ライフサイエンスコーパス: ortho-

1 ponin I using 3 assays (Abbott, Siemens, and Ortho).

2 n I using three assays (Abbott, Siemens, and Ortho).

3 ponin I using 3 assays (Abbott, Siemens, and Ortho).

4 n NMN(+)-specific glucose dehydrogenase (GDH Ortho).

5 alitatively to the field effect parameter (F(ortho)).

6 bserved at the ipso (k(12)C/k(13)C = 1.024), ortho (1.017), and meta (1.013) carbons, indicative of s

7 lic cyclization of the resulting N,N-dialkyl-ortho-(1-alkynyl)anilines with arylsulfenyl chlorides or

8 ree different isomers of phenylboronic acid (ortho, 2; meta, 3; and para, 4) as chelating binding sit

9 substitution are chlorine atoms that occupy ortho- (2, 2', 6, 6') positions.

10 fonic acid (HOTf) promoted cross-coupling of ortho-[2-(4-methoxylphenyl)-alkynyl]acetophenones with o

11 The lowest energetic span (dE(ortho) = 26 kcal/mol with 8-AQ) is noted in the ortho bo

12 on, relative to that in the chelate mode (dE(ortho) = 26 kcal/mol).

13 ra-substituted PBA (4CPBA), much higher than ortho- (2CPBA) and meta- (3CPBA) substituted PBA, indica

14 coupling reaction between PhMgBr and (pseudo-ortho) 4,12-diiodo-1,1,2,2,9,9,10,10-octafluoro[2.2]para

15 l Epipodophyllotoxin (W1), and camptothecin-(ortho)-4beta-amino-4'-O-demethyl Epipodophyllotoxin (W2)

16 he level of sensitivity was intermediate for Ortho (92.4% to 96.5%) and Wiener (94.0% to 97.1%); both

17 Here we present the development of Nox Ortho, a reduced NMN(+) (NMNH)-specific oxidase, that co

18 o react with dialkyl ditellurides to provide ortho-(alkyltelluro)phenols in low yields.

19 The quenching of peroxyl radicals by ortho-(alkyltelluro)phenols occurs by a more complex mec

20 of ortho-(alkynyl)benzyl thiosulfonates and ortho-(alkynyl)benzyl sulfurothioates (Bunte salts) have

21 A new type of ortho-(alkynyl)benzyl thiosulfonates and ortho-(alkynyl)

22 onalized naphthalenes from easily accessible ortho-(alkynyl)styrenes under mild reaction conditions.

23 aromatization and intermolecular coupling of ortho-(alkynyl)styrenes with allylic alcohols catalyzed

24 conical intersection seam suggest that 1,2 (ortho) and 1,3 (meta) will be the preferred chemical pro

25 tron-withdrawing substituents in their para, ortho, and meta positions in THF at room temperature.

26 ee different configurations, meta-meta, meta-ortho, and ortho-meta, were systematically explored thro

27 nked immunosorbent assays (ELISAs) (Hemagen, Ortho, and Wiener) and one rapid test (InBios) are FDA c

28 lls) and of cartwheel cells were recorded to ortho- and antidromic activation of the granule cells (i

29 findings, we conclude that the evolution of ortho- and aquareoviruses has included a series of discr

30 irion, a trait previously unseen among other ortho- and aquareoviruses.

31 rinated biphenyls (PCBs), including four non-ortho- and eight mono-ortho-substituted congeners, and 2

32 of Henry's law constants (HLCs) for four non-ortho- and eight mono-ortho-substituted polychlorinated

33 shift of the inner NH protons as well as the ortho- and meso-protons of the pyridyl groups of the por

34 port the efficient separation of pX from its ortho- and meta- isomers by a microporous calcium-based

35 A wide variety of ortho- and meta-C-H functionalizations stand as examples

36 ition to the unsubstituted isomers (known as ortho- and meta-COSAN), four derivatives bearing organic

37 sis efficiency showed that the decaging from ortho- and meta-derivatives takes place efficiently in a

38 tabilize transition states that form bulkier ortho- and meta-isomers, thereby resulting in high intri

39 twofold alkylation of the Ph-substituent at ortho- and meta-positions, that leads to a 1,2,7,8,9,10-

40 eleration allows for the development of both ortho- and meta-selective C-H olefination of phenol deri

41 teration of regioselectivity to furnish both ortho- and meta-substituted alkynylation products.

