ライフサイエンスコーパス: ortholog

1 ground truth, computational cost of calling orthologs).

2 ut little is known about the role of its NTS ortholog.

3 odent TRPA1 without affecting the Drosophila ortholog.

4 irst sequenced bacterium with a recognizable ortholog.

5 nscription factor gene with the myxoma virus ortholog.

6 o IL-23R is different from that in the human ortholog.

7 f protein-coding zebrafish ISGs had no human ortholog.

8 active in yeast even if it does not have an ortholog.

9 n endogenous arsRBC operon but lacks an arsH ortholog.

10 issues more often replace their single yeast ortholog.

11 these activities vary among different Cas12a orthologs.

12 on allowed for functional analyses of lethal orthologs.

13 ith the pharyngeal arch expression of Pou3f3 orthologs.

14 ve lignan- and aromatic terpenoid-forming DP orthologs.

15 ing functional observations in multiple MscL orthologs.

16 volutionary rate of functional changes among orthologs.

17 s, we predicted the structures of several gK orthologs.

18 ons and dinucleotide percentages to identify orthologs.

19 mer's disease risk genes lack adequate mouse orthologs.

20 nce of antigen-specific T cells against both orthologs.

21 uitment capacities of human MIF by its plant orthologs.

22 n Domains (RDs), which are unique to Pumilio orthologs.

23 FAMIN and its prokaryotic orthologs additionally have adenosine deaminase, purine

24 Although these orthologs adopt similar structural architectures, they r

25 e compare recombinant human and baboon APOL1 orthologs, along with interspecies chimeras and individu

26 A co-occurrence analysis of Hps orthologs among cyanobacteria identified an extended set

27 is transcriptional regulation: a barley PHR1 ortholog and a TF containing an uncharacterized MYB doma

28 match type and position and vary with Cas12a ortholog and CRISPR RNA sequence.

29 n for dnd revealed that tdnd encodes the dnd ortholog and its transcript is detectable only in the te

30 unctional relationship among eukaryotic FAAH orthologs and features that contribute to versatility an

31 We examined the receptor activity of 14 ACE2 orthologs and found that wild-type and mutant SARS-CoV-2

32 ated into crop species using endogenous PBS1 orthologs and holds strong potential for GMO-free develo

33 expression of two adjacent genes, pb (a Hox2 ortholog) and zen2 (a divergent Hox3 paralog), with disp

34 e arms, contains 95% of expected single copy orthologs, and a nearly complete assembly of this indivi

35 tic diversity of the PAM recognition by Cas9 orthologs, and provide a basis for the further engineeri

36 diverged dispensability at 12% of conserved orthologs, and validation experiments confirmed 22 diffe

37 (TFL1) and FLOWERING LOCUS T (FT) and their orthologs antagonistically regulate these life history t

38 tains a DUF538 domain with unknown function; orthologs are exclusively found in Viridiplantae.

39 for cancer and AIDS treatment, DDX3X and its orthologs are extensively studied, yielding a wealth of

40 vival of many pathogens and no apparent ClpB orthologs are found in metazoans.

41 y conserved esterase domain in putative PMR5 orthologs are necessary for PMR5 function.

42 Here, we show that SREBP orthologs are not involved in the regulation of sterol b

43 motifs, highly conserved between the studied orthologs, are critical for TTC29 axonemal localization

44 model of SOD1-linked ALS identified the USP7 ortholog as a suppressor of proteotoxicity in the nervou

45 osophila tau (dTau) is a true vertebrate tau ortholog as it interacts with the neuronal microtubule a

46 We find that the Atlastin-1 ortholog, atln-1 is required for neuronal ER morphology.

47 tations and establish a role for the SMARCD1 ortholog Bap60 in the regulation of neurodevelopmental g

48 iotic resistance (VAMPr), to (1) derive gene ortholog-based sequence features for protein variants; (

49 we dissected the function of Brachypodium FT orthologs BdFTL1 and BdFTL2 using overexpression and gen

50 nctions are retained or partitioned among co-orthologs between species and within gene families.

