ライフサイエンスコーパス: oral

1 These data suggest PET at 2 h after oral (18)F-FDG administration should yield images that a

2 ut lineages, respectively) followed a strict oral/aboral profile.

3 efore use audiovisual correlations rooted in oral acoustics to extract detailed spectrotemporal infor

4 ation during myocardial infarction (MI) with oral administration immediately post-MI.

5 tate cancer chemotherapy regimens, but their oral administration is hampered by very low and highly v

6 Mouse pharmacokinetic studies with oral administration of 23dd demonstrated good plasma exp

7 Herein, the authors examined the effects of oral administration of a small molecule inhibitor for CC

8 subjected to experimental colitis induced by oral administration of dextran sulfate sodium (DSS).

9 Oral administration of gingipain inhibitors to mice with

10 A single high-dose oral administration of nCyp c 1 but not of mCyp c 1 indu

11 Oral administration of NPA101.3 (10 mg/kg/day) completel

12 tion-resistant prostate cancer (CRPC) as the oral administration of these drugs is largely hampered b

13 Oral administration of UAB126 ameliorated obesity, insul

14 e DCP4 up to 5,000 mg/L level was safety for oral administration, since a minor number of dead cells

15 n (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administration.

16 er a short period of time especially through oral administration.

17 a specific bacterial gene within the gut by oral administration.

18 toires, and functions of innate cells in the oral and gut mucosa of infants.

19 able non-inhalation administration including oral and intravenous routes.

20 (except administration route) were used for oral and intravenous studies.

21 tor frequently used for bone regeneration in oral and maxillofacial surgery.

22 ble to infection, with a prolonged period of oral and nasal viral shedding that is not accompanied by

23 romotion of immune-mediated diseases by gut, oral and skin microbiota.

24 GB001 is an oral antagonist of the prostaglandin D2 receptor that ma

25 Oral anti-hyperglycaemics cross the placenta, so effects

26 tudy was to describe trends in US outpatient oral antibiotic prescriptions from 2011-2016.

27 Oral antibiotics were noninferior to intravenous antibio

28 -centered best practices for the delivery of oral anticancer and supportive care drugs was performed

29 ty and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) versus t

30 Dabigatran etexilate is a direct oral anticoagulant with potential to overcome the limita

31 higher total costs than patients with direct oral anticoagulant-associated major bleeding.

32 d States require long-term treatment with an oral anticoagulant.

33 warfarin while 79.8% received direct acting oral anticoagulant.

34 4%), parenteral heparins (27.7%), and direct oral anticoagulants (22.6%).

35 Stroke reduction with direct oral anticoagulants (DOACs) in atrial fibrillation (AF)

36 cal patients with atrial fibrillation, novel oral anticoagulants (NOACs) have been shown to confer eq

37 The study aimed to compare oral anticoagulants across the range of kidney function

38 Direct oral anticoagulants are noninferior to warfarin with reg

39 The introduction of 4 direct oral anticoagulants beginning in 2010 has significantly

40 ansion was not associated with higher direct oral anticoagulants prescription rates (DID estimate [95

41 gn of the Randomized Controlled Trial of New Oral Anticoagulants vs. Warfarin for post Cardiac Surger

42 linked laboratory data, 34 569 new users of oral anticoagulants with atrial fibrillation and estimat

43 ihypertensives, P2Y12 inhibitors, and direct oral anticoagulants.

44 A prospective subset of patients not on oral anticoagulation enrolled in the Evolut Low Risk ran

45 ase [B, 49.3 (95% CI, 1.90-96.77), P=0.042]; oral anticoagulation present [B, 44.8 (95% CI, 27.90-61.

46 rnitine palmitoyltransferase IB)-protein and oral anticoagulation were independent factors for predic

47 patients with atrial fibrillation receiving oral anticoagulation.

48 he infected tongue but not to alterations in oral antimicrobial peptide expression.

49 disease 2019, thus advocating application of oral antiseptics.

50 loss and exercise, positive airway pressure, oral appliances that hold the jaw forward during sleep,

51 e report that prophages are widespread among oral-associated TM7, while absent from environmental TM7

52 were randomized to either a 3-day course of oral azithromycin (10 mg/kg; n = 32) or placebo (n = 38)

53 nt to analyse the abundance and diversity of oral bacteria, and pH, lactate, glucose, nitrate and nit

54 hich are directly and indirectly mediated by oral bacteria.

