ライフサイエンスコーパス: orally

1 ly or intravenously and dexamethasone (20 mg orally).

2 measured with 6 cognitive tests administered orally.

3 proved, compared to parent drug administered orally.

4 glitazone (30 mg/kg weight) was administered orally 1.5 h before and 2 h after the initiation of isch

5 Ivosidenib was administered orally (100 mg twice daily to 1,200 mg once daily) in co

6 and reconvalescent serum cannot be delivered orally(2,3), making them poorly suitable for transmissio

7 ical doses of FTC/TAF (n = 6) or TAF (n = 9) orally 24 hours before and 2 hours after each weekly vir

8 When given orally, 3d was mainly found to locate in the liver and l

9 loading dose of 1000 mg pexidartinib per day orally (400 mg morning; 600 mg evening) for the first 2

10 Ibrutinib was given orally (420 mg/day) for 7 days, then up to six 28-day cy

11 s with at least one allergic parent received orally a bacterial lysate consisting of heat-killed Gram

12 ination of four basic deformations: bending (orally, aborally; inward, outward), torsion (clockwise,

13 The early replication of some orally-acquired prion strains upon stromal-derived folli

14 In vivo delivery of an orally active inhibitor of C5aR1 (PMX53) reversed the ph

15 AR-42 is an orally active inhibitor of histone deacetylases (HDACs)

16 Here we show that an orally active inhibitor of p53-MDM2 interaction, DS-5272

17 Treatment with midostaurin, an orally active multikinase/KIT inhibitor now approved for

18 Administering an orally active p38 inhibitor to elderly individuals rescu

19 AL-794 is an orally active prodrug of ALS-033719, which selectively i

20 Here, we report the discovery of an orally active small-molecule inhibitor (termed CB-103) o

21 an investigational new drug for IBD that is orally active, gut restricted, and targets the lanthioni

22 NX-13 is an orally active, gut-restricted novel drug candidate that

23 n the dosimetry and potential suitability of orally administered (18)F-FDG as an alternative to intra

24 Results: Blood uptake after orally administered (18)F-FDG peaked at 45-50 min after

25 Orally administered [(11)C]biotin was rapidly absorbed i

26 his study describes point-of-sale prices for orally administered anticancer drugs offered through Med

27 Atabecestat is an orally administered BACE inhibitor developed to treat Al

28 ribaxamase (SYN-004) is an orally administered beta-lactamase that was designed to

29 Verubecestat is an orally administered beta-site amyloid precursor protein-

30 2019; 26:145-158) shows that an orally administered cellular prion protein antagonist ca

31 tients were randomly assigned 1:1 to receive orally administered daily deferiprone (75-100 mg/kg per

32 ms which can influence the biodisposition of orally administered drugs.

33 In mouse models of RA and SLE, orally administered evobrutinib displayed robust efficac

34 and potentially incomplete absorption of the orally administered fructose load.

35 9 SOT recipients at our center who received orally administered human immunoglobulin for norovirus e

36 fects of RBX7455, a room temperature-stable, orally administered investigational live biotherapeutic.

37 We aimed to test the efficacy and safety of orally administered low-dose azithromycin prophylaxis in

38 l intestinal adsorbents (enterosorbents) are orally administered materials which pass through the gut

39 This study assessed orally administered monosodium glutamate (MSG) as a pote

40 Conclusion: Orally administered MSG significantly decreased salivary

41 annel organ chips-predicts PK parameters for orally administered nicotine (using gut, liver and kidne

42 ate the clinical and immunological impact of orally administered omega-3 PUFA and ASA as adjuncts to

43 ts the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epit

44 Bile acid sequestrants are orally administered polymers that bind bile acids in the

45 fe, and mean residence time in comparison to orally administered sildenafil citrate of the same dose.

46 can be evaluated using RBC incorporation of orally administered stable iron isotope.

47 serum, making them of particular interest as orally administered therapeutic agents.

