ライフサイエンスコーパス: organic anion

1 ower the concentration of uric acid, another organic anion.

2 monolayer is important to the uptake of the organic anion.

3 porters and implied that it may transport an organic anion.

4 +) signals and of secretion of a fluorescent organic anion.

5 as previously thought to primarily transport organic anions.

6 artments (e.g. kidney, olfactory mucosa) via organic anions.

7 ly diverse array of endogenous and exogenous organic anions.

8 to assist in interaction with non-bile acid organic anions.

9 ti-cancer agents and transports a variety of organic anions.

10 atment impairs the biliary excretion of some organic anions.

11 was identified as one of several fluorescent organic anions.

12 e permeability of the blood-brain barrier to organic anions.

13 ss that is distinct from that of these other organic anions.

14 lly expressed metabolites were water-soluble organic anions.

15 mily use divergent mechanisms to concentrate organic anions.

16 (G 1)(16).2Ba(2+).4A(-) containing different organic anions: 2,4,6-trinitrophenolate (2), 2,6-dinitro

17 Canalicular secretion of the organic anion 5-chloromethylfluorescein diacetate (CMFDA

18 The organic anion (99m)Tc-N-[2-[(3-bromo-2,4,6-trimethylphen

19 11), phospholipids (ABCB4), and nonbile acid organic anions (ABCC2), lack initial residence in the ba

20 dent transport of bile acid and nonbile acid organic anions across the canalicular membrane.

21 in (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma membrane.

22 (MRP1/ABCC1) extrudes a variety of drugs and organic anions across the plasma membrane.

23 ential nephrotoxicity of clinically relevant organic anion agents.

24 with fluorescent bile salts (BS) and non-BS organic anion analogues.

25 d marked up-regulation of orthologs of known organic anion and bile salt transporters in the kidney,

26 ucts feature strong interactions between the organic anion and both Li(+) and AlH(3).

27 cetic acids, and various other inorganic and organic anions and are investigated.

28 lyte to concentrate samples containing small organic anions and DNA fragment.

29 ferent ABC family that transports conjugated organic anions and in which sequences of the two NBDs ar

30 ium-independent, saturable, and inhibited by organic anions and steroids, including the major skate b

31 The lifetimes of organic anions and their radicals produced by reduction

32 itions, and their role in the elimination of organic anions and therapeutic drugs.

33 ession may permit urinary excretion of toxic organic anions and xenobiotics under conditions in which

34 ted in understanding how bilirubin and other organic anions are transferred from the plasma through t

35 We conclude that organic anion/base exchange is an important, potentially

36 On the other hand, organic anion binding selectivity between Oat6 and Oat1

37 es that the structure and electronics of the organic anions, bound to the assembly's periphery, are c

38 at Oatp2 mediates bidirectional transport of organic anions by a GSH-sensitive facilitative diffusion

39 ritical for recognition and translocation of organic anions by a member of the organic anion transpor

40 in the handling of endogenous and exogenous organic anions by excretory and barrier tissues.

41 nisms for impaired biliary excretion of some organic anions by PB treatment: 1) PBOH-glucuronide is a

42 lay a pivotal role in the clearance of small organic anions by the kidney, yet little is known about

43 s essential for recognition and transport of organic anions by the rat organic anion transporter, rOA

44 electron localization in nitrile-substituted organic anions by utilizing time-resolved infrared detec

45 Metal-organic anion channels based on Zn10 L15 pentagonal pris

46 uch anions and was accordingly comparable to organic anion-dependent regulatory volume decreases repo

47 of surfactant-protein and surfactant-protein-organic anion deposits is proposed on the basis of these

48 ystemic detoxification and in control of the organic anion distribution in cerebrospinal fluid.

49 protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leukotriene C(4)) and also co-trans

50 chromate, arsenate, pertechnetate, etc.) or organic anions (e.g., salicylate, pharmaceuticals, and t

51 Fourth, besides PAH, other organic anions effectively cis-inhibited the uptake of 1

52 C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing bod

53 icating the presence of apical dicarboxylate/organic anion exchange.

54 tion of organic anions through dicarboxylate/organic anion exchange.

55 d cotransporter, ntcp, and the multispecific organic anion exporter, mrp2.

56 ine, and verapamil, but penicillin and other organic anions failed to produce inhibition.

57 ubstrate for Mrp2 and may compete with other organic anions for biliary excretion and 2) Mrp2 protein

58 nd efficient procedure for the extraction of organic anions from aqueous samples.

