ライフサイエンスコーパス: organic cation

1 quaternary or primary nature of the cobound organic cation.

2 ddition of an aqueous solution containing an organic cation.

3 he receptor pore permeable to NMDG+, a large organic cation.

4 on-phonon coupling to phonons located on the organic cation.

5 rganic solar absorber based on a photoactive organic cation.

6 hybrid perovskites using appropriate chiral organic cations.

7 y to various reported soil sorption data for organic cations.

8 he large cavities contain pairs of the bulky organic cations.

9 onic neurotoxins and other potentially toxic organic cations.

10 n absorption, distribution, and excretion of organic cations.

11 ons of ionic interactions to the sorption of organic cations.

12 s; both are characteristic of highly charged organic cations.

13 s but lost their transport activities toward organic cations.

14 transport, they also bind and transport some organic cations.

15 rete metal halide centers, isolated by bulky organic cations.

16 tively charged silica surface and a layer of organic cations.

17 the I(2) state that is readily permeable to organic cations.

18 rmined by the halogen atoms, rather than the organic cations.

19 ing anions, sugars, purines, amino acids and organic cations.

20 ange of both simple and complex metallic and organic cations.

21 cations, soluble polycations and amphipathic organic cations.

22 thiamine transport is not inhibited by other organic cations.

23 ery and for environmental risk assessment of organic cations.

24 e sensitive to both the number of layers and organic cations.

25 of alternating inorganic TiS2 monolayers and organic cations.

26 li cations and are permeable also to several organic cations.

27 inhibition hampers the release of the toxic organic cation 1-methyl-4-phenylpyridinium from astrocyt

28 mperature-dependent uptake of the quaternary organic cation [14C]-tetraethylammonium ([14C]-TEA), wit

29 However, decynium-22 (600 mug kg(-1) ), an organic cation 3 transporter (OCT3)/plasma membrane mono

30 ct1/Slc22a1-injected oocytes transported the organic cations [3H]-1-methyl-4-phenylpyridium and [3H]-

31 central role in mediating renal secretion of organic cations, a structurally diverse collection of co

32 However, how the chemical nature of the organic cations affects the properties of two-dimensiona

33 erovskites and the templating effects of the organic cations allow for fine structural control of the

34 MRP4 or MRP5, replacement of bath Na(+) with organic cations also hyperpolarized the cell membranes a

35 human transporter families, most notably the organic cation and anion transporters of the solute carr

36 sport proteins, in particular with mammalian organic cation and anion transporters.

37 hanced spectroscopic investigations using an organic cation and crown-ether chelated alkali metal cat

38 The wide band gap of the organic cation and distinct optical characteristics of t

39 nt, which is composed of a large, asymmetric organic cation and inorganic (or organic) anion that loo

40 Describing organic cation and zwitterion interaction with dissolved

41 this study, sorption of a diverse set of 12 organic cations and 8 neutral aromatic solutes on two po

42 Experiments with large organic cations and anions showed that cation permeation

43 for the canalicular mdr1a and b are usually organic cations and are often sequestered in high concen

44 enter the I(2) state, which is permeable to organic cations and dye molecules.

45 This trend for competition between organic cations and exchangeable inorganic cations is co

46 valve devices based on HOIPs with different organic cations and halogen atoms are fabricated.

47 e selectivity filter, and also permits large organic cations and inactivation peptides to enter the p

48 entified for the mode of association between organic cations and polar species in solution.

49 ic agents and xenobiotics, many of which are organic cations and substrates of the organic cation tra

50 lar permeability to monovalent inorganic and organic cations and to divalent cations but not to anion

51 ation-dependent binding of relatively large, organic cations and zwitterions (viz., the antibiotics c

52 ynamics, up to partial immobilization of the organic cation, are observed in the mixed MAPb(ClxBr1-x)

53 With available alkaline, alkaline earth, and organic cations as partners, four series of 5-nitrotetra

54 ls of known molecular composition with large organic cations as probes.

55 ead reflect the involvement of more unstable organic cations at their transition states.

