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1 hromosome 10p14 and designated it OPTN (for "optineurin").
2 autophagy adaptor protein and TBK1 substrate optineurin.
3 uitin and subsequent recruitment of Nemo and Optineurin.
4  Domain (IVD), is conserved between NEMO and optineurin.
5                          Here, we found that optineurin actively suppressed receptor-interacting kina
6               In the proposed working model, optineurin acts as a key regulator to link inhibition of
7  phosphorylation of TRIM2 (an E3 ligase) and optineurin (an autophagy receptor), which mediate the se
8                                              Optineurin and alphaB-crystallin levels remained unchang
9 . cerevisiae Atg19, Atg34 and the human p62, Optineurin and NDP52 cargo receptors interact with the E
10     LUBAC-synthesized polyubiquitin recruits Optineurin and Nemo for xenophagy and local activation o
11                                              Optineurin and p62/SQSTM1 are independently recruited to
12                                 In contrast, optineurin and/or its Ub-binding function was necessary
13 g misfolded proteins in foci with ubiquitin, optineurin, and LC3.
14  apoptosis-induced ligand, thrombospondin-1, optineurin, and palladin.
15  functional complex consisting of myosin VI, optineurin, and probably the GTPase Rab8 plays a role in
16  dimeric cargo adaptor protein of myosin VI, optineurin, and the myosin VI-binding segment from a mon
17 uilin 2, p62, valosin-containing protein and optineurin are all linked to aggrephagy, a cargo-specifi
18  of optineurin in mitophagy, as mutations in optineurin are causative for amyotrophic lateral scleros
19                                 Myocilin and optineurin are two genes linked to glaucoma, a major bli
20 rs previously linked to xenophagy, NDP52 and optineurin, are the primary receptors for PINK1- and par
21     In a yeast 2-hybrid screen we identified optineurin as a binding partner for myosin VI at the Gol
22 vanced imaging and mouse models, we identify optineurin as a key regulator that tunes phagocytosis an
23  our study establishes an important role for optineurin as an autophagy receptor in parkin-mediated m
24 ucose-transporter binding protein (GIPC) and optineurin binding and a site that binds specifically an
25     On the other hand, the overexpression of optineurin blocks the protective effect of E3-14.7K on c
26 d by expression of siRNA-resistant wild-type optineurin, but not by an ALS-associated mutant in the u
27                     PINK1 recruits NDP52 and optineurin, but not p62, to mitochondria to activate mit
28         We show that the analogous region of optineurin can functionally replace the core region of t
29 complex containing IKKalpha and IKKbeta, and optineurin cannot substitute for NEMO in lipopolysacchar
30  found three genes associated with glaucoma, optineurin, cochlin, and CYP1B1 (cytochrome P450, family
31                                              Optineurin competitively antagonized NEMO's binding to p
32              Transfection with the wild-type optineurin construct, but not with that of the wild-type
33     In contrast, neither transfection of the optineurin constructs pOPTN(WT)-EGFP and pOPTN(E50K)-EGF
34 The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become ass
35 ma membrane-to-nucleus signaling mediated by optineurin ensures outer segment degradation under condi
36 ed that the two glaucoma genes, myocilin and optineurin, exhibited differential effects on neurite ou
37   Comparison of NEMO and the related protein optineurin from a variety of evolutionarily distant orga
38                                          The optineurin gene and protein are evolutionary conserved b
39 n is a homolog of NEMO, and mutations in the optineurin gene are found in a subset of patients with g
40                            Here we show that optineurin has a K63-linked polyUb-binding region simila
41 encoding myocilin and the gene OPTN encoding optineurin have been identified to harbor causal mutatio
42             Two further binding partners for optineurin have been identified: huntingtin and Rab8.
43 utes for protein clearance, in processing of optineurin in a retinal ganglion cell model line RGC5 an
44  These results reveal a physiologic role for optineurin in dampening TNFalpha signaling, and this rol
45                      We examined the role of optineurin in mitophagy, as mutations in optineurin are
46 High-resolution live-cell imaging implicates optineurin in scissioning outer segment tips prior to en
47                      Depletion of endogenous optineurin inhibits LC3 recruitment to mitochondria and
48                 Altogether, a combination of optineurin insufficiency and ageing did not induce ALS/F
49 rved no phenotype in the unmanipulated young optineurin insufficiency mice (Optn(470T)), designed to
50 static situation, the turnover of endogenous optineurin involves mainly UPP.
51                                              Optineurin is a gene linked to amyotrophic lateral scler
52                                              Optineurin is a homolog of NEMO, and mutations in the op
53                                              Optineurin is a multifunctional polyubiquitin-binding pr
54                                              Optineurin is a widely expressed polyubiquitin-binding p
55                                         When optineurin is depleted from cells using RNA interference
56                        Therefore, endogenous optineurin is dispensable for NF-kappaB activation but n
57                                              Optineurin is essential for recruiting light chain 3 (LC
58                                              Optineurin is expressed in trabecular meshwork, nonpigme
59              Further, our data indicate that optineurin is phosphorylated by PKA at Ser342 in a Rab32
60                                         When optineurin is up-regulated or mutated, the UPP function
61             It was found that the endogenous optineurin level in neuronal cells was increased by trea
62                      These results show that optineurin links myosin VI to the Golgi complex and play
63 h PTEN-induced kinase (PINK)-1(PINK1)-Parkin-Optineurin mediated mitophagy in an effort to preserve t
