ライフサイエンスコーパス: otitis media

1 crease the risk of clinically relevant acute otitis media.

2 t a role for A2ML1 in the pathophysiology of otitis media.

3 coccus and influenza virus in the context of otitis media.

4 halis has become a high-priority pathogen in otitis media.

5 use of pneumonia, meningitis, sinusitis, and otitis media.

6 iseases including pneumonia, meningitis, and otitis media.

7 tenuated during pulmonary infection, but not otitis media.

8 luding pneumonia, bronchitis, sinusitis, and otitis media.

9 brosis, burn wounds, and chronic suppurative otitis media.

10 ldren younger than 2 years of age with acute otitis media.

11 were not significantly associated with acute otitis media.

12 pper respiratory tract infections, including otitis media.

13 ion, and Eustachian tubes in the etiology of otitis media.

14 pared with nonbacteremic pneumonia and acute otitis media.

15 ehiscence is usually associated with chronic otitis media.

16 nflammatory infections such as pneumonia and otitis media.

17 molecular pathogenesis and host response to otitis media.

18 nce and disease severity during experimental otitis media.

19 s, such as pneumonia, meningitis, sepsis and otitis media.

20 acterial persistence in chronic pneumococcal otitis media.

21 is the most common pathogen associated with otitis media.

22 diseases such as pneumonia, meningitis, and otitis media.

23 observation in children diagnosed with acute otitis media.

24 hyperplasia is a characteristic component of otitis media.

25 al hyperplasia in animal models of bacterial otitis media.

26 oat and ear specimens of eight children with otitis media.

27 ble role in middle ear survival and/or acute otitis media.

28 oadens and enhances protection against acute otitis media.

29 two H. influenzae pathotypes associated with otitis media.

30 iddle ear aspirates from children with acute otitis media.

31 ng that they may play a role in virulence in otitis media.

32 a chinchilla (Chinchilla lanigera) model of otitis media.

33 enzae (NTHi) is a leading causative agent of otitis media.

34 ivo analyses of the middle ear mucosa during otitis media.

35 tract infection, asthma, bronchiolitis, and otitis media.

36 omes including all-cause pneumonia and acute otitis media.

37 loping NTHi-associated infections, including otitis media.

38 verity in a chinchilla model of experimental otitis media.

39 (NTHi) are frequently implicated in complex otitis media.

40 lower than in samples from children without otitis media.

41 crobial resistance among children with acute otitis media.

42 play between bacterial species implicated in otitis media.

43 use of pneumonia, meningitis, bacteremia and otitis media.

44 f disease in an animal model of experimental otitis media.

45 had microscopic haemorrhages (5/5) and mild otitis media (1/5) in the freshest cases.

46 ns [95% CI, 48-64]), followed by suppurative otitis media (47 antibiotic prescriptions [95% CI, 41-54

47 n the retrospective cohort (19179 with acute otitis media; 6746, group A streptococcal pharyngitis; a

48 d in the prospective cohort (1100 with acute otitis media; 705, group A streptococcal pharyngitis; an

49 the pneumococcus) remains a leading cause of otitis media, a significant public health burden, in lar

50 tious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adeno

51 s (acute bronchitis, sinusitis, pharyngitis, otitis media, allergic rhinitis, influenza, pneumonia, a

52 d a leading cause of bacterial pneumonia and otitis media, among other invasive diseases.

53 described by the doctor to be due to a cold, otitis media, an upper respiratory infection, croup, ast

54 ins many of the observations seen in chronic otitis media and chronic bronchitis.

55 t in Haemophilus influenzae isolates causing otitis media and chronic obstructive pulmonary disease (

56 formed a biofilm in the chinchilla model of otitis media and demonstrated a propensity to also form

57 axella catarrhalis (Mx) is a common cause of otitis media and exacerbation of chronic obstructive pul

58 nflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pu

59 axella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pu

60 The introduction of vaccines for otitis media and global shifts in antimicrobial suscepti

61 young children and is an important cause of otitis media and invasive disease.

62 For example, NTHI is a leading cause of otitis media and is the most common cause of airway infe

63 e human nasopharynx and a causative agent of otitis media and other diseases of the upper and lower h

64 tential target for new therapies for chronic otitis media and other eardrum injuries.

65 are warranted to reduce the global burden of otitis media and other NTHi diseases.

66 ecies persist in vivo within biofilms during otitis media and other persistent infections.

