ライフサイエンスコーパス: optimization

1 sing a proposed method coined "Nano-Topology Optimization".

2 illustrates a novel strategy for base editor optimization.

3 y sustained for over 1 year after the 6-week optimization.

4 ivity relationship enabled efficient potency optimization.

5 candidates as well as for vaccine design and optimization.

6 s SAR transfer, which is of interest in lead optimization.

7 ectrode preparation and device configuration optimization.

8 n partitions (BLPs) are incorporated for the optimization.

9 ers can use to streamline program design and optimization.

10 ethods, often requires critical revision and optimization.

11 nding validation and further structure-based optimization.

12 and identify potential areas for diagnostic optimization.

13 lobally good accuracy, especially after data optimization.

14 sets were fitted simultaneously using global optimization.

15 sonalized health monitoring, and performance optimization.

16 y providing a reliable tool for rapid design optimization.

17 ies and promising lead compounds for further optimization.

18 for any desired compound without additional optimization.

19 would allow for treatment stratification and optimization.

20 e, potentially opening the door to treatment optimization.

21 the reaction knowledge base and further code optimization.

22 Fast96-qPCR requires further optimization.

23 We adapted multiscale topology optimization, a mesh parametrization-based algorithm and

24 ted experimentation platform with a Bayesian optimization, a self-driving laboratory is constructed t

25 as a promising lead compound for structural optimization aimed at selective targeting of ClpB and/or

26 otocols motivated by the quantum approximate optimization algorithm (QAOA), we generate nontrivial th

27 Finally, we employ an optimization algorithm in conjunction with the weighted

28 We derive an efficient optimization algorithm whose convergence to a local opti

29 ta from the first few cycles, and a Bayesian optimization algorithm(10,11), which reduces the number

30 We used Monte Carlo and optimization algorithms to generate two different intens

31 This optimization allows for accurate modeling of receptors u

32 The optimization analysis allowed to identify new combinatio

33 ce structures, with computer simulations and optimization analysis predicting that immobilized gradie

34 By performing an optimization analysis, we identified six fractions with

35 Multi-response optimization and characterization of physical, chemical,

36 y of small molecule inhibitors of p97, their optimization and characterization, and therapeutic poten

37 tagenomic-SIP datasets which facilitates the optimization and development of metagenomic-SIP experime

38 rnative for the quantitative prioritization, optimization and development of novel drugs.

39 to establish the real working mechanism for optimization and diagnosis.

40 For intact glycopeptides, through systematic optimization and evaluation using a glycoprotein interfe

41 were developed and validated for hydrolysis optimization and for quantification of eight major aglyc

42 cle magnetization dynamics is fundamental to optimization and further development of these applicatio

43 monolithic sensors because of simpler assay optimization and improved selectivity.

44 This study offers a viable therapy optimization and invigorates the research and developmen

45 brain SGR may represent a mechanism for gene optimization and long-term cellular memory, whereas its

46 The combination of dual threshold optimization and network inference greatly expands the h

47 Here, we introduce Sequence-based Toehold Optimization and Redesign Model (STORM) and Nucleic-Acid

48 city), a Markov modeling algorithm that uses optimization and resampling to compute best-fit rates an

49 Herein, we describe the chemical optimization and resulting structure-activity relationsh

50 Optimization and reverse-engineering to remove ER activi

51 s because they allow shorter reaction times, optimization and scale up, safer working environments, a

52 The optimization and scope and limitations of this short and

53 ultrafast sintering technique for the rapid optimization and screening of high-performance SSEs.

54 Future work should focus on assay optimization and streamlining the assay workflow.

55 se two microbial hosts was enhanced by codon optimization and truncation of the putatively autoregula

56 Here, we discuss recent development, optimization, and applications of optical approaches to

57 onal monitoring, scientific research, system optimization, and community development, each of which h

58 t their approximation power, the dynamics of optimization, and good out-of-sample performance, despit

59 ntal studies have facilitated the discovery, optimization, and rational design of three major categor

60 Using mathematical optimization, and subsequently the Liver Simulation Allo

61 , maximizing preoxygenation, and hemodynamic optimization; and 3) recognition and management of failu

62 This ligand mimetic design and optimization approach can be expanded to apply to other

63 We present a holistic perioperative optimization approach led by a CI team with the goal to

64 nfirms the effectiveness of a multiobjective optimization approach to the structural determination of

65 aced on the rationale behind warhead choice, optimization approach, and inhibitor design.

