ライフサイエンスコーパス: osteopontin

1 F-alpha, IFN-gamma, IL-6, CCL2, CCL3, G-CSF, osteopontin).

2 lactoferrin, lysozyme, antitrypsin, IgA, and osteopontin).

3 C) signal sequence with that of prolactin or osteopontin.

4 in the pleural space by elaborating CCL2 and osteopontin.

5 his was reversed by neutralizing antibody to osteopontin.

6 iators, like Calgranulin A, Cathepsin S, and Osteopontin.

7 peptidase-9 (MMP-9), a protease that cleaves osteopontin.

8 sporter 1 (encoded by the SLC20A1 gene), and osteopontin.

9 cantly associated, aside from that of plasma osteopontin.

10 tion and reduction in the retentive molecule osteopontin.

11 tory mediators, such as C5a, bradykinin, and osteopontin.

12 olecule-1, vascular adhesion molecule-1, and osteopontin.

13 stimulates colon carcinoma tumor growth via osteopontin.

14 ceptor (VDR)-regulated genes osteocalcin and osteopontin.

15 eral density through candidate genes such as osteopontin.

16 ralization inhibitors matrix Gla protein and osteopontin.

17 of even a highly disordered protein such as osteopontin.

18 on in fibroblasts plated on fibrotic matrix, osteopontin.

19 tion and expression of p65, TLR4, MCP-1, and osteopontin.

20 d extracellular matrix genes fibronectin and osteopontin.

21 3 are the major integrins for this effect on osteopontin.

22 ion of plasminogen activator inhibitor 1 and osteopontin 1.

23 quantify the putative ovarian cancer markers osteopontin (38 mum diameter sphere), CA-125 (53 mum dia

24 The most highly upregulated gene was osteopontin (47-fold increase; P=9.6x10(-45)), an inflam

25 pressed, also in a CD44-dependent manner, by osteopontin, a component of chronically inflamed ECM, in

26 owth factors, such as IL1beta, IL6 and SPP1 (osteopontin, a key biomarker for PCa), were upregulated

27 r volume, as well as the expression level of osteopontin, a known factor of bone remodeling and osteo

28 bited elevated macrophages and deposition of osteopontin, a potent macrophage chemokine.

29 breast cancer cells, and tumor cell-secreted osteopontin activated a CAF phenotypes in normal mammary

30 might be a biomarker for incident ACS, using osteopontin adds moderately to traditional cardiovascula

31 AE (P = .033) and the mean percent change in osteopontin after TAE (P = .024) were significantly grea

32 he expression of osteogenic related markers (osteopontin, alkaline phosphatase activity, Alizarin red

33 Adding osteopontin alone or in combination with CRP modestly im

34 Finally, our experiments have revealed that osteopontin, an important immunomodulator, contributes t

35 of (18)F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprot

36 ) was 1.29 (1.06-1.57) per 1-SD increase for osteopontin and 1.30 (1.02-1.66) for CRP, respectively.

37 nalysis of cytoskeleton, Ki67, expression of osteopontin and alkaline phosphatase, and formation of m

38 extracellular matrix phosphoproteins such as osteopontin and bone sialoprotein have yielded important

39 entin matrix protein 1, and higher levels of osteopontin and bone sialoprotein than the normal.

40 ffects with the integrin-activating proteins osteopontin and CD44.

41 the Dongfeng-Tongji cohort, and found plasma osteopontin and CRP concentrations were associated with

42 eral matrix molecules including fibronectin, osteopontin and fibrillin-1.

43 When osteopontin and hyaluronic acid, the two major ligands o

44 o was associated with elevated deposition of osteopontin and macrophage recruitment.

45 known regulators of mineralization, such as osteopontin and matrix Gla protein, but not osteocalcin,

46 Osteopontin and matrix metalloproteinase-9 were confirme

47 ponse mechanisms, in part, via regulation of osteopontin and MMP-9 activity.

