ライフサイエンスコーパス: organismal

1 As biologically significant organismal activities often occur at particular times of

2 he relationship between genome evolution and organismal adaptation of considerable interest.

3 c plasticity and biotic interactions mediate organismal adaptation to changing environments, however,

4 remarkably controllable pathway facilitating organismal adaptation to new environments.

5 boptimal, or fallacious decisions that drive organismal adaptation, health, longevity, and life histo

6 eration, chronic age-associated diseases and organismal ageing.

7 development [3, 4], tissue repair [5-8], and organismal aging [9].

8 r organ function and homeostasis, leading to organismal aging and death.

9 between host and indigenous bacteria impacts organismal aging and life span.

10 Organismal aging is associated with changes at the molec

11 icate an uncoupling of cellular, tissue, and organismal aging through inhibition of ISC proliferation

12 cell-autonomously manipulated during normal organismal aging to delay neuron morphological aging.

13 portant regulator of cellular senescence and organismal aging, in part through the regulation of gene

14 tes signaling between tissues, and regulates organismal aging.

15 is not causally required to slow tissue and organismal aging.

16 cellular and genetic mechanisms that control organismal aging.

17 skeletal muscle hypertrophy, but also drives organismal aging.

18 Here, biochemical, cell biological, and organismal analysis was used to determine that TMTC3 sup

19 anization of archaeal chromatin, on both the organismal and domain level.

20 tigation and intervention tools that support organismal and ecosystem survival in the immediate futur

21 tages of pulque fermentation to characterize organismal and functional diversity.

22 e current understanding of polyploidy at the organismal and suborganismal levels, identify shared res

23 Organismal appearances are shaped by selection from both

24 mation, and how particular phenotypes impact organismal behavior and ecology.

25 sm for controlling intestinal fat stores and organismal behavioral states in C. elegans, and establis

26 r the simplest of assumptions about adaptive organismal behaviour, habitat selection strength should

27 iven cell-autonomous clocks in the timing of organismal bioenergetics.

28 Body shape is a fundamental expression of organismal biology, but its quantitative reconstruction

29 important to better understand EVs' roles in organismal biology, EVs in solid tissues have received l

30 of fundamental questions in evolutionary and organismal biology.

31 e for conflict in shaping diverse aspects of organismal biology.

32 process on multiple, interlinked aspects of organismal biology.

33 ers, as opposed to producers, often dominate organismal biomass.

34 ides a highly sensitive technique to measure organismal biomechanical fitness and delivers an approac

35 , is the best baseline from which to predict organismal body nutrient content.

36 We conclude that bilirubin strongly affects organismal body weight by reshaping the PPARalpha coregu

37 unction endogenously, some can travel across organismal boundaries between hosts and microbes and sil

38 es such as developmental programs, day/night organismal changes, intercellular signaling, and prolife

39 Organismal circadian rhythms are coordinated by behavior

40 tural systems, from cellular transport up to organismal circulatory systems.

41 /osas#9 signaling system represents an inter-organismal communication channel that evolved via co-opt

42 of three-dimensional (3D) tissues increased organismal complexity and reproductivity.

43 tional entities, such as lncRNAs, that fuels organismal complexity does not seem to be driven by stro

44 How cellular and organismal complexity emerges from combinatorial express

45 transition that allowed for the increase of organismal complexity in multiple lineages, a process th

46 and facilitating the evolution of increased organismal complexity.

47 benefit from dissecting ecosystems into the organismal components and their inherent limitations to

48 g will be driven more strongly by changes in organismal composition than by gene regulatory mechanism

49 To understand the cellular and organismal consequences of aneuploidy, it is important t

50 slet cells ex vivo or other cell-types in an organismal context will be immensely valuable in advanci

51 onstrates that depending on the cellular and organismal context, orthologous proteins may exert both

52 aracterize these human genes in a simplified organismal context.

53 mportance of the UPR in diverse cellular and organismal contexts.

54 Here, we identify a mechanism by which organismal copper homeostasis is maintained by intestina

55 trates that the application of in vivo whole organismal CRISPR screening has great potential to accel

56 Aging is a natural process of organismal decay that underpins the development of myria

57 Biomarkers for organismal decline and aging are urgently needed for dia

58 of cell death execution modules involved in organismal defense.

