ライフサイエンスコーパス: otitis

1 al conjugate vaccine (PCV13) on pneumococcal otitis.

2 associated with the disease bovine parasitic otitis.

3 tanding of the pathogenesis of pneumonia and otitis.

4 sma are important pathogens in pneumonia and otitis.

5 iratory tract infections (0.77 [0.59-0.99]), otitis (0.14 [0.05-0.42]), and fever (0.69 [0.47-1.01]).

6 ally cause the same disorders (pneumonia and otitis), and that high neonatal bacterial load is a key

7 e of rhinitis, respiratory tract infections, otitis, and fever were assessed by weekly health diaries

8 presentations in cattle, including mastitis, otitis, arthritis, and reproductive disorders.

9 oplasma bovis causes pneumonia, pharyngitis, otitis, arthritis, mastitis, and reproductive disorders

10 in severity from mild (e.g. gastroenteritis, otitis, etc.) to life-threatening (e.g. necrotizing fasc

11 ion with intact tympanic membranes and acute otitis externa (AOE).

12 t Staphylococcus aureus skin infections with otitis externa; recurrent, severe herpes simplex virus o

13 sulting in recurring respiratory infections, otitis, hydrocephaly and infertility.

14 had microscopic haemorrhages (5/5) and mild otitis media (1/5) in the freshest cases.

15 ns [95% CI, 48-64]), followed by suppurative otitis media (47 antibiotic prescriptions [95% CI, 41-54

16 Subjects were followed closely for acute otitis media (AOM) development.

17 en to be prone to repeated episodes of acute otitis media (AOM) has long been sought.

18 )-approved antibiotics and that causes acute otitis media (AOM) in children.

19 Acute otitis media (AOM) is a common complication of upper res

20 Acute otitis media (AOM) is a leading cause of bacterial pedia

21 Acute otitis media (AOM) is a leading cause of visits to physi

22 Acute otitis media (AOM) is among the most common pediatric di

23 Acute otitis media (AOM) is the most common condition for whic

24 URIs) are common and often precipitate acute otitis media (AOM), caused by bacterial otopathogens, in

25 se against Streptococcus pneumoniae in acute otitis media (AOM), we investigated the susceptibility t

26 vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement

27 respiratory tract infections, such as acute otitis media (AOM).

28 bial treatment reduces the symptoms of acute otitis media (AOM).

29 choviruses (HPeVs) have been linked to acute otitis media (AOM).

30 to be involved in the pathogenesis of acute otitis media (AOM).

31 zae (NTHi) is a major pathogen causing acute otitis media (AOM).

32 with increased odds of pneumonia (aOR 1.36), otitis media (aOR 1.32), and antibiotic prescription fil

33 e middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence

34 Chronic suppurative otitis media (CSOM) is one of the most common infectious

35 Chronic suppurative otitis media (CSOM) refers to the middle ear inflammatio

36 haryngeal (NP) colonization and experimental otitis media (EOM) in an animal model.

37 y of children to recurrent episodes of acute otitis media (hereafter, "otitis-prone children").

38 ritonitis (n = 1), septic arthritis (n = 1), otitis media (n = 10), and sinusitis (n = 3).

39 n = 76,243), chronic sinusitis (n = 15,745), otitis media (n = 237,833), pneumonia (n = 52,946), and

40 ing 14 isolates, isolated from patients with otitis media (n = 6), bacteremia (n = 6), meningitis (n

41 and 48 isolates from pediatric patients with otitis media (noninvasive) from 2011 to 2014 was charact

42 hilus influenzae (NTHI)-induced experimental otitis media (OM) after intranasal immunization of chinc

43 nized as an important pathogenetic factor in otitis media (OM) and associated diseases.

44 Reductions in otitis media (OM) burden following rollout of pneumococc

45 4104 acute conjunctivitis (AC) cases, 11 767 otitis media (OM) cases, and 1587 nasopharyngeal specime

46 on on the occurrence of first and subsequent otitis media (OM) episodes in early childhood is unclear

47 treptococcus pneumoniae is a common cause of otitis media (OM) in children; mastoiditis remains an im

48 gainst Streptococcus pneumoniae during acute otitis media (OM) in mice.

49 Otitis media (OM) is a common pediatric disease for whic

50 Otitis media (OM) is a leading cause of pediatric health

51 Otitis media (OM) is common in early childhood.

52 x (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent and is often caused by a m

53 Otitis media (OM) is the most common childhood bacterial

54 Otitis media (OM) is the most common childhood bacterial

55 Otitis media (OM) is the most common disease of childhoo

56 Otitis media (OM) is the most common illness in childhoo

57 cT are potentially essential in a chinchilla otitis media (OM) model.

