ライフサイエンスコーパス: ossification

1 hondrogenic differentiation and endochondral ossification.

2 ne union, and resulted in robust heterotopic ossification.

3 ypertrophic chondrocytes during endochondral ossification.

4 revealed delayed or incomplete endochondral ossification.

5 repair and substantially limited heterotopic ossification.

6 hondrogenic differentiation and endochondral ossification.

7 of TRPM7 in endochondral and intramembranous ossification.

8 expression rheostatically controls skeletal ossification.

9 in phosphatase Phlpp1 regulates endochondral ossification.

10 hondrogenic differentiation and endochondral ossification.

11 oliferating chondrocytes during endochondral ossification.

12 1/2/4 may regulate Runx2 during endochondral ossification.

13 scular invasion, and subsequent endochondral ossification.

14 t stature, joint laxity, and advanced carpal ossification.

15 erentiate, leading to defective endochondral ossification.

16 der, thereby explaining the overall delay in ossification.

17 transcriptional repertoire that can lead to ossification.

18 ensive placoid fibrous metaplasia with focal ossification.

19 ed metalloproteinase ADAM17, in endochondral ossification.

20 cification and has many similarities to bone ossification.

21 P63alpha and TAP63alpha, during endochondral ossification.

22 abnormal tissue repair: fibrosis and ectopic ossification.

23 hondrocytes during growth plate endochondral ossification.

24 ible hypoplasia and deficits in cranial base ossification.

25 ian skull vault form through intramembranous ossification.

26 ification centers and disrupted endochondral ossification.

27 reducing hedgehog signaling and endochondral ossification.

28 ed to therapeutically stimulate endochondral ossification.

29 of de novo appositional and intramembraneous ossification.

30 by bone through the process of endochondral ossification.

31 d in digit/limb development and endochondral ossification.

32 of Atf4 in chondrocytes during endochondral ossification.

33 egion of the mandible undergoes endochondral ossification.

34 tered skeletal development and extraskeletal ossification.

35 th plates reflecting defects in endochondral ossification.

36 se hypertrophy would result in apoptosis and ossification.

37 eletal elements derived through endochondral ossification.

38 I) is an important regulator of endochondral ossification.

39 peptide, a potent stimulator of endochondral ossification.

40 tinct from archetypical physeal endochondral ossification.

41 olysis syndromes are regions of subarticular ossification.

42 tropic control groups underwent endochondral ossification.

43 ion to osteoblasts and impaired endochondral ossification.

44 minantly through the process of endochondral ossification.

45 al base are both formed through endochondral ossification.

46 ding reduced cartilage formation and delayed ossification.

47 areas where repair occurs by intramembranous ossification.

48 uted tomography in the exact localization of ossifications.

49 uous supply of chondrocytes for endochondral ossification(1).

50 particularly in MSX1/2, through endochondral ossification 6 weeks post-injection.

51 gamma (RARgamma) agonist blocks heterotopic ossification, a pathological bone formation that mostly

52 ian hedgehog signaling activity, and ectopic ossification along its lateral border.

53 he palatal shelves accompanied by a delay in ossification along the fusion area of secondary palatal

54 stingly, there was excessive intramembranous ossification along the perichondrium, accompanied by exc

55 stingly, there was excessive intramembranous ossification along the perichondrium, accompanied by loc

56 Endochondral ossification, an important process in vertebrate bone fo

57 lanx forms late in gestation by endochondral ossification and continues to elongate until sexual matu

58 p107 in cartilage development, endochondral ossification and enchondroma formation that reflects the

59 p107 in cartilage development, endochondral ossification and enchondroma formation that reflects the

60 owards abnormal tissue growth and perfusion, ossification and endochondral bone development, leading

61 se model is the first with both subcutaneous ossification and fibroepithelial polyps related to G(s)a

62 e undergoes intramembranous and endochondral ossification and forms a trabecular-like bone organ incl

63 rant mechanical loading leads to accelerated ossification and hypertrophy of EP, decreased IVD volume

64 reas the ossifying hypochord undergoes rapid ossification and hypertrophy; second, thyroid hormone di

65 o severe skeletal defects, including delayed ossification and low bone mass, short stature and short

66 uces not only genes commonly associated with ossification and mineralization but also genes important

67 We report here both the late onset ossification and occurrence of benign cutaneous fibroepi

68 sibly be repurposed for treating heterotopic ossification and other diseases caused by GNAS inactivat

69 Relationships among pulmonary ossification and parenchymal patterns, clinical paramete

70 Low levels of phosphate can disrupt bone ossification and predispose to fractures.

71 with Wnt antagonists results in endochondral ossification and suture closure.