66 ased or genetic optimization) time-intensive optimization approaches.

67 Using sampling-based optimization, ART provides a set of recommended strains

68 ry to cell-surface TFR1, therefore, warrants optimization as a potential new therapeutic option in DL

69 nomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with the

70 efficacy and is well-positioned for further optimization based on the structure of its complex with

71 In this work, we introduce a novel optimization-based decision-making framework for managin

72 n integrative machine learning algorithm and optimization-based feature selection.

73 this problem through the lens of normative, optimization-based modeling.

74 nes for TPOT-based ML pipeline selection and optimization-based on various clinical phenotypes and hi

75 Lead optimization, beginning with narrower-spectrum, weakly a

76 We found that optimization beyond potency of degradation, including de

77 support this vision of CDS-facilitated care optimization, but limited guidance is available in the l

78 Natural evolution tackles optimization by producing many genetic variants and expo

79 onomous system for materials exploration and optimization (CAMEO) is implemented at the synchrotron b

80 We report herein a lead optimization campaign focused on a pyrazole-based series

81 with cell line phenotypes and guide process optimization, comprehensive omics data analysis and mana

82 Bayesian hyper-parameter optimization confirmed our notion that architectures des

83 Within Dutch eating habits, satisfying optimization constraints required a shift away from beef

84 We combine two key elements to reduce the optimization cost: an early-prediction model(5), which r

85 We investigated whether CT optimization could lead to abrogation of recurrence of a

86 piratory syncytial virus (RSV) to codon pair optimization (CPO) by increasing the content of codon pa

87 actors important for future structure-guided optimization delivering IMP-105 (43), a compound with mo

88 e provide a complete characterization of and optimization details for the class of unimodal distribut

89 netic analysis as a routine part of reaction optimization/development.

90 ss this problem, we introduce dual threshold optimization (DTO), a new method for setting significanc

91 .com/gersteinlab/siglasso) to carry out this optimization efficiently.

92 ne 2 with weak ATR inhibitory activity, lead optimization efforts focusing on potency, selectivity, a

93 azolinone scaffold are described, along with optimization efforts that overcame a configurational sta

94 ouling-resistant RO membranes via structural optimization: first, a smooth selective layer should be

95 Further optimization focuses the generative model toward functio

96 eclinical models in enabling pharmacokinetic optimization for acid/zwitterionic drug candidates.

97 ed selectivity against K(+) We conclude that optimization for ammonium transport in plant AMT represe

98 is in fact equivalent to Lagrange multiplier optimization for constrained problems.

99 However, the extraction procedure needs optimization for environmentally low NP concentrations.

100 outcomes; thus, herein we present structural optimization for HER2-selective targeting.

101 onents provides a new example of electrolyte optimization for improved LMBs.

102 94.76% viability were used for further media optimization for Taxol and Baccatin III production in fi

103 We detail our full synthetic optimization for the isolation of these clusters and com

104 d cells of origin, thereby providing further optimization for tumor stratification to improve the cli

105 prioritize the vast array of potential TCR-T optimizations for future clinical products.

106 l is an easy-to-use, easy-to-extend sequence optimization framework allowing to freely define and com

107 ionary game theory, we formulated a bi-level optimization framework termed NECom for which any feasib

108 This model is embedded within an optimization framework that selects which samples to tes

109 ls and Methods In this prospective study, an optimization framework was used to obtain the optimal in

110 s the required changes needed, the resulting optimization function, and algorithms for learning a tra

111 was also modelled using a multiphase single-optimization GrOE-FBA model and this approach gave accur

112 in principle, unbounded so that the barrier optimization has to be regularized.

113 Our results showed that structural optimization improved accuracy by 27.99%, 16.44%, and 13

114 y of approximately 1.5 MBq nmol(-1) Reaction optimization improved the radiochemical conversion of (8

115 ndamental insights, laying the framework for optimization in cell-based therapeutics intended to miti

116 ethod allows its application to chemotherapy optimization in different cancers.

117 be an effective strategy for multiparameter optimization in drug design, whereby substantial improve

118 therefore essential for process control and optimization in industry.

119 circuit connectivity, as well as to explore optimization in neural systems, in ways that traditional

120 species, mandatory for a successful compound optimization in vivo.

