ライフサイエンスコーパス: osteoclast number

1 of bone cancer with only a modest effect on osteoclast number.

2 ot affect osteoblast apoptosis but increases osteoclast number.

3 ation rate, and bone mass, but do not affect osteoclast number.

4 ) mice, correlating with the increase in the osteoclast number.

5 ring properties and its capacity to decrease osteoclast number.

6 is no systemic inflammation and no change in osteoclast number.

7 cumference and increased cortical periosteal osteoclast number.

8 itis via impacting synovial inflammation and osteoclast number.

9 in osteopenia associated with an increase in osteoclast number.

10 vivo increased calvarial vessel density and osteoclast number.

11 rosis factor-alpha, consistent with elevated osteoclast numbers.

12 reduced osteoprogenitor cells and increased osteoclast numbers.

13 evented MM-induced bone damage and decreased osteoclast numbers.

14 ne mineralization/resorption, and osteoblast/osteoclast numbers.

15 l molecule ERK5 pathway inhibitors increased osteoclast numbers.

16 y, reduced osteoblast numbers, and increased osteoclast numbers.

17 ion, but with parallel notable reductions in osteoclast numbers.

18 iosteoclastic activity, and the reduction in osteoclast numbers.

19 also causes high bone mass due to decreased osteoclast numbers.

20 honates suppress osteoclast activity but not osteoclast numbers.

21 bone gain that could be ascribed to reduced osteoclasts numbers.

22 ine after injury and suggest that osteoblast/osteoclast number alone is insufficient to predict bone

23 e is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclast

24 ficiency triggers a drastic increase in both osteoclast number and activity (hyper-activation), mecha

25 bone metastases are characterized by excess osteoclast number and activity.

26 a concomitant increase in TRAP staining for osteoclast number and area in HFD-PI mice over LFD-PI mi

27 Histological analysis revealed a decrease in osteoclast number and bone resorption in trabecular bone

28 hibit marked osteopenia because of increased osteoclast number and bone resorption.

29 e had mild osteopetrosis caused by decreased osteoclast number and bone resorption.

30 This was followed by a decrease in osteoclast number and eroded surface, which was associat

31 ine decreases bone loss through reduction of osteoclast number and induces reduction of IL-6, MMP-1,

32 ll mice, this was followed by an increase in osteoclast number and normalization of bone volume.

33 signaling suppressed, rather than enhanced, osteoclast number and osteoclast surface as well as urin

34 umber and osteoblast activity with unaltered osteoclast number and osteoclast surface in knockout ani

35 nsistently, boldine caused a decrease in the osteoclast number and RANKL/OPG ratio in periodontal les

36 orption as demonstrated in vivo by increased osteoclast number and serum C-terminal telopeptides, a m

37 e/WT);Hes1( / ) mice displayed a decrease in osteoclast number and size and decreased bone-resorbing

38 ponsive to RANKL and showed elevated ex vivo osteoclast number and size and enhanced bone resorption

39 Osteoclast number and surface are significantly lower in

40 se staining of tibia indicated a decrease in osteoclast number and surface area/bone surface from kno

41 calcin; but increased trabecular separation, osteoclast number and surface, and RANKL expression.

42 s; however, no correlation was found between osteoclast number and the amount of resorption.

43 etric analysis was performed to quantify the osteoclast number and the area of bone resorption.

44 teocytes were protected from the increase in osteoclast number and the bone loss caused by ovariectom

45 rption in trabecular bone and an increase in osteoclast number and void or pore area in cortical bone

46 mesenchymal cell-derived MMP13 may regulate osteoclast number and/or activity, bone resorption, and

47 Lack of MMP-9 decreased osteoclast numbers and abrogated angiogenesis in respons

48 This change coincided with elevated osteoclast numbers and accelerated removal of cartilage

49 pe 2 diabetic group had significantly higher osteoclast numbers and activity (P < 0.05).

50 While osteoclast numbers and activity are regulated by osteopr

51 Castration greatly increases osteoclast numbers and activity in GRKO mice and promote

52 in fXIIIA(-/-) mice concurrent with reduced osteoclast numbers and activity.

