ライフサイエンスコーパス: organellar

1 structure (vascular, neuronal, cytoskeletal, organellar).

2 ruit, we demonstrate directly the unique sub-organellar accumulation sites of specific carotenoids us

3 show that treatments with drugs diminishing organellar acidification may reduce the inflammatory res

4 However, the individual contribution of organellar acidification to virulence and its associated

5 t of core intracellular functions, including organellar acidification, granule secretion, and microbi

6 The V-ATPase is the main regulator of intra-organellar acidification.

7 lved in maintaining electroneutrality during organellar acidification.

8 Only one of the three eukaryotic organellar ACPs allowed growth.

9 nes to enable high-resolution imaging of sub-organellar actin dynamics.

10 als to the nucleus to coordinate nuclear and organellar activities.

11 lleviate pathological states associated with organellar alkalinization.

12 s that discriminate them from the termini of organellar amino acid transporters.

13 erstanding of molecular mechanisms shared by organellar and bacterial group II introns.

14 organisms requires an effective response to organellar and cellular damage either by repair of such

15 lar ion channels are essential regulators of organellar and cellular function, yet the molecular iden

16 in intracellular homeostasis, sterility, and organellar and cellular functionality.

17 which is accompanied by a more rapid loss of organellar and cytoplasmic proteins.

18 nt model wherein TOPs sustain interconnected organellar and cytosolic pathways that modulate the oxid

19 , including cytoplasmic, nuclear, nucleolar, organellar and endomembrane compartments.

20 pisomes, revealing a potential mechanism for organellar and foreign DNA acquisition.

21 However, translocation in organellar and in vivo demonstrates strong specificity t

22 he membrane-binding motif is conserved among organellar and prokaryotic homologs.

23 Organellar and secretory RNases, associated with differe

24 gh the concerted action of genes in both the organellar and the nuclear genome.

25 at folate polyglutamylation is essential for organellar and whole-plant folate homeostasis.

26 Identified via complementary biochemical, organellar, and cellular approaches, we report that MDM2

27 ing or SNPs within the chromosomally encoded organellar (apicoplast) isoleucyl-tRNA synthetase.

28 Control of organellar assembly and function is critical to eukaryot

29 isoforms in Arabidopsis thaliana [AtPRORP1 (organellar), AtPRORP2 and AtPRORP3 (nuclear)].

30 To determine the organellar basis of this process, we investigated the su

31 trient induces transcriptional repression of organellar biogenesis involving epigenetic alterations.

32 ses play key roles in apicomplexan invasion, organellar biogenesis, and intracellular survival.

33 isms that export drugs or toxins from cells, organellar biogenesis, and mechanisms that protect again

34 A build-up of degradative organellar by-products and decreased recycling of cellul

35 The only known example of non-organellar C to U editing of tRNAs occurs in trypanosoma

36 Regulated increases in cytosolic and organellar Ca(2+) concentrations in lymphocytes control

37 NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP.

38 of how the spatial organization of discrete, organellar Ca(2+) stores may underpin the generation of

39 Mitochondrial morphology regulates organellar Ca(2+) uptake and changes cellular Ca(2+) hom

40 Several types of plasma membrane and organellar Ca(2+)-permeable channels are functional in T

41 fic probes demonstrated that major swings in organellar [Ca(2+)] parallel the changes occurring in th

42 ighlight some of the challenges in observing organellar Ca2+ and the alternative strategies researche

43 structure was revealed nonetheless by their organellar cargo and the grooves they formed indenting M

44 disruption of intracellular transport of key organellar cargo, such as mitochondria.

45 usly expressed in both animals and plants as organellar cation channels.

46 oreover, they show, for the first time, that organellar caveolin-1 significantly affects tissue funct

47 hondrion-intrinsic but results from an inter-organellar circuit initiating and culminating in the mit

48 Organellar clones comprised approximately 10% of each li

49 domains that emerged as a product of nuclear-organellar coevolution.

