ライフサイエンスコーパス: orthologue

1 C-terminal dimerization domain of Bim1 (EB1 orthologue).

2 nly affected the activation of Mgv1, an Mps1 orthologue.

3 s in a pattern conserved with the human Cdh1 orthologue.

4 imilar evolutionary dynamics in the metazoan orthologues.

5 s with impaired expression of ATP13A2 or its orthologues.

6 pts, including an overlapping subset of 8331 orthologues.

7 lish putative M. truncatula and L. japonicus orthologues.

8 n, HEBO, specifically present in Hebo direct orthologues.

9 e robust to small amounts of mislabelling of orthologues.

10 conservation of active sites with the human orthologues.

11 pecificity of mouse and human RIPK3 for MLKL orthologues.

12 human PIF1 protein from bacterial and yeast orthologues.

13 SPR effectors and 167 AAV VP1-capsid-protein orthologues.

14 press the expression of its two duplicate AG orthologues.

15 or correlations in methylation levels across orthologues(1,2).

16 ng these high effect size genes was a single orthologue (14-3-3 protein zeta/YWHAZ) that was downregu

17 ominates the set of genes that are shared as orthologues across the tree of life.

18 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitary tuberculosi

19 Sik3 orthologues also regulate sleep in fruitflies and roundw

20 Lentiviral co-expression of specific BacNav orthologues, an inward-rectifying potassium channel, and

21 t we characterized the Arabidopsis ABI1 gene orthologue and Brassica napus gene paralogues encoding p

22 Notably, the VEX2-orthologue and CAF-1 in mammals are also implicated in e

23 small-molecule inhibitors of the human CTF4 orthologue AND-1.

24 conserved among primate and carnivore TRIM5 orthologues and among 3 of the 7 mouse Trim5 homologues

25 limitations, we screened eleven diverse Cas9 orthologues and identified four that are broadly functio

26 growth, more robust and reproducible sets of orthologues and paralogues, and enriched views of gene e

27 ammaherpesvirus subfamily, and they identify orthologues and potential homoplastic circRNAs, implying

28 Here, we characterize six smaller Cas9 orthologues and show that Cas9 from Staphylococcus aureu

29 c to enable easier sharing of evidence among orthologues and support next generation sequencing, plus

30 representing the C-terminal domains of ProP orthologues and variants in vitro was compared with subc

31 ubcellular localization of the corresponding orthologues and variants in vivo.

32 ring system (CD1) to enable comparisons with orthologues and with other GPCR classes.

33 tors of alginate production AlgU (a sigma(E) orthologue) and AlgR repress CRISPR-Cas activity during

34 howed selectivity for AtIPCS2 over the yeast orthologue, and activity against Arabidopsis seedlings.

35 activity of Minion is conserved in the human orthologue, and co-expression of Minion and the transmem

36 viously reported for the Anopheles albimanus orthologue anophelin, cE5 binds both thrombin exosite I

37 The zebrafish APP orthologue, Appb, is strongly expressed during early dev

38 a bioinformatic analysis, we found that PqqD orthologues are associated with the RS-SPASM family of p

39 ized to this lineage in the mouse, the human orthologues are either absent or expressed in alternativ

40 Interestingly, putative METTL20 orthologues are found in a subset of alpha-proteobacteri

41 BamA orthologues are found in all Gram-negative bacteria and

42 gene expression analyses demonstrate exWAGO orthologues are highly conserved and abundantly expresse

43 We hereby show that all four Fat orthologues are transcriptionally downregulated in the c

44 berculosis TA systems and found that most TA orthologues are well-conserved among the members of the

45 Using a FOXP3 orthologue as a marker, we identified CD4-enriched, matu

46 s the suitability of two different bacterial orthologues as surrogates for human OGA.

47 elegans CEP-290 (mammalian Cep290/Mks4/Nphp6 orthologue) as a central assembly factor that is specifi

48 tion factors, including many with bilaterian orthologues, associate with diverse neurosensory structu

49 ive born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine

50 ied out an expression study of its zebrafish orthologue at different embryonic stages.