72 n 4 is functionally involved in endochondral ossification and that its loss impairs fracture healing,

73 processes of chondrogenesis and endochondral ossification and their control at the molecular level.

74 canonical Wnt signaling enable endochondral ossification and therefore PF-suture closure, whereas co

75 aling in the PF suture inhibits endochondral ossification and therefore, suture closure, In contrast,

76 ype lectin domain in regulating endochondral ossification and, thereby, height.

77 critical role in the control of endochondral ossification, and bone growth and mutations that cause h

78 , impaired formation of secondary centres of ossification, and joint abnormalities including elbow di

79 impairs hypertrophy, cartilage angiogenesis, ossification, and longitudinal bone growth in mice.

80 points preceding periosteal vascularization, ossification, and mineralization.

81 eatic saponification, heterotopic mesenteric ossification, and pseudolipoma of the capsule of Glisson

82 r of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 inte

83 epiphyseal and metaphyseal shape, secondary ossification, and the perichondrium on 1.5-T echo-planar

84 lin Archaeopteryx are bridged by interspinal ossifications, and form a rigid notarium-like structure

85 a rare genetic disease in which heterotopic ossifications appear in early childhood and are accompan

86 y which gadolinium could induce fibrosis and ossification are not known.

87 Chondrogenesis and endochondral ossification are precisely controlled by cellular intera

88 Chondrogenesis and endochondral ossification are the cartilage differentiation processes

89 pression to control the rate of endochondral ossification as a negative feedback mechanism.

90 and had enhanced early and late endochondral ossification as demonstrated by Safranin O, Picrosirius

91 Osteoclast differentiation and endochondral ossification as the major pathways associated with disea

92 formation at CT, with a subtle focus of new ossification at 3 weeks and a larger focus of ossificati

93 ssification at 3 weeks and a larger focus of ossification at 6 weeks.

94 rophic chondrocytes accelerates endochondral ossification at both E17.5 and P1 stages.

95 ressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressing HIF signali

96 irment to the middle ear, demonstrating over-ossification at the round window ridge, ectopic depositi

97 The absolute size at which limb ossification began differs greatly between individuals,

98 ollectively, our data implicate endochondral ossification, bone formation that proceeds through a car

99 egulate Fmn1 function at the hypertrophic-to-ossification border, thereby explaining the overall dela

100 se in Fmn1 expression at the hypertrophic-to-ossification border.

101 n via either intramembranous or endochondral ossification, both within and outside of the craniofacia

102 fferentiation does not occur by endochondral ossification but by the direct ossification of blastema

103 growth plate maturation during endochondral ossification but simultaneously results in massively ele

104 (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms i

105 ntiation of chondrocytes during endochondral ossification by activating the TGFalpha/EGFR signaling a

106 athway plays essential roles in endochondral ossification by regulating osteoblast proliferation and

107 e deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modul

108 Thus, the tight regulation of endochondral ossification by TBX1 is crucial for the normal progressi

109 sized that hMSCs pushed through endochondral ossification can engineer a scaled-up ossicle with featu

110 se, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activi

111 in a delay in the formation of the secondary ossification center (SOC).

112 nto two distinct structures by the secondary ossification center (SOC).

113 thus impairing the formation of the primary ossification center and causing severe limb shortening.

114 c mice showed delayed formation of secondary ossification center and localized increase of bone mass

115 clast numbers were reduced in both secondary ossification center and proximal metaphysis.

116 vascular invasion and formation of the early ossification center at least in part by interfering with

117 lowed by the formation of a new endochondral ossification center at the distal end of the bone stump.

118 The endochondral ossification center contains proliferating chondrocytes

119 zone comes to be subdivided by the secondary ossification center into distinct articular and growth c

120 he chondrocytes of the prospective secondary ossification center precludes its development.

121 structures by stimulating a new endochondral ossification center that utilizes an existing network of

122 ication orientation in the condylar ramus (1 ossification center) versus long bone ossification forma

123 wo longitudinal founder ridges formed at the ossification center.

124 portant role in the formation of the primary ossification centers (POCs) and secondary ossification c

125 ry ossification centers (POCs) and secondary ossification centers (SOCs) of mammalian long bones.

