ライフサイエンスコーパス: organic anion transporter

1 inated by its interaction with the classical organic anion transporter.

2 s was effectively limited to the "classical" organic anion transporter.

3 c2), the principal canalicular multispecific organic anion transporter.

4 acids is an important function of the renal organic anion transporter.

5 rular filtration and tubular secretion using organic anion transporters.

6 state of four members of the SLC17 family of organic anion transporters.

7 Human organic anion transporter 1 (hOAT1) belongs to a superfa

8 Human organic anion transporter 1 (hOAT1) plays a critical rol

9 MDCK cells transfected stably with the human organic anion transporter 1 (hOAT1), the hypothesis that

10 cell line stably transfected with the human organic anion transporter 1 (hOAT1).

11 m a human renal library and designated human organic anion transporter 1 (hOAT1).

12 to other anionic substrates, the human renal organic anion transporter 1 (hOATI) is capable of transp

13 Organic anion transporter 1 (OAT1) mediates the body dis

14 Organic anion transporter 1 (OAT1), expressed at the bas

15 Organic anion transporter 1 (OAT1), originally identifie

16 nces the kinetic interaction of ligands with organic anion transporter 1 (OAT1).

17 entially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6, originally N

18 Organic anion transporter 1 (OAT1/SLC22A6) is a drug tra

19 Importantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable,

20 and 2-K (hMATE1/2-K), but not for the renal organic anion transporter 1 and 3 (hOAT1/3).

21 ids are substrates for the renal basolateral organic anion transporter-1 (Oat1) from rat kidney.

22 Notably, organic anion transporter-1 (OAT1) knockout mice express

23 Organic anion transporter-1 (OAT1) mediates the body dis

24 Organic anion transporter-1 (OAT1) mediates the body's d

25 nd non-steroidal anti-inflammatory drugs) is organic anion transporter-1 (OAT1), originally identifie

26 induce their secretion by up-regulating the organic anion transporter-1 (OAT1).

27 MDCK cells that were transfected with human organic anion transporter-1 were used.

28 Organic anion transporter 2 (OAT2 or SLC22A7) plays an i

29 droxylase (Cyp7a1) and the Na(+)-independent organic anion transporter 2 (Oatp2).

30 is the major regulator of the Na+-dependent organic anion transporter 2.

31 of compound in the kidneys mediated by human organic anion transporter 3 (hOAT3) was hypothesized as

32 f central nervous system (CNS) riboflavin by organic anion transporter 3 (OAT-3), highlighting the ne

33 ried out a targeted disruption of the murine organic anion transporter 3 (Oat3) gene.

34 In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower

35 mate 80% decrease in the expression level of organic anion transporter 3 (SLC22a8).

36 Human organic anion transporter 4 (hOAT4) belongs to a superfa

37 ew locus identified was SLC22A9 that encodes organic anion transporter 7 (OAT7).

38 +) taurocholate cotransporter, multispecific organic anion transporter, and P-glycoprotein) were also

39 n 1 (MRP1) and the canalicular multispecific organic anion transporter (cMOAT or MRP2) are ATP-bindin

40 protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are closely related ma

41 ctive in the liver canalicular multispecific organic anion transporter (cMOAT) protein.

42 protein (MRP)1 and canalicular multispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding c

43 ) (a substrate for canalicular multispecific organic anion transporter [cMOAT]).

44 These results identify an organic anion transporter composed of a putative seven-h

45 er fatty acid binding proteins (L-FABP), and organic anion transporters--determine the distribution,

46 ing is independently correlated with hepatic organic anion transporter expression.

47 ily 10 member 1 (Slc10a1) and solute carrier organic anion transporter family member (Slco) 1a1 and 1

48 rritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), i

49 the structure-function relationships of the organic anion transporter family.

50 the structure-function relationships of the organic anion transporter family.

51 ocation of organic anions by a member of the organic anion transporter family.

52 sazurin is taken up by tubular cells through organic anion transporters, followed by conversion to a

53 uggests the presence of distinctly different organic anion transporters for the efflux of VPA at the

54 We have previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT).

55 These cells had organic anion transporter function.

56 nce was associated with polymorphisms in the organic anion transporter gene SLCO1B1 (P = 2.1 x 10(-11

57 Human organic anion transporter hOAT1 belongs to a superfamily

58 Human organic anion transporter hOAT1 plays critical roles in

59 The human organic anion transporter (hOAT1) is a key component in

60 a role in the functional maturation of human organic anion transporter hOAT4.