48 The adjuvant-free vaccine candidates were orally administered to mice and generated a humoral immu

49 Hydroxychloroquine (HCQ), an orally administered Toll-like receptor antagonist widely

50 ugh these immunomodulating therapies are all orally administered, and thus convenient for patients, t

51 Mavacamten, an orally administered, small-molecule modulator of cardiac

52 Atogepant is an orally administered, small-molecule, calcitonin gene-rel

53 Orally-administered vancomycin is the drug of choice to

54 Consistent with our expectations, orally administrated 6-S-NL exhibits a superior anti-inf

55 2 h after the initiation of ischemia and was orally administrated daily to mice from day 0-21.

56 The peptide was orally administrated to mice that were then IgE-sensitiz

57 r 5-day adaption, piglets (n = 8/group) were orally administrated with either sterile saline or PEDV

58 Synthetic miR-30d given orally ameliorates EAE through expansion of regulatory T

59 tial sorafenib dose was 400 mg twice per day orally, amended to 400 mg daily.

60 ily orally plus prednisone (5 mg) once daily orally and ADT (abiraterone acetate plus prednisone grou

61 All drugs were administered orally and doses varied by drug combination and site.

62 anut or placebo (oat) flour was administered orally and participants and the study team were masked t

63 All interventions were administered orally and were given for 3 months after discharge from

64 e twice daily for 2 years doxycycline 100 mg orally (as capsules) (n = 133) or placebo (n = 128).

65 olimus was started 3 days before HSCT, taken orally at 2 mg once daily and adjusted to maintain troug

66 dose escalation, ivosidenib was administered orally at 200-1200 mg daily in 28-day cycles in a standa

67 Lenalidomide was administered orally at a dose of 25 mg on days 1 to 21 of a 28-day cy

68 Ibrutinib was administered orally at a dose of 560 and 420 mg once daily in 46% and

69 re intensity per month to receive rimegepant orally at a dose of 75 mg or matching placebo for the tr

70 itive solid tumours who received entrectinib orally at a dose of at least 600 mg once per day in a ca

71 d to the ruxolitinib group received the drug orally at a starting dose of 10 mg twice a day.

72 ered clinical trial; however, small-molecule orally available antiviral drugs have yet to be develope

73 e discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344, which exhibi

74 itors may help accelerate the development of orally available broad-spectrum antiviral drugs to stop

75 re we report the identification of MSA-2, an orally available non-nucleotide human STING agonist.

76 ted whether administration of cipemastat, an orally available potent inhibitor of MMP-7, could reduce

77 Thus, an orally available SCD inhibitor potently ameliorates PD p

78 n and optimization of a new series of potent orally available SERDs, which led to the discovery of 6-

79 neered to bind to hRBP4 when loaded with the orally available small molecule A1120.

80 Domatinostat, an orally available small-molecule inhibitor targeting hist

81 to the discovery of compound BAY 1214784, an orally available, potent, and selective hGnRH-R antagoni

82 ration of recombinant glucocerebrosidase and orally-available glucosylceramide synthase inhibitors.

83 f potent type I inhibitors of ALK2 which are orally bio-available and brain-penetrant.

84 Herein, we report the discovery of a new, orally bioavailable and CNS-penetrant metabotropic gluta

85 Orally bioavailable and peripherally selective compounds

86 eries culminating in the discovery of 12, an orally bioavailable and selective FD inhibitor.

87 It is orally bioavailable and showed good brain penetration in

88 The ester prodrug of ETX1317, ETX0282, is orally bioavailable and, in combination with cefpodoxime

89 esulted in the development of two potent and orally bioavailable anti-fibrotic agents that were capab

90 DNA hypomethylating compound, is not readily orally bioavailable because of rapid clearance by cytidi

91 scaffold hopping to discover a new class of orally bioavailable BRD4-selective inhibitors.

