ライフサイエンスコーパス: origin of life

1 ng been sought by chemists interested in the origin of life.

2 lusion with significant implications for the origin of life.

3 onucleic acid (RNA) at an early stage in the origin of life.

4 to be involved in chemical evolution and the origin of life.

5 idy, genomic complexity, speciation, and the origin of life.

6 tion with their possible contribution to the origin of life.

7 plets is considered an essential step in the origin of life.

8 environments of early earth and possibly the origin of life.

9 ng the possible pathways responsible for the origin of life.

10 for nonenzymatic RNA replication during the origin of life.

11 of potential relevance to understanding the origin of life.

12 and would seem to be a prerequisite for the origin of life.

13 entory with left-handed molecules before the origin of life.

14 utable that peptides were key players in the origin of life.

15 grated behaviors was a crucial aspect of the origin of life.

16 tifying in its implications for the chemical origin of life.

17 e patterns, we attempt to glance at the very origin of life.

18 ts, where they may have played a role in the origin of life.

19 d to the organic inventory necessary for the origin of life.

20 tions for organic chemical evolution and the origin of life.

21 and thus possibly played a vital role in the origin of life.

22 catalysts available at an early stage in the origin of life.

23 two hydrophobic faces, was essential to the origin of life.

24 unlikely that cytosine played a role in the origin of life.

25 an RNA-like substance, played a role in the origin of life.

26 for this enzyme in the proposed autotrophic origin of life.

27 ating peptides may have played a role in the origin of life.

28 biomedical utility and implications for the origin of life.

29 c evolution and geological scenarios for the origin of life.

30 0(6) yr) to be involved in a low-temperature origin of life.

31 n the origin of metabolism, and probably the origin of life.

32 nce on organic chemical evolution before the origin of life.

33 nd nucleobases may well have extended to the origin of life.

34 in the absence of enzymatic machinery at the origin of life.

35 ate-rich lakes as plausible settings for the origin of life.

36 he primary driver of the early stages of the origin of life.

37 nd a critical step towards understanding the origin of life.

38 thiols must have preceded pantetheine at the origin of life.

39 ound in hydrothermal systems linked with the origin of life.

40 of prebiotic ingredients and ultimately the origin of life.

41 Hyperthermophilic archaea are close to the origin of life.

42 eplication of genetic information during the origin of life.

43 or studying the emergence of heredity at the origin of life.

44 acid replication is a central process at the origin of life.

45 ages that occurred during and just after the origin of life.

46 ation of specific replicators at or near the origin of life.

47 ve formed spontaneously from monomers at the origin of life.

48 of prebiotic environments that supported the origin of life.

49 proto)biomolecules with implications for the origin of life.

50 cine, and it may have been a conduit for the origin of life.

51 to one of the possible explanations for the origin of life.

52 ortant role in research on the synthesis and origin of life.

53 amyloids) may also have played a role in the origin of life.

54 ides that are relevant in the context of the origin of life.

55 dels help us understand living cells and the origin of life.

56 support for the hypothesis of the abiogenic origin of life.

57 enable molecular processes necessary for the origin of life.

58 tion is considered an important stage in the origin of life.

59 to the molecular diversity essential for the origin of life.

60 atalyzed oxidation reactions relevant to the origin of life.

61 tion is a key challenge in understanding the origin of life.

62 rality remains an unresolved question in the origin of life.

63 hat connects present-day productivity to the origin of life.

64 cross all living matter, is a mystery in the origin of life.

65 s of nonenzymatic RNA replication during the origin of life.

66 ing of the early solar system as well as the origin of life.

67 implications for RNA world scenarios for the origin of life.

68 ids probably played an important role in the origin of life.

69 critical role in metabolic processes at the origin of life.

70 ivity and evolutionary adaptation during the origin of life.

71 e they can potentially play key roles in the origin of life.

72 oligonucleotides was a critical step in the origin of life.

73 has become a key unanswered question in the origin of life.