55 al, rather than compositional, properties of oral bacterial communities have more relevance to cancer

56 is review, we reveal the basic principles of oral bacterial delivery, from internal genetic engineeri

57 is hampered by very low and highly variable oral bioavailabilities resulting from their poor absorpt

58 s containing such a salt bridge reached high oral bioavailability and oral exposure.

59 ith desired FXIa inhibitory potency and good oral bioavailability but high in vivo clearance.

60 fforts focusing on potency, selectivity, and oral bioavailability led to the discovery of the potent,

61 ass spectrometry-based characterization, its oral bioavailability was measured in the fasted state wi

62 harmacophores while retaining solubility and oral bioavailability, and achieving circulating free pla

63 T inhibitors are limited by their potency or oral bioavailability.

64 robial infection resulting from dysbiosis of oral biofilms, we hypothesized that sucrose can introduc

65 taining patient instructions, mechanical and oral bowel preparation, chlorhexidine washes, and carboh

66 iples of image-based approaches to detecting oral cancer are placed within the context of clinical ne

67 an available drug to effectively treat both oral cancer metastasis and pain in a preclinical model.

68 argets a pathway shown to be dysregulated in oral cancer patients, using gene therapy and repurposing

69 , nonspecialists such as dentists screen for oral cancer risk, and then they refer high-risk patients

70 outcomes were periodontal diseases (42%) and oral cancers (30%).

71 m(2) administered intravenously over 2 h and oral capecitabine 1000 mg/m(2) twice daily on days 1-14

72 Treatment of MG with an oral carbonic anhydrase inhibitor hastened anatomic reco

73 ET(A)R and ET(B)R play dichotomous roles in oral carcinogenesis and pain, such that ET(A)R activatio

74 fluorescent PARP1 inhibitor can also detect oral carcinoma in a patient when applied as a mouthwash,

75 etion of volatile sulfur compounds (VSCs) in oral cavities.

76 Oral cavity cancer has a low 5-y survival rate, but outc

77 The diversity of bacterial species in the oral cavity makes it a key site for research.

78 The oral cavity, an essential part of the upper aerodigestiv

79 ed from the environment may be viable in the oral cavity, and although they may not play a significan

80 ize throughout the human body, including the oral cavity, the skin, and the gastrointestinal tract.

81 n essential regulator of inflammation in the oral cavity.

82 f oral pathobiont-reactive Th17 cells in the oral cavity.

83 plex in the primary gateway to the body: the oral cavity.

84 Oral cedazuridine/decitabine (100/35 mg) produced simila

85 ear element 1 (LINE-1) DNA demethylation for oral cedazuridine/decitabine vs IV decitabine, and clini

86 Avadomide (CC-122) is a novel oral cereblon-modulating agent with promising activity i

87 cutaneous," and "intradermal" skin testing, "oral challenge or provocation," "cross-reactivity," and

88 Deferasirox and deferiprone are the only two oral chelators used in adult patients with transfusion-d

89 alabrutinib monotherapy, or obinutuzumab and oral chlorambucil.

90 inical trial, we investigated the effects of oral cholecalciferol supplementation on serum hepcidin a

91 with meropenem, piperacillin-tazobactam, and oral ciprofloxacin is associated with decreased bla(CTX-

92 reatly expanded the known pangenomes of many oral clades, including the enigmatic Saccharibacteria cl

93 pical mupirocin (1.96-log(10) reduction) and oral clindamycin (1.24-log(10) reduction), which are use

94 cipants were randomized to receive 960 mg of oral co-trimoxazole twice daily (n = 170) or matched pla

95 r to systemic impact that extends beyond the oral compartment.

96 An oral compound, SEP-363856, that does not act on dopamine

97 ounted for a disproportionate number of both oral concurrent sessions and symposium speakers.

98 Oral contraception (OC) is used by approximately fifty-f

99 In particular, differences in use of oral contraceptives (which it was not possible to contro

100 ine with aura, young age, female sex, use of oral contraceptives and smoking habits.