92 We have recently reported two classes of orally bioavailable C-glycosidic inhibitors of the Pseud

93 he discovery of these potent, selective, and orally bioavailable CCR4 antagonists, and their activity

94 P-5244 (35) proved to be a highly potent and orally bioavailable CD73 inhibitor.

95 sosomes from mice treated with either of two orally bioavailable class I PI3K inhibitors, pictilisib

96 hibition of Complex I, using IACS-010759, an orally bioavailable Complex I inhibitor in clinical tria

97 an core led to the identification of potent, orally bioavailable compound 19.

98 e discovered a potent, highly selective, and orally bioavailable CSF1R inhibitor, IACS-9439 (1).

99 Reported here is a novel, orally bioavailable diazabicyclooctane (DBO) beta-lactam

100 hit 8 to a potent, metabolically stable, and orally bioavailable diazaspirononane OGA inhibitor (+)-5

101 risingly permeable, comparable to many known orally bioavailable drugs.

102 nd preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demet

103 ring animals with Telaglenastat (CB-839), an orally bioavailable GLS inhibitor, successfully inhibits

104 and selective FXIa inhibitors which are also orally bioavailable has been a challenge.

105 cell lines, CB-839, a potent, selective, and orally bioavailable inhibitor of GLS, suppressed cell pr

106 development of MI-3454, a highly potent and orally bioavailable inhibitor of the menin-MLL1 interact

107 r efforts to identify potent, selective, and orally bioavailable inhibitors of FXIa.

108 overy and optimization of a class of potent, orally bioavailable inhibitors of glucose transporters,

109 he prominent role of FB in the AP, selective orally bioavailable inhibitors, beyond our own efforts,

110 Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 with good an

111 f aminomethylenethiophenes (AMTs) as potent, orally bioavailable LOX/LOXL2 inhibitors, we report here

112 A new orally bioavailable Menin-MLL inhibitor (VTP-50469) appe

113 series of quinolinones to provide potent and orally bioavailable mIDH1 inhibitors with selectivity ov

114 ead to tail, like the membrane permeable and orally bioavailable natural product cyclosporine A.

115 he authors assessed the effects of the first orally bioavailable Npt2a inhibitor (Npt2a-I) PF-0686920

116 led optimization to a potent, selective, and orally bioavailable PAR4 antagonist, UDM-001651.

117 w P1 groups, led to the discovery of potent, orally bioavailable pyridine-based macrocyclic FXIa inhi

118 ng in the identification of JNJ-53718678, an orally bioavailable RSV inhibitor that was shown to be e

119 nce supporting a pathophysiological role, no orally bioavailable selective TRPC6 inhibitor has yet be

120 tes mellitus (T2DM) motivated our search for orally bioavailable small molecules that can activate th

121 volving an iv-dosed TTK/CLK2 inhibitor to an orally bioavailable TTK inhibitor is described.

122 on of a new series of potent, selective, and orally bioavailable TTK inhibitors.

123 compound 41, a highly potent, selective, and orally bioavailable USP7 inhibitor.

124 ch to develop a series of potent, selective, orally bioavailable, and brain-penetrant ALK2 inhibitors

125 ll tolerated (selectivity index > 7,111) and orally bioavailable, and provided complete protection ag

126 mization leading to GDC-0339 (16), a potent, orally bioavailable, and well tolerated pan-Pim kinase i

127 ead compounds to identify FT-2102, a potent, orally bioavailable, brain penetrant, and selective mIDH

128 identified mitochondrial uncoupler BAM15 is orally bioavailable, increases nutrient oxidation, and d

129 armacokinetics, prompting the development of orally bioavailable, nonsteroidal SERDs, currently in cl

130 Orally bioavailable, potent, and reversible MetAP-2 inhi

131 equired information about which drugs, taken orally, can be detected via the skin.

132 Larotrectinib was administered orally (capsule or liquid formulation), on a continuous

133 Gnotobiotic piglets were orally challenged with C hominis oocysts, and oral treat

134 coated microneedles or not treated, and then orally challenged with PE.