51 lishing a precedent for distribution of perA orthologs beyond genus Epichloe.

52 EME1 and GEN1, as well as by the human RecQ orthologs BLM and RECQL4-surprising potential procancer

53 ed the structural properties of several ACE2 orthologs bound to the SARS-CoV-2 spike protein.

54 can be chosen to not only assemble presumed orthologs but also paralogous gene loci in distinct cont

55 Plants possess MIF orthologs but lack the associated receptors, suggesting

56 Furthermore, consensus ortholog calls derived from public benchmark submissions

57 simulations demonstrating that when only one ortholog can replace its corresponding yeast equivalent,

58 The more compact Type II-C Cas9 orthologs can help to overcome the size limitation of Sp

59 itis elegans strain deficient in the ATP13A2 ortholog catp-6 These animals exhibited a basal elevated

60 In Drosophila, loss of SORD orthologs caused synaptic degeneration and progressive m

61 Mutation of the maize LPE1 ortholog causes a photosystem II (PSII) deficiency and a

62 Knockdown of the SCAF4 ortholog CG4266 in the model organism Drosophila melanog

63 ncBAF complex members, including the BRD9/7 ortholog, CG7154, and is the defining member of the ncBA

64 e pattern of replaceability across different ortholog classes, with an obvious trend toward different

65 PanOCT (pan-genome ortholog clustering tool) is a tool for pan-genome analy

66 unction, we find strong evidence against the ortholog conjecture in the context of function predictio

67 rom over 80 000 publications, to revisit the ortholog conjecture in two pairs of species: (i) Homo sa

68 The 'ortholog conjecture' proposes that orthologous genes sho

69 research has provided little support for the ortholog conjecture, though the incomplete nature of the

70 genomes to identify S. oneidensis chemotaxis orthologs conserved in the genus.

71 Unlike other Cas9 orthologs, Corynebacterium diphtheriae Cas9 (CdCas9) rec

72 ter oilseed rape, expression of multiple FLC orthologs declines not during winter but predominantly d

73 ated depletion, we report here that the ELYS ortholog (dElys) plays critical roles during Drosophila

74 Here, we characterized two Cas9 II-C orthologs, DfCas9 from Defluviimonas sp.20V17 and PpCas9

75 Interestingly, human hepsin and prostasin orthologs did not activate H3, but they did activate IBV

76 ful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of

77 eceptor (H(3)R) and especially for the H(4)R orthologs [e.g., human (h) and mouse (m)] are highly nee

78 onin receptors SER-1 and SER-7, and the G(q) ortholog EGL-30.

79 deletion of the AMP-activated protein kinase ortholog-encoding gene SNF1 can restore the oxygen consu

80 In D. radiodurans, the Ro60 ortholog enhances the ability of 3'-to-5' exoribonucleas

81 ference, we discovered over 400 unique human ortholog erosion events across 58 mammals.

82 CRISPR/Cas9 methodologies to identify a CPR5 ortholog essential for proper trichome growth in soybean

83 ecapitulating the depth and scale of natural ortholog evolution on laboratory timescales.

84 restriction, and that diverse mammalian RTP4 orthologs exhibit striking patterns of specificity again

85 Interestingly, FgSR orthologs exist only in Sordariomycetes and Leotiomycete

86 However, a functional Ptr1 ortholog exists in Nicotiana benthamiana and potato, and

87 l receptor for JUNV, while hamster and mouse orthologs fail to support viral entry/infection of pseud

88 es fibroblast growth factor 15 (FGF15; human ortholog FGF19) in the gut to potently inhibit bile acid

89 The recent identification of Spo13 orthologs, fission yeast Moa1 and mouse MEIKIN, suggests

90 The Caenorhabditis elegans NPY/NPF ortholog FLP-34 displays conserved structural hallmarks

91 activities of three different natural Cas12a orthologs (FnCas12a, LbCas12a, and AsCas12a).