51 he P4 and P3 positions, similar to the human orthologue autophagin-1 (HsAtg4B).

52 he transmembrane domain occurs in all ERECTA orthologues but not in the parental ERECTA-like clade.

53 inase-like tertiary fold similar to archaeal orthologues but with significant differences in some sec

54 A mammalian cloche orthologue can also rescue blood vessel formation in zeb

55 ta-barrel or POTRA domains from various BamA orthologues, can functionally replace E. coli BamA.

56 Insillicoanalysis identified two putative orthologue candidate proteins in mammals.

57 is required for up-regulation of caspase-11 orthologues, caspase-4 and -5, in primary human macropha

58 eover, RNAi knockdown of the Drosophila CLP1 orthologue, cbc, promotes biogenesis of mature tRNAs and

59 e element that is directly bound by the NRF2 orthologue, CncC, which can induce ref(2)P expression al

60 d by higher and broader expression of lizard orthologues compared with those of other sex-linked gene

61 Synima takes orthologues computed from reciprocal best BLAST hits or

62 at FAMK-1, the Caenorhabditis elegans Fam20C orthologue, contributes to fertility, embryogenesis, and

63 These assemblies can include different sHSP orthologues, creating additional complexity that may aff

64 ment of nervous system gene sets using mouse orthologue databases.

65 veal that, like OCRL, the Dictyostelium OCRL orthologue Dd5P4 binds two proteins closely related to t

66 or future research, the data revealed a YtfE orthologue, Ddes_1165, that is implicated in the repair

67 ed with a habitat in both species, but these orthologues did not show parallel expression patterns ac

68 , while overexpression of the human dnTCF7L2 orthologue (dnTCF4) in human chondrocytes promoted the e

69 iciency of the Drosophila SLC25A1 or SLC25A4 orthologues, dSLC25A1-sea and dSLC25A4-sesB, affected sy

70 ed across placental mammals: human and mouse orthologues effectively modulate complex I enzymatic act

71 that manifests persuasive evidence that Nrf2 orthologues emerged, and then diverged, at two time poin

72 cation and characterization of secreted S1PL orthologues encoded by the facultative intracellular bac

73 mbined with a lack of parallel expression of orthologues (except 14-3-3 protein zeta) suggests that p

74 These bacterial orthologues exhibited S1PL enzymatic activity, functiona

75 oliferation is regulated by Eyeless, a Pax-6 orthologue, expressed in mushroom body neuroblasts.

76 ding Syp1 in budding yeast and its mammalian orthologue, FCHo1.

77 transcriptional repression of MYC by the Hfp orthologue, FIR, might provide one mechanism for cancer

78 ested vmhc and vmhcl as functional zebrafish orthologues for human genes MYH6 and MYH7, respectively,

79 not CHG or CHH levels, are correlated across orthologues for species as distantly related as ferns an

80 PR2) but low activity for the mouse receptor orthologue (Fpr2), rendering them inapplicable in murine

81 ochemical similarities between POMT1 and its orthologue from bakers' yeast Pmt4.

82 mine the structures of human SERINC5 and its orthologue from Drosophila melanogaster at subnanometer

83 phA displays high sequence similarity to its orthologue from M. tuberculosis and generally high struc

84 ive human FAM173B or with a putative FAM173B orthologue from the nematode Caenorhabditis elegans Inte

85 serine-rich Asn-63-Glu-82 region (absent in orthologues from anophelines of the New World species A.

86 Here, we show that the FimA orthologues from Escherichia coli, Shigella flexneri, an

87 and the phiX(D/E) motif are conserved in A55 orthologues from other poxviruses, but not in the vaccin

88 report X-ray crystal structures of the Mep2 orthologues from Saccharomyces cerevisiae and Candida al

89 ted large structural differences between the orthologues from these two eukaryotic kingdoms.