61 In contrast to the organic anion transporters identified to date, a transpo

62 7-kDa membrane-associated protein; cMOAT, an organic anion transporter implicated in multidrug resist

63 Organic anion transporters in the kidney proximal tubule

64 ne of direct evidence implicating one of the organic anion transporters in the uptake of a mercuric c

65 city, and circumstantial evidence implicates organic anion transporters in these processes.

66 inhibited in the presence of probenecid, an organic anion transporter inhibitor.

67 translational modification of a mouse kidney organic anion transporter (mOAT), in a mammalian cell sy

68 P-glycoprotein (P-gp) and the multispecific organic anion transporter (MOAT), the liver-specific hom

69 transport in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an importa

70 rates to characterize functional activity of organic anion transporter (Oat) 3, P-glycoprotein (P-gp)

71 Exogenous stimulation of proximal tubule organic anion transporter (OAT) and organic cation trans

72 In vivo studies implicate the organic anion transporter (OAT) family as a pivotal comp

73 assessment of the contributions of specific organic anion transporter (OAT) family members to detoxi

74 rate) include two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, o

75 mal tubule cells by the basolateral membrane organic anion transporters (Oat) 1 and Oat3.

76 Renal organic anion transporters (OAT) are known to mediate th

77 Organic anion transporters (OAT) play essential roles in

78 The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC2

79 tro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3

80 The organic anion transporters OAT1 (SLC22A6, originally ide

81 organic cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and monoamine transpor

82 the entire plant Primula macrocalyx with the organic anion transporters (OAT1 and OAT3) and microorga

83 o acid transporter (LAT1) used by leucine to organic anion transporters (OAT1 and OAT3) and the monoc

84 The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC

85 The organic anion transporter OAT4 (SLC22A11) and organic an

86 ferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the

87 Organic anion transporters (OATs) and organic cation tra

88 Organic anion transporters (OATs) are believed to mediat

89 Organic anion transporters (Oats) are located in the bar

90 min, fatty acid binding proteins (FABPs) and organic anion transporters (OATs) have been identified a

91 Studies of the organic anion transporters (Oats) have focused mainly on

92 Given the selective expression of organic anion transporters (OATs) in renal proximal tubu

93 luding the proximal tubule-specific drug and organic anion transporters (OATs) OAT1 (SLC22a6) and OAT

94 Organic anion transporters (OATs) play a critical role i

95 Organic anion transporters (OATs) play a pivotal role in

96 With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic

97 s are secreted by the recently characterized organic anion transporters (OATs), which are expressed i

98 Organic anion transporters (OATs, SLC21) are important i

99 Organic anion transporters (OATs, SLC22) interact with a

100 Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NK

101 Organic anion transporters play an essential role in eli

102 gnificant associations were with SNPs in the organic anion transporter polypeptide, SLCO1B1.

103 Rat organic anion transporter polypeptide1 (Oatp1) is known

104 Members of the Organic Anion Transporter Polypeptides (OATP) are integr

105 stance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the apical membrane

106 tance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane

107 y the brain, which was possibly modulated by organic anion transporters present at the blood-brain ba

108 ly keratinocytes expressed the organic anion organic anion transporter protein (OATP) 2B1 transporter

109 odium taurocholate cotransporter protein and organic anion transporter protein 1.

110 selectively taken up by a sodium-independent organic anion transporter protein-1B1 (OATP1B1) exclusiv

111 The rat organic anion transporter, rOAT3, mediates the transport

112 n and transport of organic anions by the rat organic anion transporter, rOAT3.

113 , as well as organic cation transporters and organic anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2

114 trolled by URAT1 (SLC22A12), a member of the organic anion transporter superfamily.

115 oatp1 is an hepatic sinusoidal organic anion transporter that mediates uptake of variou

116 ase in the expression of rOat2 (Slc22a7), an organic anion transporter that regulates, in part, the t

117 The mechanisms that target organic anion transporters to different domains of the i

118 taurocholate cotransporter and multispecific organic anion transporter were more profoundly diminishe

119 ransporter hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in

120 porter 1 (hOAT1) belongs to a superfamily of organic anion transporters, which play critical roles in

121 substrates for the canalicular multispecific organic anion transporter whose activity has recently be

122 closely related to MRP, cMOAT, and the yeast organic anion transporter YCF1.