101 The majority of women choose combined oral contraceptives.

102 Oral corticosteroid (OCS) treatment for severe asthma is

103 Oral corticosteroid bursts are frequently prescribed in

104 lth care utilization (r = 0.48; P = .03) and oral corticosteroid use (r = 0.43; P = .05) at baseline.

105 sthma severity, health care utilization, and oral corticosteroid use.

106 rom the age of fourteen, and the addition of oral corticosteroids and omalizumab to regular inhaled c

107 2)EDTA for 2 days followed by treatment with oral D-penicillamine for 90 days.

108 m of the intravenous d6-alpha-tocopherol and oral d3-alpha-tocopherol doses shows both liver and inte

109 lease mechanism and show that it facilitates oral delivery of phage in vivo.

110 Oral delivery of protein drugs is considered a life-chan

111 is bovinization process is a means to enable oral delivery of proven therapeutic antibodies as well a

112 ratio to receive a 2-week tapering course of oral dexamethasone, starting at 8 mg twice daily, or pla

113 ne use, select co-usage elevated the risk of oral disease.

114 ecognition among those in public health that oral diseases such as dental caries and periodontal dise

115 Accurate detection and early diagnosis of oral diseases such as dental caries and periodontitis, c

116 The utility of mycotypes as biomarkers for oral diseases warrants further study.

117 health, as well as prevent and treat common oral diseases, including appropriate rehabilitative serv

118 mg and emtricitabine 200 mg, and once-daily oral dolutegravir 50 mg; once-daily oral fixed-dose comb

119 mg and emtricitabine 200 mg, and once-daily oral dolutegravir 50 mg; or once-daily oral fixed-dose c

120 C]CIMBI-36 PET scans before and 3 h after an oral dose of d-amphetamine (0.5 mg/kg).

121 Remarkably, pretreatment with just 2 oral doses of the BTKi acalabrutinib completely prevente

122 asured in the fasted state with high and low oral doses, before and after parenteral replenishment of

123 Upon oral dosing in rats, CAGE increased peak blood concentra

124 and occurring at concentrations relevant to oral dosing.

125 ASBT, and the development of bile acid-based oral drug delivery for ASBT-targeting, including bile ac

126 rointestinal (GI) absorption of drugs and in oral drug development.

127 ric infection influences immune responses to oral enteric vaccines.

128 hemical activities commonly occurring in the oral environment.

129 st for the complex variance structure of the oral environment.

130 tion facilitated by the synthetic TAR RNA in oral epithelial cells.

131 ous cell layer but since teeth penetrate the oral epithelium, a modified barrier has evolved, called

132 ession in periderm, frontonasal ectoderm and oral epithelium.

133 d future use of Minoxidil and was started on oral eplerenone therapy 50 mg/day for 4 consecutive week

134 While we found oral eplerenone to be safe and effective, further studie

135 ere evaluated by calibrated dentists through oral examinations.

136 bridge reached high oral bioavailability and oral exposure.

137 Compound 27 attains high oral exposures in preclinical species, with strong in vi

138 daily oral dolutegravir 50 mg; or once-daily oral fixed-dose combination of tenofovir disoproxil fuma

139 cipants were randomly assigned to once-daily oral fixed-dose combination tenofovir alafenamide 25 mg

140 ce-daily oral dolutegravir 50 mg; once-daily oral fixed-dose combination tenofovir disoproxil fumarat

141 tic) cannabinoid activity can be detected in oral fluid (OF) and, if so, whether it correlates with S

142 ealed that loud speech can emit thousands of oral fluid droplets per second.

143 randomized placebo-controlled pilot trial of oral FMT capsules performed at a single US academic medi

144 The oral food challenge remains the gold standard to confirm

145 The Randomized Efficacy and Safety Trial of Oral GABA(A) alpha5 antagonist S44819 after Recent ische

146 ark chocolate through in vitro simulation of oral, gastric and intestinal digestions.

147 ositive control [ethinyl estradiol (EE2)] by oral gavage beginning on gestational day (GD)6 and conti

148 Associations persisted after oral glucocorticoid adjustment.

149 of Parkinson's disease of users of any other oral glucose lowering drugs.