59 pecies traits explained as much variation in organismal densities as species identity.

60 can now be recognized as a core principle of organismal design.

61 this pathway often results in defects during organismal development and can be a causative mechanism

62 inherently stochastic process(1,2); however, organismal development and homeostasis require cells to

63 enance of population size is fundamental for organismal development and homeostasis.

64 Copper is an essential element for proper organismal development and is involved in a range of pro

65 This activity is required for normal organismal development and maintenance of gene expressio

66 natal period, can have a life-long impact on organismal development and physiology.

67 has profound and highly specific effects on organismal development and physiology.

68 final-exon-truncating mutations in REST for organismal development and the association with the HGF

69 enger RNA (mRNA) metabolism and transport in organismal development and, in cancer, its mis-regulatio

70 Cell division and organismal development are exquisitely orchestrated and

71 Robust organismal development relies on temporal coordination o

72 ransitions constitute key decision points in organismal development that enable access to a developme

73 tion, recombination/repair, gene expression, organismal development, cell-to-cell signaling/interacti

74 al control of gene activity is essential for organismal development, growth, and survival in a changi

75 Cell-cell interactions orchestrate organismal development, homeostasis and single-cell func

76 o dramatically increase our understanding of organismal development.

77 given to these mechanisms in the context of organismal development.

78 C-poor and enriched in genes associated with organismal development.

79 expression of genes is essential for proper organismal development.

80 o dramatically increase our understanding of organismal development.

81 ggest that ABL1 has an important role during organismal development.

82 ssembly is critical for mitotic fidelity and organismal development.

83 poral gene expression programs that underlie organismal development.

84 roles of Sac1 in subcellular homeostasis and organismal development.

85 f complex life and its utilization for their organismal development.

86 to be dispensable for cellular function and organismal development.

87 hylogenetically from other bacteria, but the organismal distribution of their protein families remain

88 rentiation could also be driving dynamics of organismal diversity across time and space.

89 m shared polyploid cellular processes across organismal diversity, levels of biological organization,

90 suggesting that resource competition shapes organismal diversity.

91 ng statistical approaches derived from macro-organismal ecology, we found that more bacterial taxa we

92 rating at larger spatial scales encompassing organismal, edaphic, and environmental diversity of targ

93 effects of complex exposures at higher level organismal effects without prior mechanistic knowledge o

94 ction) is critical for any general theory of organismal energetics.

95 f experiment and theoretical analysis of the organismal energy balance, we further show that the mass

96 sensing and signaling pathway that regulates organismal energy balance.

97 -tissue communication is critical to control organismal energy homeostasis in response to temporal ch

98 e-like glial cells play a role in regulating organismal ER stress resistance and longevity.

99 oss biomes and lineages, thereby influencing organismal evolution and community assembly.

100 h large fat reserves, when opportunities for organismal experimental work are limited.

101 ive intermediates which may crucially affect organismal fitness and are frequently implicated in dise

102 are key units of adaptive evolution because organismal fitness depends on their performance.

103 Haploinsufficiency describes the decrease in organismal fitness observed when a single copy of a gene

104 enerationally inherited epigenetic states to organismal fitness remains unknown as well-documented ex

105 n quantity is a critical factor in impacting organismal fitness.

106 se to high frequencies even if they decrease organismal fitness.

107 which if left unpurged, can impact brain and organismal fitness.

108 ochondrial function and dramatically impacts organismal fitness.

109 degradation of proteins, a process vital to organismal fitness.

110 vision, tissue homeostasis, and cellular and organismal fitness.

111 e circadian clock, an important regulator of organismal fitness.

112 l-autonomous circadian clocks to synchronize organismal food intake with cellular bioenergetics.

113 ajor limitation in studying the evolution of organismal form.

114 ess acting at specific life phases to induce organismal frailty, rather than contributing to a consta

115 s [10-13], divergence along multiple axes of organismal function is expected to accompany switches in

116 ion of individual tRNA genes to cellular and organismal function remains unknown.

117 e importance of RNA surveillance to cell and organismal function.

118 es are a fundamental element of cellular and organismal function.

119 ave the way for cooption of TE sequences for organismal function.

120 This challenges our understanding of organismal functioning, as the link among electron trans

121 ical approaches in the study of cellular and organismal functions, discuss current challenges, and pr

122 e regulation of key biological processes and organismal functions.