64                                              Optineurin mutations are associated with amyotrophic lat
65                           Akin to C-terminal optineurin mutations found in patients with certain neur
66              However, the pathogenic role of optineurin mutations is unclear.
67 -expressed wild-type and mutant myocilin and optineurin on neurite outgrowth in neuronal cells, we tr
68 al sclerosis (ALS)-associated genes, such as optineurin (OPTN) and angiogenin (ANG), showed that the
69                   Autophagy adaptors such as optineurin (OPTN) and NDP52 facilitate mitophagy by recr
70  in innate immunity and autophagy, including optineurin (OPTN) and p62 (SQSTM1/sequestosome), both of
71                                 Mutations in optineurin (OPTN) are linked to the pathology of primary
72                       We recently identified optineurin (OPTN) as a novel gene for glaucoma and deter
73                   While the related receptor Optineurin (OPTN) can drive damage-dependent lysophagy w
74      It has been shown that mutations in the optineurin (OPTN) gene are involved in the etiology of a
75                             Mutations in the optineurin (OPTN) gene have been implicated in both fami
76                                              Optineurin (OPTN) has been associated with numerous neur
77                                              Optineurin (OPTN) has recently been linked to glaucoma,
78  explored the role of the autophagy receptor optineurin (Optn) in autophagosome formation.
79                                              Optineurin (OPTN) is a conserved autophagy receptor with
80                 Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma ge
81                                              Optineurin (OPTN) mutations are linked to amyotrophic la
82                        SOD1, TDP-43, FUS and optineurin (OPTN) proteins were identified to form intra
83 ctrometry (RAP-MS) revealed MaIL1 binding to optineurin (OPTN), a ubiquitin-adapter platforming TBK1
84                                     Although optineurin (OPTN), an autophagy receptor involved in mit
85 NEMO)-related polyubiquitin-binding protein, optineurin (OPTN), as a novel binding partner of TBK1.
86 erize, associate with the mitophagy receptor optineurin (OPTN), autoactivate, or catalyze phosphoryla
87                                              Optineurin (OPTN), implicated genetically in glaucoma an
88 ed mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (S
89               Mitophagy receptors, including optineurin (OPTN), nuclear dot 52 kDa protein (NDP52), a
90 vide evidence that the Nemo-related protein, optineurin (OPTN), plays a key role in restricting HSV-2
91 nce binding to candidate mitophagy receptors optineurin (OPTN), sequestosome-1 (p62), and nuclear dot
92 own normal-tension glaucoma genes, including optineurin (OPTN), TANK-binding kinase 1 (TBK1), and myo
93 action between Rab32 and the adaptor protein optineurin (OPTN), which regulates Golgi dynamics.
94 itophagy by regulating m(6)A modification of optineurin (OPTN).
95  the structurally related mitophagy adaptor, optineurin (OPTN).
96 or proteins, sequestosome 1 (p62/SQSTM1) and optineurin (OPTN).
97 me (p62/SQSTM1) and of the mitophagy adaptor optineurin (OPTN).
98 A and protein expression patterns for murine optineurin (Optn).
99 s not required for the recruitment of either optineurin or LC3 to damaged mitochondria.
100 ion cascade that was negatively regulated by optineurin phosphorylation via a feedback mechanism.
101 FP-N1 (mock control) as well as myocilin and optineurin plasmids including pMYOC(WT)-EGFP, pMYOC(P370
102 sion and tissue distribution between the two optineurin proteins suggests that this nonhuman primate
103 oreactive to anti-ubiquitin were seen in the optineurin pulldown, indicating that optineurin was ubiq
104    Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and
105  of TFEB target genes temporally tracks with optineurin recruitment and that lysosomal and autophagy
106                                    Following optineurin recruitment, the omegasome protein double FYV
107 protein levels because microRNA silencing of optineurin resulted in markedly enhanced TNFalpha-induce
108                                     Although optineurin shares considerable homology with NEMO, in re
109 FP and pOPTN(E50K)-EGFP nor the myocilin and optineurin small-interfering RNA treatments induced sign
110 oversial, with in vitro studies finding that optineurin suppressed TNF-mediated NF-kappaB activation
111                                    ATG13 and optineurin target mitochondria in a discontinuous oscill
112   In cells overexpressing wild type and E50K optineurin, the level of the proteasome regulatory beta5
113                                              Optineurin then induces autophagosome formation around d
114 onstrate the parkin-dependent recruitment of optineurin to mitochondria damaged by depolarization or
115 er mitochondrial membrane proteins, allowing optineurin to stably associate with ubiquitinated mitoch
116 evealed recruitment of p62, ubiquilin-2, and optineurin to TDP-43 aggregates.
117                        The foci formed after optineurin transfection were increased upon treatment of
118 in binding domain; in the absence of parkin, optineurin transiently localizes to damaged mitochondria
119                       Moreover, the level of optineurin-triggered apoptosis was reduced by rapamycin.
120 ed macrophages (BMDMs) from mice carrying an optineurin Ub-binding point mutation had normal TLR-medi
121 ion, we generated a mouse in which wild-type optineurin was replaced by the polyubiquitin binding-def
122  in the optineurin pulldown, indicating that optineurin was ubiquitinated.
123 s implicated in glaucoma (PITX2, CYP1B1, and optineurin) were also represented.
124  the ubiquitin binding domain (E478G), or by optineurin with a mutation in the LIR domain.

 
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