126 ociated with poor vascularization of primary ossification centers and disrupted endochondral ossifica

127 one formation would accelerate the fusion of ossification centers and limit the endochondral bone gro

128 In addition, secondary ossification centers do not form in the central regions

129 have neither craniosynostosis nor additional ossification centers in interfrontal suture and displaye

130 Using the polarity of the endochondral ossification centers induced by BMP2 at two different am

131 asts migrate from perichondrium into primary ossification centers of cartilage templates of future bo

132 ) versus long bone ossification formation (2 ossification centers).

133 ed protein accumulation in marrow, secondary ossification centers, and periosteum.

134 adiograph: the appearance, size and shape of ossification centers, the width and the shape of growth

135 During vascular invasion and formation of ossification centers, these Nes(+) cells were closely as

136 promote synchondrosis closure and fusion of ossification centers.

137 lization in primary and secondary enchondral ossification centers.

138 inciding with the formation of the secondary ossification centre, chondroprogenitors acquire the capa

139 ebral delineation should include all primary ossification centres and growth plates, and therefore in

140 report that osteoclasts that colonize fetal ossification centres originate from embryonic erythro-my

141 D673V mutation induces delayed endochondral ossification characterized by transiently reduced chondr

142 sect the causative relationships between neo-ossification, cholesterol crystal deposition, and Eustac

143 During endochondral ossification, chondrocytes embed themselves in a proteog

144 periosteal cells during primary endochondral ossification, consistent with a role in bone development

145 Heterotopic ossification consists of ectopic bone formation within s

146 ) PF-sutures lack physiological endochondral ossification, contain ectopic cartilage and display dela

147 g to severe intramembranous and perichondral ossification defects.

148 was defined as 10 or more bilateral nodular ossifications (definition 1) or as one or more lobes wit

149 re lobes with five or more bilateral nodular ossifications (definition 2).

150 by defects in skeletal structures, including ossification delay in several membranous bones and enlar

151 ent of the appendicular skeleton, and carpal ossification delay.

152 Endochondral ossification depends on an avascular cartilage template

153 Moreover, physiological endochondral ossification did not occur, rather an ectopic cartilage

154 , a debilitating and progressive heterotopic ossification disease caused by activating mutations of A

155 estigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstiti

156 east in part, as a regulator of endochondral ossification during osteogenesis.

157 pathway promotes chondrocyte maturation and ossification events, and may exert this important role b

158 se that involves redifferentiation by direct ossification (evolved regeneration), the BMP-induced res

159 nchymal stem cells in vitro and endochondral ossification ex vivo, and GEP-knockdown mice display ske

160 mus (1 ossification center) versus long bone ossification formation (2 ossification centers).

161 or calvaria that do not undergo endochondral ossification formed only bone without marrow in our assa

162 n of the digit tip occurs by intramembranous ossification forming a trabecular bone network that repl

163 Heterotopic ossification frequently occurs following injury as cells

164 to 20% of civilians who develop heterotopic ossification (HO) after blast-related extremity injury a

165 Heterotopic ossification (HO) and fatty infiltration (FI) often occu

166 a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating ge

167 Heterotopic ossification (HO) is an aberrant regenerative process wi

168 xuberant osteogenesis results in heterotopic ossification (HO) of soft tissues.

169 a mouse model of trauma-induced heterotopic ossification (HO) to examine how cell-extrinsic forces i

170 extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, b

171 Heterotopic ossification (HO), or the abnormal formation of bone in

172 Heterotopic ossification (HO), the abnormal formation of bone within

173 genetic disorder of progressive heterotopic ossification (HO).

174 according to risk of developing heterotopic ossification (HO).

175 tribution of lymphatic tissue to heterotopic ossification (HO).

176 The classic model of endochondral ossification holds that chondrocytes mature to hypertrop

177 ion at its distal end occurs by appositional ossification, i.e. direct ossification on the surface of

178 racterized by hypotonia, cataracts, abnormal ossification, impaired motor development, and intellectu

179 Indian hedgehog (Ihh) regulates endochondral ossification in both a parathyroid hormone-related prote

180 ermore, FST-loaded microbeads decreased bone ossification in developing chick femora (6%) and tibiae

181 wless fishes and the absence of endochondral ossification in early fossil gnathostomes appear to lend

182 a phenotype paralleled by premature clavicle ossification in Eif4a3 haploinsufficient embryos.

183 Endochondral ossification in embryos from embryonic day 16.5 was asse

184 st injury-induced and congenital heterotopic ossification in humans.

185 al cartilage origin and subsequent stages of ossification in JOCD.

