ライフサイエンスコーパス: ortho position

1 s in proximity to react at the less hindered ortho position.

2 on in order to guide the latter to the arene ortho position.

3 sequently direct the nitrenoid to add to the ortho position.

4 ne phenyl group bearing a substituent in the ortho position.

5 lide substrates with directing groups at the ortho position.

6 creased by the presence of a chlorine in the ortho position.

7 icals on tyrosines with substitutions at the ortho position.

8 d that arylation proceeds selectively at the ortho position.

9 drogen bonds involving hydrogen atoms in the ortho position.

10 e keto-nitrile directs self-metalation at an ortho position.

11 set up for a 5-endo-trig cyclization at the ortho-position.

12 p directs the isocyanate electrophile to the ortho-position.

13 t of tyrosine and shows a preference for the ortho positions.

14 s direct the protonation to their respective ortho positions.

15 of aryl azides having methyl groups in both ortho positions.

16 ferring hydrogen atoms between the ortho and ortho' positions (1,4-shifts of hydrogen atoms).

17 zides containing a substituent at one of the ortho positions (2,4-dimethoxyphenyl azide (1a) and 2-me

18 Generally, the reaction takes place in the ortho position, adjacent to the substituent.

19 , hitherto unstudied in pCps, between pseudo-ortho-positioned amides of a pCp-4,7,12,15-tetracarboxam

20 al imidazoles with the basic nitrogen at the ortho position and efficiently integrates pai-stacking m

21 ariety of electron-withdrawing groups at the ortho position and evaluating their effects on oral bioa

22 ffold with chemical alterations in the para-/ortho-positions and performed an in-depth study into the

23 n solution, it selectively protonates at the ortho position, and the resulting eta(2)-arenium species

24 es with electron donating groups at para and ortho positions are generally successful with our method

25 The mutually ortho-positioned B- and N-atoms also induce a multi-reso

26 ation not only partially fails at one of the ortho positions but also is completely prevented by a co

27 ssible pathways for the C-C coupling between ortho-positioned carbon atom of benzoic acid and the dia

28 When both ortho positions carry methyl substituents, cyclooctane a

29 Substitution at ortho positions caused the yield of C-H insertion produc

30 A sulfinyl group in an ortho position confers enough chemical and configuration

31 merization of aromatic nitrile monomers with ortho-positioned dicyano groups in the presence of metal

32 o form the C-O bond without the "compulsory" ortho-position directing groups (yields up to 96%), outp

33 atom replacement: Azide introduction at the ortho position enables a photoinitiated rearrangement of

34 ing coordinating groups (particularly in the ortho position) gave lower, and in one case even reverse

35 resence of an oxygen-containing group at the ortho position (I) were important determinants for the a

36 uorines from the meta positions in 18 to the ortho positions in 20 reverses the binding orientation,

37 corresponds to direct bond formation between ortho positions in DPC, referred to as ortho,ortho' coup

38 hosphino)biphenyl, such as the unsubstituted ortho positions in the non-phosphine ring.

39 ts of aryl propargyl ethers to the alternate ortho positions in unsymmetrical reactants.

40 te is available or meta to the halide if the ortho position is already substituted.

41 te that in these analogues, hindrance at the ortho position is relaxed relative to poly(phenylenes).

42 ilization of the radical intermediate in the ortho-position is distinctly more favored for aromatic t

43 in the close proximity of the metal center (ortho position) is essential for the electrostatic facil

44 CYP3A4, resulting in oxygen transfer to the ortho position, is proposed.

45 bearing alkene-containing side-chains in the ortho-position) leads to formation of aliphatic aldehyde

46 N atom directed the aroylating group to the ortho position, leaving behind the nondirected metalatio

47 the other hand, single substitutions at the ortho position led to the loss of binding affinity.

48 CHO coupled with substitution with CN in the ortho-positions makes the open and bridged radical appro

49 oxidant-promoted benzoyl/acyl radical to the ortho position of 1-phenyl-1H-indazoles.

50 or the introduction of various groups to the ortho position of a benzene ring.

51 e-specific (13)C-(1)H enrichment of a single ortho position of aromatic amino acid side chains in an

52 Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenes

53 facile introduction of a phenyl group at the ortho position of phenols and anilines.

54 al H/D exchange for the hydrogen atom in the ortho position of pyridine and concomitant formation of

55 hat small electron-withdrawing groups on the ortho position of the anilide, i.e., chloro, acetyl, or

56 xygen atom of the NOO moiety reacts with the ortho position of the aromatic ring.

57 in, which is not further deprotonated at the ortho position of the aromatic ring.

58 cient, or when chelating substituents at the ortho position of the aryl ring are capable of binding w

59 udies demonstrated that substitutions at the ortho position of the aryl ring improved binding and fun

60 ed via addition of the phenyl radical to the ortho position of the benzyl radical.

61 lan-2-yl or 1,3-dithian-2-yl substituents at ortho position of the C-phenyl ring, respectively, trans

62 groups, depending on the substitution in the ortho position of the phenol ligand.