42 were successfully arylated with a variety of ortho- and meta-substituted aryllead compounds generated

43 t-hand side variants showed a preference for ortho- and meta-substituted benzene rings linked directl

44 erging bicyclic hydrocarbon bioisosteres for ortho- and meta-substituted benzenes, but are difficult

45 can also be used to dearomatize toluene and ortho- and meta-xylene with unexpectedly high regio- and

46 lmorphans, all but two of the racemates, the ortho- and para-b-oxide-bridged phenylmorphans 20 and 12

47 catechol and MHQ are auto-oxidized to toxic ortho- and para-benzoquinones which act like diamide as

48 acid, vanillic acid, caffeic acid, vanillin, ortho- and para-coumaric acids, were identified and quan

49 stituted oxide-bridged phenylmorphans in the ortho- and para-d-oxide-bridged phenylmorphan series (51

50 Irradiation of ortho- and para-derivatives resulted, respectively, in t

51 The synthesis of the ortho- and para-e isomers in the oxide-bridged 5-phenylm

52 n = 1 Sn- and Pb-based LHPs with a series of ortho- and para-functionalized phenethylammonium (PEA) i

53 Here we report observations of ortho- and para-H2D(+) emission and absorption, respecti

54 rientations, giving rise to the spin isomers ortho- and para-hydrogen.

55 the doses required for stabilization by the ortho- and para-NO-ASA were 300- to 3,000-fold lower tha

56 dependence of cycloaromatization kinetics of ortho- and para-NO2 substituted enediynes on the concent

57 The coupling of ortho- and para-phenols with secondary and tertiary boro

58 ols were hydroxyl- and amino-substituents in ortho- and para-positions, causing 100% ClO(2)(-) and 0%

59 h exclusively feature bromo-substitutents in ortho- and para-positions.

60 a common intermediate are achieved by using ortho- and para-quinone methide chemistry.

61 of potential catalysts has been screened for ortho- and para-selective chlorination of phenols.

62 ly detrimental to biodegradability; however, ortho- and para-substituted benzene rings in the backbon

63 vestigated for n-propyl thiol reactions with ortho- and para-substituted benzo-1,2-dithiolan-3-one 1-

64 Here, a series of ortho- and para-substituted NBD dimers bearing methoxy,

65 bond in a series of differently substituted ortho- and para-tolanes has been studied by NMR and comp

66 Despite the prevalence of ortho- and pyrophosphate in biochemistry, operationally

67 Ortho- and retronasal olfaction are particularly crucial

68 Both ortho- and retronasal olfaction produce highly salient p

69 of our factor Xa inhibitors with a series of ortho- and/or para-substituted phenylpyrazole derivative

70 tween ortho-(chloro)arylphosphine oxides and ortho-(bromo)aryl ethers.

71 y is profoundly increased by the presence of ortho- (but not other) hydroxyl substituent(s) on the ar

72 terminations can modularly couple with this "ortho" C-H methylation to constitute a versatile methyla

73 cross- and atroposelective coupling between ortho-(chloro)arylphosphine oxides and ortho-(bromo)aryl

74 For the lower pressure polymorphs (ortho-, clino-, and protoenstatite), all oxygen species

75 The ortho,ortho' coupling must take place in a higher excited stat

76 rbene rearrangement dominates over the ortho,ortho' coupling under all conditions employed.

77 ortho positions in DPC, referred to as ortho,ortho' coupling.

78 tor were engineered to create an orthogonal (ortho) cytokine-cytokine receptor pair capable of delive

79 en synthesized by the reaction of C(alpha),C(ortho)-dilithiated phosphazenes with aldehydes and keton

80 lows the highly selective Ir-catalyzed ortho,ortho'-directed diborylation of aromatic N,N-dimethylhyd

81 propagating along the crystallographic (101)(ortho) direction.

82 ated to the development of directed proximal ortho, distal meta/para, aliphatic (racemic and enantios

83 The "ortho" effect also had the beneficial effect of directin

84 observed in prior studies on NdNiO(3) (101)(ortho) films and RENiO(3) single crystals.

85 donor GYY4137 on enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families, for which

86 0-diphenylanthracene atropisomers with ortho,ortho'- formyl substituents are presented.

87 ound state free energy of the haloarene (G(o)ortho - G(o)H or G(o)ortho - G(o)para) by inflicting mol

88 y of the haloarene (G(o)ortho - G(o)H or G(o)ortho - G(o)para) by inflicting molecular strain and con

89 esence of tert-butoxide base, to the para or ortho (if para is substituted) position of nitrobenzene.

90 gives complementary site selectivity at the ortho- instead of ipso-position of aryl halides.

