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1 ed from the lesion confirmed infection by an Orthopoxvirus.
2 s (Old World vs North American) of the genus Orthopoxvirus.
3 ontributing to host defense against zoonotic orthopoxviruses.
4 or the subsequent spread and pathogenesis of orthopoxviruses.
5  vaccinia virus gene I2L is conserved in all orthopoxviruses.
6  the first demonstration of its existence in orthopoxviruses.
7 rus formation and are highly conserved among orthopoxviruses.
8  underlying innate immunity against emerging orthopoxviruses.
9 t of infections caused by herpes viruses and orthopoxviruses.
10 ell epitopes that are highly conserved among orthopoxviruses.
11 , including the herpes group viruses and the orthopoxviruses.
12 viral evaluation against cytomegalovirus and orthopoxviruses.
13  life cycle and present in multiple distinct orthopoxviruses.
14        Most epitopes were conserved in other orthopoxviruses.
15  by a synthetic promoter designed for use in orthopoxviruses.
16 amics of the immune modulating mechanisms of orthopoxviruses.
17 uld offer a novel antiviral approach against orthopoxviruses.
18 on against evolving MPXV strains and related orthopoxviruses.
19 -generation vaccine against MPXV and related orthopoxviruses.
20 enomic accordion" evolutionary strategies of orthopoxviruses.
21 t remained negative for HSV and other tested orthopoxviruses.
22 nd T-cell memory in cross-protection against orthopoxviruses.
23 g, such as the cross-reactivity presented by orthopoxviruses.
24 oncern about the pandemic potential of novel orthopoxviruses.
25 ed similar to findings associated with other orthopoxviruses.
26 conferred by smallpox vaccines against other orthopoxviruses.
27 XV and VACV, indicating cross-reactivity for orthopoxviruses.
28 ighlight the threat of zoonotic spillover by Orthopoxviruses.
29 ed mouse strains are relatively resistant to orthopoxviruses.
30 ich is most closely related to the Old World orthopoxviruses.
31 ular contacts, this feature may be unique to orthopoxviruses.
32  neutralizing antibody responses for diverse orthopoxviruses.
33 otes and are present in some prokaryotes and orthopoxviruses.
34 diverged from a common ancestor of all known orthopoxviruses.
35 lticomponent DNA or protein vaccines against orthopoxviruses.
36 ration, safer vaccines for highly pathogenic orthopoxviruses.
37 o FDA-approved drug for humans infected with orthopoxviruses.
38 1R is an early gene present in MVA and other orthopoxviruses.
39 g of the C7L family of host range genes from orthopoxviruses.
40 s (VV) in individuals exposed to 3 different orthopoxviruses: 154 individuals previously vaccinated w
41 ct all Eurasian-African species of the genus ORTHOPOXVIRUS: A single nucleotide mismatch resulting in
42 sis) of full-length vaccinia virus (VACV; an orthopoxvirus) A36 protein with the cellular microtubule
43 eoxyuridine, which was itself devoid of anti-orthopoxvirus activity in these assays.
44                                     The anti-orthopoxvirus activity of pyrimidine may be favored by t
45                                           As orthopoxviruses adapt to new environments, the selection
46             Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smal
47  A33, A34, and B5 are highly conserved among orthopoxviruses and have roles during extracellular viri
48 lyclonal antibodies cross-reacted with other orthopoxviruses and herpes simplex 1, but commercially a
49 covirimat has more specific activity against orthopoxviruses and inhibits the formation of the extrac
50 s present at both ends of the genome of many orthopoxviruses and is highly conserved in most, includi
51                                              Orthopoxviruses and leporipoxviruses are among the most
52 f the A36R protein is highly conserved among orthopoxviruses and may overlap binding sites for cellul
53                                              Orthopoxviruses and the human complement component C6 ge
54 e demonstrate that TRIM5alpha also restricts orthopoxviruses and, via its SPRY domain, binds to the o
55 d 96.1% sensitivity and 100% specificity for orthopoxviruses, and 94.1% sensitivity and 100% specific
56  against MPXV and other potentially emerging orthopoxviruses, and as probes to investigate the functi
57 r and NIM811 have antiviral activity against orthopoxviruses, and because these drugs target a cellul
58 poxPlex, able to measure IgG responses to 12 Orthopoxvirus antigens concurrently and distinguish betw
59 All patients had detectable IgM responses to orthopoxvirus antigens.
60  To facilitate the development of additional orthopoxvirus antivirals, we summarize the antiviral act
61 COVID-19 pandemic have reignited interest in orthopoxvirus antivirals.
62 sm of action, and mechanism of resistance of orthopoxvirus antivirals.