58 Otitis media (OM) remains the most common childhood dise

59 Otitis media (OM), a middle-ear infection, is the most c

60 Otitis media (OM), a very common disease in young childr

61 isease (IPD), all-cause pneumonia (ACP), and otitis media (OM), defined by ICD-10-AM codes, and to ex

62 Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineura

63 Otitis media (OM), the inflammation of the middle ear, i

64 from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tra

65 Mucin overproduction is a hallmark of otitis media (OM).

66 tions, including infectious endocarditis and otitis media (OM).

67 mococcal disease, including the incidence of otitis media (OM).

68 be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenoty

69 conjugated vaccines (PCVs) impact on complex otitis media (OM; including recurrent, nonresponsive, an

70 2432 participants), Streptococcus pneumoniae otitis media (OR = 2.51; 95% CI = 1.29-4.88; n = 921 par

71 ins many of the observations seen in chronic otitis media and chronic bronchitis.

72 t in Haemophilus influenzae isolates causing otitis media and chronic obstructive pulmonary disease (

73 formed a biofilm in the chinchilla model of otitis media and demonstrated a propensity to also form

74 axella catarrhalis (Mx) is a common cause of otitis media and exacerbation of chronic obstructive pul

75 nflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pu

76 axella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pu

77 The introduction of vaccines for otitis media and global shifts in antimicrobial suscepti

78 For example, NTHI is a leading cause of otitis media and is the most common cause of airway infe

79 e human nasopharynx and a causative agent of otitis media and other diseases of the upper and lower h

80 tential target for new therapies for chronic otitis media and other eardrum injuries.

81 are warranted to reduce the global burden of otitis media and other NTHi diseases.

82 ecies persist in vivo within biofilms during otitis media and other persistent infections.

83 educed cost, and improved protection against otitis media and pneumococcal pneumonia.

84 r respiratory pathogen, causing noninvasive (otitis media and pneumonia) and invasive diseases (sepsi

85 portant human pathogen causing both mucosal (otitis media and pneumonia) and systemic (sepsis and men

86 oronasopharynx can cause diseases including otitis media and pneumonia.

87 formation available developed complications; otitis media and sinusitis were the most common complica

88 We examined risks of acute otitis media associated with specific combinations of re

89 cavirus, and adenovirus in addition to acute otitis media bacterial pathogens.

90 ombinations of respiratory viruses and acute otitis media bacterial pathogens.

91 st that GAS naturally forms a biofilm during otitis media but that biofilm formation is not required

92 It is clear that most otitis media cases involve simultaneous infection with m

93 moniae, engendering protection against acute otitis media caused by emerging unencapsulated otopathog

94 fic viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infect

95 a major cause of bacteremia, pneumonia, and otitis media despite vaccines and effective antibiotics.

96 In children aged <3 years, acute otitis media developed in 58%, and 66% of children in th

97 viral load plays an important role in acute otitis media development, but symptomatic upper respirat

98 s interact and play important roles in acute otitis media development.

99 1 children 6 to 23 months of age, with acute otitis media diagnosed with the use of stringent criteri

100 hearing impairment associated with bouts of otitis media during human infancy.

101 ective protection against pneumococcal acute otitis media for non-PCV-13 serotypes and enhances prote

102 le ear-specific gene A2ML1 cosegregates with otitis media in an indigenous Filipino pedigree (LOD sco

103 respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in pati

104 e is an opportunistic human pathogen causing otitis media in children and chronic bronchitis and pneu

105 Moraxella catarrhalis causes otitis media in children and exacerbations of chronic ob

106 halis is a strict human pathogen that causes otitis media in children and exacerbations of chronic ob

107 ommon respiratory tract pathogen that causes otitis media in children and infections in adults with c

108 human respiratory tract pathogen that causes otitis media in children and lower respiratory tract inf

109 oraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract inf

110 human pathogen that is an important cause of otitis media in children and lower respiratory tract inf

111 Moraxella catarrhalis is a common cause of otitis media in children and of lower respiratory tract

112 he bactericidal activity of serum and causes otitis media in children and respiratory tract infection

113 tarrhalis is an important bacterial cause of otitis media in children and respiratory tract infection

114 en known for being a frequent cause of acute otitis media in children and respiratory tract infection

115 meningitis, pneumonia, sinusitis, and acute otitis media in children.