186 or postnatal day 1 (P1) observed accelerated ossification in long bone, digit and tail bones compared

187 l cartilage differentiation and endochondral ossification in mandibular condylar cartilage.

188 Lineage tracing of heterotopic ossification in mice using a Tie2-Cre construct also sug

189 delay of osteoblast differentiation and bone ossification in mice.

190 lls and disrupted caALK2-induced heterotopic ossification in mice.

191 gonists are potent inhibitors of heterotopic ossification in mouse models and, thus, may also be effe

192 play a role in systemic fibrosis and ectopic ossification in nephrogenic systemic fibrosis.

193 ormed the rudiment elongates by appositional ossification in parallel with unamputated control digits

194 Endochondral ossification in the diaphysis of long bones has been stu

195 rocyte proliferation and an overall delay in ossification in the double-knockout mice.

196 o-cartilaginous metaplasia with endochondral ossification in the last case.

197 ee joint and remarkable defects of postnatal ossification in the long bones.

198 on of cartilage and promotes intramembranous ossification in the skull.

199 coronary artery SMC phenotype and suppresses ossification in these cells.

200 on, an RAR-gamma agonist blocked heterotopic ossification in transgenic mice expressing activin recep

201 Smad7 is actually required for endochondral ossification in vivo is unclear.

202 composed of distinct cartilages and gnathal ossifications in both jaws, and a dermal element in the

203 sible to precisely determine the position of ossifications in relation to the internal organs and blo

204 ositis ossificans refers to the formation of ossifications in the muscles, ligaments and fascias, usu

205 ibute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT

206 , a major negative regulator of endochondral ossification, in Col2a1-TAP63alpha transgenic mice.

207 The gnathal ossification is a composite of distinct teeth that devel

208 Endochondral ossification is a highly regulated process that relies o

209 The ossification is confined to subcutaneous tissues and so

210 function mouse (Foxc1(ch/ch)), endochondral ossification is delayed and the expression of Ihh target

211 Moreover, ossification is initiated from the inferior portion of m

212 Ossification is severely reduced after condensation of t

213 The established dogma of endochondral bone ossification is that hypertrophic chondrocytes undergo a

214 dothelial cell masses, abnormal endochondral ossification, leading to stunted long bone growth and in

215 Disruption to endochondral ossification leads to delayed and irregular bone formati

216 cle architecture adjacent to the heterotopic ossification lesion, suggesting that RARgamma agonist ma

217 rmal bone formation in areas of subarticular ossification may explain the site-specific distribution

218 onstitutive BMP signaling during heterotopic ossification, may be re-purposed for OA treatment.

219 repair of most bones proceed by endochondral ossification, namely through formation of a cartilage in

220 to subcutaneous tissues and so resembles the ossification observed with AHO.

221 sts that two different forms of endochondral ossification occur.

222 Murine forepaw ossification occurred sequentially.

223 essiva (FOP), a disease in which heterotopic ossification occurs as a result of activating ALK2 mutat

224 ssive sesamoids that employ a patchy mode of ossification of a massive cartilaginous precursor and th

225 endochondral ossification but by the direct ossification of blastema cells that form the rudiment of

226 ion of articular chondrocytes and the timely ossification of bones in joint regions.

227 Craniosynostosis, the premature ossification of cranial sutures, is a developmental diso

228 bone malformations resulting from premature ossification of developing bones.

229 osteoblasts, negatively regulates secondary ossification of epiphyses.

230 and FGFR3 have roles during intramembranous ossification of mandibular bones.

231 unctional role of syndecan 4 in endochondral ossification of mouse embryos and in adult fracture repa

232 d to inappropriate signaling and heterotopic ossification of soft tissues.

233 and dilation of the aorta, calcification and ossification of the aortic wall, and inflammation, resul

234 Except for sloths, all mammals show the late ossification of the caudal-most centra in the neck after

235 Ossification of the cranial skeleton varies from 20% in

236 nvestigated the role of Phd2 on endochondral ossification of the epiphyses by conditionally deleting

237 bers, blunted revascularization, and delayed ossification of the fracture callus.

238 All three displayed a severely disturbed ossification of the skull and multiple fractures with pr

239 Notably, ossification of vessels and astrocytic neurotoxic respon

240 rs by appositional ossification, i.e. direct ossification on the surface of the terminal phalanx, whe

241 Heterotopic ossification or postoperative osteolysis was not signifi

242 Endochondral ossification orchestrates formation of the vertebrate sk

243 ide new evidence of a distinct difference in ossification orientation in the condylar ramus (1 ossifi

244 roteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT sign

245 he association of these two key endochondral ossification pathway genes with BMD and osteoporosis in

246 focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH.