59 TP-binding cassette transporters that export organic anions from cells.

60 nsporters that mediates the apical efflux of organic anions from hepatocytes, enterocytes, and renal

61 that they were involved in hepatic uptake of organic anions from plasma.

62 try (SIMS) was used to monitor the uptake of organic anions from solution by aminoethanethiol (AET) m

63 This carrier mediates uptake of organic anions from the bloodstream in exchange for intr

64 uent reuptake will drive placental uptake of organic anions from the fetal circulation.

65 In the case of the organic anion, furosemide, loss of renal secretion in th

66 activities directed toward large amphipathic organic anions have recently been identified on the vacu

67 The transport of organic anions in proximal convoluted tubules plays an e

68 ed the levels of approximately 60 endogenous organic anions in the plasma and urine of wild-type and

69 para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent man

70 n fractions, designated Y and Z, which bound organic anions including bilirubin, and thus we proposed

71 ssential role in eliminating a wide range of organic anions including endogenous compounds, xenobioti

72 ssential role in eliminating a wide range of organic anions including endogenous compounds, xenobioti

73 -sensitive, and inhibited by a wide range of organic anions including vitamins, anti-hypertensive dru

74 onstrated that both endogenous and exogenous organic anions, including biliverdin, bile salts, and BS

75 nd basolateral Mrp3 mediate the excretion of organic anions, including conjugated and unconjugated xe

76 ls which are permeable to a variety of small organic anions, including the excitatory amino acids (EA

77 VRAC are permeable to small inorganic and organic anions, including the excitatory neurotransmitte

78 Measurements of permeability ratios of organic anions indicated that the lysine mutant has an i

79 rters mediate exchange whereby uptake of one organic anion is coupled to efflux of a counter-ion.

80 eic hepatocytes metabolize and excrete human organic anions is unclear.

81 absence of renal excretion of metabolizable organic anions, leaving only the nonmetabolizable fracti

82 the high concentrations of K(+), Na(+), and organic anions like glutamate.

83 tive and was inhibited by several conjugated organic anions (MRP1 substrates) as well as the metalloi

84 in and the alkalinizing effect of potassium (organic anions), NEAP can be predicted with confidence f

85 this study was to determine the direction of organic anion (OA) transport across the ciliary body and

86 t, although only keratinocytes expressed the organic anion organic anion transporter protein (OATP) 2

87 al for the renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a larg

88 rganic anions, we find a correlation between organic anion potency (pKi) and hydrophobicity (logP) su

89 The organic anions probenecid, octanoate, and alpha-ketoglut

90 and raise the possibility that it may be an organic anion pump relevant to cellular detoxification.

91 nic analogues of squaramides (a key class of organic anion receptor).

92 athic cations, phospholipids, and conjugated organic anions, respectively.

93 Renal organic anion secretion has been implicated in numerous

94 anic anion transporters (OATs), the study of organic anion secretion has entered the molecular age.

95 InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to t

96 is a canalicular transporter responsible for organic anion secretion into bile.

97 The "classical" organic anion secretory pathway of the renal proximal tu

98 bit renal proximal tubules is limited to the organic anion secretory pathway.

99 saturating concentration of the prototypical organic anion substrate para-aminohippurate (PAH) reduce

100 x = 20.6 pmol/106 cells min), a prototypical organic anion substrate.

101 reduced or eliminated the transport of five organic anion substrates by MRP1 and abrogated the bindi

102 In contrast to organic anions, substrates for the canalicular mdr1a and

103 ransporter, rOAT3, mediates the transport of organic anions such as p-aminohippurate (PAH) and estron

104 taurine and chenodeoxycholyltaurine) and two organic anions (sulfobromophthalein and sulfolithocholyl

105 Luminal accumulation of the fluorescent organic anions sulforhodamine 101 and fluorescein methot

106 asymmetric organic cation and inorganic (or organic) anion that loosely fit together, is extending t

107 cient in mrp2, a canalicular transporter for organic anions), the isolated perfused rat liver, and he

108 for metabolic purposes and for secretion of organic anions through dicarboxylate/organic anion excha

109 evaluate the mechanism of renal clearance of organic anions, to assess potential drug-drug interactio

110 e knock-out mice manifest a profound loss of organic anion transport (e.g. para-aminohippurate) both

111 e the first demonstration that regulation of organic anion transport by mOAT is likely to be tightly

112 henotype manifested by a substantial loss of organic anion transport capacity in kidney and CP was id

113 n of genes related to metabolic pathways and organic anion transport in cKO mice compared with contro

114 inked glycosylation, significantly inhibited organic anion transport in COS-7 cells expressing a mous

115 ons of non-radioactive ALA or probenecid (an organic anion transport inhibitor) and, therefore, appea

116 ls undergoing apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone

117 To test whether organic anion transport is coupled to HCO3- extrusion, w

118 ecent studies implicate a role in hepatocyte organic anion transport of a plasma membrane protein tha

119 Although many organic anion transport protein (Oatp) family members ha

120 membrane protein that has been termed oatp1 (organic anion transport protein 1).