63 indicated that a pyrrole substituent in the ortho position of the side chain phenyl ring was most li

64 The ortho positioning of hydroxyl groups in catechol facilit

65 Ortho positioning of substituents reverses this C-O bond

66 s to the incorporation of deuterium into the ortho positions of 4-AP, where the source of deuterium i

67 orted by DFT calculations, revealed that the ortho positions of aromatic phenols preferentially attac

68 A symmetrical strap, attached to ortho positions of phenyl groups at opposing meso positi

69 Selective nitrogen substitution into the ortho positions of the aromatic rings allows for the rin

70 ation of the ligand to have Ad groups at the ortho positions of the aryloxide arms is sufficient to s

71 Upon removing the steric bulk from the ortho positions of the N-aryl group of the thiazole-2-yl

72 y-2-butene increasing the steric bulk at the ortho positions of the N-aryl substituents results in ca

73 the alpha-position of the vinyl group or the ortho positions of the phenyl results in increased pheny

74 emissive peaks for the hydrogen spins at the ortho positions of the pyridine substrate (both free and

75 methylanilinium groups are introduced at the ortho positions of the TPP phenyls.

76 rin unit, carrying bromomethyl groups at the ortho positions of two trans-positioned meso-phenyl grou

77 elta-carbon of an arginine side chain to the ortho-position of a tyrosine-phenol.

78 trolled introduction of an amide unit at the ortho-position of an electron-deficient arylamide system

79 trolled introduction of olefin motifs at the ortho-position of benzamides.

80 further increased with a halogen atom in the ortho-position of the 1-phenyl ring.

81 lfoxide partner prior to its delivery to the ortho-position of the aromatic ring by rearrangement of

82 eocenter and the sulfur functions located at ortho-position of the aryl group, on their stereoselecti

83 l electrophilic aromatic substitution of the ortho-position of the phenyl group adjacent to the oxime

84 l acceptors with varying substituents in the ortho-position of their beta-phenyl rings were investiga

85 ructures, binaphthyl is covalently linked to ortho-positions of azobenzene, and four different substi

86 xocyclic double bonds to direct links to the ortho-positions of both adjacent meso-phenyl groups.

87 h as fluorine are tolerated at the meta- and ortho-positions of the 4-phenoxy to retain a good in vit

88 y introducing fluorine substituents into the ortho-positions of the phenyl ring of phenylcarbene, the

89 the addition of a methyl substitutent at an ortho position on the beta-aromatic ring increases the a

90 owever, if the substituted nitrogen is in an ortho position relative to one acetylene linker and a pa

91 meta- vs para-) and the methyl groups in the ortho-position relative to the carbamate exhibited an in

92 ith excellent levels of regiocontrol for the ortho position(s) over all others.

93 The oxidation state of sulfur at the ortho position significantly influenced the compound's a

94 does not require prefunctionalization at the ortho-position since direct C-H activation is efficient.

95 antify the degree of steric hindrance in the ortho positions that is required for atropisomerism to r

96 wever in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes

97 f steric hindrance or electron donors at the ortho position to suppress the Tishchenko reaction, an u

98 nd between the azo group and a Te-Ph unit in ortho position to the azo group.

99 rs do not allow chlorine substitution in the ortho-position to influence the prediction.

100 e incorporated the hetero atoms (O/S) at the ortho-position to investigate the steric influence on co

101 step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the anil

102 ols the reaction occurred exclusively at the ortho-position to the benzamido functionality, in pyridi

103 ong electron-donating group (-NMe(2)) at the ortho-position to the benzoselenazole ring was further i

104 nds strongly on the substituent -CH2X in the ortho-position to the tether.

105 Burkholderia cepacia G4 hydroxylates at the ortho position, toluene 3-monooxygenase (T3MO) of Ralsto

106 uence of the tBu group of the Mamx ligand in ortho position was evaluated by optimizing molecular str

107 Moreover, when one ortho position was labeled with deuterium, no selectivit

108 groups on the phenyl rings in all ortho and ortho' positions was immobilized on carbon nanotubes via

109 masked oxygen or nitrogen nucleophile in the ortho position were generated from thioacetals, using lo

110 ng an amide substituent in the meta, but not ortho position were up to 17-fold more potent inhibitors

111 l ligands bearing fluoro substituents in the ortho positions were used, the formation of the correspo

112 y, requires that the methoxy group be at the ortho position where it is positioned in the developing

113 d that hydroxylated toluene primarily at the ortho-position while converting naphthalene to 1-naphtho

114 as observed in the other benzene ring in the ortho position with respect to the carbonyl group.

115 requirement for chlorine substitution at the ortho-positions, with 2,2',3,5',6-pentachlorobiphenyl ha

116 idin-2-ylethynyl)-benzene, nitrogen atoms in ortho positions], with an IC(50) value in the nanomolar

117 be site-selectively introduced at the arene ortho position without using sterically or electronicall