63                                              Orthopoxviruses are dermatotropic DNA viruses that cause
64 nt from other poxviral subfamilies, however, orthopoxviruses are not known to evade recognition by CT
65                                       In the Orthopoxvirus assay, consensus Orthopoxvirus PCR primers
66 ose that the F1 orthologs represent the only orthopoxvirus Bcl-2 homolog to directly inhibit the Bak/
67 tro, recombinant Crm proteins from different orthopoxviruses bound to membrane-associated TNF and dam
68                                    A related orthopoxvirus, but neither a flavivirus nor a rhabdoviru
69 f G1R are present in a variety of pathogenic orthopoxviruses, but not in vaccinia virus, and expressi
70 differentiation of smallpox virus from other orthopoxviruses by melting-curve analysis.
71                                              Orthopoxviruses can transmit via inhalation of virus-lad
72 ruses and, via its SPRY domain, binds to the orthopoxvirus capsid protein L3 to diminish virus replic
73 etent vaccinia protects against heterologous orthopoxvirus challenge.
74  agents with activity against mpox and other orthopoxviruses: cidofovir, brincidofovir, and tecovirim
75                 Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola virus, the caus
76                 Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola, the etiologica
77                  Much of the threat posed by orthopoxviruses could be eliminated by vaccination; howe
78 fied nucleosides against cells infected with orthopoxviruses, cowpox, and vaccinia virus.
79 the cause for the restriction and identified orthopoxvirus CP77 as a unique inhibitor capable of anta
80 a virus (VACV) as a model organism for other Orthopoxviruses, CRISPR-Cas9 technology was used to targ
81 l-to-cell spread of vaccinia virus and other orthopoxviruses depends on the wrapping of infectious pa
82 in lesions of all 3 patients; 2 patients had orthopoxvirus detected by immunohistochemistry in skin l
83                              Mouse models of orthopoxvirus disease provide great promise for probing
84 e it clear that naturally occurring zoonotic orthopoxvirus diseases remain a public health concern.
85 axis and immunotherapy of smallpox and other orthopoxvirus diseases.
86 iagnosis can be made through the presence of Orthopoxvirus DNA in PCRs from lesion swabs or body flui
87                                              Orthopoxvirus DNA was present in 3 of 20 environmental s
88                                         Some orthopoxviruses, e.g., the cowpox, ectromelia, and racco
89 le number of MOCV RNAs mapped to homologs of orthopoxvirus early genes, but few did so to homologs of
90 he role of RIPK3 and MLKL in controlling the Orthopoxvirus ectromelia virus (ECTV), a natural pathoge
91  to mousepox, a lethal disease caused by the orthopoxvirus ectromelia virus (ECTV), and that this res
92 /6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus.
93                                          The orthopoxviruses ectromelia virus (ECTV) and vaccinia vir
94 lly bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells.
95                    A series of novel, potent orthopoxvirus egress inhibitors was identified during hi
96                                   Genomes of orthopoxviruses encode proteins with sequences similar t
97                                         Both orthopoxviruses encode tumor necrosis factor receptor (T
98                                              Orthopoxviruses evade host immune responses by using a n
99 n is considered to be an important driver of orthopoxvirus evolution.
100    O3 is conserved with 100% identity in all orthopoxviruses except for monkeypox viruses, whose O3 h
101 l MPXV infection versus vaccination or other orthopoxvirus exposures.
102                           Smallpox and other orthopoxviruses express virulence factors that inhibit t
103          Vaccinia virus (VV), the prototypic orthopoxvirus, expresses products that inhibit this anti
104 wn structure that is highly conserved in the orthopoxvirus family.
105                                          The orthopoxvirus gene p4c has been identified in the genome
106 of numerous postreplicative as well as early orthopoxvirus genes.