135 once daily on days 1-5 of each 21-day cycle orally (CHP), plus either rituximab 375 mg/m(2) intraven

136 rions directly into the CNS and subsequently orally co-infected with T. muris before the onset of cli

137 f cutaneously-derived 25(OH)D(3,) but not of orally consumed 25(OH)D(2), differed between breeds.

138 nse system, to receive letrozole (2.5 mg/day orally, continuously) with either 4 mg of oral taselisib

139 Participants were given atrasentan 0.75 mg orally daily during an enrichment period before random g

140 ule) in combination with lenalidomide (15 mg orally daily for 18 weeks).

141 Ivosidenib was administered orally daily in 28-day cycles.

142 randomly assigned to receive afatinib 40 mg orally daily plus cetuximab 500 mg/m(2) intravenously ev

143 dnisone twice daily) or enzalutamide (160 mg orally daily).

144 ved one capsule (sertraline 50 mg or placebo orally) daily for one week then two capsules daily for u

145 e-nab-paclitaxel along-with ATRA (45 mg/m(2) orally, days 1-15/cycle).

146 tions, the device can serve as a platform to orally deliver therapeutic doses of macromolecule drugs.

147 We have developed an orally deliverable, effective Xe formulation for long-te

148 y has potential to reduce adverse effects of orally delivered antimicrobials, but has potential for o

149 Orally delivered Chlamydia muridarum can reach the colon

150 y of insulin and exenatide, with 10 U kg(-1) orally delivered insulin sustaining hypoglycaemia for a

151 s substantial interest in the development of orally delivered non-peptide drugs.

152 We report that orally delivered OVA rapidly disseminates through the bl

153 t TYK2 inhibitors have great potential as an orally delivered therapeutic for SpA.

154 Compared to injection-administered bacteria, orally-delivered bacteria improve patient compliance whi

155 intestinal expansion to high densities of an orally-delivered Listeria monocytogenes strain carrying

156 PBMCs taken from ASD patients in response to orally-delivered sulforaphane.

157 quality attribute for a tablet classed as an Orally Disintegrating Tablet (ODT).

158 ine, a single 75 mg dose of rimegepant in an orally disintegrating tablet formulation was more effect

159 At 2 h postdose, rimegepant orally disintegrating tablet was superior to placebo for

160 ndomly assigned to receive rimegepant (75 mg orally disintegrating tablet) or placebo and instructed

161 Yet, a significant amount of the orally dosed compound is eliminated in the feces, and a

162 tially useful in enhancing the absorption of orally dosed compounds from drug delivery systems that g

163 Thus, NEC-stressed (N-S) rat pups were orally dosed with breastmilk components lysozyme (N-S-LY

164 heterozygous (G(96)/S(96)) white-tailed deer orally dosed with CWD from homozygous (G(96)/G(96)) deer

165 Adult male Japanese quail were orally dosed with wheat seeds coated with an imidaclopri

166 n the parent compound, LQZ-7, and when given orally effectively inhibits xenograft tumor growth and i

167 series of cyclopropylthiazines as potent and orally efficacious BACE1 inhibitors.

168 led to the identification of SHP394 (1), an orally efficacious inhibitor of SHP2, with high lipophil

169 We previously reported the development of an orally efficacious ribonucleoside analogue inhibitor of

170 can-4-amine (1), a highly potent, selective, orally efficacious, and first-in-class SHP2 inhibitor cu

171 mg and ivacaftor 188 mg (bodyweight >=14 kg) orally every 12 h for 15 days in part A (to assess pharm

172 ry, blinded switch to delafloxacin at 450 mg orally every 12 hours.

173 lus ibuprofen 200 mg (n = 140; HS-PCM + IBU) orally every 6 hours for 24 hours postoperatively, start

174 electrospinning technique for the purpose of orally fast-dissolving antioxidant food supplement.

175 lication rate compared to patients that were orally fasted.

176 0 mg once daily on days 1 to 5 of each cycle orally, followed by either brentuximab vedotin 1.8 mg/kg

177 s were administered diethylnitrosamine (DEN) orally for 12 weeks to induce hepatic fibrosis.