121 To construct the optimization informatics workflow, a number of critical

122 Lead optimization involved modulating potency, selectivity, a

123 Optimization is a major part of human effort.

124 Notably, this resource conservation optimization is encoded in the structure of the standard

125 Once a protocol optimization is identified, the steps are as follows: id

126 Further, we show that this optimization is in fact equivalent to Lagrange multiplie

127 While numerical optimization is increasingly and successfully used in ph

128 Lead structure optimization is needed to minimize the percentage of A9

129 ion (2.03 nano-radian) after a comprehensive optimization is reported.

130 After detailed optimizations, it can be noted that larger sized AuNPs m

131 s from greater task demands constraining the optimization landscape in a fashion that reduces the num

132 are based on linear algebra and constrained optimization, leading to efficient algorithms and fast c

133 The hit-to-lead optimization led to the discovery of a novel chemotype s

134 f a series of oxadiazole ketones, which upon optimization, led to the identification of compound 12.

135 torsions that emerge in theoretical geometry optimizations, makes these compounds poor photosensitize

136 mimetic inhibitors was employed for scaffold optimization, mapping of subsite interactions, and profi

137 e also implement a fast mass calibration and optimization method, allowing optimization of the mass t

138 PFG) NMR measurements, combined with a novel optimization method, are used to determine the compositi

139 As such conventional optimization methods fail to capture the global optimum

140 view summarizes novel approaches to glucagon optimization, methods with potential application to the

141 e slag (GGBS) in Ontario was studied, and an optimization model to find the least GHG-intense way of

142 ding upper and lower bounds, then solving an optimization model which closes the gap between the two

143 otion tracking, motion prediction, parameter optimization, model fitting, electromyography-driven sim

144 which a FD measure was derived using convex optimization modeling for microstructure informed tracto

145 Optimization of 7 identified oxadiazol-2-one 23dd as a p

146 ibitor GNF2133, which was identified through optimization of a 6-azaindole screening hit.

147 Herein, we describe the discovery and optimization of a class of potent, orally bioavailable i

148 Optimization of a lead series of PI3Kdelta inhibitors ba

149 Here we report optimization of a previously identified series of benzen

150 Herein, we describe optimization of a pyrrole-based series identified using

151 Herein we report the optimization of a series of phenyl sulfonamides that exh

152 The one-dimension optimization of a single energy function may take the st

153 Through the systematic optimization of a standard intestinal digestion protocol

154 will be greatly aided by the development and optimization of a suitable pseudotyping system.

155 te (A=Cu or In) substitution and a resulting optimization of adsorbate interactions.

156 systematic structural activity studies; lead optimization of aggregate-binding affinity, unbound frac

157 -Glo Assay, which streamlines the process of optimization of an antigen binding domain with desirable

158 g and trafficking via the secretory pathway, optimization of antigenic cargo, final release to the ce

159 we propose a novel method for computational optimization of associative learning experiments.

160 Optimization of BETi using growth inhibition in fulvestr

161 sessment, selection, and mutation results in optimization of biomaterials designs.

162 The synergistic optimization of bulk and surface properties, as a result

163 Optimization of cardiovascular risk factors and increase

164 cular orientation of the OSC layer, enabling optimization of carrier transport.

165 tructure-based design concepts, coupled with optimization of cellular potency, in vitro drug-target r

166 relationships is critical to the design and optimization of cysteine-targeted covalent inhibitors.

167 terization, particularly to enable the rapid optimization of DAR for a given ADC and thus better unde

168 ical variables will likely contribute to the optimization of DBS target selection and improved outcom

169 -DTIM-MS have the potential to enable better optimization of dosing owing to the high precision capab

170 ced characterization techniques to guide the optimization of electrode material design.

171 Without extensive optimization of experimental parameters, we were able to

172 that metagenomic-SIP performance depends on optimization of experimental parameters.

173 of the U.S. Department of Energy's (DOE) Co-Optimization of Fuels and Engines (Co-Optima) initiative

174 sents a more defined media for the continued optimization of growth factors required to support the p

175 FTC transmissions in the OptiLink HF trial (Optimization of Heart Failure Management Using OptiVol(T

176 sm regulating metal/oxide interfaces for the optimization of heterogeneous catalysis.

177 Herein, we report the multifactorial optimization of high-throughput screening hit 8 to a pot

178 composite design (CCD) was conducted for the optimization of HS-SPME conditions. Under optimal condit

179 thesis and medicinal chemistry allow further optimization of lead epothilone analogues aiming to impr

180 rved in sensor and actuator miniaturization, optimization of microelectronic circuits and, ultimately

181 ic Open Project (miRTOP) working towards the optimization of miRNA analyses.