150 ith family history of T2DM (FH+) received an oral glucose tolerance test and two-step hyperglycemic c

151 , or 2 consecutive HbA1c >=8.5% while on >=2 oral glucose-lowering drugs (OGLDs), with validation in

152 e position of the labrum relative to the pre-oral great appendages of L. illecebrosa indicates that t

153 erse events occurred in 12/72 (16.7%) in the oral group and 13/77 (16.9%) in the intravenous group.

154 tics and prebiotics might be useful to treat oral halitosis.

155 sing the Australian National Survey of Adult Oral Health 2004 to 2006.

156 erial species, playing a significant role in oral health and disease.

157 in, and provides a vital tool to investigate oral health and its interaction with systemic health con

158 cleaning is associated with better perceived oral health and less self-reported gingivitis.

159 roscience strategy to potentially rejuvenate oral health and reverse periodontal disease in the elder

160 Positive oral health beliefs and higher self-esteem predicted hig

161 Essential oral health care covers the most prevalent oral health p

162 most commonly used restorative materials in oral health care due to its strength and longevity (ref.

163 Second, not all dental care is essential oral health care, and not all essential care is also urg

164 mpact of detrimental socioeconomic status on oral health changes over time, 2) the role of unfavorabl

165 ophy and, further, its interaction with poor oral health elevated the risk of ESCC in a high-risk reg

166 nderwent both general health examination and oral health examination during a National Korea Health S

167 ly stress the importance of maintaining good oral health for multiple reasons, including its link to

168 ciation between vision impairment and poorer oral health of adults; adults aged 40-64 years with visi

169 to facilitate behavior change improving the oral health of children at high caries risk (ISRCTN 2495

170 tion (P < .05) between vision impairment and oral health outcomes by age group, sociodemographics, an

171 l oral health care covers the most prevalent oral health problems through an agreed-on set of safe, q

172 impairment reported 90%-150% greater odds of oral health problems, including fair/poor oral health st

173 primary care providers delivering preventive oral health services (POHS) to young children in medical

174 of oral health problems, including fair/poor oral health status, mouth problems, and teeth problems,

175 f unfavorable patterns of dental visiting on oral health, 3) associations between general and oral he

176 health, 3) associations between general and oral health, 4) nutritional and dietary effects on oral

177 ealth, 4) nutritional and dietary effects on oral health, and 5) intergenerational influences on oral

178 l and community level to promote and protect oral health, as well as prevent and treat common oral di

179 Thus, while periodontal therapy may improve oral health, it may be effective at impacting CHD incide

180 gical variations and precision therapies for oral health.

181 gmatine pathway metabolites as biomarkers of oral health.

182 king/vaping produces differential effects on oral health.

183 alth, and 5) intergenerational influences on oral health.

184 e investigated effects of HIV and smoking on oral HPV risk.

185 Gingival status (bleeding on probing) and oral hygiene effectiveness (dental calculus) were evalua

186 The latter was directly linked to greater oral hygiene effectiveness.

187 In this regard, professional-administered oral hygiene measures have been suggested to play a domi

188 investigating the influence of adjuvants to oral hygiene procedures on the recurrence of periodontit

189 tients were instructed to resume proper home oral hygiene procedures.

190 situations with waning efficacy of personal oral hygiene.

191 The oral immunomodulator laquinimod did not reach the primar

192 considerable body of data exists supporting oral immunotherapy (OIT) as a promising, novel treatment

193 Oral immunotherapy (OIT) for food allergy improves the q

194 experiments and evaluated susceptibility to oral inflammatory disease in mice harboring distinct mic

195 Oral inflammatory load (OIL) was assessed in a salivary

196 cytic leukemia (CLL) include venetoclax, the oral inhibitor of B-cell lymphoma-2, and inhibitors of k

197 Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1

198 ndings suggest that 1 year of treatment with oral insulin slows metabolic deterioration in individual

199 In study 2, PHep was increased 24 h after oral iron (P = 0.014), and mean FIA [+/-SD](%) from the

200 3, PHep was not increased 48 and 72 h after oral iron (P = 0.384), and the geometric mean FIA[-SD, +

201 In adults, oral iron doses increase plasma hepcidin (PHep) for 24 h

202 ce or unresponsiveness to 1 month or more of oral iron were recruited from 30 outpatient clinic sites

203 ia who were intolerant of or unresponsive to oral iron, iron isomaltoside (now called ferric derisoma

204 nt safety to placebo with less toxicity than oral iron.