56 id-water sorption coefficients (Kd) for four organic cations (benzylamine, 2,4-dichlorobenzylamine, p

57 The metal ion/organic cation binding properties of the newly synthesiz

58 In contrast, 1.5 mM tetraethylammonium, an organic cation, blocked uptake of 1 microM OTA by only 7

59 orting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesti

60 of both agents was inhibited by a variety of organic cations, but the pattern of inhibition was diffe

61 s [PbBr4 (2-)]infinity are surrounded by the organic cations C4N2H14 (2+) to form the bulk assembly o

62 The organic cations can be completely exchanged with sodium

63 ulation of the electron-accepting ability of organic cations can be utilized in electron-transfer-ini

64 Toxic organic cations can damage nigrostriatal dopaminergic pa

65 transport was competitively inhibited by the organic cations carnitine, diphenhydramine, and verapami

66 transporters, confirming that defects in the organic cation/carnitine transporter OCTN2 are responsib

67 OCTN2 is an organic cation/carnitine transporter that is responsible

68 is condition maps to 5q31.2-32 and OCTN2, an organic cation/carnitine transporter, also maps to the s

69 vel organic cation transporter (OCTN2) is an organic cation/carnitine transporter, and two missense m

70 metal nuclearity concomitant with increasing organic cation contribution supports the hypothesis that

71 The size of the organic cation dictates both the composition and the ext

72 ADP.3Na(+) structure indicated that 1) bound organic cations differentially distorted the ion binding

73 ganic layers and their modification, and the organic cation diversity.

74 These findings suggest that the organic cation, DNR, is largely sequestered in cells suc

75 eveal that the induced atomic motions of the organic cations do not alter the absorption or the photo

76 TEA uptake was inhibited by several other organic cation drugs, but was not inhibited by the organ

77 ), Hg(2+), and a large, synthesized divalent organic cation, ((Et)(3)N)(2)Bu(2+).

78 The divalent organic cation, ethyl diamine, inhibited PMCA but was no

79 Though highly selective organic cation exchange resins have been developed for m

80 Consistently, the organic cations exhibited little to no antagonism to cyt

81 o(III)(+) or Cp(*)2Co(+)] as an ultra-stable organic cation for polymer HEMs.

82 ased on the binding affinities of the tested organic cations for Oat3 was generated.

83 Polyamines are small organic cations found in all cells, and the biosynthetic

84 transporter that mediates the uptake of many organic cations from the blood into the liver where the

85 lium, consistent with a role of transporting organic cations from the CSF into CP epithelial cells.

86 tion of a metal cation and even of the large organic cation guanidinium, reminiscent of Shaker's omeg

87 bI3 is an all-inorganic analog to the hybrid organic cation halide perovskites, but the cubic phase o

88 Chemical tuning of spacer organic cations has attracted great interest due to thei

89 CP, but its specific role in CP transport of organic cations has not been clearly defined.

90 ize-tunable, ion-exchangeable extraframework organic cations have been prepared.

91 cells (AFCs); however, the commonly employed organic cations have limited alkaline stability.

92 which transports amino acids, polyamines and organic cations in a multitude of biological roles, incl

93 st exchange on realizing accurate release of organic cations in a stepwise manner under light irradia

94 natural mutation abolished the transport of organic cations in addition to carnitine.

95 to manipulate exciton diffusion by modifying organic cations in layered perovskites.

96 us a potentially relevant sorption phase for organic cations in many soils.

97 The structural effects from solely the organic cations in the 2D system highlight the importanc

98 s still debated, with the role played by the organic cations in the light-harvesting process remainin

99 diating both epithelial uptake and efflux of organic cations in the secretory cells of salivary gland

100 ransporter that transports a wide variety of organic cations including biogenic amines, cationic drug

101 bidirectional, multispecific transporters of organic cations (including 5-HT, dopamine, and norepinep

102 c exchange ions, sorption coefficients of 10 organic cations (including eight pharmaceuticals and two

103 e, dehydroascorbic acid, alditols) and small organic cations (including polyamines) also lacked consi

104 racts with a variety of structurally diverse organic cations, including clinically used drugs as well

105 wide enough to allow the permeation of large organic cations, including natural ones.

