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1 hey resulted from activation of postsynaptic orexin receptors.
2 ulin contain OXA and both cell types express orexin receptors.
3 like immunoreactivity and express functional orexin receptors.
4 ior, as well as transcription of hippocampal orexin receptors.
5 rexin receptor 2 (HcrtR2/OX(2)R) or the Hcrt/orexin receptor 1 (HcrtR1/OX(1)R) but not to Kirsten mur
6 duced drug-seeking behavior is attenuated by orexin receptor 1 (OX(1)R) antagonists.
7  in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor
8 significantly reduced in the presence of the orexin receptor 1 (OX1R) antagonist SB334867A at concent
9                   C57BL/6J mice received the orexin receptor 1 (Ox1r) antagonist, SB-334867, prior to
10 locus coeruleus, an area that also expresses orexin receptor 1 (OX1R) messenger RNA (mRNA).
11                          Finally, we blocked orexin receptor 1 signaling in the mPFC and showed that
12 sed gene and protein expression of orexin A, orexin receptor 1, and orexin receptor 2 in the hypothal
13  hypothalamic neurons expressed orexin A and orexin receptor 1.
14                         We hypothesized that orexin receptor-1 (OX(1)R) in the retrotrapezoid nucleus
15 n of lateral hypothalamic orexin neurons and orexin receptor-1 signaling in the mesolimbic dopamine s
16 nese hamster ovary cells containing the Hcrt/orexin receptor 2 (HcrtR2/OX(2)R) or the Hcrt/orexin rec
17                              Agonists of the orexin receptor 2 (OX(2)R) have shown promise as novel t
18                         While the effects of orexin receptor 2 (OX2R) agonists have been explored on
19                    Clinical trials show that orexin receptor 2 (OX2R) agonists substantially improve
20 on histochemistry to map the distribution of orexin receptor 2 (OX2R) mRNA within the rat brainstem.
21 ng neurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) and that activation of these GA
22        Furthermore, both genetic ablation of orexin receptor 2 and lemborexant treatment reduced wake
23 prolactin receptor expression in females and orexin receptor 2 expression in males.
24  responses, increased prolactin receptor and orexin receptor 2 expression was observed in female and
25 reas of the brain, while the mutation of the orexin receptor 2 gene has been implicated in canine nar
26 pression of orexin A, orexin receptor 1, and orexin receptor 2 in the hypothalamic paraventricular nu
27 y is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2).
28  antagonistic activities against hypocretin (orexin) receptor 2.
29 llele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have im
30    Exon skipping mutations of the Hypocretin/Orexin-receptor-2 (Hcrtr2) gene were identified as the c
31                                              Orexin receptor agonists would be of potential value for
32 psychotics, first-generation H1 antagonists, orexin receptor agonists, melatonin, and melatonin recep
33              It has been proposed that OX(1) orexin receptors and CB(1) cannabinoid receptors can for
34 say and western blot measurement of orexins, orexin receptors and CRH in multiple brain regions.
35 that this effect is signaled by postsynaptic orexin receptors and expressed presynaptically, presumab
36 lly distinct subset of ARC neurons coexpress orexin receptors and glutamate decarboxylase-67 and are
37 e explore the connection between hippocampal orexin receptors and learning during stress.
38  accumbens shell (AccSh) and the presence of orexin receptors and varicosities within the AccSh, we h
39  therapeutic potential of targeting sleep by orexin receptor antagonism to prevent abnormal tau phosp
40 ss species, similarly to that seen with dual orexin receptor antagonism.
41 t our discovery efforts starting from a dual orexin receptor antagonist and describe a serendipitous
42 triction significantly increased, and a dual orexin receptor antagonist decreased, Abeta plaque forma
43 roval of suvorexant as a first-in-class dual orexin receptor antagonist for the treatment of insomnia
44                             Suvorexant is an orexin receptor antagonist for treatment of insomnia.
45                               Conversely, an orexin receptor antagonist inhibits food consumption.
46 rvation in a tauopathy model; and (4) a dual orexin receptor antagonist is capable of restoring sever
47 okinetics in a leading HTS-derived diazepane orexin receptor antagonist led to the identification of
48  demonstrate that administration of the dual orexin receptor antagonist lemborexant in the P301S/E4 m
49                   Suvorexant (MK-4305) is an orexin receptor antagonist shown to be efficacious for i
50                             The nonselective orexin receptor antagonist suvorexant has been the first
51 xazole to provide 3 (MK-4305), a potent dual orexin receptor antagonist that is currently being teste
52           This study examined whether a dual-orexin receptor antagonist would improve sleep and withd
53 elective antagonist R715 but not by the dual orexin receptor antagonist, ACT 462206, suggesting that
54 ors using an orally administered potent dual orexin receptor antagonist, almorexant, in SHRs and norm
55 ) Antagonism of orexin receptors with a dual orexin receptor antagonist, almorexant, normalizes the a
56 ral locations by an orally administered dual orexin receptor antagonist, almorexant, will substantial
57 safety and efficacy of daridorexant, a novel orexin receptor antagonist, on night-time and daytime sy
58                  Suvorexant, a dual (OX1/2R) orexin receptor antagonist, reduced cocaine-evoked prema
59 usion, but decreased with infusion of a dual orexin receptor antagonist.
