ライフサイエンスコーパス: osteoblast-specific

1 Remarkably, for our purpose, an osteoblast-specific ablation of sympathetic signaling re

2 ice that were genetically altered to produce osteoblast-specific, activated PTH/PTHrP receptors (PPRs

3 In contrast, the AP1 site mediates an osteoblast-specific activation caused by the preferentia

4 steoblasts abolishes the binding of OSF2, an osteoblast-specific activator of transcription that bind

5 When multimerized, CE1 conferred an osteoblast-specific activity to a heterologous promoter

6 er, multimers of this OSE2 at -1347bp confer osteoblast-specific activity to a minimum alpha1(I) coll

7 timers of this alpha2(I) OSE2 element confer osteoblast-specific activity to the minimum alpha1(I) co

8 Through osteoblast-specific alteration of p53 status, we develop

9 To address this mechanism, we generated late-osteoblast-specific and osteocyte-specific WNT1 loss- an

10 These results indicate that osteoblast-specific aptamer-functionalized LNPs could ac

11 generation and analysis of chondrocyte- and osteoblast-specific Bmp2 conditional knockout (cKO) mice

12 subunit in osteoblasts in vivo, we generated osteoblast-specific Capn4 knock-out mice using the Cre-L

13 proliferation, resulted in the induction of osteoblast-specific cell death in vitro.

14 ly of transcription factors that binds to an osteoblast-specific cis-acting element (OSE2) activating

15 This osteoblast-specific cis-acting element binds Osf2, a rec

16 transcription that binds to OSE2, a critical osteoblast-specific cis-acting element present in OG1 an

17 We previously identified an osteoblast-specific cis-acting element, termed OSE2, in

18 is study indicates the existence of multiple osteoblast-specific cis-acting elements of equal importa

19 two mouse osteocalcin genes, identified two osteoblast-specific cis-acting elements, OSE1 and OSE2,

20 aPPR), whose expression was regulated by the osteoblast-specific Col1a1 promoter (Col1a1-caPPR), supp

21 blasts from Col-luc transgenic mice carrying osteoblast-specific Col1alpha1 promoter reporter, lucife

22 Furthermore, osteoblast-specific Col2.3-Cre(+)/OTR(fl/fl) mice, but n

23 nction in the hypothalamus, pair-feeding and osteoblast-specific conditional deletion of Ksr2 reveals

24 Our data show that osteoblast-specific CXCR4 deletion has profound effects

25 Osteoblast-specific deletion of Hnf4alpha resulted in im

26 Osteoblast-specific deletion of PPARdelta in mice, in tu

27 Osteoblast-specific deletion of Tak1 resulted in clavicu

28 Accordingly, osteoblast-specific deletion of TC-PTP promotes insulin

29 Using transgenic mice with osteoblast-specific deletion of Vegfa, we demonstrated t

30 es still exist because of the lack of direct osteoblast-specific delivery systems for osteogenic siRN

31 oximal OSE2 element is critical to confer an osteoblast-specific, developmentally regulated pattern o

32 Although Lrp5 is viewed as a Wnt coreceptor, osteoblast-specific disruption of beta-Catenin does not

33 ng bone remodeling, we generated a postnatal osteoblast-specific disruption of Bmpr1a that encodes th

34 Of particular interest is the single osteoblast specific element known as osteocalcin specifi

35 sence of 12 putative Cbfa1 binding elements (osteoblast-specific element 2 (OSE(2))), suggesting a po

36 Cbfa1-binding site (-248 base pairs) termed osteoblast-specific element 2 (OSE2) decreased ameloblas

37 to -113, the OCFRE is juxtaposed to OSE2, an osteoblast-specific element that binds Runx2 (Osf2, Cbfa

38 e data represent the first description of an osteoblast-specific element within the bone sialoprotein

39 The runt domain site is identical to an osteoblast-specific element-2 or acute myelogenous leuke

40 In summary, this study identified an osteoblast-specific enhancer in the Cbfa1 promoter whose

41 ased binding to OSE1, a previously described osteoblast-specific enhancer in the mOG2 promoter.

42 sis mapped the PC1-responsive region to the "osteoblast-specific" enhancer element between -420 and -

43 rs C/EBPb, TEAD1, FOSL2 and JUND at putative osteoblast-specific enhancers.

44 fa1 is one of the positive regulators of the osteoblast-specific expression of both type I collagen g

45 -acting element as important as OSE2 for the osteoblast-specific expression of OG2 in cell culture an

46 The osteoblast-specific expression of the HGPS mutation incr

47 tive in transgenic mice and unable to direct osteoblast-specific expression.

