ライフサイエンスコーパス: oral administration

1 travenous administration) and 18.1 muSv/MBq (oral administration).

2 lating lymphocytes from patients after HDACi oral administration.

3 and CNS-stage disease, even at low doses and oral administration.

4 le is known about their absorption following oral administration.

5 ) were tested as Lf encapsulation system for oral administration.

6 ,4-dinitrobenzenesulfonic acid in rats after oral administration.

7 a specific bacterial gene within the gut by oral administration.

8 b) in vivo on tumor growth in mice following oral administration.

9 and pharmacokinetic properties suitable for oral administration.

10 sevenfold lower dose of BYL719 compared with oral administration.

11 , and improve patient compliance by enabling oral administration.

12 7) proof of biological effects in mice after oral administration.

13 with improved pharmacokinetic profile after oral administration.

14 ovir diphosphate to lymphoid cells following oral administration.

15 cant delay and diminished symptoms of EAE by oral administration.

16 t 230 appears rapidly in the blood following oral administration.

17 rs with overall ADME properties suitable for oral administration.

18 nanoencapsulants and their performance upon oral administration.

19 n colorectal carcinoma xenograft model after oral administration.

20 low adverse reaction rate when compared with oral administration.

21 ich can be an advantageous route compared to oral administration.

22 in the dose range of 5-100 mg/kg x 4 days by oral administration.

23 ability and suitable physical properties for oral administration.

24 low permeability, and degradation following oral administration.

25 ch potentially makes it a good candidate for oral administration.

26 tic study in rats for detection of GLB after oral administration.

27 lability of pinometostat relative to CIV and oral administration.

28 mice in the absence or presence of rofecoxib oral administration.

29 acterial infections, by both intravenous and oral administration.

30 d preclinical pharmacokinetic properties for oral administration.

31 c profile in mice, following intravenous and oral administration.

32 n (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administration.

33 e and other analogues of adenosine following oral administration.

34 more likely to be reached with IV than with oral administration.

35 - and 7-fold higher than that recorded after oral administration.

36 er a short period of time especially through oral administration.

37 hallenged with house dust mite extract after oral administration (50 mg/kg, qd).

38 odrugs to deliver PPA to the brain following oral administration and confirms incorporation of the pr

39 icient PC3 prostate tumor bearing mice after oral administration and showed complete inhibition of tu

40 thal and sublethal influenza challenge after oral administration, and effectively neutralizes virus i

41 ets to enable release in the intestine after oral administration as a possible oral treatment for inf

42 MX-1 breast cancer xenograft model following oral administration as a single-agent or in combination

43 Due to oral administration, broad efficacy, and manageable toxi

44 18)F-FDG has excellent bioavailability after oral administration, but peak organ activities occur lat

45 owever, miltefosine's long half-life and its oral administration could make it a good option for main

46 Additionally, oral administration, coupled with gastric residency, ser

47 Additionally, compared to oral administration, despite the lower plasma C(max) and

48 Compound 15 exhibited in vivo efficacy after oral administration, determining a 62% increased surviva

49 hed in an SCID mouse model of malaria, after oral administration (ED(90) = 1.5 mg/kg, once a day for

50 Following oral administration, ileal recovery of V565 was investig

51 ation during myocardial infarction (MI) with oral administration immediately post-MI.

52 from poor systemic availability (14%) after oral administration in addition to other side effects on

53 stant parasites; (2) curative efficacy after oral administration in an erythrocytic Plasmodium yoelii

54 ch afforded excellent release of 1 following oral administration in both mice and dog.

55 HD1 and DHD3, as the major metabolites after oral administration in humans and rodents.

56 dulatory effects in vitro, but not following oral administration in humans.

57 After oral administration in mice, ARN2508 engages its intende

58 ure and desired bioavailability of 45% after oral administration in rats.

59 ibutes to a concentration-time profile after oral administration in the cynomolgus monkey that showed

60 efore levels of full length SMN protein upon oral administration in two mouse models of SMA.

61 CB07 with intraperitoneal, subcutaneous, and oral administration increased food intake and body weigh

62 tate cancer chemotherapy regimens, but their oral administration is hampered by very low and highly v

63 Their toxicity for mice after oral administration is low, and, when administered indiv

64 short- and long-term inhibition of CSF1R by oral administration leads to a robust decline in nerve m

65 ar-normal life; however, the daily burden of oral administration may lead to non-adherence and drug r

66 odialysis experiments also demonstrated that oral administration of (+)-67 significantly elevated ext

67 C]carfentanil PET scans, before and after an oral administration of 0.5 mg/kg of d-amphetamine.

68 5-fold higher plasma levels of 1 compared to oral administration of 1 itself.