53 uced obesity (DIO) diabetic mice, it reduced osteoclast numbers and alveolar bone loss significantly

54 -/-) mice, although having normal basal bone osteoclast numbers and bone density, are resistant to ph

55 well as the effects of lactation to increase osteoclast numbers and decrease trabecular bone volume,

56 ing as evidenced by decreased osteoblast and osteoclast numbers and decreased bone formation rate; as

57 from mu-calpain(-/-) mice revealed increased osteoclast numbers and decreased trabecular bone volume

58 lasts from the Acvr1-floxed mice had reduced osteoclast numbers and demineralization activity, wherea

59 Furthermore, osteoclast numbers and expression of osteoclast marker g

60 Increased osteoclast numbers and increased eroded surface areas su

61 s of Ank (KI/KI) incisors revealed decreased osteoclast numbers and osteoclast surfaces.

62 ce expressing p62(P392L) developed increased osteoclast numbers and progressive bone loss, but osteob

63 Phlpp1 deficiency elevated osteoclast numbers and size in ex vivo osteoclastogenesi

64 eopenic phenotype characterized by increased osteoclast numbers and surface, which are normalized in

65 nvestigated the impact of cigarette smoke on osteoclast numbers and underlying mechanisms in a mouse

66 as abrogated, as evidenced by maintenance of osteoclast numbers and, additionally, loss of bone densi

67 clodronate and AppCCl2p on bone resorption, osteoclast number, and apoptosis in vitro were compared.

68 ed with osteoclast differentiation, enhanced osteoclast number, and bone matrix degradation.

69 greater periodontal ligament surface, higher osteoclast number, and greater lamina dura apposition wi

70 Periodontal tissue destruction, osteoclast number, and inflammation were assessed by his

71 e in empty lacunae, necrotic bone formation, osteoclast number, and surface area in antibiotic-treate

72 In summary, Phlpp1 critically regulates osteoclast numbers, and Phlpp1 deficiency enhances bone

73 tor activator of NF-kappaB ligand levels and osteoclast numbers, and reduction of bone loss.

74 eased interleukin-6 (IL-6) levels, increased osteoclast numbers, and significant trabecular bone loss

75 Osteoblast and osteoclast number as well as mineral apposition rate wer

76 nsion on the graft outcome and assessment of osteoclast numbers as an indirect measure of a connectio

77 t numbers (68%) as well as a 40% decrease in osteoclast numbers as compared with the values from cont

78 cluded that SR can reduce RANKL activity and osteoclast numbers, as well as ABL.

79 ficient animals correlated with increases in osteoclast numbers, as well as with elevated expression

80 sis of hypertrophic chondrocytes and reduced osteoclast number at the border of marrow space.

81 olume in the femur and tibia were higher and osteoclast number at the endocortical surfaces was lower

82 pletion elevated gingival Il1b and increased osteoclast numbers at diseased sites (P < 0.05).

83 ion, MMP-7 null mice had significantly fewer osteoclast numbers at the tumor-bone interface compared

84 deficiency enhances bone mass despite higher osteoclast numbers because it apparently disrupts PKCzet

85 Significantly increased osteoclast number/bone perimeter in SCD mice was reduced

86 findings demonstrate that estrogens decrease osteoclast number by attenuating respiration, and thereb

87 In vitro, 2ME(2) repressed osteoclast number by inducing apoptosis of osteoclast pr

88 stage of the experiment to downregulate the osteoclast number by inhibiting Th1 and Th17 cells, whic

89 eport that 17beta-estradiol (E(2)) decreased osteoclast number by promoting the apoptosis of early os

90 ing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the

91 tration (MPO+ staining), Il1b (qRT-PCR), and osteoclast numbers (cathepsin K+ staining).

92 c1, DC-STAMP, ATP6v0d1, and CD44, markers of osteoclast number, fusion, or activity, is lower in Cx37

93 turbed bone micro-architecture and increased osteoclast number, highlighting a new biological pathway

94 lume, decreased cortical bone, and increased osteoclast number in bone explants in adiponectin knock-

95 ly active PPR induced a dramatic increase in osteoclast number in both trabecular and compact bone in

96 n vitro studies suggested that the increased osteoclast number in the mu-calpain(-/-) bones resulted

97 d bone resorption, as evidenced by decreased osteoclast number in vivo and impaired osteoclast format

98 teoporosis that is associated with increased osteoclast numbers in a rat model of the human disease o

99 amining the host response, colonization, and osteoclast numbers in aged versus young mice.

100 Osteoclast numbers in ligated group were significantly h

101 histomorphometry analysis revealed decreased osteoclast numbers in Notch2 ASO-treated Notch2(tm1.1Eca

102 gnificant reduction in bone erosion area and osteoclast numbers in Siglec-15(-/-) mice, whereas the i

103 nd was associated with a failure to increase osteoclast numbers in the conditional knock-out mice.