50 organization, subcellular dynamics and inter-organellar communication during the immune response.

51 Inter-organellar communication in plant-microbe interactions 1

52 Inter-organellar communication is vital for successful innate

53 important platforms for non-vesicular, inter-organellar communication.

54 nate protease domains by sensing pH of their organellar compartments as they transit the secretory pa

55 o reveal the organization of organelles, sub-organellar compartments, protein complexes, functional n

56 d quantitative view of HeLa cell anatomy and organellar composition, at the protein level.

57 ces in our understanding of these remarkable organellar contact sites.

58 ize range between 123 and 161 kb, an average organellar content of 0.4%-4.1% and nonrecombinant conte

59 ranslational modifications, to delineate the organellar control of NLRP3.

60 Maternal organellar cranberry inheritance was inferred by analyzi

61 wding on the micrometer scale, which we term organellar crowding.

62 lace via their sequestration into a specific organellar deposit site we termed intramitochondrial pro

63 and have similar pathological responses and organellar disorders with pancreatitis-causing treatment

64 olarized cells present unique challenges for organellar distribution and dynamics.

65 section of cell biological processes such as organellar division and cell motility, and for the ident

66 several Geranium species containing foreign organellar DNA from diverse eudicots, including many tra

67 It also reduces contamination from organellar DNA in preparations of nuclear DNA.

68 ments demonstrate that the nuclear influx of organellar DNA is a potentially a source of mutation for

69 aTI activity within the Arabidopsis thaliana organellar DNA polymerase gene POLgamma2.

70 eting and sequence alignment features of two organellar DNA polymerase genes from Arabidopsis thalian

71 Zea mays), white2 (w2), encoding a predicted organellar DNA polymerase.

72 Organellar DNA sequences are widely used in evolutionary

73 lear DNA suggests that the genetic impact of organellar DNA transfer to the nucleus is potentially fa

74 mounts of specific repeats and insertions of organellar DNA.

75 , and effectors of the cAMP cascade in these organellar domains remain largely undefined.

76 b cellular morphology, membrane traffic, and organellar dynamics and to trigger cell death.

77 consequence of alterations in molecular and organellar dynamics within the cellular milieu of cardio

78 l interface is central to calcium signaling, organellar dynamics, and lipid biosynthesis.

79 rvous system, including protein importation, organellar dynamics, and programmed cell death.

80 The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails severa

81 sesses only one each of the following likely organellar enzymes: polynucleotide phosphorylase, hydrol

82 ylogenetic reconstructions based on complete organellar exomes and a comparable set of nuclear genes

83 that of MM PCs, associated with distinctive organellar features and expression patterns indicative o

84 heRS enzymes, a cytoplasmic (ctPheRS) and an organellar form.

85 Immunoblot analysis of organellar fractions showed that the location of NCLX is

86 d protein degradation (CHLORAD) is vital for organellar functions and plant development.

87 lity of proteomics in the discovery of novel organellar functions and resulted in 1) a protein profil

88 roles in regulating fundamental cellular and organellar functions including bioenergetics.

89 ding quality control, analogous to the above organellar functions of higher eukaryotes.

90 demonstrated a role for Rab14 in stimulating organellar fusion between phagosomes and early endosomes

91 d gametes that normally undergo the multiple organellar fusions required for the genetic unity of the

92 e found in metazoans and plants and regulate organellar gene expression at different levels.

93 g factors that control almost all aspects of organellar gene expression.

94 on of the 5' region of other nucleus-encoded organellar genes suggests that several genes may incorpo

95 er diversifying selection than autosomal and organellar genes.

96 ng RNA pathway, and extensive RNA editing of organellar genes.

97 t the potential for independent evolution of organellar genes.

98 s are required for the correct expression of organellar genes.

99 Cells that lose their organellar genome ([rho(0)] cells) dramatically induce t

100 ticipate in maintenance or expression of the organellar genome at the inner surface of the inner memb

101 n the mitochondrion and plastid to influence organellar genome behavior and plant growth patterns.