107                      While K1L is limited to orthopoxviruses, genes that are homologous to C7L are fo
108 hese evolutionary processes still present in orthopoxvirus genomes and suggests that these viruses ar
109 ke it one of the smallest non-vector derived orthopoxvirus genomes to be reported.
110            Beyond MPXV, other members of the Orthopoxvirus genus also pose growing risks of zoonotic
111 Alaskapox virus) is a zoonotic member of the Orthopoxvirus genus first identified in a person in 2015
112  Comparative genomics has suggested that the Orthopoxvirus genus in particular has undergone reductiv
113                     Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae family, which also
114 us is most closely related to viruses in the Orthopoxvirus genus, but it is clearly distinct from pre
115 s highly conserved among most members of the orthopoxvirus genus, including viruses that produce ATIs
116 k of monkeypox virus (MPXV), a member of the Orthopoxvirus genus, which includes the etiologic agent
117  is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and V
118  possesses one of the largest genomes in the Orthopoxvirus genus.
119 t of smallpox caused by the variola virus of Orthopoxvirus genus.
120                        Monkeypox virus is an Orthopoxvirus (genus includes variola [smallpox] and vac
121                   An interaction between the orthopoxvirus glycoproteins A34 and B5 has been reported
122  population that is immunologically naive to orthopoxviruses has increased significantly due to cessa
123                                              Orthopoxviruses have complex proteomes.
124                                              Orthopoxviruses have repeatedly confounded expectations
125 l the microorganisms and toxins, poxviruses (Orthopoxvirus) have the greatest potential for use by te
126  assay is based on TaqMan chemistry with the orthopoxvirus hemagglutinin gene used as the target sequ
127 us, effectively distinguishing it from other orthopoxviruses, herpes simplex virus, and varicella-zos
128 strains examined and absent in various other orthopoxviruses; however, four strains of ectromelia vir
129           We conclude that the unique CTD of orthopoxvirus IFN-gammaBPs is important for the assembly
130 ive, yet this region is conserved within all orthopoxvirus IFN-gammaBPs.
131 l-time PCR and by detection of positive anti-orthopoxvirus IgM antibodies.
132 is for rational design of inhibitors against orthopoxvirus IL-18BP (for treating orthopoxvirus infect
133 the 2.0-A resolution crystal structure of an orthopoxvirus IL-18BP, ectromelia virus IL-18BP (ectvIL-
134  family member, 14L, which is similar to the orthopoxvirus IL-18BPs.
135 s infection closely resembles human systemic orthopoxvirus illness.
136                 The targeting of FCRL5 by an orthopoxvirus immunoevasin strongly implicates it in con
137 ipants who received molecular tests for mpox/orthopoxvirus in California from November 2022 through J
138 rence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future c
139 ic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as the variola, vaccinia
140  genes can occur upon extensive passaging of orthopoxviruses in cell culture leading to attenuation i
141 dinal study assessing the natural history of orthopoxviruses in Georgia.
142    Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised de
143  in controlling smallpox or other pathogenic orthopoxviruses in some immunodeficient human population
144                         VARV is unique among orthopoxviruses in that it is an exclusively human patho
145 ettings, addressing the global resurgence of orthopoxviruses in the context of declining smallpox imm
146 compound had broad-spectrum activity against orthopoxviruses in vitro.
147                                              Orthopoxviruses include many important pathogens such as
148                                              Orthopoxviruses include the prototypical vaccinia virus,
149 logs of Bcl-2 proteins that are conserved in orthopoxviruses, including A46, A52, B14, C1, C6, C16/B2
150  a number of proteins highly conserved among orthopoxviruses, including F13, which is required for th
151 s warrant testing of CsA derivatives against orthopoxviruses, including monkeypox and variola.
152  efficient antiviral drug against pathogenic orthopoxviruses, including smallpox.
153                            A majority of the orthopoxviruses, including the variola virus that causes
154 % = >40 microM), and active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox
155                         In response, several orthopoxviruses, including vaccinia, rabbitpox, cowpox,
156 actor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative
157 homologs of human IL-18BP are encoded by all orthopoxviruses, including variola virus, the causative
158 icry of NF-kB may be conserved because other orthopoxviruses, including variola, monkeypox and cowpox
159  of NF-kappaB may be conserved because other orthopoxviruses, including variola, monkeypox and cowpox
160 te into full protection against the onset of orthopoxvirus-induced disease.