178 Venetoclax was administered orally for 14 days each cycle.

179 received firibastat for 8 weeks (250 mg BID orally for 2 weeks, then 500 mg BID if automated office

180 0 mg/kg/day + sulfamethoxazole 50 mg/kg/day) orally for 7 days for UFI treatment in Nepal.

181 oses, we found that 3 mg of TAM administered orally for five consecutive days provides maximal report

182 um antibiotics intravenously for 10 days and orally for the remainder, for a total of 6 weeks.

183 g per day orally or anastrozole 1 mg per day orally) for 14 days before and following surgery or no P

184 luate the effect of bacterial lysate applied orally from the second until seventh months of life on t

185 nter the brain was revealed by appearance of orally gavaged [(125)I]-labeled and antibody-probed milk

186 metabolome rhythmicity in male C57BL/6 mice orally gavaged with 2,3,7,8-tetrachlorodibenzo-p-dioxin

187 Mice were fed high-fat (HF) diet and orally given arctigenin at 50 mg/kg body weight daily or

188 loped chronic liver inflammation and tumors, orally given aspirin and clopidogrel or the anti-inflamm

189 Mice were then orally given the multiple tyrosine inhibitor nintedanib

190 Synthetic human alpha-defensin 5 (HD5) was orally given to alcohol-fed mice to test the therapeutic

191 Male Wistar rats received orally: Group 1) Low aluminum level (AlCl(3) at a dose o

192 r, for flow cytometry, were systemically and orally healthy.

193 ded phase II dose: venetoclax 600 mg per day orally in 28-day cycles, with LDAC (20 mg/m(2) per day)

194 , or 10.0 mug), or placebo were administered orally in two doses 2 weeks apart.

195 Both drugs were administered orally, in tablet formulation.

196 eptide (I10) or the complete GALNS enzyme to orally induce tolerance to GALNS prior to ERT resulted i

197 Orally induced anaphylaxis in CC027/GeniUnc mice was cor

198 To examine viral population dynamics in orally infected mice, we produced over 100 CVB3 clones h

199 e, newly molted 5th-instar T. ni larvae were orally infected with AcMNPV occlusion bodies and the tra

200 Rats were orally infected with Blastocystis subtype 4 (ST4) cysts,

201 The brains of mice orally infected with P. gingivalis show evidence of P. g

202 transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila.

203 Here, we used infant rhesus macaques orally infected with simian/human immunodeficiency virus

204 All pigs were orally infused D-xylose (0.1 g/kg BW) on day 5 post PEDV

205 Participants orally ingested approximately 350 mL of water, and had a

206 Maternal RBC iron incorporation of an orally ingested tracer underestimated true maternal iron

207 An orally-ingested lethal dose of APAP appears to be a huma

208 Boldine, administered orally, inhibited the alveolar bone resorption and modul

209 Surprisingly, orally inoculated Chlamydia sp. deficient in only plasmi

210 Surprisingly, orally inoculated CVB3 was detectable in pancreas and li

211 Furthermore, we orally inoculated five groups of 5-day-old gnotobiotic p

212 We found that orally inoculated Listeria monocytogenes, a bacterial fo

213 In orally inoculated mice, M132V had a slight fitness cost

214 Nevertheless, orally inoculated plasmid-free Chlamydia sp. was still a

215 When administrated orally, it shows a considerably high plasma exposure (ar

216 received placebo and 0.2 mg/kg of psilocybin orally on 2 different test days.

217 Palbociclib 125 mg/d was administered orally on a 21-days-on, 7-days-off schedule.

218 hesus macaques received 3.9 mg/kg of MK-8591 orally on day 0 and once weekly for the next 14 weeks.