48 ith hypertrophy, increased oxidative stress (osteopontin and NOX4 gene expression), and normal systol

49 n of many osteoblast-related genes including osteopontin and osteocalcin, whilst the DN subset presen

50 Osteopontin and osteoprotegerin were significantly eleva

51 he nucleus where it led to the expression of osteopontin and other FN-type matrix in both mouse embry

52 ng theme in these diseases is a link between osteopontin and pathogenic T cells, particularly T helpe

53 ese mice also had pronounced upregulation of osteopontin and RUNX2 (osteogenic markers), CD63, AnX2 (

54 pression of the WNT-pathway surrogate marker osteopontin and the metastasis-associated genes SASH1 an

55 lphavbeta3 binding to the alphavbeta3 ligand osteopontin and to the monoclonal antibody WOW-1.

56 Osteopontin and VCAM-1 demonstrated sustained upregulati

57 line phosphatase, secreted phosphoprotein 1 (osteopontin), and bone gamma-carboxyglutamate protein (o

58 mation (high-sensitivity C-reactive protein, osteopontin), and leukocyte adhesion (soluble vascular c

59 metastasis-inducing proteins S100A4, S100P, osteopontin, and AGR2 (P < or = 0.002).

60 associated with mineralized differentiation, osteopontin, and alkaline phosphatase in DPSCs cultured

61 f bone morphogenetic protein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alv

62 glycoproteins (SIBLINGs): bone sialoprotein, osteopontin, and dentin matrix protein 1, respectively.

63 renal macrophages that expressed Il10, MMPs, osteopontin, and growth factors, including Pdgfc and Hbe

64 kaline phosphatase, osteocalcin, osteonectin/osteopontin, and in vitro mineralized nodule formation c

65 threads coated with antibodies against CRP, osteopontin, and leptin proteins.

66 ms (SNPs) in candidate genes (SPP1, encoding osteopontin, and LTBP4, encoding latent transforming gro

67 glycan secretion and production of aggrecan, osteopontin, and matrix extracellular phosphoglycoprotei

68 ial cell-specific molecule]-1, cathepsin L1, osteopontin, and MCSF-1) was also identified.

69 ins, such as alpha-lactalbumin, lactoferrin, osteopontin, and milk fat globule membrane proteins.

70 e responsible for degrading type I collagen, osteopontin, and other bone matrix proteins.

71 CD163 (sCD163), chitinase-3-like protein 1, osteopontin, and pentraxin-3, in hOE cells; however, the

72 d the specific role of alpha/beta integrins, osteopontin, and related extracellular matrix proteins;

73 vels of RANKL, osteoprotegerin, osteocalcin, osteopontin, and serum glycosylated hemoglobin A1c, insu

74 f cholangiocytes including cytokeratin 7 and osteopontin, and the transcription factors SOX9 and hepa

75 ch the staining profile for the MIPs S100A4, osteopontin, anterior gradient-2, and S100P has already

76 r (TGF)-beta1, lysyl oxidase, periostin, and osteopontin are elevated.

77 ndent transcriptional effects and implicates osteopontin as a contributor to these phenotypes.

78 d (RANKL), osteoprotegerin, osteocalcin, and osteopontin as potential biomarkers of alveolar bone los

79 onal assay with physiological TRAP substrate osteopontin, AubipyOMe inhibited mouse macrophage migrat

80 beta3, but not alphaIIbbeta3 (D552A), caused osteopontin binding to alphavbeta3, but not fibrinogen b

81 We report that macrophage-secreted osteopontin binds to CD44s on the tumor cells and promot

82 gramming and neutralizing antibodies against osteopontin-blocked fibroblast activation induced by tum

83 The total NCPs were separated into osteopontin-, bone sialoprotein-, and dentin matrix prot

84 regulated in cancer survivors while MMP9 and Osteopontin both had significant positive correlations w

85 ression of alkaline phosphatase, MMP-13, and osteopontin but decreased expression of osteocalcin, ost

86 tested for their role in Th differentiation, osteopontin, but not hyaluronic acid, promoted Th1/Th17

87 active protein by 13% (95% CI, -14% to -9%), osteopontin by 12% (95% CI, -14% to -10%), soluble vascu

88 sms, and involves the processing of elevated osteopontin by activated MMP-9, and subsequent macrophag

89 and the up-regulation in liver production of osteopontin by NKT cells and hepatic macrophages.