182 We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by

183 netics, accelerating reaction discovery, and optimization of polymer coatings.

184 of this study was to evaluate the impact of optimization of preoperative comorbidities by nonsurgica

185 ld provide a significant step forward in the optimization of quantum circuits and quantum algorithms,

186 These fluctuations are implicated in the optimization of reaction barriers for enzyme catalyzed r

187 This new knowledge can employed for the optimization of reactions to achieve the desired targete

188 This spectroscopic method enables optimization of sample and mixer conditions to maximize

189 nes, expanding the toolbox for discovery and optimization of selectiveand effective covalent inhibito

190 re used for quantitative analysis, after the optimization of several analytical parameters.

191 Simultaneous optimization of side chain conformations across all conf

192 ntribute to the better targeting, design and optimization of solid-state natural food bio-preservativ

193 ts to allow for the rapid identification and optimization of superior reaction conditions.

194 Further optimization of test conditions would be useful in order

195 We carried out optimization of the 9-N-position of harmine to synthesiz

196 uture of this practice relies heavily on the optimization of the cellular microenvironment.

197 These findings reveal that optimization of the cleavable bond location can be used

198 er formation was achieved through systematic optimization of the electronic properties of aryl fluoro

199 mL(-1) range, a protocol was devised for the optimization of the fast, accurate assays of 100-fold di

200 rious amino acids, and only Gly required the optimization of the Fmoc removal cocktail composition.

201 Here, we describe optimization of the imidazole-based macrocyclic series a

202 Here, we report the optimization of the in vivo potency of pyrazolopyrimidin

203 Optimization of the isomerization reaction mode led to a

204 alibration and optimization method, allowing optimization of the mass tolerances and other key search

205 The optimization of the method was carried out by multivaria

206 larger number of possible side products, the optimization of the methodology and the study of the dri

207 n detectability was realized through careful optimization of the mirror lengths and locations combine

208 ty (e.g., MACOCHA score); 2) preparation and optimization of the patient and team for difficulty-incl

209 In this study, optimization of the peptidyl inhibitor yielded PGD97, wh

210 The structure-guided optimization of the pyridone hit 3 using this biochemica

211 itaries of an HRE quantum memory achieve the optimization of the readout procedure in an unsupervised

212 Further optimization of the series led to identification of the

213 Optimization of the solid phase extraction conditions wa

214 be used to select reasonable strategies for optimization of the thermoelectric performance.

215 We proceeded with optimization of the thioxotriazinoindole scaffold of the

216 th both an exhaustive search and closed-loop optimization of the variational parameters, approximatin

217 etic oligonucleotides (oligos), allowing the optimization of thermodynamic properties together with t

218 Simultaneous optimization of these control parameters yields rapid fa

219 Future studies will focus on optimization of these new anti-HCMV compounds along with

220 Future optimization of this approach may lead to a novel, mecha

221 Herein, we detail the development and optimization of this chemical cleavage acDrug PK assay,

222 in vivo profiling of MLT-231 support further optimization of this in vivo tool compound toward precli

223 bioisostere for phenyl, allowing the further optimization of this molecule.

224 aline ring can be used as a lead for further optimization of this novel class of survivin inhibitors.

225 Optimization of this series from HTS was supported by a

226 Optimization of this technique with adaptation of standa

227 ing procedures with regular team review, (3) optimization of tissue collection and yield methodology,

228 nt with amisulpride as part of the OPTiMiSE (Optimization of Treatment and Management of Schizophreni

229 or wearable monitoring technologies, and the optimization of treatment strategies, ranging from strok

230 he potential for rapid diagnostics and early optimization of treatment to impact outcomes in MSSA bac

231 lex imaging technique that requires thorough optimization of various experimental parameters to yield

232 cs software packages developed for automated optimization of XCMS parameters can lead to a false nega

233 r ICPMS experiments, significantly different optimization parameters (radio frequency power and gas f

234 racteristics, its neural correlates, and the optimization principles from which it originates.

235 ynergies and trade-offs, we proposed element optimization priorities: High priority (deoxidized water

236 We then augment the nanoparticle design optimization problem by considering drug diffusivity, wh

237 ety of techniques, we are able to solve this optimization problem numerically.

238 ich can be used to solve other combinatorial optimization problems through polynomial-time mapping.

239 s were implemented implicitly and trajectory optimization problems were solved with direct collocatio

240 dynamics have been proposed for solving hard optimization problems.

241 een developed to solve the resulting bilevel optimization problems.