161 llular virus formation can protect mice from orthopoxvirus-induced disease.
162      This is of particular importance, since orthopoxviruses infect mammals and include variola, the
163 promising candidate for development to treat orthopoxvirus-infected individuals.
164 ementing modern diagnostic methods to assess orthopoxvirus infection and adverse events following vac
165 ived inbred strain, is highly susceptible to orthopoxvirus infection by intranasal and systemic route
166 long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (m
167                                              Orthopoxvirus infection should be considered in persons
168 ox virus DNA and serologic evidence for past orthopoxvirus infection was detected in multiple small-m
169  against orthopoxvirus IL-18BP (for treating orthopoxvirus infection) or hIL-18 (for treating certain
170 equired for protection against a respiratory Orthopoxvirus infection, such as human smallpox or monke
171  of the skin immune response as a feature of orthopoxvirus infection.
172 on are needed for optimal protection against orthopoxvirus infection.
173 its significance as a target of SPI-1 during orthopoxvirus infection.
174 nus macrophages, IFN-gamma, and CXCR3 during orthopoxvirus infection.
175  humoral immune response induced by systemic orthopoxvirus infection.
176 rus (VACV-WR) to model a primary respiratory Orthopoxvirus infection.
177 ng the host endosomal trafficking pathway in orthopoxvirus infection.IMPORTANCE Human monkeypox is an
178 as been used therapeutically to treat severe orthopoxvirus infections but is in short supply.
179 Clinically, mpox is distinguished from other Orthopoxvirus infections by its propensity to cause seve
180 e is now an increasing incidence of zoonotic orthopoxvirus infections for which there are no effectiv
181 killer (NK) cells provide in vivo control of orthopoxvirus infections in association with their expan
182 ule antiviral therapeutics approved to treat orthopoxvirus infections of humans.
183 ffort to evaluate new therapies for virulent orthopoxvirus infections of the respiratory tract in a s
184 mals in the area had serological evidence of orthopoxvirus infections, suggesting their involvement i
185 ide potential new leads for the treatment of orthopoxvirus infections, the 5-position of the pyrimidi
186 ing onset of rash illness, to treat systemic orthopoxvirus infections.
187  be beneficial for prophylaxis or therapy of orthopoxvirus infections.
188 antiviral therapies for treatment of serious orthopoxvirus infections.
189 nd which exhibits selective activity against orthopoxviruses, inhibiting VV with 50% inhibitory conce
190 overies are the broad species specificity of orthopoxvirus interferon receptors, herpesvirus and poxv
191   The conservation of the p4c gene among the orthopoxviruses, irrespective of their capacities to pro
192                           Human infection by orthopoxviruses is being reported with increasing freque
193                 The threat of MPXV and other orthopoxviruses is increasing due to the absence of rout
194 amino-terminal domain, while conserved among orthopoxviruses, is dispensable in cell culture.
195  these GeneChips with some known non-Variola orthopoxvirus isolates, including monkeypox, cowpox, and
196 otein of 53 amino acids that is conserved in orthopoxviruses, leporipoxviruses, yatapoxiruses, and mo
197                              Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and
198 oach by encoding a soluble NKG2D ligand, the orthopoxvirus major histocompatibility complex (MHC) cla
199                                         This orthopoxvirus MHC class I-like protein (OMCP) is conserv
200                   We previously described an orthopoxvirus MHC class I-like protein (OMCP) that binds
201 n comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical tr
202               The spread of monkeypox virus (Orthopoxvirus monkeypox) clade Ib from the Democratic Re
203 a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV).