219 Patients received 60 mg selinexor orally on days 1 and 3 weekly until disease progression

220 mg orally on days 1-21; dexamethasone 12 mg orally on days 1, 18, and 15 every 28 days) until diseas

221 11 every 21 days), and dexamethasone (20 mg orally on days 1, 2, 4, 5, 8, 9, 11, and 12 every 21 day

222 omparing eight cycles of lenalidomide (25 mg orally on days 1-14 every 21 days), bortezomib (1.3 mg/m

223 sly on days 1, 8, and 15; lenalidomide 15 mg orally on days 1-21; dexamethasone 12 mg orally on days

224 atus of 2 or less, and were given umbralisib orally once daily (400 mg, 600 mg, or 800 mg) and ibruti

225 ly (400 mg, 600 mg, or 800 mg) and ibrutinib orally once daily (420 mg for chronic lymphocytic leukae

226 Umbralisib was given orally once daily at 800 or 1200 mg (initial formulation

227 n = 56), 30 mg (n = 56), or placebo (n = 28) orally once daily for 24 weeks.

228 nib 150 mg versus matching placebo was taken orally once daily for 26 weeks followed by nilotinib 300

229 y twice daily or 50 mg sunitinib monotherapy orally once daily for 4 weeks per 6-week cycle.

230 revir/pibrentasvir (300 mg/120 mg) was given orally once daily for 8 weeks (for patients without cirr

231 ults 60 mg, children [<16 years] 40 mg/m(2)) orally once daily in 28-day cycles until disease progres

232 Patients received cabozantinib 60 mg orally once daily in 28-day cycles until disease progres

233 ock size of four) to either tivozanib 1.5 mg orally once daily in 4-week cycles or sorafenib 400 mg o

234 OATD-01 given orally once daily in a range of doses between 30 and 100

235 All patients received 225 mg ensartinib orally once daily on a continuous dosing schedule.

236 rmulated capsules in 3.0 mg and 4.0 mg doses orally once daily on days 1-5 followed by 2 days off (5-

237 mulating factor) versus abiraterone (1000 mg orally once daily plus 5 mg prednisone twice daily) or e

238 0 mg orally twice daily plus trametinib 2 mg orally once daily versus two matched placebos.

239 ystem) to quizartinib (60 mg [30 mg lead-in] orally once daily) or investigator's choice of preselect

240 in a 2:1 ratio, to receive relugolix (120 mg orally once daily) or leuprolide (injections every 3 mon

241 OCA (25 mg orally once daily) was better than placebo in improving

242 All patients received 5 mg of folic acid orally once daily.

243 escalation, participants received venetoclax orally once per day in continuous 28-day cycles at eithe

244 ved entrectinib at a dose of at least 600 mg orally once per day, with at least 12 months' follow-up.

245 venously) every 2 weeks; or sunitinib (50 mg orally) once daily for 4 weeks (6-week cycle).

246 ized to an FAAH inhibitor (PF-04457845, 4 mg orally, once daily; n = 16) or placebo (n = 29) for 10 d

247 gned (2:1) to POAI (letrozole 2.5 mg per day orally or anastrozole 1 mg per day orally) for 14 days b

248 Twenty one Wistar rats were given omeprazole orally or intravenously for 30 days, and caerulein as a

249 toxify chemicals and metabolite administered orally or intravenously.

250 enic when administered to BALB/c mice either orally or subcutaneously.

251 Sertraline was administered orally or via nasogastric tube at a dose of 400 mg/day f

252 three to receive venetoclax (800 mg per day orally) or placebo with bortezomib (1.3 mg/m(2) subcutan

253 o intensified regimens including 750-1350 mg orally, or a 600-mg intravenous infusion.

254 tudy and received ezogabine up to 900 mg/day orally over the course of 10 weeks.

255 A fraction of phytochemicals consumed orally passes through the gut lumen, where it modulates

256 andom assignment was 1:1 to gefitinib 250 mg orally per day (Gef) or gefitinib 250 mg orally per day

257 mg orally per day (Gef) or gefitinib 250 mg orally per day plus pemetrexed 500 mg/m(2) and carboplat

258 Patients took lenvatinib 20 mg once daily orally plus pembrolizumab 200 mg intravenously once ever

259 ive abiraterone acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT

260 Fifty-two percent of educators orally recommended transplant to patients, 31% had in-ce

261 ng to a larger extent than when administered orally shortly after reperfusion.