102 nucleic acids, possibly representative of an organellar genome comparable with those described for mi

103 SWIB family members suggests a link between organellar genome maintenance and cell proliferation.

104 MSH1 is a plant-specific protein involved in organellar genome stability in mitochondria and plastids

105 o ceriantharians to see whether the complete organellar genome would provide more support for the phy

106 of which are the largest of any green plant organellar genome.

107 vansi, a form of the latter stage lacking an organellar genome.

108 lacement therapy have roused interest in the organellar genome.

109 The nontarget cytoplast organellar genomes and metabolites are removed by centri

110 Plant organellar genomes are complex compared with their anima

111 Instead, their organellar genomes are generally larger and more intron

112 In most eukaryotes, organellar genomes are transmitted preferentially by the

113 Extant cytoplasmic organellar genomes contain very few genes compared with

114 velopment of transformation technologies for organellar genomes has made it possible to reconstruct t

115 It appears that organellar genomes have already been reduced in free-liv

116 ansfer complexes are consistently encoded by organellar genomes in multicellular organisms, suggestin

117 fects of the endosymbiotic transition on the organellar genomes of eukaryotes.

118 the endosymbiotic lifestyle has affected the organellar genomes of photosynthetic green algae, we gen

119 evidence that the coevolution of nuclear and organellar genomes spurred the evolution of diverse nonc

120 e translocation of genetic material from the organellar genomes to the nucleus.

121 uticosa subgenome of sour cherry, and cherry organellar genomes were targeted with 6942, 2020, and 38

122 rtunity to study possibly ancestral forms of organellar genomes, a unique glimpse into the evolutiona

123 enome assembly includes nuclear (~29 Mb) and organellar genomes, and contains 9,052 gene models.

124 ile group II introns, found in bacterial and organellar genomes, are both catalytic RNAs and retrotra

125 Initially identified in organellar genomes, group II introns are found in bacter

126 and are particularly prevalent within plants organellar genomes.

127 omplexa are known to contain greatly reduced organellar genomes.

128 te to the understanding of gene retention in organellar genomes.

129 ble to correctly perform this task in plants organellar genomes.

130 e sequence repeats in 12 Juglans nuclear and organellar genomes.

131 positive diagnostics, and checks for missing organellar genomes.

132 species and new combinations of nuclear and organellar genomes.

133 olecular function of proteins encoded in the organellar genomes.

134 hough there is no doubt that prokaryotic and organellar group II introns are evolutionary related, th

135 In eukaryotes, these organellar gymnastics are controlled by numerous pathway

136 utophagy genes that function in immunity and organellar homeostasis.

137 ate to the nucleus in response to changes in organellar homeostasis.

138 ern in a diverse subset of 165 bacterial and organellar Hsp70s.

139 t the cellular level, CF is characterized by organellar hyperacidification, which results in altered

140 t2 Therefore, PAPST2 represents an important organellar importer of PAP, providing a piece of the puz

141 s two types of microscopically visible intra-organellar inclusions: a large crystalline lattice of me

142 ystems ensuring maintenance of proteostasis, organellar integrity, function and turnover, and overall

143 e measurement and perturbation of ROS at the organellar interface has proven difficult.

144 sing mechanisms inside organelles and at the organellar interfaces, revealed how Ca(2+) binding might

145 ese cascades, in particular through impaired organellar interfacing, to propose 'subcellular lipidome

146 potential for gene flow to lead to extensive organellar introgression in hybridizing taxa.

147 tterns reflect incomplete lineage sorting or organellar introgression.

148 Splicing of organellar introns requires the activity of numerous nuc

149 eate factors that facilitate the splicing of organellar introns.

150 me complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are t

151 de are discussed and put into the context of organellar ion homeostasis in general.