92 GTP binding protein C homolog 1 RAGC-1, the ortholog for mammalian RagC/D GTPases, conferred starvat

93 ilize human ACE2 and a number of animal-ACE2 orthologs for cell entry, indicating risks of spillover

94 ous insects are 'Drosophila-like', using PRG orthologs for PR patterning, most Of-PRGs are expressed

95 kilobase indels containing entire genes, and orthologs for which most amino acid residues are polymor

96 Anophensin, the albicin ortholog from An. stephensi, is only weakly active as an

97 cobacterium kansasii is 86% identical to the ortholog from M. tuberculosis and catalytically active.

98 Comparison with its ortholog from S. thermophilus reveals an activation mech

99 f Cas9 nucleases and identified a small Cas9 ortholog from Staphylococcus auricularis (SauriCas9), wh

100 g domain of SmacCas9 to its well-established ortholog from Streptococcus pyogenes (SpyCas9), and furt

101 Moreover, a Dsup ortholog from the tardigrade Hypsibius exemplaris simila

102 ative structure/functional analysis of CYP51 orthologs from different biological kingdoms and employe

103 ds of essential yeast genes with their human orthologs from gene families that have undergone lineage

104 ted gene projections from our 'Tool to infer Orthologs from Genome Alignments' (TOGA) software with d

105 Cas9 orthologs from other bacterial species may provide a ric

106 rom Ochromonas spp. (OcP1) together with its orthologs from other species, leading us to propose the

107 Functional characterization of two orthologs from the dicot Arabidopsis (Arabidopsis thalia

108 r constructing contiguous regulatory element orthologs from the outputs of halLiftover.

109 ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous

110 In this study, we analyzed TolC and its two orthologs, FtlC and SilC, present in the fully virulent

111 The identification of orthologs-genes in different species which descended fro

112 11 571 RBPs with RBDs (corresponding to 6368 ortholog groups) and 3,651 non-canonical RBPs without kn

113 plex, and deficiency of its highly conserved orthologs has been consistently shown to cause defective

114 Orthologs have been found and characterized in prokaryot

115 in patients with rheumatic disease, and Ro60 orthologs have been identified in 3% to 5% of bacterial

116 ated with the down-regulation of genes whose orthologs have been implicated in programmed cell death

117 uman cell culture, deletion of the human HIP orthologs HIP1 and HIP1R led to decreased infection by C

118 ysis of Drosophila Labial and its mouse HOX1 orthologs (HOXA1, HOXB1, and HOXD1) as a paradigm to add

119 d tissue-specific expression of the human co-orthologs, i.e., the human proteins that are less diverg

120 OMA and OrthoFinder, JustOrthologs decreases ortholog identification runtime by more than 96% and ach

121 The oldest CFTR ortholog identified is from dogfish shark, which retains

122 A. officinalis, AoCYP94B1, and its putative ortholog in Arabidopsis (Arabidopsis thaliana), AtCYP94B

123 Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH-30, play an impor

124 ed the vital roles of pezo-1, the sole PIEZO ortholog in Caenorhabditiselegans, in regulating reprodu

125 as not able to complement the broadly acting ortholog in Escherichia coli.

126 We also verified that the VdAtf1 ortholog in Fusarium graminearum mediates nitrogen metab

127 It was further revealed the EmhR ortholog in Pseudomonas syringae was also responsible fo

128 etion and two frameshift mutants of the ANT1 ortholog in the C4 millet Setaria viridis by the CRISPR/

129 evious studies have revealed a single Arl13b ortholog in the evolutionarily divergent Trypanosoma bru

130 ny, we identified a highly divergent basalin ortholog in the related Leishmania species.

131 We observed that knockdown of TRIM28 ortholog in zebrafish resulted in developmental vascular

132 axonal pathfinding induced by loss of NOVA2 ortholog in zebrafish.

133 2 MIKC*) through phylogenetic analysis with orthologs in Arabidopsis and sorghum.

134 atterns of synteny between the Hox2 and Hox3 orthologs in Arthropods are consistent with a shared reg

135 Phylogenetic analysis of CEK orthologs in Brassicaceae species showed evolutionary di

136 Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endo

137 Furthermore, we describe BST-2 orthologs in multiple avian species from 12 avian orders

138 Recent work identified BST-2 orthologs in nonmammalian vertebrates, including birds.

139 h differential expression of zebrafish plvap orthologs in the hypophysis versus brain.

