been linked with an array of positive healt

146 That optimism has been tempered by the potential risks of the

147 obust biomarkers with predictive value, some optimism has come from the identification and study of i

148 e limited progress toward this goal, renewed optimism has followed the recent success of the RV144 va

149 antation into medical practice, progress and optimism have been abundant.

150 ssociated with reduced social support, lower optimism, higher hostility, and greater early life adver

151 Early optimism, however, was soon tempered by the hard realiti

152 ficiency of endovascular cooling has offered optimism in cerebral protection during neurovascular sur

153 pling on only the clusters for estimation of optimism in model performance when data are clustered.

154 iently with bootstrapping to assess possible optimism in model performance.

155 The 2-step approach overestimated the optimism in model performance.

156 r only clusters showed accurate estimates of optimism in model performance.

157 emes in clustered data for the estimation of optimism in model performance.

158 has created real excitement and justifiable optimism in recent years among rheumatologists and among

159 tivated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome.

160 rsity in antigenic proteins may be cause for optimism in the difficult fight to control global tuberc

161 ned this trend: surrogates' need to register optimism in the face of a poor prognosis and surrogates'

162 e costimulatory pathways provide reasons for optimism in the search for a cure for devastating autoim

163 There is reason for optimism in the struggle against global blindness in lar

164 A novel approach stimulates new optimism in the struggle to eliminate the burden of mala

165 There is optimism in the surgical treatment of children with Down

166 ese obstacles, there is increasing cause for optimism in the treatment of diabetic and other chronic

167 Renewed optimism in this area of research comes in part from the

168 The experiments reported here encourage optimism in this respect by demonstrating targeted corre

169 ional stability, determination, control, and optimism-in 8,119 men and women aged 52 and older (mean

170 As optimism increased, risk of developing heart failure dec

171 Unfortunately, despite early optimism, inhaled nitric oxide has several significant l

172 y improve the prognosis; and the surrogate's optimism, intuition, and faith.

173 Unrealistic optimism is a pervasive human trait that influences doma

174 This is the first study to suggest that optimism is associated with a lower risk of heart failur

175 This optimism is associated with longer duration of life supp

176 Failure to account for this inherent optimism is especially pernicious when the number of pos

177 Given work indicating optimism is modifiable, these findings suggest optimism

178 e of debunking arguments and how my cautious optimism is only of the "glass half full" sort.

179 These findings indicate that optimism is tied to a selective update failure and dimin

180 Cautious optimism is warranted regarding the use of high-dose Epo

181 This well-known bias, termed unrealistic optimism, is observed across age, culture, and species,

182 found a dose-dependent association of higher optimism levels at baseline with increased longevity (P

183 Participants with highest versus lowest optimism levels had 1.5 (women) and 1.7 (men) greater od

184 riers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homo

185 Psychological resources--optimism, mastery, and self-esteem--buffer the deleterio

186 ly positive affect (1.52%; P = 0.06) but not optimism, mastery, or purpose.

187 timism is modifiable, these findings suggest optimism may provide a valuable target to test for strat

188 This increased optimism may represent an optimal foraging strategy for

189 Optimism measured using the Life Orientation Test scale,

190 ingly resistant to evidence, suggesting that optimism might also influence how new information is sel

191 lth purposes, it is critical to consider how optimism might be related to a full scope of health cond

192 ess differences in life span associated with optimism; models adjusted for demographic confounders an

193 sex, social constraint, survivor depression, optimism, multiple life changes, and social support.

194 These advances allow optimism not only for the advancement of our understandi

195 n; anxiety; conduct problems; marijuana use; optimism; not in education, employment, or training (NEE

196 f 0.768 (95% CI 0.735-0.801) with an average optimism of 0.037.

197 tive nature of LO decisions and the inherent optimism of project teams, very few attempts have been m

198 reasing sample size did not correct the over optimism of single-arm studies.