90 Nv-derived SDR orthologues generally had higher epimerisation rates, wh

91 of-function mutations in the C. elegans REST orthologue genes spr-3 and spr-4 elevate neural excitati

92 gene expression (by RT-qPCR) of A. thaliana orthologue genes were performed across different plant s

93 owever, in mice and other rodents, the IFIT1 orthologue has been lost, and the closely related Ifit1b

94 ailing view, Doa10 (and presumably its human orthologue) has the capacity for recognizing intramembra

95 n TRIM5alpha, in contrast with many nonhuman orthologues, has not generally been ascribed substantial

96 r 2 of the amino acids from the warthog RELA orthologue have been generated by gene editing.

97 meronasal receptor mFpr-rs1 and its sequence orthologue hFPR3 also react to signal peptides but are m

98 d transcription of pro-apoptotic Smac/DIABLO orthologue, Hid in germline stem cells.

99 ous studies established that, like the human orthologue HtrA1, BbHtrA is proteolytically active again

100 e At2OGO-KO lines with a barley (cv. Conlon) orthologue, Hv2OGO, restored susceptibility to Fg.

101 ns between the fitness landscapes of distant orthologues implicate both sequence and structure as pri

102 ically enriched in increasing-level enhancer orthologues, implicating immune processes in AD predispo

103 enome editing revealed that the single hodor orthologue in Anopheles gambiae is an essential gene.

104 hemolytic activity associated with the choA orthologue in Bacteroides fragilis.

105 Secondly, we show that the NEK9 orthologue in Caenorhabditis elegans, nekl-1, is almost

106 Here we characterize the single Nin orthologue in Drosophila Drosophila Nin localizes to the

107 Attempts to delete the NCgl2760 orthologue in Mycobacterium smegmatis were unsuccessful,

108 While STmOmpD differs from its orthologue in S.

109 We have identified the single Dig1 orthologue in the fungal pathogen Candida albicans.

110 SpxA1 is an Spx-family orthologue in the intracellular pathogen Listeria monocy

111 A phylogenetic analysis identified PmC11 orthologues in bacteria, archaea, Chromerids, Coccidia,

112 elerated compared with their divergence from orthologues in closely related species.

113 c steatosis and that mutation of the SLC13A5 orthologues in Drosophila melanogaster and Caenorhabditi

114 rthologues-which we validated for three Cas9 orthologues in mice-yet we anticipate broad immune cross

115 h S. latifolia PAR boundary genes with their orthologues in S. dioica, including all three regions of

116 ghly conserved in angiosperm and there are 4 orthologues in soybean (GmBZL1-4).

117 rpholino-mediated knockdown of the two MYO9A orthologues in zebrafish, myo9aa/ab, demonstrated a requ

118 l model species and human; alignments of the orthologues including information on known SNPs (Single

119 We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius ni

120 n 1000 genes, ~50% of which have their human orthologue involved in ASD, in particular genes encoding

121 here that the Drosophila melanogaster SETD1A orthologue is required in postmitotic neurons of the fly

122 ar whether a downregulation of mammalian Fat orthologues is associated with neurodegeneration in mice

123 The HTH of the yeast and mammalian orthologues is essential for function.

124 Briefly, natural variation across orthologues is exploited to identify suitable cysteine r

125 TRAPPC4, like its yeast Trs23 orthologue, is a core component of the TRAPP complexes a

126 Pavarotti, the Drosophila MKLP1 orthologue, is a kinesin-like protein that works with Tu

127 also highlighting differences with the yeast orthologue Kap121p.

128 Proteins that are still not annotated lack orthologues, lack protein domains, and/ or are membrane

129 In Caenorhabditis elegans, the closest BUBR1 orthologue lacks the B56-interaction domain and Shugoshi

130 ncreased expression of the Drosophila PICALM orthologue lap could rescue Abeta42 toxicity in an adult

131 we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet respond

132 th impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate receptor

133 ical localization of the dynein-binding NuMA orthologue LIN-5.