152 NHE6 and NHE9 are organellar isoforms that can appear transiently on plasm

153 CIT rapidly induced tri-organellar junctions and perturbed intended membrane lip

154 illustrate how a cascade of failures at the organellar level can scale to impact cell and organ leve

155 s, thus allowing an unprecedented measure of organellar lipid heterogeneity and opening new quantitat

156 In addition, the relative organellar localization of Psd1 is dynamically modulated

157 tail of Naa60, which is responsible for the organellar localization.

158 The rate of evolution in organellar loci is slower than for other liverwort linea

159 for Arabidopsis membrane-bound, nuclear, and organellar long coiled-coil proteins.

160 Dynamic Organellar Maps enable the proteome-wide analysis of phy

161 We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global m

162 Through a comprehensive analysis of organellar markers in mouse models of Alzheimer's diseas

163 f many organisms, but the cell signaling and organellar mechanisms underlying this capability are unc

164 member of the Omp85 family of bacterial and organellar membrane insertases, characterized by N-termi

165 d that disruption of basal autophagy impedes organellar membrane lipid turnover and hence fatty acid

166 These findings suggest that the organellar membrane potential may undergo large regulato

167 Cellular and organellar membranes are dynamic materials that underlie

168 uses have the ability to utilize alternative organellar membranes during infection that could increas

169 nknown how localization of Sac1p to distinct organellar membranes is mediated.

170 e phospholipid compositions of the different organellar membranes vary, their surface charges are sim

171 ersible lipidation occurs in both plasma and organellar membranes, and is catalyzed by a family of in

172 or the translocation of many proteins across organellar membranes, presumably by providing energy in

173 cyte 15-lipoxygenase binds and permeabilizes organellar membranes, thereby releasing the lumenal cont

174 e electrostatic properties of the individual organellar membranes.

175 the transport of Cl(-) ions across cell and organellar membranes.

176 s that regulate the association of GGA3 with organellar membranes.

177 e the movement of ions across the plasma and organellar membranes.

178 In vivo methods for interrogating organellar metabolites in specific cell types within mam

179 Concurrently, copper and organellar metal homeostasis genes, which are functional

180 istribution and polymorphisms of nuclear and organellar microsatellites (SSRs) for most Juglans genom

181 Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments

182 their functional integrity and cellular and organellar morphology using light, fluorescence, and ele

183 ese regulations couple metabolic inputs with organellar motility, cellular signaling, and transcripti

184 y with respect to its ambient cytoplasm; but organellar motion will raise that limit as a non-decreas

185 latter suggests a coordinated regulation of organellar multiple site editing through DYW2, which pro

186 Despite limited mitochondrial mass, organellar NAD(P)H is extensive because much of the sign

187 Mitochondria encompass an active organellar network that fuses, divides, and directs a my

188 eolytic systems in Arabidopsis thaliana, the organellar oligopeptidase, OOP (At5g65620).

189 ts expression and is not found in either the organellar or cytoplasmic fractions.

190 In organellar or in vitro reconstitution studies have ident

191 spread in eukaryotes in which it can provide organellar or nuclear RNase P activities.

192 veral independent occasions and recruited as organellar or nucleo-cytoplasmic RNA modifiers, operatin

193 he effects of postendosymbiotic evolution on organellar pathway partitioning.

194 To discover organellar pathways with evolutionary and biomedical sig

195 olic mosaics of ancestral and newly acquired organellar pathways.

196 nd to generate a coexpression network for 97 organellar peptidase baits (1742 genes, making 2544 edge

197 eview provides a systematic insight into the organellar peptidase network in Arabidopsis thaliana We

198 ispensable for many organisms in maintaining organellar pH homeostasis.

199 ly, we report that fertilization also alters organellar pH in a spatio-temporally complex manner.

200 Generation of low organellar pH is primarily driven by the V-ATPases, prot

201 ous PC paralogues are activated at different organellar pH values.

202 ion of their protease domains by sensing the organellar pH within the secretory pathway.