140 ovide evidence for the function of CYCLIN C1 orthologs in the promotion of flowering and the maintena

141 abidopsis (Arabidopsis thaliana), unlike its orthologs in tobacco.

142 and human genes possess clearly identifiable orthologs in yeast, and many have undergone lineage-spec

143 oforms during neocortical neurogenesis whose orthologs include risk genes for neurodevelopmental diso

144 We found that typhoid toxin and its NTS ortholog induce different clinical presentations.

145 knockdown and knockout of the unique TBC1D8B ortholog-induced proteinuria and that this phenotype was

146 interactions, whether through literature or ortholog interaction data, through multiple unique inter

147 itation data demonstrate that the maize CFM1 ortholog is bound to introns whose splicing is disrupted

148 s of Poltheta in different genomic loci; one ortholog is homologous to the Poltheta C-terminal polyme

149 e members FBP9 and FBP23, for which no clear ortholog is present in Arabidopsis, play a major role in

150 to BDNF-TrkB-CREB signaling, whereas the rat ortholog is unresponsive.

151 Moreover, miR-155 orthologs KSHV-miR-K12-11 and MDV-miR-M4, encoded by Kap

152 Like their vertebrate orthologs L1CAM and NCAM1/2, respectively, Nrg and Fas2

153 red from work on the Lotus japonicus MtLYK10 ortholog, LjEPR3.

154 In L. japonicus, two VPY orthologs (LjVPY1 and LjVPY2) were identified.

155 PLP-1 orthologs localized on RNA granules may similarly contri

156 se "crispant" zebrafish larvae of the Draper ortholog (MEGF10) or the Pez ortholog (PTPN21) exhibit a

157 Minerva's vertebrate ortholog, MFSD1, rescues the minerva mutant's migration

158 We identified the mouse ortholog Mfsd7c as a gene expressed in the blood-brain b

159 They further show that hepsin and prostasin orthologs might contribute to the differences observed i

160 ting expansion of the CRISPR toolbox through ortholog mining and PAM engineering.

161 fs conserved across bacterial and eukaryotic orthologs modulate the function of LpThi5.

162 known as Mas-related GPCR-X2 (MRGPRX2, mouse ortholog, MrgprB2), has recently been identified, which

163 We establish that the Collagen XV/XVIII ortholog Multiplexin in the tissue-basement membranes an

164 istance proteins" MxA in human cells and its ortholog Mx1 in murine cells.

165 PR-mediated homozygous deletion of the mouse ortholog of a noncoding region with candidate pacemaker-

166 Simultaneous knock-out of Mlh1, the ortholog of a third HD age-at-onset modifier gene (MLH1)

167 the phenotype revealed that PPAT, the human ortholog of ADE4, showed only partial function whereas a

168 rongly associated with truncation of Ma1, an ortholog of ALUMINUM-ACTIVATED MALATE TRANSPORTER9 (ALMT

169 n 135 strains each carrying a mutation in an ortholog of an ASD-associated gene.

170 response regulated by atfs-1, the C. elegans ortholog of ATF4, causing hypersensitivity to rotenone,

171 nurf-1 encodes an ortholog of BPTF, a large (>300 kD) multidomain subunit

172 FRM-3 then recruits LIN-2, the ortholog of CASK, that binds the synaptic adhesion molec

173 Type II M.HinfI DNA methyltransferase and an ortholog of CcrM, BabI, but not with DNA methyltransfera

174 ed polymerase II (Pol II) and Rad26, a yeast ortholog of CSB, to study the role of CSB in transcripti

175 oupled citrate transporter, is the mammalian ortholog of Drosophila INDY.