134 Phosphorylation of Rpb1 Ser2 by the Cdk12 orthologue Lsk1 positively regulated H3K36me but negativ

135 The mammalian ATG8 orthologues (MAP1LC3A/B/C and GABARAP/L1/L2) are ubiquit

136 Multiple dosing with protein orthologues may allow for sequential regimens of protein

137 Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mecha

138 found that human G9a (hG9a) unlike its mouse orthologue (mG9a) potently stimulated p53 transcriptiona

139 ration during development and its C. elegans orthologue MIG-10 also supports synaptogenesis.

140 de significance at MLH1, a locus whose mouse orthologue modifies CAG length-dependent phenotypes in a

141 mNARK, but is present upstream of the GmNARK orthologues, MtSUNN and PvNARK.

142 his redundancy is absent in the murine Anp32 orthologues; murine Anp32A is incapable of recovering IA

143 ays as well as tailless (tll) and foxo whose orthologues NR2E1/TLX and FOXO3 are transcription factor

144 We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammal

145 TRAPPC8, the mammalian orthologue of a yeast autophagy-specific TRAPP subunit,

146 studies have shown that the ectromelia virus orthologue of A55 interacts with Cul3 in cells.

147 s dopamine signaling in cooperation with the orthologue of an R-type voltage-gated calcium channel.

148 and target genes of such REs, we deleted the orthologue of an RE containing noncoding variants in the

149 SLB1 encodes an F-box protein, an orthologue of Arabidopsis thaliana STERILE APETALA (SAP)

150 Drosophila melanogaster, which has a single orthologue of ATP7A and ATP7B.

151 Rad3 is the orthologue of ATR and the sensor kinase of the DNA repli

152 a highly conserved region of the Drosophila orthologue of BICD2 to further-explore how the p.Glu774G

153 In this study, the orthologue of BRI1 in the model legume species Medicago

154 The single orthologue of CAPZA genes in Drosophila is cpa.

155 Asterless (Asl), the Drosophila melanogaster orthologue of Cep152, prevents centriole duplication, wh

156 an Sperm Associated Antigen 6 (SPAG6) is the orthologue of Chlamydomonas PF16, a protein localized in

157 Mammalian Spag6 is the orthologue of Chlamydomonas PF16, which encodes a protei

158 entify the fission yeast protein Sdj1 as the orthologue of DJ-1 and calculate by in silico saturation

159 Mutation of OCRL1, the human orthologue of dOCRL, causes oculocerebrorenal Lowe syndr

160 emonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in

161 Here we studied variants of Mpk1, a yeast orthologue of Erk, which is essential for cell wall inte

162 eria monocytogenes Ca(2+)-ATPase (LMCA1), an orthologue of eukaryotic Ca(2+)-ATPases.

163 Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elong

164 An orthologue of granulin from the human parasitic liver fl

165 Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a

166 ent TEX1 or in the mRNA export factor MOS11 (orthologue of human CIP29) are mildly affected.

167 Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by

168 to flies deficient in boule, the Drosophila orthologue of human Dazl.

169 n gba1 (gba1(c.1276_1298del)), the zebrafish orthologue of human GBA1.

170 thrin adaptor-interacting protein Irc6 is an orthologue of human p34, which is mutated in the inherit

171 nd basal body protein HYLS-1, the C. elegans orthologue of hydrolethalus syndrome protein 1, is requi

172 ue to the virus's inability to use the mouse orthologue of its human entry receptor angiotensin-conve

173 Hereby we characterize the phylogenetic orthologue of Ls in Antirrhinum, ERAMOSA (ERA).

174 ed the hypothesis that ERA is a phylogenetic orthologue of Ls, although it plays a broader role.

175 li, PqiB and YebT, the latter of which is an orthologue of MAM-7 that was previously reported to be a

176 of the Mec1 kinase that is the budding yeast orthologue of mammalian ATR.