90 e production of the mMDSC chemotactic factor osteopontin by tumor cells.

91 e show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasome

92 egulate chemotaxis-related proteins, such as osteopontin, CCR2, and CXCR6.

93 These data identify osteopontin-CD44-TIAM1-Rac1 axis as a RhoGDI2-sensitive

94 Osteopontin-CD44s-TIAM1 promotes clonal growth in vitro

95 Osteoprogenitor cells and endosteal-lining osteopontin(+) cells were reduced, and osteocalcin mRNA

96 Recently, coagulation-activated osteopontin, chemerin, and protease-activated receptor s

97 Osteopontin, chemokine ligand 23, brain derived neurotro

98 Me inhibited mouse macrophage migration over osteopontin-coated membranes.

99 In general, osteopontin contributes to pathology in these diseases,

100 Salivary osteopontin correlated positively with serum and salivar

101 IL-6 and osteopontin correlated significantly with radiologic res

102 g with reduction in malignant serum markers (osteopontin, Cxcl12) were noted.

103 In osteopontin-deficient mice, global matrix phosphorylatio

104 VCAM-1 and osteopontin demonstrated sustained upregulation, whereas

105 c (up- and then down-regulation) of the Spp1/osteopontin-dependent network and up-regulation of mRNA

106 tions of interleukin 6, interleukin 8, VEGF, osteopontin, E-selectin, and HGF with continuous tumour

107 A biomarker index of SP-D, MMP-7, and osteopontin enhanced diagnostic accuracy in patients wit

108 ort that mice deficient in the expression of osteopontin exhibit reduced numbers of the IEL subpopula

109 ited reduced mesodermal fibronectin (FN) and osteopontin expression and died during mesoderm developm

110 Osteopontin expression correlates with tumor aggressiven

111 ILK also regulated osteopontin expression in cardiomyocytes in vitro.

112 ogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induct

113 structure with distinct Ihh, collagen X, and osteopontin expression patterns.

114 in D(3) -induced increase of osteocalcin and osteopontin expression was significantly decreased in th

115 Thymic stromal lymphopoietin and osteopontin expression were detected by means of reverse

116 AT3KO) mice are defective in alpha4beta1 and osteopontin expression, defects that correlated with ina

117 7 and 28 days and evaluated by histology and osteopontin expression.

118 work maintaining MSPCs by the suppression of osteopontin expression.

119 RNA sequencing analysis revealed that Spp1 (osteopontin) expression is markedly upregulated in Snai2

120 r alpha genes, and a high level of IGF-1 and osteopontin genes compared to mdx(5cv) controls.

121 metalloproteinase (MMP)-7 > 1.75 ng/ml, and osteopontin > 6 ng/ml each significantly distinguished p

122 ally secreted form, an intracellular form of osteopontin has been identified, which participates in s

123 he calcium-regulating proteins, fetuin-A and osteopontin, have been found in the serum of patients wi

124 f this study is to produce recombinant human osteopontin (hOPN) in plants for inducing dental bone re

125 In this review, we focus on the role of osteopontin in a series of immune-related diseases, part

126 inent association for matrix Gla protein and osteopontin in ABCC6-related dystrophic cardiac calcific

127 In addition, a role for osteopontin in B-cell differentiation is becoming clear.

128 esmon in stromal cells and the expression of osteopontin in both tumor cells and stroma were signific

129 ence the inflammatory cytokines TNF-alpha or osteopontin in epididymal ATMs of obese mice caused sign

130 ltered levels of dentin matrix protein 1 and osteopontin in Fam20C-deficient bone may be significant

131 evelopment of Sjogren's disease, the role of osteopontin in inflammatory conditions in the oral cavit

132 ole for paracrine signaling by tumor-derived osteopontin in reprograming normal fibroblasts into tumo

133 promotes brain development by up-regulating osteopontin in the brain in early life.