67 educed cost, and improved protection against otitis media and pneumococcal pneumonia.

68 r respiratory pathogen, causing noninvasive (otitis media and pneumonia) and invasive diseases (sepsi

69 portant human pathogen causing both mucosal (otitis media and pneumonia) and systemic (sepsis and men

70 oronasopharynx can cause diseases including otitis media and pneumonia.

71 formation available developed complications; otitis media and sinusitis were the most common complica

72 specific gene regions among a large panel of otitis media and throat strains was determined by dot bl

73 Inflammation of the middle ear cavity (otitis media) and the abnormal deposition of bone at the

74 associated with increased odds of pneumonia, otitis media, and antibiotic prescription fills in the s

75 ination for measles, antibiotic treatment of otitis media, and antiviral treatment of pandemic influe

76 receptive language disorder, chronic serous otitis media, and expressive language disorder.

77 Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrom

78 ted with mild light sensitivity, nonspecific otitis media, and mild developmental delay during the fi

79 ine, providing protection against pneumonia, otitis media, and other diseases caused by S. pneumoniae

80 rst-line antibiotic selection for sinusitis, otitis media, and pharyngitis.

81 ations (eg, quinsy, impetigo and cellulitis, otitis media, and sinusitis) or reconsultation with new

82 Subjects were followed closely for acute otitis media (AOM) development.

83 en to be prone to repeated episodes of acute otitis media (AOM) has long been sought.

84 )-approved antibiotics and that causes acute otitis media (AOM) in children.

85 Acute otitis media (AOM) is a common complication of upper res

86 Acute otitis media (AOM) is a leading cause of bacterial pedia

87 Acute otitis media (AOM) is a leading cause of visits to physi

88 Acute otitis media (AOM) is among the most common pediatric di

89 Acute otitis media (AOM) is the most common condition for whic

90 URIs) are common and often precipitate acute otitis media (AOM), caused by bacterial otopathogens, in

91 se against Streptococcus pneumoniae in acute otitis media (AOM), we investigated the susceptibility t

92 vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement

93 bial treatment reduces the symptoms of acute otitis media (AOM).

94 choviruses (HPeVs) have been linked to acute otitis media (AOM).

95 to be involved in the pathogenesis of acute otitis media (AOM).

96 zae (NTHi) is a major pathogen causing acute otitis media (AOM).

97 respiratory tract infections, such as acute otitis media (AOM).

98 with increased odds of pneumonia (aOR 1.36), otitis media (aOR 1.32), and antibiotic prescription fil

99 efects in the chinchilla infection model for otitis media, as well as in a murine model for COPD.

100 We examined risks of acute otitis media associated with specific combinations of re

101 agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis.

102 causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia.

103 cavirus, and adenovirus in addition to acute otitis media bacterial pathogens.

104 ombinations of respiratory viruses and acute otitis media bacterial pathogens.

105 ing otitis media with effusion and recurrent otitis media, biofilms commonly develop.

106 olated from the middle ears of children with otitis media but that are not associated with NT H. infl

107 st that GAS naturally forms a biofilm during otitis media but that biofilm formation is not required

108 It is clear that most otitis media cases involve simultaneous infection with m

109 moniae, engendering protection against acute otitis media caused by emerging unencapsulated otopathog

110 e human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations

111 e middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence

112 Among 94 additional otitis media, commensal, and serotype b-negative invasiv

113 ability to survive in a chinchilla model of otitis media compared with the parent strain.

114 fic viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infect

115 Chronic suppurative otitis media (CSOM) is one of the most common infectious

116 Chronic suppurative otitis media (CSOM) refers to the middle ear inflammatio

117 a major cause of bacteremia, pneumonia, and otitis media despite vaccines and effective antibiotics.

118 In children aged <3 years, acute otitis media developed in 58%, and 66% of children in th

119 viral load plays an important role in acute otitis media development, but symptomatic upper respirat

120 s interact and play important roles in acute otitis media development.

121 1 children 6 to 23 months of age, with acute otitis media diagnosed with the use of stringent criteri

122 increasing proportion of children with acute otitis media due to Streptococcus pneumoniae have seroty

123 seen limited use as a model for experimental otitis media, due primarily to the small size of its mid

124 hearing impairment associated with bouts of otitis media during human infancy.

125 haryngeal (NP) colonization and experimental otitis media (EOM) in an animal model.

126 ulence in a chinchilla model of experimental otitis media (EOM).