205 sure (geometric least-squares mean [LSM]) of oral/IV 5-day area under curve from time 0 to last measu

206 ort 3: > 1 to < 3 months) were randomized to oral JNJ-8678 or placebo once daily for 7 days.

207 ell type of mesenchymal HNSCC and its normal oral keratinocyte counterpart.

208 Lesions with the impression of oral lichen planus were unlikely to be either dysplastic

209 ronger platelet inhibition by an intensified oral loading strategy (ILS) before PCI impacts on outcom

210 ase in the levels of NK cells in tonsils and oral lymph nodes.

211 of PARP inhibitor-sensitive cancers in which oral medications are not tolerated.

212 In wild-type mice, oral metformin increased circulating GDF15, with GDF15 e

213 o four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only

214 rol), or counseling plus intermittent use of oral metronidazole, Ecologic Femi+ vaginal capsule (cont

215 However, the precise role that oral microbes play in the extraoral organs, including th

216 ed data exist on a healthy maturation of the oral microbial ecosystem in children.

217 to investigate metabolic differences between oral microbial metabolism of endogenous (i.e., salivary

218 udies have investigated the link between the oral microbiome and these cancers.

219 The oral microbiome is one of the most stable ecosystems in

220 The human oral microbiome with its diverse habitats and abundant,

221 he host-associated microbiome, including the oral microbiome, presents itself in a complex ecosystem

222 mily were more similar to each other than to oral microbiomes from non-related individuals.

223 We further evaluated transmissibility of oral microbiomes from parents and during cohousing exper

224 Additionally, oral microbiomes from participants of the same family we

225 approximately 200 types of bacteria from the oral microbiota have remained uncultured in the laborato

226 Novel associations of sputum and oral microbiota to immunologic features were observed in

227 Oral miltefosine in monotherapy has proven high efficacy

228 eoadjuvant therapy without (control) or with oral MK-2206 135 mg/week.

229 s (OPC) is an opportunistic infection of the oral mucosa caused by the commensal fungus Candida albic

230 Cs) and other innate immune cells patrol the oral mucosa for infecting microbes.

231 ntedanib prevented vascular pathology in the oral mucosa, lungs, and liver of the BMP9/10ib mice, as

232 dida serves as the main etiological agent of oral mucosal candidiasis, in which a Candida-bacteriome

233 Because the clinical appearance of oral mucosal lesions is not an adequate indicator of the

234 nd platelet-rich fibrin (L-PRF), on a mature oral multispecies biofilm on a rough titanium surface.

235 Low-abundance oral mycobiome members acquired from the environment may

236 ch cultivation revealed Malassezia as viable oral mycobiome members, although the low-abundance Malas

237 livery approaches, and demonstrates a novel, oral nanoformulation for PKD.

238 When oral nutrition is not feasible, enteral nutrition by eit

239 Oral-only anticoagulation strategies are now available,

240 d (1:1) to either anastrozole (1 mg per day, oral) or matching placebo daily for 5 years.

241 r an independent causal effect of smoking on oral/oropharyngeal cancer (IVW OR 2.6, 95% CI = 1.7, 3.9

242 study was to compare downstream and upstream oral P2Y(12) inhibitors administration strategies in pat

243 sults in nutrient malabsorption and requires oral pancreatic enzyme replacement.

244 llel, periodontitis results in generation of oral pathobiont-reactive Th17 cells in the oral cavity.

245 ture that forms a protective barrier against oral pathogens and abrasive particles(1).

246 n led to I-BET469, which possesses favorable oral pharmacokinetic properties, displays activity in vi

247 eased from all breads' matrix already at the oral phase of digestion.

248 ) and L. bulgaricus (6.48 log cfu/mL) was in oral phase.