134 e immune system, we investigated the role of osteopontin in the homeostasis of IEL.

135 creted phosphoprotein 1 (SPP1, also known as osteopontin) increases in pulmonary fibrosis, and Spp1 t

136 te survival of different IEL populations via osteopontin, indicating an important role for iCD8alpha

137 aracterized by increased expression of COX2, osteopontin, inflammatory cytokines, and chemokines but

138 actor 2 (TRAF2) and intracellular isoform of osteopontin (iOPN) whereas TLR4 signaling provides IFN r

139 Osteopontin is a pleiotropic cytokine that is involved i

140 Secreted osteopontin is cleaved by few known proteases, modulatin

141 The phosphoprotein osteopontin is important for critical physiological proc

142 roperty of highly phosphorylated isoforms of osteopontin is their ability to sequester nanoclusters o

143 naling through the reestablished Jagged1 and osteopontin levels correlated with the rescue of the fun

144 Osteopontin levels in splenic macrophages were upregulat

145 Indeed, the detection limit falls within the osteopontin levels reported in the literature for patien

146 of inflammatory cytokines interleukin-6 and osteopontin, lowered plasma endothelin-1 and blood press

147 Our findings suggested that osteopontin might be a biomarker for incident ACS, using

148 Importantly, blocking antibodies to osteopontin mitigated but did not fully rescue the funct

149 Osteopontin mRNA and cleaved protein was up-regulated in

150 Cathepsin K, NFATc1, and osteopontin mRNA expression decreased in EPAC1/2-KO cell

151 Cathepsin K and osteopontin mRNA expression increased in control and ZM2

152 Osteopontin null kidney grafts had reduced injury after

153 gher cell viability and larger extracellular osteopontin (OPN) accumulation.

154 Tissue expression of osteopontin (Opn) and 11 osteogenic transcription factor

155 s (M1 macrophages) with higher expression of osteopontin (OPN) and an increase in number of prolifera

156 factors were selected for further analysis: osteopontin (OPN) and clusterin (CLU) which were upregul

157 terns of osteoblast-derived proteins such as osteopontin (OPN) and osteocalcin (OCN) modulate osteobl

158 vels among RGCs and also selectively express osteopontin (OPN) and receptors for the insulin-like gro

159 s of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up-regulated genes.

160 18 cirrhosis and 17 HCC patients identified osteopontin (OPN) as significantly up-regulated in HCC c

161 Thrombin cleavage alters the function of osteopontin (OPN) by exposing an integrin binding site a

162 Debris triggered the release of osteopontin (OPN) by tumor cells and host macrophages.

163 s), IgG anti-Helicobacter pylori (HpAb), and osteopontin (OPN) can be used as a panel for GC diagnose

164 er proinflammatory cytokines, high levels of osteopontin (Opn) during experimental colitis.