116 ause of respiratory infections in adults and otitis media in children.

117 mucosal hyperplasia during in vivo bacterial otitis media in guinea pigs.

118 ella catarrhalis is a human pathogen causing otitis media in infants and respiratory infections in ad

119 toward the reduction of the burden of acute otitis media in the last decade.

120 ly related commensal can delay onset of NTHi otitis media in vivo Human challenge studies investigati

121 Success in reducing acute otitis media incidence will rely mainly on prevention of

122 In the serum samples from children with otitis media infected with M. catarrhalis, antibody leve

123 nt persistence defect in vivo during chronic otitis media infection.

124 ilus influenzae (NTHI) is a leading cause of otitis media infections, which are often chronic and/or

125 s NTHI virulence in the chinchilla model for otitis media infections.

126 Otitis media is a common childhood infection of the midd

127 Otitis media is an extremely common pediatric infection

128 Otitis media is an extremely common pediatric inflammati

129 Vulnerability to otitis media is due to eustachian tube dysfunction as we

130 te from the chinchilla model of experimental otitis media is insufficient for direct analysis of gene

131 Acute otitis media is one of the most common childhood infecti

132 he actual burden of bacteria in experimental otitis media is significantly greater than was previousl

133 A case of AAS secondary to an otitis media is studied.

134 Treatment of acute otitis media is the most frequent indication for prescri

135 agent of pharyngitis, but the role of GAS in otitis media is underappreciated.

136 zation and virulence, we transformed an NTHI otitis media isolate with a reporter plasmid containing

137 A10, account for over two-thirds of clinical otitis media isolates surveyed.

138 ically significant association of modM3 with otitis media isolates.

139 onclude from these studies that a chinchilla otitis media model provides a means to evaluate pathogen

140 dle ear of the chinchilla in an experimental otitis media model, and in sputum samples recovered from

141 tion and disease in vivo using a murine NTHi otitis media model.

142 s operon was significantly more prevalent in otitis media NTHI strains (106/121; 87.7%) than in throa

143 Acute otitis media occurs as a complication of viral upper res

144 here has been increasing evidence that acute otitis media occurs during upper respiratory infection,

145 Only 1/12 M. muris-pretreated mice developed otitis media on day 5 compared to 8/15 mice with no pret

146 ore likely to be from the throat than either otitis media or COPD isolates.

147 n-otitis-prone children at the time of acute otitis media or nasopharyngeal colonization with S. pneu

148 e material, resembling the biofilms of other otitis media pathogens, was visible in the middle ear as

149 Acute otitis media prevention efforts should consider methods

150 For example, otitis media reduces sound to the ear, which can cause l

151 Mucosal infections such as acute otitis media remain prevalent, even those caused by vacc

152 Acute otitis media risk differs by the specific viruses and ba

153 presence of key viruses, bacteria, and acute otitis media risk factors, acute otitis media risk was i

154 , and acute otitis media risk factors, acute otitis media risk was independently associated with high

155 10(7) copies/ml) experienced increased acute otitis media risk.

156 of a modA2 strain in the chinchilla model of otitis media show a clear selection for ON switching of

157 ection studies using the chinchilla model of otitis media showed a direct correlation between PCho ex

158 luenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI st

159 We suggest that some human otitis media susceptibility reflects underlying genetic

160 revalent in NTHi isolates from children with otitis media than in those from the throats of healthy c

161 A wait-and-see approach to acute otitis media that empowers families by using a shared de

162 hypothesis' as we found common pathogens of otitis media to be both prevalent and abundant.

163 en that causes infections ranging from acute otitis media to life-threatening invasive disease.

164 clinical syndromes from uncomplicated acute otitis media to more complex recurrent and chronic cases

165 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either f

166 Otitis media was induced by the inoculation of nontypeab

167 Otitis media was modeled in BALB/c mice using coinfectio

168 n vivo studies using the chinchilla model of otitis media were performed using a beta-lactamase-produ

169 d with PE-PilA, and in chinchillas, signs of otitis media were significantly reduced in animals that

170 li are expressed by NTHI during experimental otitis media when these bacteria form a biofilm in the m

171 ntal abnormality, congenital defect, chronic otitis media with cholesteatoma, and high-riding jugular

172 Chronic otitis media with effusion (COME) is the most common cau

173 Otitis media with effusion (OME) is a common inflammator

174 Otitis media with effusion (OME) is characterized by the

175 Otitis media with effusion (OME) is the most common caus

176 Chronic Otitis media with effusion (OME) often leads to conducti

177 avity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 wee

178 of outcome reporting using the Management of Otitis Media with Effusion in Children with Cleft Palate

179 chest infections, perennial rhinosinusitis, otitis media with effusion, and bronchiectasis.