203 somes, plays an important role in regulating organellar pH.

204 Nuclear and organellar phylogenies for B. napus and its progenitors

205 (2)(+) (Ca(2)(+) mito) is needed to maintain organellar physiology, Ca(2)(+) mito overload can lead t

206 teins, in mammals, the mechanism of how this organellar pool is generated has remained obscure.

207 oteins involved in endocytotic recycling and organellar positioning and an apicomplexan family.

208 recognition in vitro, preprotein binding in organellar, precursor binding in vivo, and the recogniti

209 survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and c

210 presequences and the subunit composition of organellar processing peptidases evolved in concert.

211 orhoods defining functional complexes and/or organellar protein compositions.

212 sts of coexpressing in cultured cells (i) an organellar protein fused to the streptavidin-binding pep

213 Saccharomyces cerevisiae suggested that the organellar protein might lack the editing activity.

214 isciplines to retrieve and analyze pertinent organellar protein properties of interest.

215 hondria and the cytosol suggests that either organellar protein synthesis quality control is focused

216 findings change our view of the evolution of organellar protein synthesis.

217 Hsp70 activity and, hence, are essential for organellar protein translocation and folding.

218 an essential role for Magmas and DnaJC19 in organellar protein translocation and mitochondria biogen

219 log of the bacterial RecG translocase, is an organellar protein with multiple roles in mtDNA maintena

220 A significant proportion of nucleus-encoded organellar proteins are dual targeted, and the process b

221 d to occur not only on histones, but also on organellar proteins in plants and animals.

222 anslation, and support membrane targeting of organellar proteins.

223 more constitutively expressed genes encoding organellar proteins.

224 ntified and characterized a component of the organellar proteolytic systems in Arabidopsis thaliana,

225 hloroplast protein import contributes to the organellar proteome changes that occur during plant deve

226 tal cues, enabling dynamic regulation of the organellar proteome, and suggest new approaches for impr

227 During evolution, organellar proteomes are modified by gene gain and loss,

228 Organellar proteomes therefore provide cumulative feedba

229 As a fuzzy organelle, it defies classical organellar proteomics and cannot be described by a singl

230 teomic imaging' as described here integrates organellar proteomics with multiple imaging techniques t

231 nclear how fluctuations in ER calcium impact organellar proteostasis.

232 peroxidase (APEX) that bypasses the need for organellar purification when applied to membrane-bound c

233 gy has emerged as a key cellular process for organellar quality control, yet this pathway apparently

234 nges compared to control can be modulated by organellar Ras signalling.

235 as other peptidase families were exclusively organellar; reasons for such biases are discussed.

236 m multiple samples from any organism with an organellar reference genome (mitochondrial or plastid) a

237 istory from a secondary endosymbiosis, inter-organellar regulation of biochemical activities may be o

238 MNRR1 (CHCHD2) is a bi-organellar regulator of mitochondrial function that dire

239 as a much broader role in biology, including organellar remodeling, protein and organelle quality con

240 cterized recombination factors and extensive organellar remodeling.

241 ecificity being necessary to maintain larger organellar repertoires.

242 he analysis of individual LDs makes possible organellar resolution of molecular compositions and will

243 rmis provide a model system for the study of organellar response to osmotic stress within the context

244 Taken together, this study shows that organellar restructuring during zygotic diploidization d

245 tochondrial and chloroplast ribosomes (i.e., organellar ribosomes).

246 ments from bacterial, archaeal, eukaryal and organellar ribosomes, using nucleotide numbers from repr

247 of eubacterial or eukaryotic (cytoplasmic or organellar) ribosomes to our knowledge.

248 useful for characterizing the specificity of organellar RNA accumulation mutants.