106 ansport process recognizes a large number of organic cations, including the neurotoxin 1-methyl-4-phe

107 annel decreased as the ionic diameter of the organic cation increased.

108 lar dynamics simulations indicate that bound organic cations induce minor distortion of the binding s

109 Hepatic uptake of organic cations is essential for the metabolism and secr

110 d on how similar the charge density in these organic cations is to that in the proton removed.

111 Certain inorganic and organic cations known to activate the Ca2+ receptor were

112 er of inorganic atomic layers in between the organic cation layers.

113 The organic cations (MA(+)) interact with Au atoms, forming

114 cholesterol on the molecular transport of an organic cation, malachite green (MG), across large unila

115 These findings suggest that amino acids and organic cations may interact with the transporter throug

116 mains (TM) 1-6, and interaction of PMAT with organic cations may involve aromatic residues.

117 Previous reports have shown that the organic cations methylamine, dimethylamine, ethylamine,

118 of band-edge charge carriers by rotation of organic cation molecules can be a major contribution to

119 pertaining to the lead-halide framework and organic cation motions, respectively.

120 T3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) upt

121 (4) PbMn(0.69) Sn(0.31) Br(8) , in which the organic cation N-benzylhexamethylenetetrammonium (HMTA(+

122 c cation drugs, but was not inhibited by the organic cation n-methyl-nicotinamide (NMN), being instea

123 First, we compared the permeation of organic cations of different sizes.

124 Organic cations of increasing size were used as current

125 The impact of intercalated organic cations on the diffusion dominated mass transpor

126 The effects of three classes of organic cations on the inhibition of the plasma membrane

127 s show that specific adsorption of metal and organic cations on the Pt surface at the conditions rele

128 g the indirect but powerful influence of the organic cations on the structure and consequently on the

129 her by synthetic manipulation (shuffling the organic cations or inorganic elements) or by application

130 tial replacement of extracellular Na(+) with organic cations or sucrose induced a rapid and reversibl

131 22 subfamily members (including those of the organic cation, organic carnitine, and unknown substrate

132 determinant of inorganic ion selectivity and organic cation permeation.

133 e-evolution behavior of FA1-x MAx PbI3 mixed-organic-cation perovskite (MOCP) is studied.

134 ofen, were not removed from water, while the organic cation propranolol showed biouptake similar to t

135 the inorganic layers and then stabilized by organic cations, providing n-type carriers for current a

136 s shown that the mechanism of melting of the organic cation regenerated bR is different than for the

137 1575A had negligible effects on inorganic or organic cation selectivity and block by tetrodotoxin (TT

138 Hille's (1971) seminal study of organic cation selectivity of eukaryotic voltage-gated s

139 rostatic potential influence the sorption of organic cations, seven smectites were chosen with differ

140 Our data on ion-exchange affinities for 80 organic cations show many examples where specific chemic

141 al k(IAM) values presented in this study for organic cations show that the net IAM surface charge is

142 Current predictive models of organic cation sorption assume that sorbates interact wi

143 re is a need for robust predictive models of organic cation sorption coefficients (Kd).

144 Organic cation sorption coefficients exhibited consisten

145 f natural exchange ions in the prediction of organic cation sorption coefficients for environmental s

146 To better understand how organic cation sorption is influenced by surface-associa

147 tography was evaluated as a method to obtain organic cation sorption isotherms for environmental soli

148 identity and abundance for the prediction of organic cation sorption to soils and soil minerals.

149 actors derived from this literature model of organic cation sorption, along with phenyltrimethylammon

150 er of magnitude in sorption coefficients) on organic cation sorption.

151 s indispensable for optimal interaction with organic cation substrates.