247 Analysis of the ossification pattern in mammals with specialized extremi

248 equired modification of frontal neurocranial ossification patterns.

249 Endochondral ossification plays an important role in the formation of

250 growth and bone healing via intramembranous ossification proceeded normally in the absence of B cell

251 light on the key role of the XT-I during the ossification process.

252 were independently associated with pulmonary ossification profusion.

253 Secondary ossification (r(2) = 0.777) was not observed until 25 we

254 e BMP-induced response involves endochondral ossification (redevelopment).

255 l4 were expressed at decreased levels in the ossification region in the posterior palatal shelf mesen

256 dyle MSCs expressed higher levels of several ossification-related genes.

257 splayed that TGF-beta pathway activation and ossification-related processes were significantly influe

258 that drives skeletal growth and endochondral ossification, remain unclear.

259 l aorta (DA), but the reason for hypochordal ossification remains obscure.

260 progenitor cells can lead to mosaic ectopic ossification reminiscent of that seen in POH.

261 genetic disorder that inhibits endochondral ossification, resulting in disproportionate short statur

262 al regulation in vitro resisted endochondral ossification, retained the expression of cartilage marke

263 ion of behavioural types, and stress-induced ossification schedules.

264 g a possible posterior-to-anterior vertebral ossification sequence and the first evolutionary appeara

265 X-ray computed tomography data, into cranial ossification sequences in extant saurian taxa and in wel

266 gs support deep-time conservation of cranial ossification sequences in saurians including dinosaurs,

267 Subarticular regions of endochondral ossification showed morphologic and calcification patter

268 ndylar cartilage, in contrast to the initial ossification site in long bone, which is in the center.

269 During endochondral ossification, small, immature chondrocytes enlarge to fo

270 During endochondral ossification, Spry genes are expressed in prehypertrophi

271 pair site during the periosteal endochondral ossification stage.

272 tion in markers associated with endochondral ossification such as Ihh, Alpl, and Sdf-1.

273 pression of factors involved in endochondral ossification, such as osterix and vascular endothelial g

274 The late onset of limb ossification suggests that the juveniles were exclusivel

275 g also led to osteophyte formation, meniscal ossification, synovial hyperplasia and fibrosis, and cru

276 mandibular primordium where intramembranous ossification takes place.

277 tion mutations of GNAS can result in ectopic ossification that tends to be superficial and attributab

278 Heterotopic ossification, the pathologic formation of extraskeletal

279 During endochondral ossification, the presence of fully formed vasculature e

280 in cartilage development during endochondral ossification, the process by which long bones form.

281 the calvarium, indicating that endochondral ossification, the process needed for the formation of HS

282 ysis decreases endochondral angiogenesis and ossification, thereby inhibiting fracture repair.

283 TAP63a may promote endochondral ossification through interaction with genes relevant to

284 +) mouse model of injury-induced heterotopic ossification to examine the fibroproliferative tissue pr

285 MP2 in neonatal mice stimulates endochondral ossification to regenerate the stump bone.

286 ly regulates chondrogenesis and endochondral ossification via associating with progranulin growth fac

287 typical growth plate zones, and endochondral ossification was delayed.

288 Here we show that heterotopic ossification was essentially prevented in mice receiving

289 Endochondral ossification was not disrupted any further in mice with

290 l2a1-DeltaNP63alpha transgenic mice, reduced ossification was observed in the digit and tail bones of

291 Pulmonary ossifications were recorded when nodules (<4 mm diameter

292 reveals significant heterochrony in cranial ossifications when compared with non-sauropod sauropodom

293 e mandible is formed through intramembranous ossification whereas the proximal region of the mandible

294 ignaling is sufficient to induce heterotopic ossification, whereas inhibition of this signaling pathw

295 r frontal (PF) suture closes by endochondral ossification, whereas sagittal (SAG) remain patent life

296 ted chondrocyte hypertrophy during secondary ossification, which in turn caused reduction of joint ca

297 iofacial cartilage malformations and delayed ossification, which is shown to be associated with aberr

298 AIIS) that emerges via a secondary center of ossification, which is unique to hominids (i.e., all tax

299 he cranial vault closes through endochondral ossification, while other sutures remain patent.

300 a 31-year-old woman with massive heterotopic ossifications who suffered multiple injuries.