74 ns a mystery in the puzzle to understand the origin of life.

75 ropagation of genetic information during the origin of life.

76 mond Bernal proposed a role for clays in the origin of life.

77 believed to have been a key event during the origin of life.

78 and are thought to have been crucial for the origin of life.

79 ave been a critical process required for the origin of life.

80 able C1 feedstock molecule is crucial to the origin of life.

81 mperature gradients might play a role in the origin of life.

82 isms that must have been available since the origin of life.

83 and have been implicated in theories of the origin of life.

84 communities and their potential role in the origin of life.

85 cation is considered a key transition in the origin of life.

86 ctions, and possibly virus evolution and the origin of life.

87 tion have the potential to shed light on the origins of life.

88 nvestigate various scenarios relevant to the origins of life.

89 s such as Mars and Earth are relevant to the origins of life.

90 arly relevant to prebiotic chemistry and the origins of life.

91 solutions to many basic questions about the origins of life.

92 possible progenitor candidates of RNA in the origins of life.

93 create novel proteins and to understand the origins of life.

94 n evolutionary development as ancient as the origins of life.

95 have made a significant contribution to the origins of life.

96 ular fossil that provides a telescope to the origins of life.

97 sses to vital biomolecules necessary for the origins of life.

98 future research in synthetic biology and the origins of life.

99 ke TNA could have played a vital role in the origins of life.

100 oligomers and polymers was important in the origins of life.

101 stem bodies, potentially contributing to the origins of life.

102 ses, key classes of molecules central to the Origins of Life.

103 gesting relevance to natural systems and the origins of life.

104 plication is considered a key process in the origins of life.

105 d promiscuity, that underpin biology and the origins of life.

106 and is thus essential for understanding the origins of life.

107 natural link between modern genetics and the origins of life.

108 ing geodynamics, climate regulation, and the origins of life.

109 structures evolve, with implications for the origins of life.

110 ally with population density since the early origins of life.

111 aqueous conditions is a critical step in the origins of life.

112 ate problem in the "RNA first" model for the origins of life.

113 tional prebiotic compartmentalization in the origins of life.

114 igomers that would have played a role in the origins of life.

115 s may have created the first peptides at the origins of life.

116 biosphere, and may have implications for the origins of life.

117 equences arise from simpler molecules at the origin of life?

118 e catalysis under conditions relevant to the origin of life (20-75 degrees C, pH 5-7.5).

119 hat peptides played an essential part in the origins of life(5-9).

120 At some stage in the origin of life, an informational polymer must have arise

121 Urea is a key molecule in the search for the origin of life and a basic chemical produced in large qu

122 Autocatalysis is essential for the origin of life and chemical evolution.

123 atic processes may have been relevant at the origin of life and could have practical utility in membr

124 nucleic acids have led to insights into the origin of life and have also suggested potential pathway

125 cycles, and their potential to inform on the origin of life and its potential outside of Earth.

126 eful for establishing the conditions for the origin of life and its prevalence on other planetary bod

127 and polypeptides was a key transition in the origin of life and remains at the heart of all biology.

128 The finding provides insights into both the origin of life and the potential threat posed by pathoge

129 n the context of molecular evolution and the origin of life and the second for biomedical application

130 eing shed light on the role of ageing in the origin of life and the upper limits to longevity.

131 Revealing the origin of life and unambiguously detecting fossil remain

132 Although critically linked to the origins of life and identified in carbonaceous meteorite

133 e commonly thought to play a key role in the origins of life and other evolutionary transitions.