262 y aGVHD were eligible to receive ruxolitinib orally, starting at 5 mg twice daily plus corticosteroid

263 15 mg/kg of mycophenolate mofetil was given orally three times daily from day 0 until day 30, then t

264 Following treatment, mice were challenged orally to cashew and anaphylactic symptoms, as well as p

265 Furthermore, when administered orally to mice, ex vivo imaging of rhodamine-loaded chit

266 icrosomes and efficacious in rats when given orally to suppress rat paw inflammation, macrophage and

267 vailable, ranging from small molecules taken orally, to injectable therapies.

268 ntibodies, which may be dosed intravenously, orally, topically, or by other routes of administration.

269 The interviews were orally translated, transcribed, entered into Dedoose sof

270 nously treated group and in 18 (9.0%) in the orally treated group (between-group difference, 3.1 perc

271 If feasible, patients in the orally treated group were discharged to outpatient treat

272 ice with ligature-induced periodontitis were orally treated with boldine (10/20/40 mg/kg) for 15 cons

273 n prevent T1D onset, groups of NOD mice were orally treated with Lactococcus lactis (LL) expressing C

274 ozotocin-induced diabetic rats and mice were orally treated with PPARalpha agonist fenofibrate.

275 idine (45, 67.5, 90, or 112.5 mg) or placebo orally twice a day for 52 weeks.

276 Patients received olaparib 300 mg orally twice a day until progression.

277 domized (1:1) to receive apabetalone, 100 mg orally twice daily (n = 1215), or matching placebo (n =

278 lead-in cohort and were given axitinib 5 mg orally twice daily and pembrolizumab 200 mg intravenousl

279 ose escalation, rogaratinib was administered orally twice daily at 50-800 mg in continuous 21-day cyc

280 e daily in 4-week cycles or sorafenib 400 mg orally twice daily continuously.

281 ents received 300 mg olaparib in tablet form orally twice daily for 4 weeks and thereafter a combinat

282 Patients were instructed to take the product orally twice daily for six months.

283 ethotrexate, and maraviroc (maraviroc 300 mg orally twice daily from day -3 to day 30 after HCT).

284 her capivasertib 400 mg or matching placebo, orally twice daily on an intermittent weekly schedule of

285 weeks for up to 35 cycles plus 5 mg axitinib orally twice daily or 50 mg sunitinib monotherapy orally

286 esponse system to receive epacadostat 100 mg orally twice daily plus pembrolizumab 200 mg intravenous

287 d, phase 3 trial comparing dabrafenib 150 mg orally twice daily plus trametinib 2 mg orally once dail

288 , 5.0 mg/kg of cyclosporine was administered orally twice daily starting 3 days before HSCT, and (in

289 Patients were treated with AZD4547, 80 mg orally twice daily until progression of disease or drug

290 ycles combined with either veliparib (120 mg orally twice daily, on days -2 to 5) or matching placebo

291 o receive 150 mg of nintedanib, administered orally twice daily, or placebo.

292 Patients received 800 mg tazemetostat orally twice per day in continuous 28-day cycles until d

293 Patients received 800 mg of tazemetostat orally twice per day in continuous 28-day cycles.

294 m A, and arm A also received veliparib 80 mg orally twice per day on days 1 to 12 cycled every 3 week

295 lopram/citalopram and diphenhydramine, taken orally, were detected in forehead, nasolabial, and hand

296 on (dpi), all surviving pigs were challenged orally with a high dose of icPC22A.

297 In Sprague-Dawley rats treated orally with DEP from birth to adulthood, we identified a

298 nsive-Heart-Failure (SHHF) rats were treated orally with either water (control) or TMAO.

299 aner in comparison to permethrin at 48 h and orally with fluralaner in comparison to imidacloprid at

300 d-type and P2rx7 knockout mice were infected orally with T. gondii and their pathologic profiles were