176 HP6, an ortholog of Drosophila Persephone, activates both proHP8

177 Here, we show that Mph1, the budding yeast ortholog of Fanconi anemia helicase FANCM, prevents prec

178 he DOM-B complex incorporates H2A.V (the fly ortholog of H2A.Z) genome-wide in an ATP-dependent manne

179 18's effects are dependent on SignR3 (murine ortholog of human DC-SIGN).

180 re we explored the role of murine Fpr2/3, an ortholog of human FPR2/receptor for lipoxin A4 (ALX), in

181 ow that downregulation of galcb, a zebrafish ortholog of human GALC, affects melanoblast and melanocy

182 terized SMALL ORGAN4 (SMO4), the most likely ortholog of human GLTSCR2 and yeast Nop53 in Arabidopsis

183 tein kinase-encoding genes yielded gsk-3 (an ortholog of human GSK3B) and cdk-2 (a CDK2-related kinas

184 Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-oran

185 Here, we show that Tda1, the yeast ortholog of human Nuak1, is a direct kinase for H3pT11 u

186 h model we investigated the role of prokr1b (ortholog of human PROKR2) during early stages of GnRH ne

187 CRISPR/Cas9-mediated ablation of ptprja (the ortholog of human PTPRJ) in zebrafish, which induced a s

188 titution mutation at this locus in the human ortholog of KCC2, found previously in patients with febr

189 eported that the Drosophila Fit1 protein (an ortholog of kindlin-2) prevents abnormal spindle assembl

190 The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-ind

191 We identify LINC01271 as the human ortholog of MaTAR25, and importantly, increased expressi

192 he activity of UBE2N is restored by MvcA, an ortholog of MavC (50% identity) with ubiquitin deamidase

193 tein complex is NCBP3, a recently identified ortholog of NCBP2/CBP20.

194 caused mistrafficking of Sns, the Drosophila ortholog of nephrin.

195 We further show that INSM1, the mammalian ortholog of Nerfin-1, plays a conserved role in repressi

196 Here, we identified the evolutionary ortholog of neuropeptide Y/neuropeptide F in the nematod

197 Drak phosphorylated Sqh, the Drosophila ortholog of nonmuscle myosin regulatory light chain (MRL

198 by sequencing revealed that EDS4 encodes the ortholog of NUCLEOPORIN 205, a core component of the inn

199 e precursor cells is regulated by CMT-1, the ortholog of p31(comet), which is required for both PCH-2

200 Knockout experiments showed that TgSPY, an ortholog of plant SPINDLY and paralog of host OGT, is re

201 late and activate DinB/pol IV, the bacterial ortholog of Polkappa, to induce mutagenesis that enables

202 The ortholog of Ptr1 in tomato and in Solanum pennellii is a

203 f the nuclear lamina; mutations in the human ortholog of Ste24 diminish its activity, giving rise to

204 ously established that yeast ENV7 encodes an ortholog of STK16-related kinases that localizes to the

205 We identified Drosophila Tao kinase, the ortholog of the ASD risk gene Taok2, as a regulator of d

206 Here we show that Chlamydomonas VIG1, an ortholog of the Drosophila melanogaster Vasa intronic ge

207 ioral evidence showing that in C. elegans an ortholog of the human LAT1 transporter, AAT-1, imports K

208 in fatty acid beta-oxidation) and tub-1 (an ortholog of the human TUBBY involved in the neurological

209 he Ndc80c and is proposed to be a functional ortholog of the metazoan Ska complex [16, 17].

210 nicity, MDV-miR-M4, a highly expressed viral ortholog of the oncogenic miR-155, has received extensiv

211 revealed that Arabidopsis MYB99, a putative ortholog of the petunia (Petunia hybrida) floral scent r

212 Here, I show that CDKA1, the ortholog of the yeast and animal mitotic inducer CDK1, r

213 Since a mouse ortholog of Trpm was recently reported also to be involv

214 e plant symbiont Sinorhizobium meliloti, the ortholog of VtlR, named LsrB, is involved in the symbios

215 developmental importance of the Arabidopsis ortholog of yeast CWC15.