152 ated transport of four structurally distinct organic cation substrates: the commonly used drugs: 1) m

153 We also demonstrate that mOat3 transports organic cations such as 1-methyl-4-phenylpyridinium and

154 ntly show that the presence of intracellular organic cations (such as n-methyl-D-glucamine) induces a

155 For each organic cation tested, the currents were inhibited by ga

156 ters retained their ability to transport the organic cation tetraethylammonium indicating that their

157 e endogenous substrate (l-carnitine) and the organic cation tetraethylammonium, three variants showed

158 The prototype for organic cations tetraethylammonium (TEA) was also transp

159 Unexpectedly, also the organic cations Tetraethylammonium and Acetylcholine wer

160 The latter is an organic cation that combines the properties of good solu

161 The polyamines are small organic cations that are absolutely required for eukaryo

162 The amino acid-derived polyamines are organic cations that are essential for growth in all mam

163 r study showed that PMAT interacts with many organic cations that have heterogeneous chemical structu

164 toberberines represent a structural class of organic cations that induce topoisomerase I-mediated DNA

165 any endogenous compounds and xenobiotics are organic cations that rely on polyspecific organic cation

166 As an organic cation, the binding of methonium to protein rece

167 Even though thiamine is an organic cation, the cDNA-induced thiamine transport is n

168 Given the biological importance of organic cations, the facilitated transport of organic io

169 or by physically gating the pores with large organic cations, thus demonstrating how metal-organic fr

170 yish soils, the model shows that sorption of organic cations to clay minerals accounts for more than

171 The sorption data for organic cations to clay showed several regular trends wi

172 is structurally tailored using bulky chiral organic cations to exhibit an unusual confluence of exce

173 n of Kd values for more structurally complex organic cations to homoionic montmorillonites and to het

174 expression assays, we have tested binding of organic cations to Oat1 and Oat3 in ex vivo assays by an

175 -exchange model that defines the sorption of organic cations to soil as a summed contribution of sorp

176 Sorption of organic cations to soil organic matter was studied using

177 avenues for exploring specifically designed organic cations to stabilize otherwise inaccessible 2D H

178 We use organic cations to template the solution-state assembly

179 imated by fitting relative permeabilities of organic cations to the Renkin equation, was 0.41 nm.

180 ne substitution to phenethylammonium for the organic cations to tune the structural rigidity and octa

181 from the ability of ACh, over that of other organic cations, to trigger the subsequent channel-openi

182 arge at Glu(206) (E206Q) resulted in loss of organic cation transport activity, whereas conserving th

183 h phenylalanine or tryptophan fully restored organic cation transport activity.

184 Pump-mediated K(+)-like organic cation transport challenges the concept of rigid

185 on the carnitine transport function and the organic cation transport function of OCTN2.

186 f these mutations may not interfere with the organic cation transport function.

187 rt function but significantly stimulated the organic cation transport function.

188 cation transporter, which may play a role in organic cation transport in vivo.

189 rnitine transport is Na(+)-dependent whereas organic cation transport is Na(+)-independent, we invest

190 d rat and human organic cation transporters, organic cation transport kinetics differed markedly.

191 A carrier-mediated organic cation transport process appears to exist in the

192 ed that the carnitine transport site and the organic cation transport site were not identical.

193 In peripheral tissues, organic cation transport via some OCTs is inhibited by c

194 eft and contributes to forming a pathway for organic cation transport.

195 e interaction with the human ortholog of the organic cation transporter (hOCT1).

196 ers, however, no valid biomarker for hepatic organic cation transporter (OCT) 1 has been described to

197 other multidrug transporters, including the organic cation transporter (OCT) 2, is influenced by the

198 To determine whether organic cation transporter (OCT) family members might me

199 catinib resembles the pharmacophore of known organic cation transporter (OCT) inhibitors and reduced

200 s actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1).

201 cleotide polymorphisms (SNPs) mapping to the organic cation transporter (OCTN) genes, SLC22A4 and SLC

202 Novel organic cation transporter (OCTN2) is an organic cation/

203 In the rat organic cation transporter (rOct1), voltage- and ligand-

204 ing the hypothesis that genetic variation in organic cation transporter 1 (OCT1) affects the response

205 ized that reduced transport of metformin via organic cation transporter 1 (OCT1) could increase metfo

206 Organic cation transporter 1 (OCT1) plays a critical rol

207 Organic cation transporter 1 (OCT1) plays a role in the

208 ch are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1).