204                  In cells infected with some orthopoxviruses, numerous mature virions (MVs) become em
205 9%) were presumptive positive for nonvariola orthopoxvirus (NVO) or confirmed positive for NVO and Mo
206 nvelope of extracellular virions produced by orthopoxviruses, one that requires A33 and one that does
207      The Mpox virus, MPV, is a member of the Orthopoxvirus (OPV) genus that also contains other patho
208 ells and their ability to protect against an orthopoxvirus (OPV) infection in its natural host can de
209  of horsepox virus (HSPV) isolate MNR-76, an orthopoxvirus (OPV) isolated in 1976 from diseased Mongo
210                                          The orthopoxvirus (OPV) vaccinia virus (VACV) requires an in
211         Despite the eradication of smallpox, orthopoxviruses (OPV) remain public health concerns.
212  viral infections, including those caused by Orthopoxviruses (OPV), a genus that includes the human p
213 nd differentiate Old World, African-Eurasian orthopoxviruses (OPV): variola, vaccinia, cowpox, monkey
214                                              Orthopoxviruses (OPVs), such as the human smallpox virus
215                                              Orthopoxviruses (OPVs), which include the agent of small
216 ng rash illness is similar to human systemic orthopoxvirus (OPXV) infection, including a 7- to 9-day
217    Serologic cross-reactivity, a hallmark of orthopoxvirus (OPXV) infection, makes species-specific d
218 ce the eradication of smallpox (caused by an orthopoxvirus (OPXV) related to MPXV) and cessation of r
219                                              Orthopoxviruses (OPXVs) have a broad host range in mamma
220 ients had an mpox diagnosis code or positive orthopoxvirus or mpox virus laboratory result, and contr
221 s, which could reduce disease severity in an orthopoxvirus outbreak.
222        In the Orthopoxvirus assay, consensus Orthopoxvirus PCR primers were designed to amplify 266-2
223 need for continued development of novel anti-orthopoxvirus pharmaceuticals and the importance of both
224 irus and vaccinia virus, two closely related orthopoxviruses, prevents their efficient replication in
225                                              Orthopoxviruses produce two antigenically distinct infec
226                                              Orthopoxviruses produce two, antigenically distinct, inf
227 proteins), WR148 (a fragmented homolog of an orthopoxvirus protein that forms inclusions in cells), H
228 rained hidden Markov model, we discovered an orthopoxvirus protein, itself distantly class I-like, th
229                     Using two highly related orthopoxvirus proteins, the vaccinia and variola (smallp
230 e the structural relationships among SCRs of orthopoxvirus RCA-like proteins and those of human compl
231            The patient with encephalitis had orthopoxvirus-reactive immunoglobulin M (IgM) in cerebro
232         BRPV was eventually detected through orthopoxvirus real-time polymerase chain reaction testin
233 ranscription alters our understanding of how orthopoxviruses regulate gene expression.
234 sistance to ectromelia virus (ECTV), a mouse orthopoxvirus related to the virus causing human smallpo
235                                              Orthopoxviruses remain a threat on multiple fronts, espe
236                                     However, orthopoxvirus resolvases have not been characterized bio
237                                              Orthopoxviruses show a widely varying degree of host spe
238                      Vaccinia virus, another orthopoxvirus, showed no RNase P activity in vaccinia-in
239 gnment for representative isolates from each Orthopoxvirus species and used it to identify the nucleo
240  (previously known as Alaskapox virus) is an Orthopoxvirus species first identified in a patient livi
241 nts to test if predicted conservation across orthopoxvirus species matches experimental observation a
242 mplification of 120 strains belonging to the orthopoxvirus species variola, vaccinia, camelpox, mouse
243 ns intact orthologs of genes present in each orthopoxvirus species, numerous genes are inactivated in
244  in vaccinia virus and its homologs in other orthopoxvirus species, provides full protection from let
245 all genes present in any existing modern-day orthopoxvirus species, similar to the current Cowpox vir
246 into proteinaceous A-type inclusions in some orthopoxvirus species.
247 and DNA sequence analysis implicated a novel orthopoxvirus species.
248 ficity, diversity, or dominance hierarchy of orthopoxvirus-specific CD4 T cell responses.
249                We generated a large panel of orthopoxvirus-specific human monoclonal antibodies (Abs)
250                                              Orthopoxvirus-specific T cells count was also positively
251                                              Orthopoxvirus-specific T-cell responses were analyzed in
252 virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and has no ot
253 ruses that cause significant human diseases, orthopoxviruses spread from a peripheral site of infecti
254                       Cross-reactivity among orthopoxviruses, stemming from high sequence conservatio
255 n of virions into A-type inclusions in other orthopoxvirus strains.
256 us (VV) membrane proteins are candidates for orthopoxvirus subunit vaccines and potential targets for
257  be considered for inclusion in future human orthopoxvirus subunit vaccines.