121 atic transport of (99m)Tc-mebrofenin through organic anion transport protein 1a and 1b (Oatp1a/1b) an

122 In summary, OATP2 is a novel organic anion transport protein that has overlapping but

123 Organic anion transport proteins (OATPs) on the basolate

124 er the expression and/or function of hepatic organic anion transport proteins.

125 a indicating that DMPS is transported by the organic anion transport system and that this transport i

126 ent data have implicated at least one of the organic anion transport systems in the basolateral uptak

127 membrane localization of choroid plexus (CP) organic anion transport were determined in apical (or br

128 e the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo.

129 Oat3, and Oat6 appear to function largely in organic anion transport, they also bind and transport so

130 (K370A) suggested that K370 is important for organic anion transport.

131 evealed that this amino acid is required for organic anion transport.

132 n 1 (MRP1) and the canalicular multispecific organic anion transporter (cMOAT or MRP2) are ATP-bindin

133 protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are closely related ma

134 ctive in the liver canalicular multispecific organic anion transporter (cMOAT) protein.

135 protein (MRP)1 and canalicular multispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding c

136 The human organic anion transporter (hOAT1) is a key component in

137 translational modification of a mouse kidney organic anion transporter (mOAT), in a mammalian cell sy

138 transport in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an importa

139 In vivo studies implicate the organic anion transporter (OAT) family as a pivotal comp

140 assessment of the contributions of specific organic anion transporter (OAT) family members to detoxi

141 rate) include two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, o

142 organic cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and monoamine transpor

143 Human organic anion transporter 1 (hOAT1) belongs to a superfa

144 Human organic anion transporter 1 (hOAT1) plays a critical rol

145 MDCK cells transfected stably with the human organic anion transporter 1 (hOAT1), the hypothesis that

146 cell line stably transfected with the human organic anion transporter 1 (hOAT1).

147 m a human renal library and designated human organic anion transporter 1 (hOAT1).

148 to other anionic substrates, the human renal organic anion transporter 1 (hOATI) is capable of transp

149 Organic anion transporter 1 (OAT1) mediates the body dis

150 Organic anion transporter 1 (OAT1), expressed at the bas

151 Organic anion transporter 1 (OAT1), originally identifie

152 nces the kinetic interaction of ligands with organic anion transporter 1 (OAT1).

153 entially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6, originally N

154 Importantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable,

155 and 2-K (hMATE1/2-K), but not for the renal organic anion transporter 1 and 3 (hOAT1/3).

156 droxylase (Cyp7a1) and the Na(+)-independent organic anion transporter 2 (Oatp2).

157 is the major regulator of the Na+-dependent organic anion transporter 2.

158 of compound in the kidneys mediated by human organic anion transporter 3 (hOAT3) was hypothesized as

159 ried out a targeted disruption of the murine organic anion transporter 3 (Oat3) gene.

160 In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower

161 mate 80% decrease in the expression level of organic anion transporter 3 (SLC22a8).

162 Human organic anion transporter 4 (hOAT4) belongs to a superfa

163 ew locus identified was SLC22A9 that encodes organic anion transporter 7 (OAT7).

164 ) (a substrate for canalicular multispecific organic anion transporter [cMOAT]).

165 These results identify an organic anion transporter composed of a putative seven-h

166 ing is independently correlated with hepatic organic anion transporter expression.

167 ily 10 member 1 (Slc10a1) and solute carrier organic anion transporter family member (Slco) 1a1 and 1

168 rritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), i

169 the structure-function relationships of the organic anion transporter family.

170 the structure-function relationships of the organic anion transporter family.

171 ocation of organic anions by a member of the organic anion transporter family.

172 We have previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT).

173 These cells had organic anion transporter function.

174 nce was associated with polymorphisms in the organic anion transporter gene SLCO1B1 (P = 2.1 x 10(-11

175 Human organic anion transporter hOAT1 belongs to a superfamily

176 Human organic anion transporter hOAT1 plays critical roles in

177 a role in the functional maturation of human organic anion transporter hOAT4.