209 olymorphism (SNP) mapping to intron 1 of the organic cation transporter 1 (OCTN1; SLC22A4) gene was a

210 provide evidence for a critical role of the organic cation transporter 2 (OCT2) in satellite glial c

211 We found that the organic cation transporter 2 (OCT2) is expressed on dors

212 pounds were found to be potent inhibitors of organic cation transporter 2 (OCT2), which contributes t

213 C content, and muscle carnitine transporter [organic cation transporter 2 (OCTN2)] messenger RNA and

214 This transporter, known as OCTN2 (novel organic cation transporter 2), is expressed in most tiss

215 maging, we show that Ru265 is transported by organic cation transporter 3 (OCT3) and taken up more ef

216 Organic cation transporter 3 (OCT3) is a high-capacity,

217 The organic cation transporter 3 (OCT3) is emerging as an im

218 Here, we show that the organic cation transporter 3 (Oct3) is expressed in nond

219 ow that adipocytes can also clear NE through organic cation transporter 3 (Oct3).

220 duced blockade of dopamine clearance via the organic cation transporter 3 (OCT3).

221 Organic cation transporter 3 (OCT3, SLC22A3) is a polysp

222 on to DAT, PQ(+) is also a substrate for the organic cation transporter 3 (Oct3, Slc22a3), which is a

223 onoamine transporter 2 (VMAT2) together with organic cation transporter 3 and monoamine oxidase type

224 Expression of organic cation transporter 3, a corticosterone-sensitive

225 d they overexpressed the choline transporter organic cation transporter 3.

226 LDEHYDE 3-PHOSPHATE DEHYDROGENASE (PvGAPC1), ORGANIC CATION TRANSPORTER 4 (PvOCT4), and GLUTATHIONE S

227 ne, Solute Carrier DmSLC22A, a member of the organic cation transporter family, enhances olfactory me

228 substrate for the known members of mammalian organic cation transporter family.

229 noamine transporter (PMAT) is a polyspecific organic cation transporter in the solute carrier 29 (SLC

230 The presence of organic cation transporter inhibitors also does not sign

231 by mutations in the Na+-dependent carnitine/organic cation transporter OCTN2.

232 porter (PMAT, SLC29A4) is a new polyspecific organic cation transporter that transports a wide variet

233 emoresistance, impaired uptake through human organic cation transporter type 1 (hOCT1) (gene SLC22A1)

234 Here we demonstrate that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which

235 "extraneuronal monoamine transporter," and "organic cation transporter type-3."

236 Oct1/Slc22a1 encodes for a hepatic and renal organic cation transporter which may be important for th

237 This potential-sensitive organic cation transporter, designated as OCT3, represen

238 protein-altering variants of the human liver organic cation transporter, OCT1, in Xenopus oocytes.

239 The organic cation transporter, OCT1, is a major hepatic tra

240 The organic cation transporter, OCT2, plays a role in renal

241 is caused by mutations in the Na+-dependent organic cation transporter, OCTN2.

242 Originally described as a monoamine/organic cation transporter, we found that both human and

243 ude that PMAT can function as a polyspecific organic cation transporter, which may play a role in org

244 could be attributed to the presence of human organic cation transporter-1 (hOCT1) single nucleotide p

245 hat express two point mutations of the human organic cation transporter-1 (hOCT1), R488M and G465R, h

246 Down-regulation of SLC22A1 encoding the organic cation transporter-1 (OCT1) may affect the respo

247 .001) and expression of the molecular human organic cation transporter-1 (RR, 1.79; P = .038) as the

248 t deterioration in tubule membrane function (organic cation transporter-1 transport activity) was obs

249 glands selectively and highly express OCT3 (organic cation transporter-3), a polyspecific drug trans

250 rters; hence, we designate this gene ORCTL2 (organic cation transporter-like 2).