134 s and reconsiders their significance for the origins of life and the emergence of primitive replicati

135 tractive answers to questions concerning the origins of life and to uncover the principles that contr

136 kely to have played an important role in the origin of life, and a small number of fully synthetic se

137 e compartments is a central question for the origin of life, and has technological repercussions in d

138 forces will have been omnipresent since the origin of life, and living organisms have evolved mechan

139 geneous catalysis, endergonic synthesis, the origin of life, and many other branches of chemical scie

140 role in hydrothermal redox chemistry at the origin of life, and materials applications that utilize

141 sis is seen as a potential key player in the origin of life, and perhaps more generally in the emerge

142 ng-standing problem both with respect to the origin of life, and with regard to bottom up efforts to

143 The implications of this study in the origin of life are discussed.

144 Many open questions about the origins of life are centred on the generation of complex

145 Circadian rhythms date back to the origins of life, are found in virtually every species an

146 s its theoretical origins to a model for the origin of life as a collection of mutant RNA replicators

147 A) have been invoked as key reagents for the origin of life as activated forms of acetate analogous t

148 In the traditional concept for the origin of life as proposed by Oparin and Haldane in the

149 heory of biological evolution, including the origin of life, as multilevel learning.

150 lies that they may have played a role in the origin of life at earlier stages than previously thought

151 Phosphate is central to the origin of life because it is a key component of nucleoti

152 cal evidence for the physical setting of the origin of life because there are no unmetamorphosed rock

153 rticularly interesting in the context of the origin of life because they are sources of self-replicat

154 thought to be an unlikely mechanism for the origins of life because of unfavourable chemical conditi

155 o the hypothesis that the first stage of the origin of life began with the onset of a primitive nonen

156 s not only permit protocell formation at the origin of life but actively favour it.

157 es support for the involvement of RNA in the origin of life, but such support would be considerably s

158 s pioneered modern research on the molecular origins of life, but their actual relevance in this fiel

159 uch forces may have been instrumental in the origin of life by driving a primitive form of self-repli

160 es to an ensemble of organisms, that is, the origin of life, can be modeled as a special case of bona

161 has wide implications, including tracing the origins of life, carbon sequestration, and climate chang

162 e propose that ample future breakthroughs in origin-of-life chemistry will stem from investigations o

163 resting from both a biological/medicinal and origins of life chemistry point of view.

164 e most fascinating mysteries in the field of origins of life concerns the driving force that led to t

165 y and public health, including the microbial origin of life, diagnosis of infection, vaccine producti

166 nisms and critically linked to the molecular origins of life due to its fundamental role in metabolic

167 urrent experiments with implications for the origin of life, emphasizing the ability of unexpected ph

168 During the origin of life, encapsulation of RNA inside vesicles is

169 This latter could not occur in an anoxic, "origin of life" environment.

170 sary step towards the design of new types of Origin of Life experiments that allow testable hypothese

171 when evaluating their potential roles in the origin of life, extant biology, or biotechnology.

172 Many approaches to the origin of life focus on how the molecules found in biolo

173 nt a current view of the biochemistry of the origin of life, focusing on issues surrounding the emerg

174 arth's water is central to understanding the origins of life-fostering environments and to assessing

175 discipline that sought explanations for the origins of life from chemical and physical first princip

176 rebiotic organic molecules important for the origins of life from impacts of carbonaceous asteroids a

177 A high-temperature origin of life has been proposed, largely for the reason

178 The origin of life has puzzled molecular scientists for over

179 Breakthroughs in the study of the origin of life have demonstrated how some of the buildin

180 nt synthetic approaches to understanding the origin of life have yielded insights into plausible path

181 transitions in evolution (in particular, the origin of life), have to be analyzed in the thermodynami

182 e Earth's surface, and is central to current origin of life hypotheses as well as the search for micr

183 step in quantifying and thus testing various origin-of-life hypotheses regarding the origin and evolu

184 ation flowed symmetrically in the era of the origin of life, i.e. the primitive translation machinery

185 usses metabolic pathways of relevance to the origin of life in a manner accessible to chemists, and s

186 e reaction conditions are compatible with an origin of life in volcanic-hydrothermal sub-seafloor flo

187 p focus discussion on open questions for the origins of life in a planetary context.

188 is profoundly contingent in that independent origins of life in the universe will spawn radically dif

189 loor, this process might be relevant, at the origin of life, in an RNA world hypothesis.