178 7-kDa membrane-associated protein; cMOAT, an organic anion transporter implicated in multidrug resist

179 inhibited in the presence of probenecid, an organic anion transporter inhibitor.

180 The organic anion transporter OAT4 (SLC22A11) and organic an

181 gnificant associations were with SNPs in the organic anion transporter polypeptide, SLCO1B1.

182 Rat organic anion transporter polypeptide1 (Oatp1) is known

183 stance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the apical membrane

184 tance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane

185 odium taurocholate cotransporter protein and organic anion transporter protein 1.

186 selectively taken up by a sodium-independent organic anion transporter protein-1B1 (OATP1B1) exclusiv

187 trolled by URAT1 (SLC22A12), a member of the organic anion transporter superfamily.

188 oatp1 is an hepatic sinusoidal organic anion transporter that mediates uptake of variou

189 ase in the expression of rOat2 (Slc22a7), an organic anion transporter that regulates, in part, the t

190 taurocholate cotransporter and multispecific organic anion transporter were more profoundly diminishe

191 substrates for the canalicular multispecific organic anion transporter whose activity has recently be

192 closely related to MRP, cMOAT, and the yeast organic anion transporter YCF1.

193 +) taurocholate cotransporter, multispecific organic anion transporter, and P-glycoprotein) were also

194 ferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the

195 The rat organic anion transporter, rOAT3, mediates the transport

196 n and transport of organic anions by the rat organic anion transporter, rOAT3.

197 ids are substrates for the renal basolateral organic anion transporter-1 (Oat1) from rat kidney.

198 Notably, organic anion transporter-1 (OAT1) knockout mice express

199 Organic anion transporter-1 (OAT1) mediates the body dis

200 Organic anion transporter-1 (OAT1) mediates the body's d

201 nd non-steroidal anti-inflammatory drugs) is organic anion transporter-1 (OAT1), originally identifie

202 induce their secretion by up-regulating the organic anion transporter-1 (OAT1).

203 MDCK cells that were transfected with human organic anion transporter-1 were used.

204 c2), the principal canalicular multispecific organic anion transporter.

205 acids is an important function of the renal organic anion transporter.

206 inated by its interaction with the classical organic anion transporter.

207 s was effectively limited to the "classical" organic anion transporter.

208 mal tubule cells by the basolateral membrane organic anion transporters (Oat) 1 and Oat3.

209 Renal organic anion transporters (OAT) are known to mediate th

210 Organic anion transporters (OAT) play essential roles in

211 the entire plant Primula macrocalyx with the organic anion transporters (OAT1 and OAT3) and microorga

212 Organic anion transporters (OATs) and organic cation tra

213 Organic anion transporters (OATs) are believed to mediat

214 Organic anion transporters (Oats) are located in the bar

215 min, fatty acid binding proteins (FABPs) and organic anion transporters (OATs) have been identified a

216 Studies of the organic anion transporters (Oats) have focused mainly on

217 Given the selective expression of organic anion transporters (OATs) in renal proximal tubu

218 luding the proximal tubule-specific drug and organic anion transporters (OATs) OAT1 (SLC22a6) and OAT

219 Organic anion transporters (OATs) play a critical role i

220 Organic anion transporters (OATs) play a pivotal role in

221 With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic

222 s are secreted by the recently characterized organic anion transporters (OATs), which are expressed i

223 Organic anion transporters (OATs, SLC21) are important i

224 Organic anion transporters (OATs, SLC22) interact with a

225 uggests the presence of distinctly different organic anion transporters for the efflux of VPA at the

226 In contrast to the organic anion transporters identified to date, a transpo

227 Organic anion transporters in the kidney proximal tubule

228 ne of direct evidence implicating one of the organic anion transporters in the uptake of a mercuric c

229 city, and circumstantial evidence implicates organic anion transporters in these processes.

230 The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC2

231 The organic anion transporters OAT1 (SLC22A6, originally ide

232 Organic anion transporters play an essential role in eli

233 , as well as organic cation transporters and organic anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2

234 The mechanisms that target organic anion transporters to different domains of the i

235 The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC

236 ransporter hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in

237 porter 1 (hOAT1) belongs to a superfamily of organic anion transporters, which play critical roles in

238 er fatty acid binding proteins (L-FABP), and organic anion transporters--determine the distribution,

239 ; 3) mRNA expression of hepatic transporters organic anion transporting polypeptide (Oatp) 1a1, Oatp1

240 Human organic anion transporting polypeptide (OATP) 1B1 and so

241 s for active liver uptake via members of the organic anion transporting polypeptide (OATP) family.