242 erates the model training and hyperparameter optimization procedure with 8X-30X speedup over the basi

243 rated models using a Bayesian multiobjective optimization procedure, and selected and evaluated the "

244 -consuming design, fabrication, testing, and optimization procedures are needed.

245 py against MM, and the vertically integrated optimization process can be used to develop robust cell-

246 oxy-2-quinolone-3-carboxamides, a structural optimization program led to the discovery of isosteric 7

247 The purpose was to develop and test an optimization schema for the practices of pediatric radio

248 Methods: A 5-step optimization schema was developed.

249 The optimization scheme developed here provides a flexible t

250 During lead optimization, several issues were flagged such as cross-

251 After optimization, SIFTER was tested against a set of molecul

252 ed mass spectrometric/liquid chromatographic optimization significantly enhanced analytical sensitivi

253 mework allowing to freely define and combine optimization specifications via Python scripts or Genban

254 s by validated instrument, (2) lung function optimization/stabilization, (3) patient/provider agreeme

255 In the second optimization step, masking one of the hydrogen-bond dono

256 ed to protect crew against SPEs with vehicle optimization, storm shelter concepts, and/or active dosi

257 The impressive optimization story of MRTX849 highlights challenges and

258 art failure clinical trials: ROSE-AHF (Renal Optimization Strategies Evaluation in Acute Heart Failur

259 and contraindications, medical and surgical optimization strategies, protocols, medical management d

260 Our optimization strategy culminated with in vivo active RO7

261 in Acute Heart Failure), DOSE-AHF (Diuretic Optimization Strategy Evaluation in Acute Decompensated

262 Here, we describe an optimization strategy for reducing scrambling to a negli

263 , which underline the high potential of this optimization strategy for various applications in clinic

264 Herein, we describe the lead optimization studies of benzoxazolone carboxamides resul

265 The optimization study included thirteen membrane cocktails

266 The in silico cloning and codon optimization supported the proficient expression of the

267 The quantum circuit optimization technique proposed in this work would provi

268 compound, we have conducted structure guided optimization that has led to a significant (3 log) impro

269 After optimization, the limits of detection obtained were 7.37

270 After optimization, the linearities for Ni(II) and Co(II) were

271 After the optimization, the method has been validated according to

272 After gradient optimization, the RP-column retarded the eluted polar co

273 ut any material modifications or electrolyte optimizations, the gradient-tailored LLO with medium-slo

274 ventional (gradient descent based or genetic optimization) time-intensive optimization approaches.

275 We use stochastic optimization to derive triggers that ensure hospital sur

276 thways introduces the possibility of further optimization to design dual-targeted analogs.

277 Further optimization to improve BD2 selectivity and oral bioavai

278 facilitate intracellular routing, and strain optimization to improve titres.

279 esigning drug combinations includes in vitro optimization to maximize drug cytotoxicity and/or synerg

280 We applied a methodology based on Ant Colony Optimization to optimize variable selection and model fi

281 Here, we apply the tree-based pipeline optimization tool (TPOT) to predict angiographic diagnos

282 Further rounds of optimization used relative binding free-energy calculati

283 Structural optimization using DFT reveals that the complexes fit in

284 pansion strategy for functional gene modules optimization using information divergency and (iii) a ri

285 c enzymes associated with diseases by direct optimization using single purified enzymes.

286 Subsequent hit-to-lead optimization, using cocrystal structures of inhibitors b

287 watersheds will be critical to balance trait optimization versus diversification.

288 in central metabolism followed by metabolic optimization via laboratory evolution.

289 Optimization via structure- and property-based design le

290 We assessed the impact of an optimization visit on postoperative complications with u

291 Criteria optimization was based on the percentage of EGDs spared,

292 lanatory variable of interest ("preoperative optimization") was defined by whether the patient was se

293 By device structure optimization, we further realize an improved EQE of 5.2%

294 During optimization, we have also established predictive PD mar

295 We showed the absolute need for constant optimization, which formulas should be tested for compar

296 sional modeling that enables rapid parameter optimization while accommodating the complete airway net

297 omising for recovery of spirochetes, further optimization will be needed to translate this strategy f

298 Additional optimization will be required to further reduce mosaicis

299 erformed utilizing an Agile workflow process optimization with the Scrum framework.

300 onnected tasks of phase mapping and property optimization, with each cycle taking seconds to minutes.

301 simplifies and enhances the process of probe optimization without any a priori knowledge of enzyme ta