216 also report that the Caenorhabditis elegans orthologs of 14-3-3zeta and MSec regulate the size and a

217 In this study, we found that ACE2 orthologs of a wide range of domestic and wild animals c

218 We found that ACE2 orthologs of a wide range of domestic and wild mammals,

219 hree related coronaviruses to utilize animal orthologs of angiotensin-converting enzyme 2 (ACE2) for

220 nts are present in T. sinense, which has two orthologs of AtVND7, the master regulator of vessel form

221 acterization of the zebrafish and Drosophila orthologs of BICRA.

222 The most widely used orthologs of Cas9 are derived from Staphylococcus aureus

223 hat the substrate specificities of the human orthologs of caspase-11, i.e. caspase-4 and caspase-5, a

224 oci, revealing that that LATE3 and LATE4 are orthologs of CYCLIN DEPENDENT KINASE8 (CDK8) and CYCLIN

225 EPR-1 is not fungal-specific; orthologs of EPR-1 are present in a diverse array of euk

226 We identified nine orthologs of FAAH in the moss Physcomitrella patens (PpF

227 There are two conserved orthologs of FOXC1 in zebrafish, foxc1a and foxc1b.

228 Human orthologs of genes expressed by the transitional macroph

229 Whereas cowpox virus contains intact orthologs of genes present in each orthopoxvirus species

230 d with the precipitation gradient, including orthologs of genes that regulate seed size in other cere

231 lines trapped diverse proteins, including 64 orthologs of human disease-associated genes with 40 as p

232 on is inconsistent across different systems; orthologs of LSD1 have been shown to either promote or a

233 RSC1 and RSC2 are orthologs of mammalian PBRM1 (polybromo) which define tw

234 mplifies genetic regions of interest such as orthologs of P. falciparum drug resistance-associated lo

235 osoma cruzi exhibits two individual putative orthologs of Poltheta in different genomic loci; one ort

236 evealed loss of NPY/NPF-type signalling, but orthologs of PrRP-type neuropeptides and sNPF/PrRP-type

237 ol will enable users to efficiently identify orthologs of regulatory elements across hundreds of spec

238 The ba1 and ba2 genes are orthologs of rice genes, LAX PANICLE1 (LAX1) and LAX2, r

239 ricted CD8(+) T cells recognizing the murine orthologs of SCG5, urocortin-3, and proconvertase-2 infi

240 eral auxiliary domains that are conserved in orthologs of the enzyme.

241 ted by mutually antagonistic action of aspen orthologs of the flowering regulators TERMINAL FLOWER 1

242 s one of the two hitherto unknown C. elegans orthologs of the human AF4/FMR2 family proteins, which a

243 AR RNA POLYMERASE D1a (OsNRPD1a), one of two orthologs of the largest subunit of plant-specific RNA p

244 oV-2 and SARS-like viruses to utilize animal orthologs of the SARS-CoV-2 receptor ACE2 might provide

245 ndle (asp) and WD repeat domain 62 (W dr62), orthologs of the two most commonly mutated genes in huma

246 Here, we evaluated the mouse orthologs of two HD age-at-onset modifier genes, FAN1 an

247 tial analysis also revealed an enrichment in orthologs of urease, which has been linked to dysbiosis

248 entity to the S. cerevisiae and Homo sapiens orthologs of Usb1, respectively.

249 Orthologs of vertebrate neuropeptide-Y (NPY) known as ne

250 at it is secreted, similar to its C. elegans ortholog (OIG-4) [10].

251 The actions of USP7 orthologs on misfolded proteins were found to be conserv

252 Mycobacterium tuberculosis encodes FadR orthologs one of which is functional in E. coli.

253 Knockout of the MAGE-B2 mouse ortholog or overexpression of G3BP1 confers hypersensiti

254 is task, regardless of whether it comes from orthologs or paralogs, is most likely to lead to higher

255 y receptor, also known as Olfr78, with human ortholog OR51E2.

256 rface, a sequence database search and a gene orthologs page.

257 We found that each TolC ortholog participated in multidrug efflux, with overlapp

258 because it addresses the critical role CHPK orthologs play in the natural host.