177 Here, we identified the C. elegans orthologue of mammalian mediator of ErbB2-driven cell mo

178 We found that Yju3p, the functional orthologue of mammalian monoacylglycerol lipase (MGL), c

179 slo-2 but those of scyl-1, which encodes an orthologue of mammalian SCYL1.

180 e of the DBD of PCG2, the Magnaporthe oryzae orthologue of MBP1, bound to MCB-DNA.

181 RESPONSE FACTOR12 (ERF12) as the Arabidopsis orthologue of MULTIFLORET SPIKELET1 (MFS1) in rice.

182 ntified a spontaneous exonic deletion in the orthologue of MutL-Homolog 3 (HvMlh3) as the causal lesi

183 e have identified and characterized the MceG orthologue of Mycobacterium smegmatis.

184 xported from the nucleus and the trypanosome orthologue of NMD3 has been confirmed to be involved in

185 Together with Plxna1, the human orthologue of Plxna3 should therefore be investigated as

186 Prc1E, the egg orthologue of Prc1, and Kif4A were recruited to anti-par

187 er, Nin shares the property of its mammalian orthologue of promoting microtubule assembly.

188 re initially found to act on Ypt1, the yeast orthologue of Rab1, but recent studies have found that y

189 Atlastin, the vertebrate orthologue of Sey1p, forms a GTP-hydrolysis-dependent ne

190 FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein gl

191 equires signalling via Shark, the Drosophila orthologue of Syk, and Src42A, a Drosophila Src-family k

192 lethality and lethargy of unc-64 (C. elegans orthologue of syntaxin-1)-null mutants.

193 ian population, and mapping data suggest the orthologue of TERMINAL FLOWER1 (FvTFL1) as the causal fl

194 identities as well as the absence of a full orthologue of the BAD-1 gene.

195 to function similarly in mammals, where the orthologue of the central ATPase, Get3, is known as TRC4

196 We identified the Toxoplasma orthologue of the conserved kinase ERK7 as essential to

197 etween the viral spike protein and the mouse orthologue of the human receptor, angiotensin-converting

198 Furthermore, we show that the C. elegans orthologue of the Mad2 inhibitor p31(comet)(CMT-1) inter

199 Here, we show that the Arabidopsis orthologue of the mammalian NUCLEAR AUTOANTIGENIC SPERM

200 R349P desmin knock-in mice, which carry the orthologue of the most frequent human desmin missense mu

201 gene over-expression, we identified a rabbit orthologue of the mouse Rosa26 locus through genomic seq

202 the gene parcas that encodes the Drosophila orthologue of the SH3BP5 family of Rab11 guanine nucleot

203 function by binding Drosophila Twinstar, the orthologue of the vertebrate actin-severing protein Cofi

204 As in mouse, the Caenorhabditis elegans orthologue of Tmem231 localizes to and controls transiti

205 Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C11

206 biquitin in vivo We found that the fruit fly orthologue of USP5 has catalytic preferences similar to

207 ssion variation of the gene Bo2g050970.1, an orthologue of VTE4 (which encodes a gamma-tocopherol met

208 ss-of-function mutations in RLTPR, the mouse orthologue of which is essential for CD28 signaling.

209 with the fetal haemoglobin level, the mouse orthologue of which is necessary for erythroid BCL11A ex

210 We now show that the mammalian orthologue of yeast RPA49, PAF53, is required for rDNA t

211 searches, we identified MTBP as the metazoan orthologue of yeast synthetic lethal with Dpb11 7 (Sld7)

212 ncompromised when using multiple dosing with orthologues of AAVs and Cas9 in mice that were previousl

213 cation tolerance in seeds and involvement of orthologues of ABI3 and ABI5, both key regulators of see

214 rst analyse the expression of the Drosophila orthologues of all mammalian CPA factors and note that t

215 t Lactococcus lactis possesses two different orthologues of birA (birA1_LL and birA2_LL).