69 on-transferrin-bound iron resulting from the oral administration of 1) a supplemental dose of iron (6

70 n SCD mice exposed to hypoxia/reoxygenation, oral administration of 17R -RvD1 reduces systemic/local

71 In P. berghei-infected mice, oral administration of 1o drastically reduces parasitaem

72 Oral administration of 2-((4-chloro-2,6-difluorobenzyl)a

73 Mouse pharmacokinetic studies with oral administration of 23dd demonstrated good plasma exp

74 The therapeutic approach was validated by oral administration of 27 in orthotopic xenografts of en

75 Oral administration of 28 significantly reduced fibrosis

76 Notably, the oral administration of 3-amino-4-(4-fluorophenylamino)-1

77 vivo object recognition test with CD1 mice, oral administration of 36c was found to significantly im

78 We observed that oral administration of 4-MUG to mice inhibits HA synthes

79 ss in the murine CT26 syngeneic model, after oral administration of 400 mg/kg.

80 rements were performed at baseline and after oral administration of 5 mg/kg of LY2886721, a BACE1 inh

81 ects repeated the exercise 150 minutes after oral administration of 50 mg sildenafil.

82 Oral administration of 6 in mice increased the plasma ex

83 dren at high risk for type 1 diabetes, daily oral administration of 67.5 mg of insulin, compared with

84 Oral administration of 69 to rats reduced food intake in

85 ses 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of 6f exhibited inhibition of the in

86 In tumor bearing mice, oral administration of 71 causes rapid accumulation of m

87 Repeated oral administration of 83 caused marked inhibition of tu

88 man hepatocyte chimeric mice after 7 days of oral administration of 9.

89 Oral administration of 9u at 10 mg/kg could achieve rapi

90 Human studies employed oral administration of [2-(13) C]-glycine and (13) C spe

91 stered encapsulated, stimulates GAS, whereas oral administration of a caffeine solution delays GAS in

92 ination half-life (T1/2el = 135 h) following oral administration of a commercial formulation (CF).

93 reventive protocol for milk allergy with the oral administration of a Gly-m-Bd-30K soy-derived peptid

94 However, oral administration of a low dose of maraviroc protected

95 Oral administration of a novel small molecule galectin-3

96 We previously reported that oral administration of a periodontal pathogen, Porphyrom

97 ent and can be mostly reversed by long-term, oral administration of a positive allosteric modulator o

98 In this study, we report that oral administration of a selective ROCK2 inhibitor, KD02

99 of multiple doses, and bioavailability after oral administration of a single dose of different PB for

100 nd that this self-renewal can be reversed by oral administration of a small molecule (VTP-50469) that

101 Herein, the authors examined the effects of oral administration of a small molecule inhibitor for CC

102 Strikingly, oral administration of A. muciniphila suppressed selecte

103 Oral administration of ABT263 to either sublethally irra

104 In a murine allograft tumor model, oral administration of ACEE significantly inhibited LLC

105 Oral administration of acetate mediated interferon-beta

106 Oral administration of ACT-1004-1239 in mice up to 100 m

107 V was also substantially increased following oral administration of activated ester prodrug compared

108 Further, oral administration of AEA to NOD mice provides protecti

109 Oral administration of Ag induces regulatory T cells tha

110 Following oral administration of AL-794, significant dose-dependen

111 Oral administration of all major SCFAs, such as acetate,

112 CD was achieved by oral administration of alpha-methyl-para-tyrosine (AMPT)

113 together with gastric emptying studies after oral administration of an appropriately radiolabeled mea

114 e (LD) of ticagrelor, 180 mg, vs traditional oral administration of an equal dose enhances platelet i

115 ing an LD of ticagrelor, 180 mg, or standard oral administration of an equal dose.

116 Oral administration of an ErbB2-targeted CL-387,785 for

117 Thus, oral administration of an FAAH inhibitor during a brief

118 rolase (FAAH) reduces AEA, we confirmed that oral administration of an FAAH inhibitor during stress p

119 Oral administration of an HIF-P4H inhibitor, FG-4497, to

120 Accordingly, oral administration of anti-CD3 enhanced oral tolerance

121 ally involved Ag feeding, we have found that oral administration of anti-CD3 mAb induced tolerance th

122 /-) mice did not develop oral tolerance upon oral administration of anti-CD3.