251 1-3, PMAT mainly functions as a polyspecific organic cation transporter.

252 otransmitter norepinephrine (NE) via an Oct3 organic cation transporter.

253 Organic cation transporters (OCT), including multidrug a

254 The activities of exogenous organic cation transporters (OCT2 and OCT3), organic ani

255 pacity transporters for 5-HT in brain [i.e., organic cation transporters (OCTs) and plasma membrane m

256 Organic cation transporters (OCTs) are involved in the r

257 Organic cation transporters (OCTs) are members of the so

258 Organic cation transporters (OCTs) in the kidney proxima

259 Organic anion transporters (OATs) and organic cation transporters (OCTs) mediate the flux of x

260 re organic cations that rely on polyspecific organic cation transporters (OCTs) to traverse cell memb

261 KT, since the Oats share close homology with organic cation transporters (Octs), it is possible that

262 We initially found that organic cation transporters (OCTs), uptake carriers of m

263 fluid by acting on corticosterone-sensitive organic cation transporters (OCTs).

264 able to the inhibition of 5-HT transport via organic cation transporters (OCTs).

265 rough the action of corticosterone-sensitive organic cation transporters (OCTs).

266 etformin uptake depends on the expression of organic cation transporters (OCTs).

267 Both groups had increased organic cation transporters (SLC22A4 and SLC16A9) activi

268 Recently the clinical importance of human organic cation transporters 1 (hOCT1/SLC22A1) and 2 (hOC

269 This compound is an excellent substrate for organic cation transporters 1 and 2, also designated SLC

270 hat mIBG is an excellent substrate for human organic cation transporters 1-3 (hOCT1-3) and the multid

271 thers Fmo1, Cyp2d2, Cyp2d4, Nqo2, as well as organic cation transporters and organic anion transporte

272 Organic cation transporters are membrane potential-depen

273 Several hepatic organic cation transporters have been kinetically define

274 dopamine transporter (DAT) and polyspecific organic cation transporters OCT-1 and OCT-3.

275 Organic cation transporters OCT1 (SLC22A1) and OCT2 (SLC

276 Organic cation transporters play a critical role in the

277 to cells, Glc-Pt 1 exploits both glucose and organic cation transporters, both widely overexpressed i

278 omologous to previously cloned rat and human organic cation transporters, organic cation transport ki

279 tively transported into cells through BA and organic cation transporters.

280 lap in substrate specificity between the two organic cation transporters.

281 s a critical role in binding of substrate to organic cation transporters.

282 endothelium is non-vesicular and occurs via organic cation transporters.

283 ript indicated homology to integral membrane organic cation transporters; hence, we designate this ge

284 ontribution supports the hypothesis that the organic cations used in the synthesis play an important

285 (SOM) has been studied for a wide variety of organic cations using a flow through method with fully a

286 onite has been studied for a wide variety of organic cations using a flow-through method with fully a

287 f PMAT with a series of structurally diverse organic cations using MDCK cells stably expressing human

288 consisted of the clay framework, interlayer organic cation, water, and organic sorbate.

289 The recognition properties toward various organic cations were also determined.

290 In the simulations, organic cations were intercalated and benzene molecules

291 The weak permeabilities to organic cations were resolved by looking at inward tails

292 Large RyR-permeable organic cations were used to interfere with Ca(2+) condu

293 dilates, making the cell permeable to large organic cations, which eventually leads to cell death.

294 Methonium (N(+)Me3) is an organic cation widely distributed in biological systems.

295 termining whether the dynamically disordered organic cations with large dipole moment benefit the opt

296 In this work, we take advantage of organic cations with lower reduction potential than lith

297 ction factors were derived from the data for organic cations with polar functional groups.

298 xplained by stronger interaction between the organic cations with the Pb-Br frameworks compared to th

299 nsformation mechanism coupled with metal and organic cations wrapped is proposed.

300 lead-halide perovskite absorbers RPbX3 (R = organic cation; X = Br(-) or I(-)), the toxicity of lead