123 cific satellite RNAs are required for normal organismal functions.

124 n in different tissues leading to changes in organismal functions.

125 e, maintains transcriptional homeostasis and organismal functions.

126 also predicted functional profiles, based on organismal gene content, for each fermentation stage and

127 oup, we show that it can be applied to other organismal groups to advance reproducibility in trait-ba

128 hat aim to resolve deep divergences of major organismal groups.

129 d by developmental abnormalities and reduced organismal growth in addition to an involvement of the i

130 hermore, under such conditions, no effect on organismal growth rate or loss of the reddish colony phe

131 During organismal growth, body parts expand proportionally with

132 multiple phases of embryonic patterning and organismal growth.

133 ach can increase scientific understanding of organismal-habitat relationships, maintain natural biodi

134 chondrial systems function in the context of organismal health and aging.

135 rs of control has important implications for organismal health and could offer new therapeutic approa

136 llular, tissue, and systemic level to ensure organismal health and longevity.

137 f Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan, and observe a mi

138 R-phagy and its significance in cellular and organismal health are put forward.

139 mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis el

140 d immune stimuli that promote intestinal and organismal health.

141 relevance for cellular stress resistance and organismal health.

142 r cellular differentiation, homeostasis, and organismal health.

143 intain tissue homeostasis, tissue repair and organismal health.

144 C) disease, improving cellular viability and organismal health.

145 and regeneration to restore homeostasis and organismal health.

146 rdinate protein homeostasis is essential for organismal health.

147 nutrient signals to control cell growth and organismal homeostasis across eukaryotes.

148 a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily

149 Loss of BMAL1 perturbs organismal homeostasis and usually exacerbates pathologi

150 tively help to preserve cellular, organ, and organismal homeostasis at low temperature.

151 ysosome as a regulatory hub for cellular and organismal homeostasis, and an attractive therapeutic ta

152 Intercellular communication is critical for organismal homeostasis, and defects can contribute to hu

153 sure a functional liver required to maintain organismal homeostasis.

154 mones produced by the adrenals that maintain organismal homeostasis.

155 Autophagy supports both cellular and organismal homeostasis.

156 cal role in the preservation of cellular and organismal homeostasis.

157 s, shaping intestinal health, metabolism and organismal homeostasis.

158 crucial for the maintenance of cellular and organismal homeostasis.

159 stributions and diverse roles in maintaining organismal homeostasis.

160 ponses that are critical for re-establishing organismal homeostasis.

161 as critical regulators of cell function and organismal homeostasis.

162 Our work identifies a multi-signal relay of organismal humoral immunity, establishing adult Drosophi

163 demonstrate that organismal hyperinsulinemia promotes tumorigenesis by ab

164 iological cues that encode information about organismal identity and clinically relevant phenotypes s

165 melanogaster as a model for hematopoiesis or organismal immunity has been debated.

166 therefore been linked to neuropathology and organismal individuality.

167 al disease, psychological disorders, cancer, organismal injury and skeletal and muscular disorders, a

168 sociated with inflammatory response/disease, organismal injury, and respiratory diseases and were inv

169 orms nucleic acid chemical modification into organismal innate immunity.

170 and internal regulatory circuitry to secure organismal integrity.

171 entially PAH-resistant subpopulations showed organismal level bioenergetic shifts in ER fish that are

172 the animal's ability to form memories at the organismal level has not yet been fully understood.

173 How these processes are integrated at an organismal level is less clear.

174 re we show at the biochemical, cellular, and organismal level that the cooperative nature of DNA bind

175 tic variants influence complex traits at the organismal level via affecting cellular traits, such as

176 r whether neuroimmune circuits operate at an organismal level, integrating extrinsic environmental si

177 At the organismal level, NAD(+) repletion remarkably extends li

178 asis in mammals has long been studied at the organismal level, the intracellular mechanisms controlli

179 At the organismal level, we identified distinct physiological r

180 to study the effects of RIT1 mutation at the organismal level, which resulted in a phenotype resembli

181 metabolic and lifespan effects of IIS at the organismal level.

182 ar level are much stronger than those at the organismal level.

183 atalytic activity of the Rho GEF Vav2 at the organismal level.