48 and increased trabecular bone mass from pre-osteoblast specific Ezh2 deletion (Ezh2(flox/flox) Osx-C

49 rated that TNF-alpha enhanced DNA binding of osteoblast specific factor (Osf2), AP1, and CREB, transc

50 Two genes, osteoblast-specific factor 2 and corneal-derived transcr

51 Periostin was originally identified as an osteoblast-specific factor and is highly expressed in th

52 ated by members of Sp1 family instead of the osteoblast-specific factor Osf1.

53 Overexpression of c-Fos, c-Jun, osteoblast-specific factor-2, and core binding factor-be

54 The ability of osteoblast-specific FoxO1 deficiency to affect metabolic

55 Osteoblast-specific G(s)alpha deficiency leads to reduce

56 In vivo, osteoblast-specific gain of miR-34c in mice leads to an

57 Here, we show that osteoblast-specific gain of Notch function causes severe

58 Osteoblast-specific gain- and loss-of-function experimen

59 struct encoding p204 antisense RNA inhibited osteoblast-specific gene activation by Cbfa1 in an osteo

60 The molecular basis of osteoblast-specific gene expression and differentiation

61 ivation and reduced its ability to stimulate osteoblast-specific gene expression and differentiation

62 LCMV and PVM infections resulted in reduced osteoblast-specific gene expression in bone, loss of ost

63 Runx2 and Osterix, has the ability to induce osteoblast-specific gene expression in non-osteoblastic

64 displayed enhanced osteogenic potential and osteoblast-specific gene expression in vitro and in vivo

65 t the skeleton early during development, and osteoblast-specific gene expression occurs only after th

66 anscription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions

67 To elucidate the mechanisms of osteoblast-specific gene expression we are studying the

68 - and NH(2)-terminated surfaces up-regulated osteoblast-specific gene expression, alkaline phosphatas

69 Atf4 in non-osteoblastic cells would lead to osteoblast-specific gene expression, one of the most imp

70 hway has an important role in the control of osteoblast-specific gene expression.

71 teocalcin genes are excellent tools to study osteoblast-specific gene expression.

72 ired for activation of Osf2 and induction of osteoblast-specific gene expression.

73 e through the ERK/MAPK pathway can stimulate osteoblast-specific gene expression.

74 to bone lineages and is a major regulator of osteoblast-specific gene expression.

75 on with DLX5 or a related factor to activate osteoblast-specific gene expression.

76 nt model for studying mechanisms controlling osteoblast-specific gene expression.

77 inal differentiation of osteoblasts, and for osteoblast-specific gene expression.

78 We have studied the regulation of the osteoblast-specific gene osteocalcin (OC) by FGF2 in phe

79 e state, while in bone marrow pericytes, the osteoblast-specific gene Runx2 was primed for expression

80 nce to the promoter for osteocalcin, another osteoblast-specific gene with a loss-of-function phenoty

81 ying the regulation of osteocalcin, the most osteoblast-specific gene.

82 activating the expression of osteocalcin, an osteoblast-specific gene.

83 t OSE1 is present in the promoter of several osteoblast-specific genes including Cbfa1 itself.

84 transcriptional component for activation of osteoblast-specific genes like osteocalcin.

85 complexes containing the BRM ATPase repress osteoblast-specific genes to maintain the precursor stat

86 activation of Runx2 activity, expression of osteoblast-specific genes, and calcium deposition.

87 ostate cancer cells can induce expression of osteoblast-specific genes.

88 ells induces the expression of the principal osteoblast-specific genes.

89 oreover, the impact of postnatally acquired, osteoblast-specific insulin deficiency on the pancreas-t

90 The relationship between osteoblast-specific insulin signaling, osteocalcin activ

91 function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model.

92 ass in Lrp5-deficient mice, and gut- but not osteoblast-specific Lrp5 inactivation decreases bone for

93 ptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass in mice.

94 abecular bone and/or stromal cells increases osteoblast-specific marker expression in hyperactive Gja

95 keleton but fail to form bone and to express osteoblast-specific marker genes.

96 nesis in MSCs and therefore functioned as an osteoblast-specific marker.

97 ontributed to the up-regulated expression of osteoblast-specific markers (e.g., Bsp and Ocn) in Gja1(

98 Osteoblast-specific miR-23a cluster gain-of-function mic

99 igated the role of IL-3 on the regulation of osteoblast-specific molecules, receptor activator of NF-

100 e the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein, we have gen

101 tions between ATF4 and Runx2/Cbfa1 stimulate osteoblast-specific Ocn expression and suggests that thi

102 on of the Adar1 gene decreased expression of osteoblast-specific osteocalcin and bone sialoprotein ge

103 homeoprotein, which is able to regulate the osteoblast-specific osteocalcin promoter, can bind this

104 mic and transmembrane domains, driven by the osteoblast-specific osteocalcin promoter.