180 ng deficits, such as hyperacusis and chronic otitis media with effusion, which is prevalent in young

181 risk factor for the development of recurrent otitis media with effusion.

182 In addition, all Eya4(-/-) mice developed otitis media with effusion.

183 dies that have also suggested association of otitis media with polymorphism at FBX011, but this is th

184 Inflammation of the middle ear cavity (otitis media) and the abnormal deposition of bone at the

185 al of replacing clones to cause local (e.g., otitis media) or invasive disease.

186 the pneumococcus) remains a leading cause of otitis media, a significant public health burden, in lar

187 tious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adeno

188 s (acute bronchitis, sinusitis, pharyngitis, otitis media, allergic rhinitis, influenza, pneumonia, a

189 d a leading cause of bacterial pneumonia and otitis media, among other invasive diseases.

190 described by the doctor to be due to a cold, otitis media, an upper respiratory infection, croup, ast

191 associated with increased odds of pneumonia, otitis media, and antibiotic prescription fills in the s

192 ination for measles, antibiotic treatment of otitis media, and antiviral treatment of pandemic influe

193 receptive language disorder, chronic serous otitis media, and expressive language disorder.

194 Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrom

195 ted with mild light sensitivity, nonspecific otitis media, and mild developmental delay during the fi

196 ine, providing protection against pneumonia, otitis media, and other diseases caused by S. pneumoniae

197 rst-line antibiotic selection for sinusitis, otitis media, and pharyngitis.

198 ations (eg, quinsy, impetigo and cellulitis, otitis media, and sinusitis) or reconsultation with new

199 efects in the chinchilla infection model for otitis media, as well as in a murine model for COPD.

200 agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis.

201 causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia.

202 e human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations

203 Among 94 additional otitis media, commensal, and serotype b-negative invasiv

204 Otitis media, for which antibiotic treatment failure is

205 uL and with a history of recurrent sinusitis/otitis media, frequent episodes of shingles, a widesprea

206 They exhibited hearing impairment, otitis media, fusions of ossicles to the middle ear wall

207 e health conditions: respiratory infections, otitis media, gastroenteritis, necrotizing enterocolitis

208 se events were mild, and no complications of otitis media, including local cellulitis, perichondritis

209 review the contemporary management of acute otitis media, including symptomatic care, the rationale

210 cterially induced mucosal hyperplasia during otitis media, influencing tissue proliferation.

211 rane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problem

212 pread nasal colonizer and a leading cause of otitis media, one of the most common diseases of childho

213 Her parents denied a history of acute otitis media, otorrhea, otalgia, vertigo, autophony, or

214 episodes (700 each) were identified in which otitis media, pharyngitis, and urinary tract infection (

215 ed upper respiratory tract encounters (acute otitis media, pharyngitis, sinusitis, presumed viral inf

216 ococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis.

217 This response protected mice from otitis media, pneumonia, and septicemia and averted the

218 terial carriage and complications such acute otitis media, pneumonia, bacteremia, and meningitis.

219 cus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis.

220 sative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis.

221 n protected mice from pneumococcal carriage, otitis media, pneumonia, bacteremia, meningitis, and men

222 infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and

223 in mouse models of nasopharyngeal carriage, otitis media, pneumonia, sepsis, and meningitis.

224 x but can cause invasive diseases, including otitis media, pneumonia, sepsis, and meningitis.

225 ng children 6 to 23 months of age with acute otitis media, reduced-duration antimicrobial treatment r

226 g the types of viruses associated with acute otitis media, respiratory syncytial virus continues to b

227 n or middle ear effusions from patients with otitis media, revealed a statistically significant assoc

228 We report that otitis media, rhinitis and nasopharyngitis occur at high

229 ower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonar

230 es respiratory mucosal infections, including otitis media, sinusitis, and bronchitis.