184 ity of sizes and shapes at tissue, organ and organismal levels.

185 erturb metal homeostasis at the cellular and organismal levels.

186 role in DNA repair at both the cellular and organismal levels.

187 rring at the molecular, cellular, tissue and organismal levels.

188 e, and is regulated at both the cellular and organismal levels.

189 emodeling of the complex at the cellular and organismal levels.

190 ized by the lowest biological age where both organismal life and aging begin.

191 protective homeostatic plasticity, extending organismal lifespan and health span.

192 ronmental factors are key drivers regulating organismal lifespan but how these impact healthspan is l

193 extends chronological lifespan in yeast and organismal lifespan in worms and flies.

194 To endure over the organismal lifespan, neurons utilize multiple strategies

195 e stress response, cellular homeostasis, and organismal lifespan.

196 rom tRNA-cysteine, and their subcellular and organismal localization in order to consider possible fu

197 l indels, but surprisingly limited impact on organismal longevity or fitness.

198 the common factors that define cellular and organismal LR asymmetry.

199 g-related coral mortality, thus providing an organismal mechanism for demographic changes in populati

200 In this review, we describe cellular and organismal mechanisms of oxygen sensing and adaptation.

201 identified, the overall function of SIRT5 in organismal metabolic homeostasis remains unclear.

202 Here, we review topical findings in organismal metabolism and infection and highlight four e

203 tional immunological functions that regulate organismal metabolism by controlling insulin action, lip

204 a role of ISGylation to temporally reprogram organismal metabolism following infection through direct

205 as an important endocrine organ that impacts organismal metabolism.

206 T, keeps inflammation in check and regulates organismal metabolism.

207 s of peptides and discusses the relevance to organismal metabolism.

208 urn, controls genes that direct cellular and organismal metabolism.

209 ctors and coregulators in the fine tuning of organismal metabolism.HDAC3 is a critical mediator of he

210 We envisioned that the development of an organismal model system might provide new opportunities

211 proteins are signaling switches that control organismal morphogenesis across metazoans.

212 lation of Ubap1 in zebrafish causes abnormal organismal morphology, inhibited motor neuron outgrowth,

213 It typically involves shifts in organismal or biochemical phenotypes that can be seen as

214 ic plasticity (MDPP) exists at all levels of organismal organization, from the whole organism to with

215 out the relationship between temperature and organismal performance, which can be described by a ther

216 drift under stabilising selection, where an organismal phenotype is conserved, but the underlying mo

217 proximal link between genetic variation and organismal phenotype, and quantified metabolite levels i

218 arise the under stabilising selection for an organismal phenotype.

219 hey provide insight into gene regulation and organismal phenotypes (e.g., genes upregulated in cancer

220 ge, and from which a variety of cellular and organismal phenotypes emerge.

221 Organismal phenotypes frequently involve multiple organ

222 Levels of gene expression underpin organismal phenotypes(1,2), but the nature of selection

223 rich information on molecular, cellular and organismal phenotypes.

224 ling in neurons, and the extent it can alter organismal phenotypes.

225 through a complex network of trade-offs with organismal (phylogenetic) and ecological (environmental)

226 In the context of an updated organismal phylogeny and newly inferred pigment reconstr

227 ircadian clocks orchestrate daily rhythms in organismal physiology and behavior to promote optimal pe

228 dicine can provide unparalleled insight into organismal physiology and health.

229 oding genes has left the roles of Pol III in organismal physiology relatively unexplored.

230 Circadian rhythms control organismal physiology throughout the day.

231 es of lipid regulation in maintaining normal organismal physiology under different environmental cond

232 tophagy is important for normal cellular and organismal physiology, and both increased and decreased

233 sential for local skeletal muscle growth and organismal physiology, but these actions are entwined wi

234 in our understanding of immunoregulation and organismal physiology.

235 ntegrated into our understanding of cell and organismal physiology.

236 n among metabolism, cell fate decisions, and organismal physiology.

237 rtance of GARP/EARP function in cellular and organismal physiology.

238 hanisms by which environmental toxins affect organismal physiology.

239 t interactions; and hormones, which regulate organismal processes and metabolism.

240 importance of this signaling pathway and the organismal processes that it is involved in, less is kno

241 y regulators of a wide range of cellular and organismal processes.