123 Oral administration of anti-CFA/I minor pilin subunit (C

124 in NOD animals with depleted microbiota via oral administration of antibiotics.

125 on two occasions, but they disappeared after oral administration of antihistamines.

126 ET/CT images were acquired 24 and 96 h after oral administration of approximately 28 MBq of (124)I-so

127 Oral administration of arsenite in mice resulted in heav

128 Oral administration of AS1842856 in mice abrogated apopt

129 Oral administration of AvrA NPs encapsulated in alginate

130 telemetered mice, acute intraperitoneal and oral administration of azithromycin caused effects consi

131 Oral administration of azithromycin definitively decreas

132 ess Abeta40 levels in brain and plasma after oral administration of BACE1 inhibitors SCH1682496 or LY

133 Moreover, in YFV-infected hamsters, oral administration of BDAA protected 90% of the animals

134 Interestingly, oral administration of BF under enhanced gut permeabilit

135 Oral administration of Bifidobacterium alone improved tu

136 rat model of cisplatin ototoxicity following oral administration of caffeine.

137 Oral administration of canagliflozin activated AMPK in m

138 ate drug-delivery system is designed for the oral administration of cancer therapeutics.

139 tivation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevent

140 TCR to HLA-B*15:02 transgenic mice receiving oral administration of carbamazepine induces multi-organ

141 eres in vitro and to initiate tumors in vivo Oral administration of CBL0137 to mice bearing orthotopi

142 plete oral absorption was observed following oral administration of celecoxib (F% = 56-110%) and mava

143 Oral administration of CFI-402257 in monotherapy or in c

144 Following oral administration of Citrobacter rodentium, LACC1 knoc

145 =714) were randomized to acute preprocedural oral administration of colchicine 1.8 mg or placebo.

146 In a murine model of HAT, oral administration of compound 1 cured the disease.

147 Oral administration of Cu(II)(atsm) delayed the onset of

148 Oral administration of curcumin in mouse tumor models ge

149 cans with [(11)C]-(+)-PHNO, before and after oral administration of d-amphetamine.

150 a levels of D-serine in mice compared to the oral administration of D-serine alone, demonstrating its

151 ated plasma D-serine levels in monkeys after oral administration of D-serine in the presence or absen

152 magnetic resonance imaging (fMRI) following oral administration of delta-9-THC, CBD, or a placebo ca

153 r intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS).

154 Experimental chronic colitis was induced by oral administration of dextran sodium sulfate.

155 subjected to experimental colitis induced by oral administration of dextran sulfate sodium (DSS).

156 Here we show that oral administration of DHA to normal adult mice as lysop

157 ium sulfate-induced colitis, with or without oral administration of DHA.

158 Oral administration of DHED elicits a significant reduct

159 Oral administration of drugs is one of the most patient-

160 Oral administration of E coli BL21_HTW, which is able to

161 al colonization in 2-day-old (P2) rats after oral administration of E. coli K1 strain A192PP and a vi

162 Oral administration of EGCG/AA NPs in mice resulted in E

163 present work, we investigate the effects of oral administration of eicosapentaenoic acid (EPA)-rich

164 )F-DCFPyL) were performed 3-7 d apart, after oral administration of either 12.7 g of MSG or placebo.

165 In conclusion, oral administration of EPA-rich oil impairs the quality

166 Oral administration of ERG240 reduces the severity of co

167 Particularly, passive oral administration of ETEC anti-fimbrial antibodies pre

168 -loaded liposomes (EL-CSG) were prepared for oral administration of Ex-4.

169 (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote i

170 n of plasma and brain accumulation following oral administration of free or EGCG/AA NPs showed that,

171 Oral administration of gingipain inhibitors to mice with

172 In acute sleep disturbance, oral administration of glycine-induced non-rapid eye mov

173 While oral administration of heat-killed (HK) BF to prediabeti

174 Oral administration of HES promotes an ameliorative effe

175 We investigated the effects of daily oral administration of HFCS in adenomatous polyposis col

176 We investigated whether oral administration of human commensal bacteria engineer

177 line and at 2 d and 6-7 d after the start of oral administration of imatinib (400 mg/d).