216 Here, we identify orthologues of both O-GlcNAc cycling enzymes in the geno

217 We have characterised three orthologues of BslA from Bacillus amyloliquefaciens, Bac

218 and CD1(+) populations were enriched for the orthologues of cDC1 and cDC2 subsets respectively.

219 vestigate the ciliary roles of two mammalian orthologues of Chlamydomonas IFT-A gene, IFT139, namely

220 hylogenetic and functional data showing that orthologues of choA are found only in the order Bacteroi

221 that the sequential use of immune-orthogonal orthologues of CRISPR-associated protein 9 (Cas9) and ad

222 tation defects have implicated several human orthologues of cyclic genes that are associated with the

223 a liver-like CYP-cocktail, containing human orthologues of dCYP1A2, we confirm human CYP1A2 as a PCB

224 aled that this pathogen's genome encodes two orthologues of Escherichia coli LpxL.

225 re required for the expression of the spider orthologues of even-skipped (eve) and runt-1 (run-1), at

226 ematic pairwise assessment of the Drosophila orthologues of five genes implicated in clinically overl

227 Human orthologues of genes in the mouse QTL are implicated in

228 nce of expression and gene loss among Clytia orthologues of genes patterning the anthozoan aboral pol

229 ebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnase

230 In C. elegans neurons, orthologues of LRRK2 and RAB7L1 act coordinately in an o

231 Silencing the orthologues of mosGCTL in another major mosquito vector

232 17% of human unique orthologues of mouse NAP genes are known loci for cognit

233 This includes orthologues of nodulation-suppressing CLE peptides and A

234 We demonstrate that orthologues of Nrf2 first appeared in fungi around 1.5 G

235 vement of two other mak-1 paralogues and two orthologues of p38 MAP kinase.

236 Nine zebrafish orthologues of six human candidate genes were targeted s

237 This analysis revealed rLCV orthologues of the latency-associated EBV circular RNAs

238 correlated with interaction with the grivet orthologues of the SLX4 complex, suggesting a level of h

239 Silencing of orthologues of these candidate genes enhanced the DeltaF

240 Although isolated apparent orthologues of these enzymes are present in bacterial ge

241 o acid sequences between the human and mouse orthologues of two essential host factors, the tetraspan

242 pmental tissue-specific enhancers, the human orthologues of which were enriched for disease-associate

243 transcription factors Onecut (closest human orthologues: ONECUT2, ONECUT3), Optix (SIX3, SIX6), Worn

244 ugh only a minority (10 out of 57 genes with orthologues or close homologues) of the targets we ident

245 ounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effects, b

246 ry receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found to be functionally e

247 These correspond to 492 Arabidopsis orthologues, over 90% of which form a coherent protein-p

248 the most prominent effect of the Drosophila orthologue, pentagone (pent), is expanding the range of

249 PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-

250 ession of either human Lpd or its Drosophila orthologue Pico can promote growth and invasion of Ras(V

251 OR12 (ERF12), the rice MULTIFLORET SPIKELET1 orthologue pleiotropically affects meristem identity, fl

252 The yeast ATP2C1 orthologue PMR1 codes for a Mn(2+)/Ca(2+) transporter th

253 identification and characterization of a C11 orthologue, PNT1, in the parasitic protozoon Trypanosoma

254 we report the crystal structure of the yeast orthologue, Pol epsilon-P301R, complexed with DNA and an

255 The O-GlcNAcase orthologue possesses activity against O-GlcNAc proteins

256 y of 'basic' FKBPs is shared amongst related orthologues present in fungi, plants, and insects.