127 ective protection against pneumococcal acute otitis media for non-PCV-13 serotypes and enhances prote

128 Otitis media, for which antibiotic treatment failure is

129 uL and with a history of recurrent sinusitis/otitis media, frequent episodes of shingles, a widesprea

130 They exhibited hearing impairment, otitis media, fusions of ossicles to the middle ear wall

131 e health conditions: respiratory infections, otitis media, gastroenteritis, necrotizing enterocolitis

132 y of children to recurrent episodes of acute otitis media (hereafter, "otitis-prone children").

133 PCVs) target only a few serotypes that cause otitis media; however, results from studies suggest that

134 le ear-specific gene A2ML1 cosegregates with otitis media in an indigenous Filipino pedigree (LOD sco

135 respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in pati

136 e is an opportunistic human pathogen causing otitis media in children and chronic bronchitis and pneu

137 halis is a strict human pathogen that causes otitis media in children and exacerbations of chronic ob

138 Moraxella catarrhalis causes otitis media in children and exacerbations of chronic ob

139 ommon respiratory tract pathogen that causes otitis media in children and infections in adults with c

140 mophilus influenzae is an important cause of otitis media in children and lower respiratory infection

141 human respiratory tract pathogen that causes otitis media in children and lower respiratory tract inf

142 oraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract inf

143 s an important respiratory pathogen, causing otitis media in children and lower respiratory tract inf

144 human pathogen that is an important cause of otitis media in children and lower respiratory tract inf

145 Moraxella catarrhalis is a common cause of otitis media in children and of lower respiratory tract

146 he bactericidal activity of serum and causes otitis media in children and respiratory tract infection

147 tarrhalis is an important bacterial cause of otitis media in children and respiratory tract infection

148 ypeable Haemophilus influenzae, which causes otitis media in children and respiratory tract infection

149 en known for being a frequent cause of acute otitis media in children and respiratory tract infection

150 meningitis, pneumonia, sinusitis, and acute otitis media in children.

151 ause of respiratory infections in adults and otitis media in children.

152 mophilus influenzae is an important cause of otitis media in children.

153 mucosal hyperplasia during in vivo bacterial otitis media in guinea pigs.

154 ella catarrhalis is a human pathogen causing otitis media in infants and respiratory infections in ad

155 toward the reduction of the burden of acute otitis media in the last decade.

156 ly related commensal can delay onset of NTHi otitis media in vivo Human challenge studies investigati

157 Success in reducing acute otitis media incidence will rely mainly on prevention of

158 se events were mild, and no complications of otitis media, including local cellulitis, perichondritis

159 review the contemporary management of acute otitis media, including symptomatic care, the rationale

160 In the serum samples from children with otitis media infected with M. catarrhalis, antibody leve

161 nt persistence defect in vivo during chronic otitis media infection.

162 ilus influenzae (NTHI) is a leading cause of otitis media infections, which are often chronic and/or

163 s NTHI virulence in the chinchilla model for otitis media infections.

164 cterially induced mucosal hyperplasia during otitis media, influencing tissue proliferation.

165 Otitis media is a common childhood infection of the midd

166 Otitis media is an extremely common pediatric infection

167 Otitis media is an extremely common pediatric inflammati

168 Vulnerability to otitis media is due to eustachian tube dysfunction as we

169 te from the chinchilla model of experimental otitis media is insufficient for direct analysis of gene

170 Acute otitis media is one of the most common childhood infecti

171 he actual burden of bacteria in experimental otitis media is significantly greater than was previousl

172 A case of AAS secondary to an otitis media is studied.

173 Treatment of acute otitis media is the most frequent indication for prescri

174 agent of pharyngitis, but the role of GAS in otitis media is underappreciated.

175 rane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problem

176 Virulence of an otitis media isolate (NTHi strain 86-028NP) was compared

177 zation and virulence, we transformed an NTHI otitis media isolate with a reporter plasmid containing

178 A10, account for over two-thirds of clinical otitis media isolates surveyed.

179 ically significant association of modM3 with otitis media isolates.

180 enzae attenuated virulence in the chinchilla otitis media model of noninvasive disease.

181 onclude from these studies that a chinchilla otitis media model provides a means to evaluate pathogen

182 dle ear of the chinchilla in an experimental otitis media model, and in sputum samples recovered from

183 tion and disease in vivo using a murine NTHi otitis media model.