91 We report an asymmetric homocoupling of ortho-(iodo)arylphosphine oxides and ortho-(iodo)arylpho

92 ling of ortho-(iodo)arylphosphine oxides and ortho-(iodo)arylphosphonates resulting in highly enantio

93 ene exceeding 25 were observed and para- and ortho- liquid mixtures were efficiently separated, with

94 ating and electron-withdrawing groups at the ortho, meta and para positions of both aromatic rings we

95 Influence of various substituents at the ortho, meta and para positions of the aromatic core of p

96 distortion of the ortho substituents in the ortho, meta cyclization transition structures that cause

97 stituted systems show para, meta (instead of ortho, meta) selectivity.

98 t account for the near constancy of IEs from ortho, meta, and para deuteriums, but the observed IEs a

99 The ortho, meta, and para isomers of 9,10-dipyridylanthracen

100 The ortho, meta, and para isomers of manganese(III) 5,10,15,

101 4.1 x 10(6), and 3.8 x 10(6) M-1 s-1 for the ortho, meta, and para isomers, respectively.

102 nd electron-withdrawing functional groups at ortho, meta, and para positions of the diallylanilines.

103 es of PPAs substituted at the phenyl ring in ortho, meta, and para with either (S)-alpha-methoxy-alph

104 gen adatoms to three, ring carbon positions (ortho, meta, and para with respect to the phenolic OH gr

105 positions of the pyridinium nitrogen, ipso, ortho, meta, and para, we found a variation in the inter

106 nected by a bis-acetylene-phenyl pai-spacer (ortho, meta, or para positions) upon oxidizing one of th

107 tron-donating or electron-withdrawing in the ortho, meta, or para positions.

108 cribe the effect of a fluorine that is ipso, ortho, meta, or para to the site of ionization.

109 ly independent of the position of the group (ortho, meta, or para).

110 henoxide has at least one methyl substituent ortho, meta, or para.

111 or the aromatic substitution pattern (i.e., ortho, meta, para) of the parent phenylacetylene monomer

112 at these substituents are best understood as ortho, meta-directors, with a preference for meta, just

113 c measurements indicate a retention order of ortho- > meta- > para-xylene.

114 ary structure of the enzyme, we utilized the ortho-, meta, and para-isomers of phenylenedimaleimide (

115 reversed-phase test mixture, as well as for ortho-, meta- and para-disubstituted benzenes and other

116 ortho-, meta- and para-Hydroxymethylaniline methyl ether

117 s enabling ideal bioisosteric replacement of ortho-, meta- and para-substituted benzenes.

118 learly showed the preferential enrichment of ortho-, meta- or para-regioisomers, which was experiment

119 addition and abstraction processes involving ortho-, meta-, and para-benzyne have been investigated b

120 ave determined the binding constants for the ortho-, meta-, and para-boronic acid probes to be 0.12,

121 sidic 4,6-halobenzylidene acetals bearing an ortho-, meta-, and para-chloro- or -bromo substituent on

122 es of the NO3 radical-initiated oxidation of ortho-, meta-, and para-cresol have been performed in la

123 itative distinction of structural isomers of ortho-, meta-, and para-fluorotoluene.

124 0.1, 6.9 +/- 0.1, and 9.1 +/- 0.2 mM for the ortho-, meta-, and para-isomers of methoxyphenol, respec

125 as observed during gas-phase dissociation of ortho-, meta-, and para-methoxybenzoate anions.

126 and electron-donating functionalities at the ortho-, meta-, and para-positions of the isothiocyanate

127 arylacrylamides independently substituted at ortho-, meta-, and para-positions with 11 different grou

128 ergies of N,N-dimethylaniline with different ortho-, meta-, and para-substituted acceptor groups.

129 bstituents on the aromatic ring with various ortho-, meta-, and para-substituted aryl halides 3 was i

130 The reaction scope includes ortho-, meta-, and para-substituted benzaldehyde derivat

131 id substrates and aroyl CoA donors (benzoyl; ortho-, meta-, and para-substituted benzoyls; various he

132 Ortho-, meta-, and para-substituted bromoarenes underwen

133 atalyst for the neopentylglycolborylation of ortho-, meta-, and para-substituted electron-rich and el

134 Gas-phase calculations for ortho-, meta-, and para-substituted phenylcarbenes demon

135 The effects of aryl ring ortho-, meta-, and para-substitution on site selectivity

136 rates show a linear Hammett correlation for ortho-, meta-, and para-substitution.