249 Monovalent type 2 oral poliovirus vaccine (mOPV2) stockpile is low.

250 Fosmetpantotenate is an oral PPA prodrug.

251 mens: (1) conventional immunomodulators (ie, oral prednisolone >10 mg/day, thiopurines, methotrexate)

252 ficant reduction in the lowest daily dose of oral prednisolone throughout the entire treatment course

253 Oral pretreatment with highly nitrated proteins induces

254 proliferate in nutrient-rich periods during oral processing of foods and drinks and starves in betwe

255 elative effectiveness of three components of oral rabies vaccination (ORV) programmes targeting racco

256 Early oral refeeding in mild acute pancreatitis (EORVsUOR).

257 ics for pneumonia and neonatal sepsis and of oral rehydration solution for diarrhoea would together a

258 Brensocatib (INS1007) is an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP

259 Using an oral route of inoculation, and fecal shedding as a marke

260 ection that is transmitted through the fecal-oral route, shed in the stool of infected individuals, a

261 ntact and generally occurs through the fecal-oral route.

262 al that evaluated the safety and efficacy of oral S44189 in patients with recent ischaemic stroke.

263 nct functional repertoires compared to other oral Saccharibacteria.

264 robiome characteristics of induced sputum or oral samples demonstrate unique relationships to feature

265 om control subjects, and in skin, nasal, and oral samples from 302 workers from different areas of th

266 formation on the specific composition of the oral secretion is scarce.

267 iculture in North and South America, and its oral secretion may be responsible for the damage it caus

268 Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective a

269 We developed a voluntary, gelatin oral self-administration paradigm that allowed male and

270 Single-drug oral selinexor induced durable responses and had a manag

271 In a phase 1b/2 study, the combination of oral selinexor with bortezomib (a proteasome inhibitor)

272 Oral semaglutide, empagliflozin, and liraglutide also re

273 The sildenafil group were administered oral sildenafil treatment in addition to the same interv

274 rat and human data following intravenous or oral silver administration.

275 icipants from the ATLAS trial, from both the oral standard-of-care and long-acting groups, must have

276 We show that an oral streptococcal strain, SK95, and a pneumococcal stra

277 Interestingly, however, some species of oral streptococci can antagonize the phenotypes induced

278 Oral sulphonylureas, widely prescribed for diabetes, inh

279 to be missed since high-dose riboflavin per oral supplementation is often highly efficient.

280 ate-associated GLP-1 pathway in the gut, and oral supplementation with butyrate provides new insights

281 Chronic oral supplementation with KE was effective in both preve

282 ative medications to the type of periodontal/oral surgery performed will help prevent overprescribing

283 16s rRNA-based analysis was performed on oral swabs and stool samples obtained biweekly from base

284 retreatment biopsy, 6 months of once per day oral talazoparib (1 mg), followed by definitive surgery.

285 Ivosidenib (AG-120) is an oral, targeted agent that suppresses production of the o

286 proxetil, is currently in development as an oral therapy for multidrug resistant and carbapenem-resi

287 e bloodstream infections from intravenous to oral therapy impact 30-day mortality?" We conducted sepa

288 ns that may be superior in efficacy to daily oral TLZ and would be useful for treatment of PARP inhib

289 disrupt gut immune homeostasis and prevents oral tolerance induction to bystander food antigen throu

290 adversely affecting the capacity to develop oral tolerance to food antigen in early life.

291 yp c 1 but not of mCyp c 1 induced long-term oral tolerance, characterized by lack of parvalbumin-spe

292 Acetaminophen (APAP) is a proven lethal oral toxicant in reptiles but the physiological mechanis

293 vaccination did not increase the rate of SIV oral transmission or disease progression.

294 ned by an interactive web response system to oral trimetazidine 35 mg modified-release twice daily or

295 ps: placebo, 5 mg/d, 10 mg/d, and 20 mg/d of oral tropisetron.

296 minate between fresh biopsied samples of the oral tumour and the surgical resection margin with more

297 luded patients were randomized 1:1 to either oral vancomycin (dosed at 125 mg once daily while receiv

298 Patients treated with oral vancomycin were compared to those treated with metr

299 olonization is significantly associated with oral vancomycin.

300 Finally, we show that standard oral vasodilator therapy reduced contraction amplitude b