190 makeup of life as we know it, such as at the origins of life, in alien environments, or in the design

191 e components have properties relevant to the origin of life, including the ability to self-assemble i

192 This presents intrinsic challenges at the origins of life, including how condensation polymer synt

193 s in particular transformed the study of the origin of life into a respectable field of inquiry and e

194 The origin of life is also the origin of evolution.

195 nt obstacle to the "RNA-first" model for the origin of life is an inability to generate reasonable "h

196 The concept of an RNA world in the chemical origin of life is appealing, as nucleic acids are capabl

197 The origin of life is believed to have progressed through an

198 scribed, and their possible relevance to the origin of life is discussed.

199 One of the greatest mysteries concerning the origin of life is how it has emerged so quickly after th

200 A critical event in the origin of life is thought to have been the emergence of

201 The central question in the origin of life is to understand how structure can emerge

202 sembled into complex, robust networks at the origin of life is unknown.

203 nce of our calculations to understanding the origins of life is discussed.

204 ential significance of these findings to the origins of life is discussed.

205 rsal chart of pathways may be central to the origin of life, is emergent from organic chemistry, and

206 In order to approach the problem of the origin of life it is therefore reasonable to start from

207 In studying the origins of life, it is important to examine reactions of

208 ution of respiratory systems but also in the origin of life itself.

209 the major evolutionary transition since the origin of life itself.

210 important event to occur on Earth since the origin of life, marks the time when an oxygen-rich atmos

211 100 yr), we conclude that a high-temperature origin of life may be possible, but it cannot involve ad

212 sly been investigated for their relevance to origin-of-life models.

213 will provide a crucial reference for future origins-of-life models.

214 Therefore, any theory for the origin of life must address the emergence of such a syst

215 During the origin of life, mutation rates are thought to have been

216 e traditionally focused on understanding the origin of life on Earth and the potential for life elsew

217 One possible definition for the origin of life on Earth is the time at which the interva

218 The origin of life on Earth required a supply of phosphorus

219 ery of cyanide may have been crucial for the origin of life on Earth since cyanide is involved in the

220 The origin of life on Earth was a chemical affair.

221 across a membrane was a critical step at the origin of life on earth, and it is still performed in al

222 ch are believed to have been critical to the origin of life on Earth, remain important in physiology

223 organic compounds that played a role in the origin of life on Earth.

224 anic matter that may have contributed to the origin of life on Earth.

225 Synthetic life: the origin of life on the early Earth, and the ex novo trans

226 ess in the Solar System that may predate the origin of life on the Earth.

227 ents have become a candidate setting for the origins of life on Earth and beyond.

228 Understanding the origins of life on Earth guides our search for life else

229 The origins of life on Earth required the establishment of s

230 e thought to be essential to elucidating the origins of life on Earth.

231 gical processes and to better understand the origins of life on Earth.

232 ent of an RNA world and other models for the origins of life on Earth.

233 planet formation and may eventually seed the origins of life on nascent planets.

234 ould have existed in an RNA world during the origins of life on the Earth.

235 Such a scenario is interesting from an origins of life perspective because a rudimentary form o

236 as RNA is considered a key transition in the origin of life, pre-dating the appearance of protein enz

237 At the origin of life, prebiotic chemistry must have incorporat

238 is thought to have played a key role in the origin of life prior to the evolution of ribozyme-cataly

239 made on parameter estimation for determining origins of life probabilities, based on constraints from

240 vational routes for improving constraints on origins of life probabilities.

241 The origin-of-life problem has been traditionally conceived

242 olic systems, taken as a central part of the origins-of-life problem.

243 The origin-of-life quest has long been split into several at

244 anide (HCN) is believed to be central to the origin of life question.