178 Oral administration of Imm124E hyperimmune colostrum ame

179 Oral administration of Imm124E improved bowel histology.

180 Oral administration of Imm124E promoted Tregs and allevi

181 Oral administration of intestinal AP could be a valid th

182 l-F2 fraction increased glucose uptake while oral administration of KCl-F1 and final FPH decreased sy

183 om a phase 1 clinical trial demonstrate that oral administration of KD025, a selective ROCK2 inhibito

184 Most importantly, oral administration of KPT-9274 reduces tumorigenesis in

185 The results of this trial indicate that oral administration of L. rhamnosus SP1 resulted in simi

186 Oral administration of L. salivarius PS2 during late pre

187 Previous studies have shown that oral administration of lactobacilli can be an efficient

188 In previous studies we demonstrated that oral administration of Lactobacillus reuteri in healthy

189 We found that oral administration of lactose or fructo-oligosaccharide

190 Oral administration of LM11A-31 from age 15 to 18 months

191 Additionally, oral administration of lysophosphatidic acid (LPA) incre

192 Conversely, daily oral administration of lysozyme prevented expansion of E

193 , in the DSS-induced mouse model of colitis, oral administration of M2- or M13-loaded NL nanoparticle

194 ty reactions in sensitized animals following oral administration of meat.

195 nd memory-enhancing neural correlates of the oral administration of methylene blue in the healthy hum

196 Oral administration of mibefradil inhibited growth of GS

197 However, oral administration of microbes always leads to a substa

198 Oral administration of milligram amounts of YLLIP2 signi

199 Subcutaneous and oral administration of modified elafin inhibited obesity

200 uding plateau plasma PB concentrations after oral administration of multiple doses, and bioavailabili

201 In vivo investigation demonstrated that oral administration of Myr at 300 mg/kg/day for 8 weeks

202 Long-term oral administration of myricetin demonstrated glucoregul

203 A single high-dose oral administration of nCyp c 1 but not of mCyp c 1 indu

204 Moreover, the combined oral administration of NDI and 2DG reduced in vivo melan

205 ospinal fluid, which can be corrected by the oral administration of nicotinamide riboside, a recently

206 showed 20-times higher bioavailability than oral administration of NOB crystal.

207 In vivo oral administration of Nos (100 mg/kg) followed by intra

208 Oral administration of NPA101.3 (10 mg/kg/day) completel

209 In vivo results demonstrated that oral administration of NTZ (50 mg/kg) in an acute MPTP m

210 The oral administration of olives to rats and its determinat

211 Upon oral administration of our small molecules, the levels o

212 Oral administration of ovalbumin (OVA) in Was(-/-) mice

213 illus rhamnosus L34 in a new sepsis model of oral administration of pathogenic bacteria with GI leaka

214 ice fed with a Western diet, with or without oral administration of PDX.

215 Daily oral administration of PEA-OXA (10 mg/kg daily o.s.) was

216 Oral administration of Pep19 into diet-induced obese Wis

217 ch is the potential new delivery carrier for oral administration of probiotics.

218 Oral administration of proteases that can rapidly degrad

219 Oral administration of PWH (3 and 10mg/kg) reduced the g

220 However, oral administration of recombinant CCL20 to neonatal mic

221 Daily oral administration of resolvin D1, a downstream metabol

222 Oral administration of resveratrol is able to improve gl

223 Oral administration of reversible CRM1 inhibitors in pre

224 Oral administration of rh-lactoferrin was safe but did n

225 Oral administration of rolofylline for 2-wk to 14-mo-old

226 C1 had an increased burden of bacteria after oral administration of S Typhimurium and after administr

227 Subsequently, oral administration of SBI-425, a small molecule inhibit

228 Oral administration of SCFAs to mice significantly reduc

229 Oral administration of selinexor (15 mg/kg p.o. QoDx3/we

230 ally or completely, after intraperitoneal or oral administration of several indenes.

231 (90)) of LPV for HIV-1 (140 ng/mL) following oral administration of simple alkyl ester prodrug and ac

232 re/Tp53/Rosa(YFP) genetically modified mice, oral administration of SLC-0111 and injection of gemcita

233 enograft tumors grown from human PDAC cells, oral administration of SLC-0111 and injection of gemcita

234 se studies in the mdx mouse demonstrate that oral administration of SMT022357 leads to increased utro

235 Recent studies have reported that oral administration of SPD protects against liver fibros

236 Indeed, oral administration of specific microbial metabolites to

237 g mitophagy in aged, hyperlipidemic mice via oral administration of spermidine prevented the increase

238 Oral administration of SPG-56 significantly suppressed t

239 treatment with metronidazole or vancomycin, oral administration of spores of NTCD-M3 was well tolera

240 ) mice, a model of intestinal tumorigenesis, oral administration of SQ-CDDP NP curtailed spontaneous

241 Oral administration of synbiotic has been proposed as an

242 needed to clearly define the intervention as oral administration of synbiotics (combination of probio

243 st function, and in B12-deficient offspring, oral administration of taurine rescued their growth reta

244 Oral administration of tenapanor or other intestinal sod

245 ly elevated or repressed in adult animals by oral administration of tetracycline.