199 The apparent inconsistency between the optimism of stakeholders regarding mortality reductions

200 The optimism of surrogate decision makers should be balanced

201 The optimism of the early period of antimicrobial discovery

202 There is cause for optimism on this difficult problem: the prebiotic chemic

203 at target optimism can successfully increase optimism or improve cardiovascular outcomes in post-ACS

204 t were 3-4 times larger than those with high optimism or low anxiety.

205 modified by psychological factors including optimism or pessimism, anxiety, and depression.

206 moral reason are also committed to empirical optimism, or what May calls "optimistic rationalism." I

207 his latter issue, there is cause for current optimism owing to rapid increases in our knowledge of co

208 Among family member characteristics, greater optimism (p = 0.001, Hospital Anxiety and Depression Sca

209 Effects of optimism persisted even after adjusting for a wide range

210 entation Test-Revised in NHS and the Revised Optimism-Pessimism Scale from the Minnesota Multiphasic

211 Trait optimism (positive future expectations) and cynical, hos

212 nditions, women in the highest versus lowest optimism quartile had 14.9% (95% confidence interval, 11

213 0.21; 95% CI, -0.38 to -0.03), dispositional optimism (r = 0.20; 95% CI, 0.01 to 0.37), and spiritual

214 ntly more likely to report the importance of optimism regarding prognosis (79% vs 62%, P < 0.0001) an

215 st a profound misperception of and unfounded optimism regarding societal race-based economic equality

216 There is also an increased optimism regarding the use of supervisory ratings and re

217 We find that trait optimism relates to an a priori belief about the likelih

218 hic characteristics, numeracy, dispositional optimism, religiousness/spirituality, understanding of r

219 Optimism remains guarded as additional evidence accumula

220 Optimism remains that these RIT approaches will improve

221 ain family characteristics of coping such as optimism, resilience, and social support to be associate

222 sing environmental mastery, purpose in life, optimism, resilient coping, and depressive symptoms.

223 linical studies with these drugs fueled this optimism, results from early clinical trials have offere

224 estionnaires to assess SWL, physical health, optimism, retrospective evaluation of the donation exper

225 entionally defined as phi or d <0.01) (e.g., optimism score: meanregular users = 19 vs. meannonregula

226 and COPD should be interpreted with cautious optimism since much of the evidence has been published o

227 ors associated with trait anxiety were trait optimism, state anxiety, evidence of mental health care/

228 Overall, we argue that the optimism surrounding the transformational potential of g

229 ound in news media and on the Internet, with optimism tempered by evidence to support the ethical tra

230 Optimism that a highly effective malaria vaccine can be

231 Nevertheless, recent advances justify optimism that a licensed malaria vaccine is within reach

232 derstanding of fold determination, engenders optimism that a solution to the folding problem for memb

233 novel strategies under development engenders optimism that a successful candidate will emerge.

234 ng knowledge from these three areas provides optimism that additional acute stroke therapies can be d

235 Nevertheless, there is reason for optimism that advances in long-acting antiretroviral the

236 The workshop concluded on a cautious note of optimism that antibody-based treatment and prevention fo

237 Earlier results provide the initial optimism that CD44 isoform expression may be a marker fo

238 n synthetic lethal drug combinations inspire optimism that CDK inhibitors will become important weapo

239 he Human Genome project has sparked hope and optimism that cures for debilitating conditions can be a

240 Recent findings have brought optimism that development of a successful human immunode

241 These data thus provide optimism that development of nonliving vaccines which ca

242 ommon features of AML have led to widespread optimism that epigenetic therapies would dramatically ch

243 There was considerable optimism that genetic linkage and genome-wide associatio

244 s memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targe

245 d the ability to culture them in vitro lends optimism that high-throughput screenings of large chemic

246 data from clinical trials, provide cautious optimism that immune-based approaches to prevent the los

247 f many adolescent disorders gives reason for optimism that interventions that shorten the duration of

248 derstanding of the ageing process and raised optimism that interventions to slow ageing may be on the

249 There is now cautious optimism that isoform-selective PI3K inhibitors will pro

250 d the inferred abundance of water reinforced optimism that Mars was once habitable.