184 ritonitis (n = 1), septic arthritis (n = 1), otitis media (n = 10), and sinusitis (n = 3).

185 n = 76,243), chronic sinusitis (n = 15,745), otitis media (n = 237,833), pneumonia (n = 52,946), and

186 ing 14 isolates, isolated from patients with otitis media (n = 6), bacteremia (n = 6), meningitis (n

187 and 48 isolates from pediatric patients with otitis media (noninvasive) from 2011 to 2014 was charact

188 s operon was significantly more prevalent in otitis media NTHI strains (106/121; 87.7%) than in throa

189 Acute otitis media occurs as a complication of viral upper res

190 here has been increasing evidence that acute otitis media occurs during upper respiratory infection,

191 hilus influenzae (NTHI)-induced experimental otitis media (OM) after intranasal immunization of chinc

192 nized as an important pathogenetic factor in otitis media (OM) and associated diseases.

193 Reductions in otitis media (OM) burden following rollout of pneumococc

194 4104 acute conjunctivitis (AC) cases, 11 767 otitis media (OM) cases, and 1587 nasopharyngeal specime

195 on on the occurrence of first and subsequent otitis media (OM) episodes in early childhood is unclear

196 treptococcus pneumoniae is a common cause of otitis media (OM) in children; mastoiditis remains an im

197 gainst Streptococcus pneumoniae during acute otitis media (OM) in mice.

198 Otitis media (OM) is a common pediatric disease for whic

199 Chronic otitis media (OM) is a common pediatric infectious disea

200 Otitis media (OM) is a leading cause of pediatric health

201 Otitis media (OM) is common in early childhood.

202 x (ie, recurrent, nonresponsive, or chronic) otitis media (OM) is frequent and is often caused by a m

203 Otitis media (OM) is the most common childhood bacterial

204 Otitis media (OM) is the most common childhood bacterial

205 Otitis media (OM) is the most common disease of childhoo

206 Otitis media (OM) is the most common illness in childhoo

207 cT are potentially essential in a chinchilla otitis media (OM) model.

208 Otitis media (OM) remains the most common childhood dise

209 Otitis media (OM), a middle-ear infection, is the most c

210 Otitis media (OM), a very common disease in young childr

211 isease (IPD), all-cause pneumonia (ACP), and otitis media (OM), defined by ICD-10-AM codes, and to ex

212 Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineura

213 Otitis media (OM), inflammation of the middle ear, is th

214 Otitis media (OM), the inflammation of the middle ear, i

215 from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tra

216 tions, including infectious endocarditis and otitis media (OM).

217 mococcal disease, including the incidence of otitis media (OM).

218 Mucin overproduction is a hallmark of otitis media (OM).

219 be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenoty

220 conjugated vaccines (PCVs) impact on complex otitis media (OM; including recurrent, nonresponsive, an

221 Only 1/12 M. muris-pretreated mice developed otitis media on day 5 compared to 8/15 mice with no pret

222 pread nasal colonizer and a leading cause of otitis media, one of the most common diseases of childho

223 ore likely to be from the throat than either otitis media or COPD isolates.

224 n-otitis-prone children at the time of acute otitis media or nasopharyngeal colonization with S. pneu

225 2432 participants), Streptococcus pneumoniae otitis media (OR = 2.51; 95% CI = 1.29-4.88; n = 921 par

226 al of replacing clones to cause local (e.g., otitis media) or invasive disease.

227 Her parents denied a history of acute otitis media, otorrhea, otalgia, vertigo, autophony, or

228 e material, resembling the biofilms of other otitis media pathogens, was visible in the middle ear as

229 episodes (700 each) were identified in which otitis media, pharyngitis, and urinary tract infection (

230 ed upper respiratory tract encounters (acute otitis media, pharyngitis, sinusitis, presumed viral inf

231 ococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis.

232 This response protected mice from otitis media, pneumonia, and septicemia and averted the

233 terial carriage and complications such acute otitis media, pneumonia, bacteremia, and meningitis.

234 cus pneumoniae is a major causative agent of otitis media, pneumonia, bacteremia, and meningitis.

235 sative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis.

236 n protected mice from pneumococcal carriage, otitis media, pneumonia, bacteremia, meningitis, and men

237 infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and

238 in mouse models of nasopharyngeal carriage, otitis media, pneumonia, sepsis, and meningitis.

239 x but can cause invasive diseases, including otitis media, pneumonia, sepsis, and meningitis.