249 nuclear genomes encode hundreds of predicted organellar RNA binding proteins, few of which have been

250 ite recognition and proteins of the multiple organellar RNA editing factor (MORF) family as cofactors

251 The here identified family of multiple organellar RNA editing factor (MORF) proteins provides a

252 ain RNA editing interacting protein/multiple organellar RNA editing factor (RIP/MORF) boxes, which ar

253 ting by physically interacting with MULTIPLE ORGANELLAR RNA EDITING FACTOR 2 (MORF2).

254 The MEF10 protein interacts with multiple organellar RNA editing factor 8 (MORF8) but not with oth

255 >U plant organellar RNA editing is required for the translation o

256 or which are amplified in plant species with organellar RNA editing.

257 A prominent enzyme in organellar RNA metabolism is the exoribonuclease polynuc

258 l repeat proteins that bind RNA and modulate organellar RNA metabolism.

259 nts and are thought to be mostly involved in organellar RNA metabolism.

260 s data for the evolution and function of the organellar RNA polymerases is discussed.

261 processing, stability, and/or translation of organellar RNAs.

262 POP5*RPP30 reconstituted with bacterial and organellar RPRs suggests functional overlap of this bina

263 efficiency of VSG transport and fidelity in organellar segregation during cytokinesis.

264 wed by capturing of additional A-derived and organellar sequences and amplification of B-specific rep

265 Finally, there is substantial plasticity in organellar shape, with extensions such as stromules, per

266 d WRKY transcription factors associated with organellar signaling and senescence.

267 Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria

268 elles.It is yet unknown whether vesicular or organellar sites perform this function in mammals.

269 This comprehensive report of nuclear and organellar SSRs in Juglans and the generation of validat

270 subjected to proteolytic maturation prior to organellar storage and discharge.

271 tion, prompting the activation of a specific organellar stress-response mechanism, the mitochondrial

272 peraccumulated ceramides, and showed altered organellar structures and increased senescence- and path

273 n regulators of membrane trafficking between organellar subcompartments.

274 UX nanoscopy is applicable to the imaging of organellar substructures, yielding a 3D localization pre

275 t contribute to pre-protein unfolding at the organellar surface.

276 Reconstructions of pathways and organellar systems revealed that ST1 has a relatively co

277 , which suggests communication between these organellar systems.

278 isrupts the entire complex, interfering with organellar targeting and subsequent trafficking.

279 ghlight the exquisite in vivo specificity of organellar targeting mechanisms.

280 ge, the first evidence of splicing-regulated organellar targeting of a plant ion channel and identify

281 CML30 in other plants further indicates that organellar targeting of these CMLs is not a specific fea

282 d epimerase sequences examined had predicted organellar targeting peptides with a potential second st

283 -terminal extensions with characteristics of organellar targeting peptides.

284 llar bodies (LB) in lung epithelium, and its organellar targeting sequence has been identified.

285 mainline metabolic fluxes during episodes of organellar thiamin diphosphate deficiency.

286 including transfer of genetic material from organellar to nuclear genomes, de novo sequence manufact

287 d regulation of the many factors involved in organellar transcriptome quality control.

288 imentally identified sites of RNA editing in organellar transcriptomes from several species, but thes

289 d frequently contribute to the maturation of organellar transcripts.

290 ections and the establishment of nuclear and organellar transformation methods has opened the way for

291 rsion on phagosomes, allowing or disallowing organellar transition into a late endosomal compartment.

292 Defects in organellar translation are the underlying cause of a num

293 regulating both the levels and locations of organellar translation.

294 tion (in plastids and mitochondria) requires organellar transport systems for both PAPS and PAP.

295 diting has only been previously described in organellar tRNAs.

296 Organellar two-pore channels (TPCs) contain two copies o

297 ted temperatures (37-45 degrees C), with the organellar variant outperforming the nuclear counterpart

298 ully evaluate the importance of selection on organellar variants in different parts of the geographic

299 in aged cells, we observe drastic changes in organellar volume, leading to crowding on the micrometer

300 ells have an "awareness" of their volume and organellar volumes, and maintain a nuclear size that is