258 to infections by smallpox and other zoonotic Orthopoxviruses such as monkeypox.
259 lusion protein (ATIp), which is truncated in orthopoxviruses such as vaccinia virus (VACV) and variol
260 l protein called ATIp, which is truncated in orthopoxviruses such as vaccinia virus (VACV) that do no
261                            This work reveals orthopoxvirus targets for human Abs that mediate cross-p
262 lpox virus DNA, but all viruses of the genus Orthopoxvirus tested could be detected by use of the hem
263  by the three MAbs was synthesized by all 11 orthopoxviruses tested: eight strains of vaccinia virus
264                           Cowpox virus is an Orthopoxvirus that can cause infections in humans and a
265 ior to the eradication of variola virus, the orthopoxvirus that causes smallpox, one-third of infecte
266 nia virus Ankara (MVA) is a safe, attenuated orthopoxvirus that is being developed as a vaccine vecto
267                  Ectromelia virus (ECTV), an orthopoxvirus that naturally infects the mouse, spreads
268 xamined.IMPORTANCE Akhmeta virus is a unique Orthopoxvirus that was described in 2013 from the countr
269               Vaccinia virus is a prototypal orthopoxvirus that was used as a vaccine to eradicate sm
270 bitor found in cowpox virus (CPXV) and other orthopoxviruses that bound to the host SKP1-Cullin1-F-bo
271                               In contrast to orthopoxviruses, the distantly related leporipoxvirus my
272  assay was specific for members of the genus Orthopoxvirus; the DNAs of herpes simplex virus and vari
273 ; this has implications for the evolution of orthopoxviruses, their ability to infect mammalian hosts
274 , and died despite receiving investigational orthopoxvirus therapeutics.
275 ive of recombination with a variety of other orthopoxviruses; this has implications for the evolution
276 hanisms that drive virus variation, allowing orthopoxviruses to adapt to particular environmental nic
277 of mpox demonstrate the continuing threat of orthopoxviruses to global health.
278 mily are utilized specifically by pathogenic orthopoxviruses to repress the NF-kappaB signaling pathw
279  as promising candidates for next-generation orthopoxvirus treatments.
280 ever, because the smallpox vaccine is a live orthopoxvirus vaccine (vaccinia virus) administered to t
281 ination campaigns using the third-generation orthopoxvirus vaccine modified vaccinia Ankara from Bava
282 rotection, highlighting the lack of scalable Orthopoxvirus vaccines with optimal protection.
283 s well as the development of next-generation orthopoxvirus vaccines.
284 egy: epicutaneous application of the related orthopoxvirus vaccinia virus (VACV) to superficially inj
285                                          The Orthopoxvirus vaccinia virus encodes the Bcl-2-like F1 p
286 ral cell tropism of MPXV compared to another orthopoxvirus, vaccinia virus (VACV), as well as its eff
287                    Conversely, the prototype orthopoxvirus, vaccinia, causes no disease in immunocomp
288  Compound 2 inhibited the replication of two orthopoxviruses, vaccinia virus (VV) (EC(50) = 4.6 +/- 2
289 nsional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine,
290 Then, differential testing of other selected orthopoxviruses, VZV and herpes simplex virus (HSV) were
291 owever, serologic evidence of exposure to an orthopoxvirus was detected in cows in the patients' herd
292                             In 2013, a novel orthopoxvirus was detected in skin lesions of two cattle
293 ase P RNA gene in camelpox virus, one of the orthopoxviruses, was cloned and transcribed in vitro.
294 rpesviruses as well as poxviruses other than orthopoxviruses were not detected by this method.
295 e-chain-reaction assay for non-variola virus orthopoxviruses were positive, and DNA sequence analysis
296 izontally transferred from murine rodents to orthopoxviruses, where it is hypothesized to play a role
297     Monkeypox virus is an emerging, zoonotic orthopoxvirus which can cause severe and transmissible d
298 nd previously undescribed genetic lineage of Orthopoxvirus, which is most closely related to the Old
299                Human monkeypox is a zoonotic Orthopoxvirus with a presentation similar to smallpox.
300 be a reliable technique for the detection of orthopoxviruses, with the advantage that it can simultan

 
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