242 y the vulva to detect damage and initiate an organismal protective response.

243 nnate immune responses can be players of the organismal proteostasis network and discuss how both are

244 rs of metabolism highlight the importance of organismal regulation of BCAA physiology.

245 he OAT transporters in inter-organ and inter-organismal remote communication via transporter-mediated

246 se of filling gaps in spatial, temporal, and organismal representation, but also with a more ambitiou

247 ntralized regulatory mechanism that balances organismal resources between reproductive investment and

248 atmosphere and oceans steadily rise, varying organismal responses may produce ecological losers and w

249 Current understanding of organismal responses to change stems from studies over r

250 eas, including life history, physiology, and organismal responses to global change; however, transcri

251 ntal effects on living systems: Cellular and organismal responses to gravity are of central importanc

252 havior, functioning as a global regulator of organismal responses to stress.

253 Understanding and predicting organismal responses to warming requires disentangling t

254 eostasis may be a key variable in explaining organismal robustness.

255 ly associated with differential growth on an organismal scale [3].

256 nce of alterations of multiple phenotypes at organismal scale.

257 tlases, hypothesis generation, comprehensive organismal screens, and diagnostics.

258 associated molecular machinery, and so far, organismal self-recognition has never been described in

259 bacterial illness often includes a phase of organismal shedding over a period of days to months.

260 ing is arrested in the long-lived, alternate organismal state, the dauer diapause.

261 Organismal stress initiates a tightly orchestrated set o

262 igated the role of mitochondrial dynamics in organismal stress response.

263 The idea that organismal structure exerts a primary influence on innov

264 In this Review, we highlight how cross-organismal studies of endoderm morphogenesis provide a u

265 viding new candidates that may contribute to organismal survival during this stress.

266 sms that influence gene expression to govern organismal survival in metazoans.

267 in the control of metabolic homeostasis and organismal survival through exquisite coupling of oxidat

268 hepatic gluconeogenesis is essential for the organismal survival upon prolonged fasting and maintaini

269 eactions are tied to energy transduction and organismal survival.

270 posing a threat to genome integrity and cell/organismal survival.

271 perspective, sensing danger is essential for organismal survival.

272 t detrimentally affect cellular function and organismal survival.

273 eive environmental cues and are important of organismal survival.

274 ortant trophic factor promoting cellular and organismal survival.

275 environmental extremes can play in enabling organismal survival.

276 ating the implications of rapid evolution in organismal thermal sensitivity for ecosystem functioning

277 collected RNA-sequencing data to assess how organismal thermal stress translated to the cellular lev

278 nning predictions of large-scale patterns in organismal thermal stress, species' ranges and distribut

279 ological responses to temperature scale from organismal to ecosystem levels.

280 karyotic hosts and microbes extends from the organismal to the ecosystem level and underpins the heal

281 ironmental changes, but cascading effects of organismal tolerances on the assembly and functioning of

282 nce ecosystem dynamics through links between organismal traits and ecosystem processes.

283 y is to understand the relationships between organismal traits and ecosystem processes.

284 e still debated, and the role played by most organismal traits and their intraspecific variation is u

285 Finally, organismal traits related to consuming fruits or nectar

286 ough intermediate endophenotypes to modulate organismal traits remains a central question in quantita

287 g variation in DNA sequences affects complex organismal traits through networks of intermediate molec

288 (e.g. genetic variants, cellular traits and organismal traits) on a large scale for functional and m

289 Here, we examine differences in organismal traits, assemblage structure, and productivit

290 expression with variation in metabolites and organismal traits, including starvation stress resistanc

291 linking noncoding variation to variation in organismal traits.

292 een correlated with an incredible variety of organismal traits.

293 This spectacular organismal transition requires nuclear reprogramming and

294 lly explain fate, transport, transformation, organismal uptake, and toxicity of inorganic 2D NMs in t

295 stress, a characteristic that is relevant to organismal viability in evolution and in modern HSC tran

296 sis is an essential requirement for cell and organismal viability.

297 n of these issues, trait-based assessment of organismal vulnerability to environmental changes can be

298 ry processes shaping regional differences in organismal vulnerability.

299 of physiological functions is fundamental to organismal well-being.

300 ant contributions to intestinal function and organismal wellbeing.