137 s benzene, toluene, xylene (i.e., the sum of ortho-, meta-, and para-xylene isomers), and ethylbenzen

138 reactions of ozone with aromatic carbons in ortho-, meta-, or para-positions is not feasible and tha

139 adical viologen units that are linked by two ortho-, meta-, or para-xylylene bridges to provide diffe

140 ides generated from aryl/hetaryl-substituted ortho-( N, N-dimethylaminomethyl)phenols with (2 E)-3-(

141 , the dehydrogenative annulation at the C2-H/ortho-(NAr)C-H bonds operates via a cascade reaction seq

142 aleimide framework plus the proximity of the ortho-(NAr)C-H site to the coordination zone of the Ru(0

143 a monotonic relationship for dioxin-like non-ortho (non-o)-PCB TEQs [fourth vs. first quartile: 3.66

144 s pyridyl anchors with para (p), meta (m) or ortho (o) connectivities and Y represents a phenyl ring

145 8-AQ participation is found to exhibit a dE(ortho) of 24 kcal/mol for the ortho borylation, relative

146 in affinity was realized than for either the ortho- or meta-substituted analogues; 97 was the most po

147 ue of 2-substituted BCPs as replacements for ortho- or meta-substituted arene rings, general and rapi

148 es a new class of traceless linkers based on ortho- or para-hydroxybenzylamines.

149 differentiated alpha-NETA analogs (primarily ortho- or para-methoxy substitutions) with significantly

150 ety was mainly attached via C-C bonds to the ortho- or para-positions of phenolic hydroxyl/amino grou

151 fects by introducing bulky amido moieties to ortho- or para-positions of the meso-phenyl groups.

152 ontaining electron-withdrawing groups in the ortho- or para-positions was high yielding.

153 pling the reaction to the cavity, generating ortho- or para-substituted products instead of the meta

154 nal nucleotide determining whether primarily ortho- or pyrophosphate is released.

155 We found that the ortho, ortho substituent pattern and the presence of the

156 novel planar chiral cyclophanes, obtained by ortho, ortho" anchoring of the p,p'-terphenyl unit, with

157 rminal oxidant to accomplish selective ortho-ortho, ortho-para, or para-para homo-couplings of phenol

158 her Fe(0) tetraphenylporphyrin bearing eight ortho-, ortho'-phenol functionalities launches a general

159 orphyrin two of the opposite phenyl rings by ortho-, ortho'-phenol groups while the other two are per

160 t as electron-donating groups are considered ortho, para-directors, with a preference for para.

161 y (FTRMS) effectively quantifies mixtures of ortho-, para-, and meta-nitrotoluenes, the first two of

162 ) tetraphenylporphyrin bearing eight ortho-, ortho'-phenol functionalities launches a general strateg

163 two of the opposite phenyl rings by ortho-, ortho'-phenol groups while the other two are perfluorina

164 ferring hydrogen atoms between the ortho and ortho' positions (1,4-shifts of hydrogen atoms).

165 groups on the phenyl rings in all ortho and ortho' positions was immobilized on carbon nanotubes via

166 cile Rh(III)-catalyzed spiro-cyclization and ortho-(proximal) aromatic C-H activation reaction of ami

167 itro substituents on different rings: pseudo-ortho, pseudo-meta, and pseudo-para, in equal amounts.

168 mino-N-phenylbenzamide derivatives having an ortho- substituent in the N-phenyl moiety wherein the co

169 When the ortho'-substituent is a nonnucleophilic formyl group, th

170 The results show that when the ortho'-substituent is a vinyl group, the products includ

171 hindered N-tosylhydrazones 2 featuring ortho/ortho'-substituents on the aromatic ring with various or

172 on radicals is affected by the nature of the ortho'-substituents.

173 was undertaken to determine the influence of ortho'-substituted nucleophilic groups (OH, NH2, or NHR)

174 evious studies have focused on the effect of ortho'-substituted nucleophilic groups such as OH, NH(2)

175 e present study extends the investigation to ortho'-substituted vinyl and formyl groups.

176 s a continuation of studies on the effect of ortho'-substitution on the reactivity of anodically gene

177 a shift of the hydrogen bond donor from the "ortho" to the "meta" position, relative to the pyridazin

178 d functionalization of the position para (or ortho) to a fluorine atom on the aromatic ring using an

179 be enhanced by using a ligand to switch from ortho- to meta-selectivity.

180 n, a boron tribromide promoted deprotection, ortho- to para- naphthoquinone spiroketal rearrangement,

181 It employs a FeO(OH) catalyst for the ortho- to para-state conversion.

182 ectronically with the search terms "surg*", "ortho*", "trauma", "cancer", "appendic*", "laparotomy",

183 ence involving O-trichloroacetylation, N-->C(ortho) trichloroacetoxy shift, and cyclization in a sing

184 various 2-substitued quinoline N-oxides with ortho-(trimethylsilyl)aryltriflates in the presence of K

185 r and spatially smaller ORN inputs than with ortho, yet whether this is consequential for OB activity