231 e of respiratory infections, including acute otitis media, sinusitis, and chronic bronchitis, which a

232 Patients had recurrent otitis media, sinusitis, and pneumonias; recurrent Staph

233 a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbatio

234 ause respiratory tract diseases that include otitis media, sinusitis, exacerbations of chronic obstru

235 ificant association of the modM3 allele with otitis media, suggests a key role for ModM phasevarions

236 In a murine model of acute pneumococcal otitis media, the administration of annexin A2 increased

237 has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary fa

238 ng children 6 to 23 months of age with acute otitis media, treatment with amoxicillin-clavulanate for

239 In a mammalian model of human otitis media, we determined that Fur was critical for ba

240 We used a chinchilla model of otitis media, which has previously been used to study pe

241 onductive hearing loss (CHL) associated with otitis media, which may lead to long-term perceptual def

242 luenza vaccines, has led to the reduction in otitis media-related healthcare use between 2001 and 201

243 use of pneumonia, meningitis, bacteremia and otitis media.

244 f disease in an animal model of experimental otitis media.

245 crease the risk of clinically relevant acute otitis media.

246 t a role for A2ML1 in the pathophysiology of otitis media.

247 coccus and influenza virus in the context of otitis media.

248 halis has become a high-priority pathogen in otitis media.

249 use of pneumonia, meningitis, sinusitis, and otitis media.

250 iseases including pneumonia, meningitis, and otitis media.

251 tenuated during pulmonary infection, but not otitis media.

252 luding pneumonia, bronchitis, sinusitis, and otitis media.

253 brosis, burn wounds, and chronic suppurative otitis media.

254 ldren younger than 2 years of age with acute otitis media.

255 were not significantly associated with acute otitis media.

256 pper respiratory tract infections, including otitis media.

257 ion, and Eustachian tubes in the etiology of otitis media.

258 pared with nonbacteremic pneumonia and acute otitis media.

259 ehiscence is usually associated with chronic otitis media.

260 nflammatory infections such as pneumonia and otitis media.

261 molecular pathogenesis and host response to otitis media.

262 nce and disease severity during experimental otitis media.

263 s, such as pneumonia, meningitis, sepsis and otitis media.

264 acterial persistence in chronic pneumococcal otitis media.

265 is the most common pathogen associated with otitis media.

266 diseases such as pneumonia, meningitis, and otitis media.

267 observation in children diagnosed with acute otitis media.

268 hyperplasia is a characteristic component of otitis media.

269 al hyperplasia in animal models of bacterial otitis media.

270 oat and ear specimens of eight children with otitis media.

271 ble role in middle ear survival and/or acute otitis media.

272 oadens and enhances protection against acute otitis media.

273 omes including all-cause pneumonia and acute otitis media.

274 loping NTHi-associated infections, including otitis media.

275 verity in a chinchilla model of experimental otitis media.

276 (NTHi) are frequently implicated in complex otitis media.

277 lower than in samples from children without otitis media.

278 crobial resistance among children with acute otitis media.

279 play between bacterial species implicated in otitis media.

280 n the retrospective cohort (19179 with acute otitis media; 6746, group A streptococcal pharyngitis; a

281 d in the prospective cohort (1100 with acute otitis media; 705, group A streptococcal pharyngitis; an

282 PCVs) target only a few serotypes that cause otitis media; however, results from studies suggest that

283 thy calves, calves diagnosed with pneumonia, otitis or both diseases.

284 ringently defined otitis-prone (sOP) and non-otitis-prone (NOP) children as a potential mechanism to

285 e following AOM episodes in both sOP and non-otitis-prone (NOP) children.

286 lus influenzae (NTHi) in stringently defined otitis-prone (sOP) and non-otitis-prone (NOP) children a

287 Stringently-defined otitis-prone (sOP) children are susceptible to recurrent

288 B, PcpA, PhtE, and Ply were compared between otitis-prone and non-otitis-prone children at the time o

289 Non-otitis-prone and otitis-prone children with AOM or nasop

290 panic-American children but is absent in non-otitis-prone children and >62,000 next-generation sequen

291 y were compared between otitis-prone and non-otitis-prone children at the time of acute otitis media

292 in [IL]-2, IL-4 and IL-17a) were observed in otitis-prone children following AOM and NP colonization

293 Otitis-prone children have suboptimal circulating functi

294 Non-otitis-prone and otitis-prone children with AOM or nasopharyngeal (NP) co

295 episodes of acute otitis media (hereafter, "otitis-prone children").

296 -specific immunoglobulin G concentrations in otitis-prone children, compared with non-otitis-prone ch

297 in otitis-prone children, compared with non-otitis-prone children.

298 ified seven additional A2ML1 variants in six otitis-prone children.

299 tibody response has been associated with the otitis-prone condition; however, there is no precise mec

300 a founder haplotype that is also shared by 3 otitis-prone European-American and Hispanic-American chi