165 critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumors is associated wit

166 Recent in vivo studies establish that osteopontin (OPN) expression is hydrogen peroxide (H2O2)

167 A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated

168 Recently, osteopontin (OPN) has attracted attention as a promising

169 umulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of loc

170 We found that absence of osteopontin (OPN) in immunocompromised Rag2(-/-) mice, w

171 he expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of

172 To characterize the role of osteopontin (OPN) in primary open-angle glaucoma (POAG)

173 scular endothelial growth factor (VEGF), and osteopontin (OPN) in the DPSC + THSG group were signific

174 Upon aging, the expression of osteopontin (OPN) in the murine bone marrow stroma is re

175 stimulation, we previously demonstrated that osteopontin (OPN) increased STAT1 ubiquitination and 26

176 Osteopontin (OPN) is a biomarker of HFpEF and predictive

177 Osteopontin (OPN) is a component of tumor extracellular

178 Osteopontin (OPN) is a cytokine up-regulated after cell

179 Osteopontin (OPN) is a glycoprotein that is secreted by

180 Osteopontin (OPN) is a matricellular protein with proinf

181 Osteopontin (OPN) is a multifunctional phosphorylated pr

182 Osteopontin (OPN) is a multifunctional protein expressed

183 Osteopontin (OPN) is a phosphoglycoprotein secreted into

184 Osteopontin (OPN) is a pleiotropic protein and is abunda

185 Osteopontin (OPN) is a pro-inflammatory cytokine which i

186 Osteopontin (OPN) is a secreted phosphoprotein, original

187 Osteopontin (OPN) is an immunomodulator highly expressed

188 Osteopontin (OPN) is an important component of the extra

189 The anionic phosphoglycoprotein osteopontin (OPN) is highly expressed in asthma and has

190 Osteopontin (OPN) is identified as a diagnostic and prog

191 Although osteopontin (OPN) is induced in alcoholic patients, its

192 The proinflammatory chemokine osteopontin (OPN) is induced in multiple neuroinflammato

193 CD44 ligand osteopontin (OPN) is preferentially expressed in and pro

194 Overexpression of osteopontin (OPN) is strongly associated with the invasi

195 rine asbestos inhalation model, we show that osteopontin (OPN) is up-regulated by bronchiolar epithel

196 PURPOSE Plasma osteopontin (OPN) levels in advanced non-small-cell lung

197 sforming growth factor beta1 (TGF-beta1) and osteopontin (OPN) play important roles in bone remodelin

198 ion and its inhibition by the phosphoprotein osteopontin (OPN) plays a key role in COM stone-forming

199 Osteopontin (OPN) plays a role in inflammation via recru

200 IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell respo

201 l adhesion with the gene Spp1, also known as osteopontin (OPN) serving as a key common node connectin

202 Here we found that osteopontin (OPN) skewed this balance during pathogenic

203 EAD4)-dependent transcriptional induction of osteopontin (Opn) stimulated c-Met expression in EC with

204 es, deposition of mineral-regulating protein osteopontin (OPN) was increased in alveolar bone in Phos

205 ns of phosphatidylserine (DPPS) bilayers and osteopontin (OPN) were fabricated on silica substrates t

206 tory cytokines (IL1beta, TNF-alpha, IL6, and osteopontin (OPN)) were increased in MacGHR KO AT stroma

207 orm causally implicated in autoimmunity, and osteopontin (OPN), a CD44v7 ligand implicated in chronic

208 The expression of osteopontin (OPN), a gene regulating every step in tumor

209 c osteochondrogenic programs and circulating osteopontin (OPN), a matricellular regulator of arterios

210 MGB1), a sterile danger signal molecule, and osteopontin (OPN), a multifunctional phosphoprotein invo

211 s expression of the SPP1 gene, which encodes osteopontin (OPN), a pleiotropic cytokine implicated in

212 The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix

213 Osteopontin (OPN), a protein present in several body flu

214 We hypothesized that osteopontin (OPN), an extracellular matrix (ECM) cytokin

215 Here we show that osteopontin (OPN), an extracellular matrix molecule secr

216 Osteopontin (OPN), an extracellular matrix protein, has

217 Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of s

218 sthma where high levels of the glycoprotein, osteopontin (OPN), are present in the airways.