105 In contrast, deletion of Ddrgk1 with the osteoblast-specific Osteocalcin-Cre and Leptin receptor-

106 As a result, osteoblast-specific overexpression of Hnf4alpha2 prevent

107 Here, we evaluated the consequences of osteoblast-specific overexpression of or loss of insulin

108 Osteoblast-specific overexpression of TGF-beta 2 from th

109 ion and repression of the Runx2 gene via its osteoblast-specific P1 promoter (encoding mRNA for the R

110 tions observed in mice heterozygous for both osteoblast-specific Pdk1 deletion and either Runx2 or Cr

111 capitulation of RTS spectrum phenotypes with osteoblast-specific Pdk1 deletion in mice (Pdk1osx mice)

112 Osteocalcin is an osteoblast-specific peptide that is reported to be invol

113 Osteoblast-specific PGC-1alpha upregulation by 6-C-beta-

114 ly via macropinocytosis, and boosted in vivo osteoblast-specific Plekho1 gene silencing, which promot

115 scription factor, CBFA1, and associates with osteoblast-specific promoters in vivo in a CBFA1-depende

116 tic cells alters transcriptional activity of osteoblast-specific promoters, presumably via modulation

117 is activity was needed for the regulation of osteoblast-specific promoters.

118 A segment that abolished the binding of this osteoblast-specific protein also abolished lacZ expressi

119 as for examining factors which contribute to osteoblast-specific regulation of gene expression.

120 2 and MINT both target an information-dense, osteoblast-specific regulatory region of the OC proximal

121 results in synergistic transactivation of an osteoblast-specific reporter.

122 The osteoblast-specific secreted molecule osteocalcin behave

123 decreases the bioactivity of osteocalcin, an osteoblast-specific secreted molecule that enhances secr

124 SHP2's role in skeletal development, we made osteoblast-specific SHP2 deficient mice using Osterix (O

125 rBMPR-IB also blocked mRNA expression of the osteoblast specific transcription factor, Osf2/ Cbfa1, a

126 a 3/polyoma enhancer-binding protein 2alphaA/osteoblast-specific transcription factor 2 regulates ost

127 This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regula

128 keletal dysplasia caused by mutations in the osteoblast-specific transcription factor CBFA1.

129 , osteocalcin, alkaline phosphatase, and the osteoblast-specific transcription factor Cbfa1.

130 eam signaling molecules Smad1 and -5 and the osteoblast-specific transcription factor core-binding fa

131 stent with an observed downregulation of the osteoblast-specific transcription factor core-binding fa

132 Osterix (Osx) is an osteoblast-specific transcription factor essential for o

133 er being the binding site of Cbfa1, the only osteoblast-specific transcription factor known to date.

134 Since the osteoblast-specific transcription factor Osf2/Cbfa1 is i

135 Here, we report that the osteoblast-specific transcription factor Osterix (Osx),

136 Osterix (Osx) is an osteoblast-specific transcription factor required for bo

137 Osterix (Osx) is an osteoblast-specific transcription factor required for os

138 that Foxo1 is a novel negative regulator of osteoblast-specific transcription factor Runx2 and modul

139 consensus sequences which bound CREB and the osteoblast-specific transcription factor Runx2, and when

140 urf1 mediates the protein degradation of the osteoblast-specific transcription factor Runx2/Cbfa1.

141 Cbfa1 is an osteoblast-specific transcription factor that is essenti

142 Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates

143 Osterix (Osx) is an osteoblast-specific transcription factor which is essent

144 Runx2 is an osteoblast-specific transcription factor whose steady-st

145 o demonstrate that phosphorylation of Cbfa1 (osteoblast-specific transcription factor) was not requir

146 Here, we studied the role of Cbfa1, an osteoblast-specific transcription factor, in the control

147 xpression of core binding factor alpha-1, an osteoblast-specific transcription factor, increased in p

148 It is known that an osteoblast-specific transcription factor, Runx2, is esse

149 iochemical characterization of Osf1, a novel osteoblast-specific transcription factor.

150 fa1/AML3/PEBP2alphaA), a recently identified osteoblast-specific transcription factor.

151 element binds Osf2, a recently characterized osteoblast-specific transcription factor.

152 ase activity, and by increased expression of osteoblast-specific transcription factors (eg, runt-rela

153 g site is a regulatory element important for osteoblast-specific transcriptional activation of the rO

154 tagenesis established that both sites act as osteoblast-specific transcriptional enhancers and togeth

155 lls was associated with up-regulation of the osteoblast-specific transcriptor factor Cbfa1.

156 geted to osteoblasts using the murine 2.3-kb osteoblast-specific type I collagen promoter.

157 ne development and homeostasis, we generated osteoblast-specific Wls-deficient (Ocn-Cre;Wls-flox) mic

158 We developed a mouse model with osteoblast-specific Wnt16 overexpression (Obl-Wnt16).