246 Furthermore, oral administration of the clinically approved histone d

247 d higher C(trough) values of 1 compared with oral administration of the drug itself, demonstrating a

248 Oral administration of the lead compound 54 effectively

249 Oral administration of the NAD(+) precursor nicotinamide

250 Daily oral administration of the peptides in WD-fed LDLr(-/-)

251 Oral administration of the phages up to 24 h before V. c

252 Oral administration of the plasmid DNA (pDNA) encoding G

253 d for CD103(+) DC migration to the MLN after oral administration of the TLR7 agonist R848, it was not

254 (11)C-metformin uptake was pronounced after oral administration of the tracer, with tissue-to-blood

255 Oral administration of the TRPV1 agonist, capsaicin, sup

256 Finally, oral administration of the VEGFR2 kinase inhibitor Vande

257 tion-resistant prostate cancer (CRPC) as the oral administration of these drugs is largely hampered b

258 Oral administration of toll-like receptor (TLR) ligands

259 Oral administration of UAB126 ameliorated obesity, insul

260 Oral administration of UNC1999 prolongs survival of a we

261 y hypertensive rats (SHR) also revealed that oral administration of Val-Glu-Leu-Tyr-Pro can decrease

262 Oral administration of vancomycin greatly dampened both

263 tate fMRI in awake male rhesus monkeys after oral administration of various doses of MPH.

264 to determine the immunomodulatory effect of oral administration of vitamin D-enriched mushrooms extr

265 Oral administration of vitamin-D enriched mushrooms extr

266 Oral administration of VLX103 also decreased hepatotoxic

267 Importantly, oral administration of WA effectively inhibited HepG2-xe

268 Oral administration of WM382 cured mice of P. berghei an

269 ctivating enzymes, and thus we reasoned that oral administration of WR-2721 just before radiation wou

270 The beneficial effects of long-term oral administration of Xe-enriched solutions on cardiova

271 erties, with about 60% bioavailability after oral administration, only mild inhibition of cytochrome

272 Following oral administration, plasma BCAA concentrations showed a

273 We show that MAV-1 oral administration provides protection that recapitulat

274 nd energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- an

275 In vivo, Stiripentol oral administration reduced significantly urine oxalate

276 However, its rapid metabolism after oral administration results in poor bioavailability and

277 ith MDA-MB-231 cells, with inhibitor 38u via oral administration robustly inhibits breast cancer lung

278 Oral administration should be in a fasted state, with da

279 e DCP4 up to 5,000 mg/L level was safety for oral administration, since a minor number of dead cells

280 geable safety profile and the convenience of oral administration suggest that afatinib could be an ad

281 properties of this tracer mean that through oral administration, the turnover and flux through a num

282 ormin, into chitosan nanoparticles, and upon oral administration to a PKD murine model (Pkd1(fl/fl);P

283 in-1(2H)-yl)acet amide (PF-06282999, 8) upon oral administration to lipopolysaccharide-treated cynomo

284 e Wolbachia load in filarial worms following oral administration to mice.

285 vitro and blocked AP activity ex vivo after oral administration to monkeys as demonstrated by inhibi

286 able to decrease the plasma LPA levels upon oral administration to rats.

287 ring enhanced plasma trough values following oral administration to rats.

288 h detectable distribution to the lungs after oral administration to rats.

289 intact cordycepin was not absorbed following oral administration to rats.

290 sulfonamides were also found effective upon oral administration to Wistar rats and inhibited MES ind

291 s administered (from 3 days prior with daily oral administration) to mice in which aortic dissection

292 udy was to evaluate the fate of prions after oral administration, using highly purified radiolabeled

293 Following oral administration, V565 was detected at micromolar con

294 Bioavailability after oral administration vs. intraperitoneal injection was al

295 In vivo efficacy of 14 following oral administration was demonstrated in D54 glioma and A

296 estive tract and must be stabilized to allow oral administration, which can be accomplished by nanoen

297 NEFA) pool predicts brain uptake of DHA upon oral administration, which enters the plasma NEFA pool a

298 cular tissue distribution and efficacy after oral administration while minimizing systemic exposure.

299 e in acute toxicity experiment in rats after oral administration with LD50 exceeding 2000 mg/kg of bo

300 observations, evaluated whether simultaneous oral administration with the novel CDA inhibitor cedazur