240 Acute otitis media prevention efforts should consider methods

241 ng children 6 to 23 months of age with acute otitis media, reduced-duration antimicrobial treatment r

242 For example, otitis media reduces sound to the ear, which can cause l

243 luenza vaccines, has led to the reduction in otitis media-related healthcare use between 2001 and 201

244 Mucosal infections such as acute otitis media remain prevalent, even those caused by vacc

245 g the types of viruses associated with acute otitis media, respiratory syncytial virus continues to b

246 philus influenzae in the chinchilla model of otitis media results in the formation of adherent mucosa

247 n or middle ear effusions from patients with otitis media, revealed a statistically significant assoc

248 We report that otitis media, rhinitis and nasopharyngitis occur at high

249 Acute otitis media risk differs by the specific viruses and ba

250 presence of key viruses, bacteria, and acute otitis media risk factors, acute otitis media risk was i

251 , and acute otitis media risk factors, acute otitis media risk was independently associated with high

252 10(7) copies/ml) experienced increased acute otitis media risk.

253 of a modA2 strain in the chinchilla model of otitis media show a clear selection for ON switching of

254 ection studies using the chinchilla model of otitis media showed a direct correlation between PCho ex

255 ower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonar

256 es respiratory mucosal infections, including otitis media, sinusitis, and bronchitis.

257 e of respiratory infections, including acute otitis media, sinusitis, and chronic bronchitis, which a

258 ptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia.

259 Patients had recurrent otitis media, sinusitis, and pneumonias; recurrent Staph

260 a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbatio

261 NTHi causes a number of diseases, including otitis media, sinusitis, conjunctivitis, exacerbations o

262 ause respiratory tract diseases that include otitis media, sinusitis, exacerbations of chronic obstru

263 luenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI st

264 found to be significantly more prevalent in otitis media strains.

265 ificant association of the modM3 allele with otitis media, suggests a key role for ModM phasevarions

266 We suggest that some human otitis media susceptibility reflects underlying genetic

267 revalent in NTHi isolates from children with otitis media than in those from the throats of healthy c

268 A wait-and-see approach to acute otitis media that empowers families by using a shared de

269 In a murine model of acute pneumococcal otitis media, the administration of annexin A2 increased

270 has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary fa

271 hypothesis' as we found common pathogens of otitis media to be both prevalent and abundant.

272 en that causes infections ranging from acute otitis media to life-threatening invasive disease.

273 clinical syndromes from uncomplicated acute otitis media to more complex recurrent and chronic cases

274 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either f

275 ng children 6 to 23 months of age with acute otitis media, treatment with amoxicillin-clavulanate for

276 s of lic2B, hmwA, and the nine new potential otitis media virulence genes revealed two H. influenzae

277 Otitis media was induced by the inoculation of nontypeab

278 Otitis media was modeled in BALB/c mice using coinfectio

279 In a mammalian model of human otitis media, we determined that Fur was critical for ba

280 n vivo studies using the chinchilla model of otitis media were performed using a beta-lactamase-produ

281 d with PE-PilA, and in chinchillas, signs of otitis media were significantly reduced in animals that

282 li are expressed by NTHI during experimental otitis media when these bacteria form a biofilm in the m

283 We used a chinchilla model of otitis media, which has previously been used to study pe

284 onductive hearing loss (CHL) associated with otitis media, which may lead to long-term perceptual def

285 enza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected wi

286 ntal abnormality, congenital defect, chronic otitis media with cholesteatoma, and high-riding jugular

287 Chronic otitis media with effusion (COME) is the most common cau

288 Otitis media with effusion (OME) is a common inflammator

289 Otitis media with effusion (OME) is characterized by the

290 Otitis media with effusion (OME) is the most common caus

291 Chronic Otitis media with effusion (OME) often leads to conducti

292 avity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 wee

293 During otitis media with effusion and recurrent otitis media, b

294 of outcome reporting using the Management of Otitis Media with Effusion in Children with Cleft Palate

295 chest infections, perennial rhinosinusitis, otitis media with effusion, and bronchiectasis.

296 ost common pathogens associated with chronic otitis media with effusion, which has been hypothesized

297 ng deficits, such as hyperacusis and chronic otitis media with effusion, which is prevalent in young

298 risk factor for the development of recurrent otitis media with effusion.

299 In addition, all Eya4(-/-) mice developed otitis media with effusion.

300 dies that have also suggested association of otitis media with polymorphism at FBX011, but this is th