259 e The drive system targets the cardinal gene ortholog producing a red-eye phenotype.

260 er systems with different guide RNAs or Cas9 ortholog proteins.

261 e of the Draper ortholog (MEGF10) or the Pez ortholog (PTPN21) exhibit a failure in leukocyte recruit

262 Here, we identify the SEC4 ortholog RAB3 and its neuronal effector, RIM1, as essent

263 estine, genetic deletion of either mammalian ortholog, Rala or Ralb, reduced ISC function and Lgr5 po

264 laceability, showing that in the case of 1:2 orthologs, replaceability is predicted largely by the di

265 STF and LAM1 are WOX1 orthologs required for leaf blade outgrowth in Medicago

266 derstanding of the dysfunction of human pump orthologs responsible for some newly discovered neurolog

267 CRISPR/Cas9 was used to mutate the CPR5 ortholog, resulting in five plants harboring a total of

268 Ubr2 in the mouse or of the C. elegans UBR5 ortholog results in Notch signaling defects.

269 preference between METTL15 and its bacterial ortholog rsmH.

270 The ortholog ScCas9, on the other hand, derives specificity

271 Among 139 S. exigua CYPs, an ortholog (SE51385) to human EpOME synthase was predicted

272 n conjunction with a comprehensive tRNA gene ortholog set spanning 29 placental mammals to estimate t

273 Enzyme orthologs sharing identical primary functions can have d

274 a) DvSSJ1 mRNA, a Drosophila snakeskin (ssk) ortholog, show insecticidal activity and significant pla

275 e filtration barrier and express the Nephrin ortholog Sticks and stones (Sns).

276 varying properties between otherwise related orthologs, suggesting selective pressure to diversify PA

277 ao kinase, showing that its ASD-linked human ortholog, Tao kinase 2 (Taok2), could replace Drosophila

278 Here, we characterized three MIF orthologs (termed MIF/d-dopachrome tautomerase-like prot

279 trophenol-beta-D-glucuronide (pNPG), the GUS orthologs that are most efficient at processing drug-glu

280 quence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTL

281 ne and human IL-23p19 (Trp(156) in the human ortholog), the site 3 W156A substitution in hIL-23p19 di

282 minal RDs are conserved in mammalian Pumilio orthologs, the results of this work broadly enhance our

283 Here we report a bacterial ortholog to the yeast HMP-P synthase (Thi5) was necessar

284 The presence of syntenic orthologs to about 19% of the S. italica TPSs in related

285 been shown that the conserved role of poplar orthologs to Arabidopsis CONSTANS (CO) directly activate

286 We examined the evolution of mammalian orthologs to determine if the selective forces that led

287 tudy, we combine protein motifs from several orthologs to engineer two variants of Streptococcus cani

288 ify the ability of various properties of the orthologs to predict replaceability, showing that in the

289 c footprinting pipeline based on precomputed orthologs to predict the direct targets of ~67% of ECF s

290 (hlh-30), the Caenorhabditis elegans MiT/TFE ortholog, to starvation followed by refeeding to underst

291 E2 and E3 enzyme activities, including Cdc34 orthologs UBE2R1 and UBE2R2, appear to mediate SCF-catal

292 Characterization of a subset of Cas9 orthologs using purified components reveals additional b

293 y of yeast genes having more than 2 human co-orthologs was marked by retention of orthologous interac

294 mammalian Hig1 proteins and Cox3/Cox12/Cox13 orthologs, we propose that Hig1 type 2 proteins are stoi

295 to identify glycosylation substrates of NleB orthologs, we unexpectedly observed that the bacterial g

296 No mouse Mrgpr orthologs were activated by BAs.

297 Human orthologs were similarly regulated by SULF2, dependent o

298 rall, (Ss)RidA-1 is similar to the mammalian orthologs whereas (Ss)RidA-2 displays unique properties

299 e regulator Stu2 (budding yeast Dis1/XMAP215 ortholog), which we demonstrate here is likely a conserv

300 r, we identified a small set of seed-related orthologs with expression specific to desiccation-tolera