219 tures, immunoblotting revealed more abundant osteopontin (OPN), dentin matrix protein 1 (DMP1), and m

220 The glyco-phosphoprotein osteopontin (OPN), encoded by the SPP1 gene, has previou

221 mely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust C

222 ferase alpha, alpha-fetoprotein, arginase-1, osteopontin (OPN), sorbitol dehydrogenase, fatty acid bi

223 ntal chain of events by the up-regulation of osteopontin (OPN), which in turn enhances osteoclastic a

224 ion of the pro-tumorigenic secreted protein, Osteopontin (OPN), which is especially critical for meta

225 Osteopontin (OPN), which is highly expressed in malignan

226 e osteoprotegerin (OPG)-RANK-RANKL system or osteopontin (OPN)-play a role in the bone abnormalities

227 wo osteogenic genes, collagen Ia (Col1a) and osteopontin (OPN).

228 y up-regulated by the inflammatory cytokine, osteopontin (OPN).

229 f among which is Spp1, encoding the cytokine osteopontin (OPN).

230 two adjacent proteins, osteocalcin (OC) and osteopontin (OPN).

231 ctivation, focusing on the known SASP factor osteopontin (OPN).

232 d expression of the tumor-promoting protein, osteopontin (OPN).

233 d SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ci

234 The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cance

235 he signaling kinase PI(3)K and intracellular osteopontin (OPN-i), followed by translocation of OPN-i

236 (8.2+/-4.6-fold), RANKL (21+/-5.9-fold), and osteopontin (OPN; 17+/-5.3-fold), whereas C2 had little

237 sessment at Liver Transplant [REVERSE]: high osteopontin [OPN] and tissue inhibitor of metalloprotein

238 showed a strong activation of Spp1 (encoding osteopontin [OPN]) in VAT.

239 tabolism-related markers (osteocalcin [OCN], osteopontin [OPN], bone sialoprotein [BSP], osteoprotege

240 T plasma (not urine) kidney injury proteins (osteopontin [OPN], neutrophil gelatinase-associated lipo

241 lasts fail to mature, with no progression to osteopontin or osteocalcin expression.

242 t highly upregulated upon T-cell activation, osteopontin (or Eta-1, as it was designated then) has be

243 ce had significantly higher plasma levels of osteopontin, osteocalcin, and osteoprotegerin (204%, 148

244 2, osterix) and differentiation markers (eg, osteopontin, osteocalcin, and osterix).

245 n 6 (p<0.0001), interleukin 8 (p=0.002), and osteopontin (p<0.0001) were all prognostically associate

246 ative to median) of interleukin 8 (p=0.006), osteopontin (p=0.0004), HGF (p=0.010), and TIMP-1 (p=0.0

247 Here, osteopontin phosphorylation level declined in hypo- and

248 In the absence of osteopontin, phosphorylation increases electrostatic rep

249 Phosphorylation increased cohesion between osteopontin polymers, and adhesion of osteopontin to hyd

250 cells, particularly T helper 17 cells, where osteopontin produced by dendritic cells supports IL-17 e

251 Milk osteopontin promotes brain development by up-regulating

252 Our findings suggest that phosphorylated osteopontin promotes fracture toughness in a dose-depend

253 ggest that in the glioma perivascular niche, osteopontin promotes stem cell-like properties and radia

254 estines, an effect mediated by CD44, a known osteopontin receptor.

255 Furthermore, osteopontin reduces the release of proteasomes in the ex

256 n-inducible Cre recombinase under control of osteopontin regulatory region crossed with yelow fluores

257 le osteoblast markers, bone sialoprotein and osteopontin, remained unchanged.

258 classified by epithelium-derived CCL-26 and osteopontin, respectively.

259 proform of secreted phosphoprotein 1 (SPP1)/osteopontin, restraining proteolytic activation of SPP1,

260 sordered protein, the recombinant human-like osteopontin rOPN.