242 kinetics were determined in wild-type (WT), organic anion transporting polypeptide (OATP) knockout m

243 of carboxylic acid-based ACC inhibitors with organic anion transporting polypeptide (OATP) substrate

244 Here, we investigated the role of organic anion transporting polypeptide (OATP) transporte

245 T2D) have dramatically reduced expression of organic anion transporting polypeptide (OATP)1A1, a tran

246 ispecific transporters, such as those of the organic anion transporting polypeptide (OATP, SLC21) and

247 Several members of the organic anion transporting polypeptide (OATP/Oatp) famil

248 n addition, protein mass and function of the organic anion transporting polypeptide (Oatp1), another

249 possibly due to the presence of T4-selective organic anion transporting polypeptide (OATP1C1).

250 Organic anion transporting polypeptide 1B3 (OATP1B3, SLC

251 Organic anion transporting polypeptide 2 (Oatp2) mRNA wa

252 ion of the basolateral membrane transporter, organic anion transporting polypeptide 2 (Oatp2), was no

253 The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5

254 Human organic anion transporting polypeptide 2B1 (OATP2B1) is

255 Organic anion transporting polypeptide 4 (Oatp4; Slc21a1

256 on of mice with a targeted disruption of the organic anion transporting polypeptide Oatp1b2.

257 Organic anion transporting polypeptide OATP1B3 is a memb

258 rganic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1)

259 ilum specifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and k

260 The human organic anion transporting polypeptide-C (OATP-C) (gene

261 Human organic anion transporting polypeptides (OATP) 1B1 and 1

262 Organic anion transporting polypeptides (Oatp) are trans

263 lone (EtioG) using cell lines overexpressing organic anion transporting polypeptides (OATP1B1, OATP1B

264 The organic anion transporting polypeptides (OATPs) are a su

265 The hepatic organic anion transporting polypeptides (OATPs) influenc

266 ), multidrug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps).

267 lt export pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 a

268 omplete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP

269 The organic anion transporting polypeptides, Oatp1 (Slc21a1)

270 Rat organic anion transporting protein 1a1 (oatp1a1), a hepa

271 describe here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediat

272 conjugated bile salts, a process mediated by organic anion-transporting polypeptide (OATP) 1B2.

273 Human organic anion-transporting polypeptide (OATP) 2B1 (OATP-

274 hat modulates cellular entry of drugs is the organic anion-transporting polypeptide (OATP) 2B1.

275 diffusion model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we

276 The organic anion-transporting polypeptide (OATP/Oatp) super

277 sion of the hepatic anion uptake transporter organic anion-transporting polypeptide 1A1 (Oatp1a1), th

278 Organic anion-transporting polypeptide 1A2 (OATP1A2) (ge

279 In this study, organic anion-transporting polypeptide 1A2 (OATP1A2) fro

280 Organic anion-transporting polypeptide 1A2 (OATP1A2) is

281 The organic anion-transporting polypeptide 1b family (Oatp1b

282 inhibition of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and

283 Ugt1a1), sulfotransferase 2a1 (Sult2a1), and organic anion-transporting polypeptide 2 (Oatp2) in live

284 ation of agonist-stimulated platelets via an organic anion-transporting polypeptide and is retained i

285 idrug resistance protein (ABCC/MRP), and the organic anion-transporting polypeptide protein (SLCO/OAT

286 ide polymorphism in the SLCO1B1 gene for the organic anion-transporting polypeptide that regulates st

287 ines expressed comparable MRP and OATP/SLCO (organic anion-transporting polypeptide) mRNA levels, and

288 rt of the bile acid taurocholate (TC) by the organic anion-transporting polypeptide, (OATP)4A1, its e

289 Organic anion-transporting polypeptides (OATP) 1B1 and 1

290 Organic anion-transporting polypeptides (OATPs) mediate

291 hepatic disposition are OATP1B1 and OATP1B3 (organic anion-transporting polypeptides 1B1 and 1B3, res

292 The organic anion-transporting polypeptides represent an imp

293 loss was paralleled by the activation of an organic anion uptake process, supporting the role of an

294 g Oat3 does not play a major role in hepatic organic anion uptake.

295 Secretion may be inhibited by retained organic anions, urate, or acidosis.

296 No apparent transport of organic anions was observed.

297 ansporters with over 40 structurally diverse organic anions, we find a correlation between organic an

298 In addition, small organic anions were tested as inhibitors.

299 membrane and transports structurally diverse organic anions with a wide spectrum of pH sensitivities.

300 dation for activation of persulfate by other organic anions without the toxicity of phenols, such as