245 has been linked to diverse scenarios for the origin of life, ranging from an extraterrestrial origin

246 thesis of (proto)biomolecules of interest in origins of life-related research, light has also been fo

247 Theories about the origin of life require chemical pathways that allow form

248 Theories for the origin of life require the availability of reduced (or '

249 But the origin of life required, owing to conformational constra

250 Ribosomal translation at the origin of life requires controlled aminoacylation to pro

251 A key challenge in origin-of-life research is the identification of plausib

252 The main aim of origins of life research is to find a plausible sequence

253 Numerous long-standing questions in origins-of-life research center on the history of biopol

254 A central challenge in origins-of-life research is to elucidate how primitive g

255 origin of nucleotides is a major question in origins-of-life research.

256 ch as this will be increasingly necessary as origins-of-life researchers move toward systems-level in

257 rding to a current "RNA first" model for the origin of life, RNA emerged in some form on early Earth

258 ose the concept of a ribofilm in which RNA's origin-of-life role is more akin to a slowly changing pl

259 s well as being a possible precursor for the origin of life's hypothesis within prebiotic chemistry.

260 nant of peptide structure and activity in an origins-of-life scenario.

261 vides a bridge between the information-first origin of life scenarios and the paradigm of autocatalyt

262 mistry allow researchers to explore possible origin of life scenarios.

263 n the early Earth are poorly known, yet many origin-of-life scenarios depend upon their characteristi

264 l subunit, pantetheine, is important in many origin-of-life scenarios, but how pantetheine emerged on

265 blocks, our findings may have relevance for origin-of-life scenarios.

266 ility of RNA self-reproduction is central to origin-of-life scenarios.

267 are discussed, as are their implications for origins of life scenarios and their plausibility, and th

268 oxylate on a ferroan brucite surface expands origins of life scenarios.

269 Many origins-of-life scenarios depict a situation in which th

270 All scientific approaches to the origin of life share a common problem: a chemical path t

271 will be close to a full understanding of the origin of life, so the future of research in this field

272 as well as valuable protocellular models in origin-of-life studies and synthetic biology.

273 Origins of life studies represent an exciting and highly

274 branes in biophysics, synthetic biology, and origins of life studies.

275 Contemporary research into the origins of life subscribes to the Darwinian principle of

276 To address central problems in the origin of life such as the formation of linear polymers

277 Most models of the origin of life suggest organisms developed from environm

278 The hypothesis underlying the abiogenic origin of life suggests that the nonenzymatic synthesis

279 To study the origin of life, synthetic biologists construct simple 'p

280 Since the origin of life, temperatures on earth have fluctuated bo

281 uld have been a more favorable place for the origin of life than previously thought.

282 The nature of the processes at the origin of life that selected specific classes of molecul

283 During the origin of life, the biological information of nucleic ac

284 hetic drugs to biodegradable plastics to the origin of life, the chiral selection of molecules presen

285 cs of chemical reactions associated with the origin of life, the energetics of early metabolisms, and

286 ortance of molecular self-replication in the origin of life, the feasibility of peptide self-replicat

287 Because of its importance for the origin of life, the nonenzymatic copying of RNA template

288 an say nothing about the temperatures of the origin of life, the RNA world, and organisms preceding t

289 High-temperature origin-of-life theories require that the components of t

290 In this hypothesis, at the time of the origin of life there were only seven primordial amino ac

291 tion encoded in their genomes, and since the origin of life this information has been encoded using a

292 r estimates of primary productivity from the origin of life to the present day.

293 Therefore, unless the origin of life took place extremely rapidly (<100 yr), w

294 Connecting helicene templates to the Origins of Life ultimately changes our hypothesis on int

295 A crucial transition in the origin of life was the emergence of an informational pol

296 rliest ribozymes, whose emergence marked the origin of life, were low in activity but high in promisc

297 een LLPS and chiral symmetry breaking in the origin of life, while paving the way for an emerging fro

298 emergence of functional sequences during the origin of life would be possible even in the face of the

299 of biological polymers are important for the origin of life, yet few experimental examples of such re

300 chemical homochirality was a key step in the origin of life, yet prebiotic mechanisms for chiral sepa