60                                         Dual orexin receptor antagonists (DORAs) are known to promote
61                                         Dual orexin receptor antagonists (DORAs) induce sleep by bloc
62                                 In contrast, orexin receptor antagonists (ROR, 0.81 [95% CI, 0.61 to
63 gulation and neurobiologic pathways, such as orexin receptor antagonists and melatonin receptor agoni
64                     Currently available dual orexin receptor antagonists have shown efficacy in insom
65 iral alpha-hydroxyl amide metabolites of two orexin receptor antagonists, MK-8133 and MK-6096, as rev
66 cies higher than the range observed for dual orexin receptor antagonists.
67 etic nerve activity, which can be blocked by orexin receptor antagonists.
68 y neuropeptides orexins A and B by design of orexin receptor antagonists.
69 ults directly show, for the first time, that orexin receptors are able to generate potent endocannabi
70                                              Orexin receptors are G protein coupled receptors that ma
71                                          The orexin receptors are peptide-sensing G protein-coupled r
72           Importantly, intra-VTA blockade of orexin receptors attenuated food intake induced by LV gh
73  unsuspected mechanism by which postsynaptic orexin receptors can modulate glutamatergic synaptic tra
74                                  Blockade of orexin receptors can normalize the augmented CO2 chemore
75 on of Agrp neurons increases avoidance in an orexin receptor-dependent manner.
76                                     However, orexin receptor-expressing cells somehow override the HI
77 stigated the relationship between orexin and orexin receptor expression in specific brain regions ass
78 t the brain, but a systematic examination of orexin receptor expression in the brain has not appeared
79        We found that targeted restoration of orexin receptor expression in the dorsal raphe (DR) and
80 number of serotonergic neurons restored with orexin receptor expression in the DR, while the consolid
81                                     Blocking orexin receptors had no effect on blood pressure and sym
82                 Expression of the hypocretin/orexin receptor HCRTR2, which has been implicated in nar
83 leep features and brain levels of orexin and orexin receptors in adult rats neonatally subjected to e
84 halamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory.
85                         Finally, blockade of orexin receptors in the RVLM abolished the increase in A
86  in the locus coeruleus (LC) of mice lacking orexin receptors inhibited cataplexy-like episodes and p
87 s of narcolepsy and cataplexy; inhibition of orexin receptors is an effective therapy for insomnia.
88             The differential distribution of orexin receptors is consistent with the proposed multifa
89  rostral ventrolateral medulla, and blocking orexin receptors markedly lowered blood pressure (from 1
90  contrast, was involved in the activation of orexin receptor-operated Ca(2+) influx.
91 phanin FQ opioid receptor (NOP), MCHR1, both orexin receptors (ORX), somatostatin receptors 1 and 2 (
92 a positive correlation with amygdalar Type I orexin receptor (Orx1) mRNA and depressive behavior.
93 in-releasing hormone receptor (TRHR1) or the Orexin receptor (Orx1R), agonist stimulation induced rob
94                                    The OX(2) orexin receptor (OX(2)R) is a highly expressed G protein
95  that acute and selective inhibition of both orexin receptors (OX(1)R and OX(2)R) at all central loca
96                                          Two orexin receptors (OX(1)R and OX(2)R) have been identifie
97 innervation and expression of genes encoding orexin receptors (OX1 and OX2) in the mouse SCN, with OX
98 in neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant m
99 instatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 cannabinoid receptors (
100                                         Dual orexin receptor (OXR) antagonists (DORAs) such as almore
101 ffects of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsi
102                         We coupled this with orexin receptor (OxR) blockade with suvorexant (Suvo, 20
103 port that the down-regulation of hippocampal orexin receptors (OXRs) and GPR103 particularly in the c
104  lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotype
105 creased spontaneous meal size via downstream orexin receptor signaling in the laterodorsal tegmental
106              We showed previously that OX(1) orexin receptor stimulation produced a strong (3)H overf
107 nergic neurons in these areas mainly express orexin receptor subtype 1 (Ox1R).
108 them showing selectivity with respect to the orexin receptor subtype 1.
109 in the medial ventral tegmental area express orexin receptor subtype 2 (Ox2R).
110 sed a recently solved X-ray structure of the orexin receptor subtype 2 in computational docking calcu
111                       Orexin fibers and both orexin receptor subtypes are distributed in cholinergic
112  the patterns of expression of mRNA for both orexin receptors throughout the brain.
113               Here we show that signaling at orexin receptor type 1 (OxR1) in the VTA is required for
114                                 Here we show orexin receptor type 1 and 2 are predominantly expressed
115                              Inactivation of orexin receptor type 1 in serotonin transporter-expressi
116 otonergic neurons critical, yet differential orexin receptor type 1- and 2-dependent functions in the
117 cleus and raphe pallidus selectively express orexin receptor type 1.
118 ked gene cassette disrupts production of the orexin receptor type 2 (OX2R; also known as HCRTR2), but
119                    Selective inactivation of orexin receptor type 2 improved glucose tolerance and in
120 ypothalamus, operates through two receptors, orexin receptor type-1 (OX(1)) and orexin receptor type-
121 eceptors, orexin receptor type-1 (OX(1)) and orexin receptor type-2 (OX(2)), stabilizing wakefulness,
122 l ventrolateral medulla and antagonized both orexin receptors using an orally administered potent dua
123  that the peptides orexin A and B, acting on orexin receptors, which are GTP-binding-protein coupled,
124                          (iii) Antagonism of orexin receptors with a dual orexin receptor antagonist,

 
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