257 ecretory vesicles (SVs) containing the RAB11 orthologue RabE engage myosin-5 as well as plus end- and

258 wn as ERCC6) protein in humans (or its yeast orthologues, Rad26 in Saccharomyces cerevisiae and Rhp26

259 Finally, the human HemW orthologue radical SAM domain-containing 1 (RSAD1) stabl

260 Here, we show that the Drosophila p62/SQSTM1 orthologue, Ref(2)P, interacts directly with DmAtg8a via

261 The coiled-coil domain present on only some orthologues renders that phenomenon CL-dependent.

262 However, for the M. smegmatis orthologues, results from isothermal titration calorimet

263 e Caenorhabditis elegans choline transporter orthologue revealed deficits in transporter export to ax

264 vation mechanisms among nine vertebrate MLKL orthologues, revealing remarkable specificity of mouse a

265 studies indicating that the M. tuberculosis orthologue, Rv0227c, is an essential gene.

266 coding sequences and identified single copy orthologues (SCO).

267 ofiles from baseline to week 12 of the human orthologues selected on the basis of the murine transcri

268 trols the seed shattering phenotype like its orthologue SH4 gene in Asian rice.

269 ProP orthologues share an extended, cytoplasmic C-terminal do

270 trait loci, while decreasing-level enhancer orthologues show fetal-brain-specific enhancer activity.

271 f Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposom

272 ay and demonstrate that Hem25p and its human orthologue SLC25A38 are the main mitochondrial glycine t

273 interaction with Treslin/TICRR or its yeast orthologue Sld3, respectively.

274 in the catalytic domain of the MAP kinase 7 orthologue sma-5(kc1) In sma-5(kc1) mutants, pockets of

275 induced in these conditions through the AMPK orthologue Snf1 and downstream transcriptional repressor

276 Shared features among DED1 orthologues suggest that this role is conserved and may

277 ow conservation of S-acylation sites between orthologues suggesting that S-acylation has come to play

278 ar to reoccur in a wide range of plant DGAT2 orthologues, suggesting that it is a general feature of

279 ects, but selectively induce SKN-1 (Nrf1/2/3 orthologue) targets involved in oxidative stress defense

280 , T. brucei still contains a bona fide Pam18 orthologue that, while essential for normal growth, is n

281 A picture is emerging of sperm channel orthologues that employ different activation mechanisms

282 que properties compared with their mammalian orthologues that support electrosensory functions: struc

283 e WelNDLY, WelLFY shares with its angiosperm orthologue the capacity to bind promoters of Welwitschia

284 r-like kinases, but poorly conserved between orthologues through evolution.

285 Overexpression of the human orthologue TMEM258 in Drosophila proved functional conse

286 tural analyses demonstrated the apicomplexan orthologue to be a functional, homodimeric serine palmit

287 inoblastoma (Rb)-related gene, and fzr-1, an orthologue to the APC/C co-activator Cdh1, completely el

288 In Caenorhabditis elegans, the TRPC orthologues TRP-1 and -2 genetically complement the loss

289 ptide repeat domain 7A (TTC7A) and its mouse orthologue, Ttc7, result in a multisystemic disease, mos

290 ISPR/Cas9 to genetically inactivate a TWIST2 orthologue, we suppressed the effects of BRAF(V600E) and

291 After initial screening of 15 orthologues, we identified Cas13a from Leptotrichia wade

292 Only 20 orthologues were associated with a habitat in both speci

293 In yeast, there is a single VPS13 orthologue, which is required for at least two different

294 ardiomyopathy have a corresponding zebrafish orthologue, which supports the use of zebrafish as a con

295 drug resistance transcription factor (Pdr1) orthologues, which are key regulators of the multidrug r

296 e responses for 79% of the DNA-targeting Cas orthologues-which we validated for three Cas9 orthologue

297 ure of MtHDH is similar to the two bacterial orthologues whose three-dimensional structures have been

298 Orthologues with and without a C-terminal, alpha-helical

299 of strain ZYK(T) implies that it shares more orthologues with B. subtilis subsp. subtilis NCIB 3610(T

300 at yeast TRAPPII can also activate the Rab11 orthologues Ypt31/32.