104 g and wild-type mice were given ALN, and the osteoclast numbers in the inflamed joints and in the lon

105 ey increased with time with the exception of osteoclast numbers in the LIG model.

106 ALN reduced osteoclast numbers in the metaphyses by 97%, but by only

107 tibility, reflected by higher TNF levels and osteoclast numbers in the periodontium of aged versus yo

108 days of maximal mononuclear cell influx and osteoclast numbers in the rat and mouse.

109 Osteoclast numbers in the XG + ozone group were higher t

110 stimulated by mechanical force and increased osteoclast numbers in vivo.

111 tally restricted decreases in osteoblast and osteoclast numbers in vivo.

112 oblastic number was significantly lower, but osteoclast number increased, in the spine L6 of dKO-Hom

113 ined bones from these animals and found that osteoclast number is increased two-fold.

114 e (500 micrograms), significant decreases in osteoclast number occurred in mutant mice compared to wi

115 eased bone marrow osteoclast progenitors and osteoclast numbers on bone surfaces.

116 nsity (NFBD); 3) total callus area (TCA); 4) osteoclast number (ON) in the callus region; and 5) newl

117 The correlations between osteoclast number or eroded surface and serum mineral pa

118 sorption in vitro without markedly affecting osteoclast number or the F-actin "ring" structure in pol

119 These changes were associated with low osteoclast number, osteoblast number, bone formation rat

120 calvarial vault caused a greater increase in osteoclast number, osteoclast surface, and eroded surfac

121 r bearing was positively correlated with the osteoclast number (P < 0.01) and negatively correlated w

122 noscale surface-adherent BMSCs increased the osteoclast number (P < 0.01).

123 Induction of tumor in the bone elevated the osteoclast number (P < 0.05) as well as the levels of nu

124 ony-stimulating factor, and 3-fold increased osteoclast numbers (P < 0.05) in Ddr1(-/-) versus WT per

125 group, and melatonin significantly decreased osteoclast numbers (P <0.05) but had no effect on iNOS,

126 creased trabecular separation, and increased osteoclast number per bone surface length.

127 hometric analysis of bone revealed decreased osteoclast number per millimeter of tumor/bone interface

128 ise reduced and was accompanied by increased osteoclast number per trabecular bone surface.

129 ressing cells led to osteopenia and enhanced osteoclast number, size, and bone resorptive capacity in

130 g of trabecular branches, and a reduction in osteoclast number, suggestive of an early arrest of oste

131 last hyperactivation (including elevation of osteoclast number, surface area, and size) and increased

132 1 and collagen III expression, and increased osteoclast numbers than Veh-treated mice.

133 Osteoclast numbers, the size of the bone marrow spaces a

134 well-recognized negative effects of M-CSF on osteoclast numbers this seems to further downstream caus

135 gens protect against bone loss by decreasing osteoclast number through direct actions on cells of the

136 Osteoclast number was comparable in both genotypes, and

137 Bone resorption was measured by uCT and osteoclast number was determined by tartrate-resistant a

138 We revealed that the increased osteoclast number was downregulated at the end of the ea

139 hed eroded perimeters despite an increase in osteoclast number were observed in histomorphometric mea

140 mental periodontitis, osteonecrosis area and osteoclast number were significantly elevated in knock-i

141 -resistant acid phosphatase-positive (TRAP+) osteoclast numbers were also evaluated.

142 oup was not, and tooth movement distance and osteoclast numbers were assessed.

143 he role of osteoclasts in tumor development, osteoclast numbers were elevated at the bone/tumor inter

144 Accordingly, osteoclast numbers were increased 122% compared with the

145 es were severely reduced, but osteoblast and osteoclast numbers were not significantly changed in the

146 TRAP staining showed that osteoclast numbers were reduced in both secondary ossifi

147 Periodontal tissue destruction and osteoclast numbers were significantly elevated in LIGPG

148 the LAPC-9 tibias under conditions in which osteoclast numbers were significantly reduced.

149 TRAP+ osteoclast numbers were the highest in the STZ+L group,

150 ssociated with osteocyte apoptosis rates and osteoclasts numbers were increased in subchondral bone t

151 Casp1-KO mice had increased in osteoclast numbers, whereas the inflammatory infiltrate

152 reatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus c

153 Systemic M-CSF application impacted osteoclasts numbers, which were almost as low as found i

154 mice was associated with increased endosteal osteoclast numbers, with no significant effects on osteo

155 Analysis of osteoclast number within AIA joint revealed a reduction

156 Moreover, reduced osteoclast numbers within the defect site are correlated