251 g in their own right, songbirds also provide optimism that mature brains have recourse to plasticity.

252 r biology of these genes provide grounds for optimism that meaningful therapies for ALS are attainabl

253 the biology of ALS provides new reasons for optimism that meaningful therapies will be identified.

254 ial disease modifying drugs provide cautious optimism that more effective therapies are on the horizo

255 There is also optimism that pretargeting procedures, including new mol

256 pment of vaccine candidates provide cautious optimism that preventive measures are possible.

257 ransplantation biotechnologies, have created optimism that previously blinding retinal conditions may

258 agents available for evaluation provides new optimism that progress will be made over the next decade

259 tained, such patterns provide some cause for optimism that rapid evolution of PCV escape strains with

260 The original authors' optimism that RCM would provide material for future gene

261 These results increase our optimism that simulations in atomic detail may provide a

262 he genetics of BD improves, there is growing optimism that some clear biological pathways will emerge

263 The current rapid advances create realistic optimism that the establishment of RNAi as a new and pot

264 ple techniques by many laboratories provides optimism that the field is advancing toward elucidating

265 There is justified optimism that the full potential of biofuel production f

266 as and strategies, but also will reflect our optimism that the next generation of approved platinum c

267 These new findings have stimulated optimism that the progression of heart failure can be pr

268 There is considerable optimism that the targeted molecular approach being appl

269 ation in the inner ear of birds provides new optimism that there may be a treatment for hearing and b

270 ssues they have colonized has raised immense optimism that these cells may provide functional recover

271 Recent studies provide cause for optimism that this ambitious goal is achievable.

272 ransfer of tumor-specific T cells has fueled optimism that this approach may find a place as a target

273 nomodulatory approaches, there is reason for optimism that we can markedly improve survival for all p

274 ly examine subjective health assets, such as optimism, that are a core focus of positive psychology,

275 t of these findings are grounds for cautious optimism, the same cannot be said for issues of cost; re

276 After initial optimism, there is increasing recognition of the limitat

277 inked positive psychological attributes like optimism to a lower risk of poor health outcomes, especi

278 d phenomena, provided sufficient grounds for optimism to allow more extensive toxicologic evaluation.

279 ard uses Life History Theory (LHT) to relate optimism to the affluence of inventors and their societi

280 y for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that

281 ical applications range from unsubstantiated optimism to undeserved pessimism.

282 mber of recent advances have spurred renewed optimism toward initiating clinical trials and developin

283 aboratory based studies justifies a cautious optimism towards the successful translation of remyelina

284 such methods, and those that do correct for optimism use diverse methods, some of which are known to

285 Baseline optimism was also associated with lower rates of cardiac

286 Optimism was assessed at study baseline (2006 or 2008),

287 Optimism was assessed by the Life Orientation Test-Revis

288 Optimism was assessed using the Life Orientation Test-Re

289 ard models, we found that a higher degree of optimism was associated with a lower mortality risk.

290 Higher optimism was associated with a lower risk of incident he

291 Thus, we tested whether higher optimism was associated with longer life span and greate

292 Given that optimism was associated with numerous causes of mortalit

293 5,698), we examined whether higher baseline optimism was associated with subsequent increased likeli

294 egression models were used to assess whether optimism was independently associated with incident hear

295 Therefore, we examined whether higher optimism was linked with a reduced incidence of heart fa

296 Dispositional optimism was measured in 2004; all-cause and cause-speci

297 Baseline optimism was significantly associated with greater physi

298 f the physician, the most common reasons for optimism were a need to maintain hope to benefit the pat

299 outcome measures for PA/IVS may give way to optimism with the refinement of early diagnosis and earl

300 ompared with women in the lowest quartile of optimism, women in the highest quartile had a hazard rat