261 stology and immunohistochemical analyses for osteopontin, runt-related transcription factor 2 (Runx2)

262 er, our results indicate a possible way that osteopontin secreted from both NFPA cells and surroundin

263 Osteopontin, selected for this study due to its key role

264 as the main receptor for hyaluronic acid and osteopontin, serving as coreceptor for growth factor pat

265 The CD44 ligand osteopontin shared a perivascular expression pattern wit

266 Strikingly, osteopontin silencing in tumor cells in vivo attenuated

267 In this study, we demonstrate that secreted osteopontin (sOPN) plays a role in the T cell migration

268 Although a recent study implicates osteopontin (SPP1) in AH, SPP1 is also shown to have pro

269 osteocalcin (BGLAP), osteonectin (SPARC) and osteopontin (SPP1) were detected in NU-CD271(high)CD45(l

270 arkers, dentin matrix protein 1 (Dmp1/DMP1), osteopontin (Spp1/OPN), and bone sialoprotein (Ibsp/BSP)

271 snail family member (Snai3; P < 0.001), and osteopontin (Spp1; P < 0.001).

272 one marker genes (alkaline phosphatase/ALPL, osteopontin/SPP1, and bone sialoprotein II/IBSP) in a su

273 collagen 4A1/COL4A1, laminin gamma 2/LAMC2, osteopontin/SPP1, KIAA0101, and TGFbeta2 genes in the st

274 es were YFP(+) lineage-labeled; positive for osteopontin, SRY (sex determining region Y)-box 9, and e

275 BMP2 was a potent inducer of osteocalcin/osteopontin (statistically significant at P <0.01) and o

276 Moreover, we show in vitro that exogenous osteopontin stimulates the survival of murine IEL subpop

277 features demonstrated that the expression of osteopontin, TGFbeta2, and laminin in the stroma of ICC

278 arkers of renal injury including Cystatin C, Osteopontin, Tissue Inhibitor of Metalloproteinases-1 (T

279 The ability of secreted osteopontin to activate mammary fibroblasts relied upon

280 etween osteopontin polymers, and adhesion of osteopontin to hydroxyapatite, enhancing energy dissipat

281 othelial growth factor receptor 1, 2, and 3; osteopontin; transforming growth factor beta1 and beta2;

282 ansforming growth factor beta (TGF-beta)(1), osteopontin, tumor necrosis factor alpha (TNF-alpha), le

283 demonstrated that the stromal expression of osteopontin was an independent prognostic marker for ove

284 Osteopontin was highly secreted by mouse and human breas

285 ized within areas of mineralization, whereas osteopontin was more diffusely distributed in the area o

286 ubcutaneous specimens, whereas expression of osteopontin was more prominent in the GDBM group.

287 The secreted proteins analysis found that osteopontin was significantly upregulated in BD-NFPAs fi

288 Osteopontin was sufficient to induce fibroblast reprogra

289 Higher levels of circulating osteopontin were also correlated with higher severity of

290 e phosphatase, osteocalcin, osteonectin, and osteopontin were analyzed along with in vitro mineralize

291 ry concentrations of RANKL, osteocalcin, and osteopontin were higher, and osteoprotegerin was lower i

292 ntrol group, whereas RANKL, osteocalcin, and osteopontin were not related with periodontal status.

293 Furthermore, IL-1alpha and osteopontin were suggested to be mediators of M2-like ma

294 (ST2, CXCL9, matrix metalloproteinase 3, and osteopontin) were necessary to compose a four-biomarker

295 bumin, beta-2-microglobulin, cystatin C, and osteopontin) were undetectable in most AASK-N samples.

296 Osteopontin, which can activate NK cells to mediate tubu

297 tified the secreted proinflammatory mediator osteopontin, which has been implicated in inflammation,

298 e differences and the specific receptors for osteopontin will be a research challenge for the future.

299 a phosphoprotein has some characteristics of osteopontin with respect to amino acid composition and s

300 , respectively), and inverse associations of osteopontin with standing and walking at 12 mo (P = 0.00