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1  that we identified to be in wildtype murine otoconia.
2 ribute to the site-specific calcification of otoconia.
3 cule of the inner ear, which completely lack otoconia.
4 ium and occasional malformation of utricular otoconia.
5 ium used in the formation and maintenance of otoconia.
6 ation in a thickened sensory epithelium, and otoconia, all of which are found in the endogenous otic
7 anistic similarities and differences between otoconia and bone calcification.
8 eration of sensory cells and malformation of otoconia and otoconial membranes occur, as revealed by s
9 required for the normal biomineralization of otoconia and otoliths in the inner ear of vertebrates.
10 ies could direct the formation and growth of otoconia and regulate other biomineralization processes.
11                                              Otoconia are biominerals of the vestibular system that a
12                                              Otoconia are biominerals within the utricle and saccule
13                                              Otoconia are complex calcium carbonate (CaCO(3)) biomine
14                                  In mammals, otoconia are composed of proteins (otoconins) and calciu
15  canalithiasis and cupulolithiasis, in which otoconia are dislocated.
16  This underscores the need to understand how otoconia are formed and maintained and how to prevent th
17                     The skeleton, teeth, and otoconia are normally the only mineralized tissues or or
18 ntial for formation of the organic matrix of otoconia by specifically recruiting other matrix compone
19 review postulates a working model of how the otoconia complex is assembled specifically above the mac
20 balance system is the embryonic formation of otoconia, composite crystals that overlie and provide op
21 lamus was assessed in wild-type C57BL/6J and otoconia-deficient tilted mice during locomotion within
22 ers upon the elderly population that involve otoconia degeneration, as well as by canalithiasis and c
23                                       During otoconia development, the organic matrix forms prior to
24 nlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular
25 endolymph fluid space, and abnormally formed otoconia (extracellular calcite-protein composites) at l
26                                 Otoliths and otoconia form over sensory maculae and are attached to t
27                        Otop1 is required for otoconia formation and a candidate mammalian sour taste
28 ependent vestibular oxidase are critical for otoconia formation and may be required for interactions
29     Despite their importance, the process of otoconia genesis is largely unknown.
30 ochemically inactive and led to an arrest of otoconia genesis, characterized by a complete lack of ca
31            We show that this matrix controls otoconia growth and morphology by embedding the crystall
32 eir counterparts in the mammalian inner ear, otoconia, have a primarily vestibular function.
33 ry organs are the biomineralized structures--otoconia in higher vertebrates or otoliths in fish--that
34 led about the development and maintenance of otoconia in humans.
35                                  The loss of otoconia in the mutants may be attributed, at least in p
36 and a significant reduction in the number of otoconia in the saccule and the utricle, were consistent
37 domain protein required for the formation of otoconia in the vertebrate inner ear.
38  members: OTOP1 is required for formation of otoconia in the vestibular system and it forms the recep
39 ckness of the molecular layer, an absence of otoconia in the vestibular system, and a range of abnorm
40              Degeneration or displacement of otoconia is a significant etiology of age-related balanc
41                            The importance of otoconia is clearly demonstrated by the impact of balanc
42  find no evidence for extracellular magnetic otoconia or intracellular magnetite crystals, suggesting
43  formation of abnormally shaped, or ectopic, otoconia, or otoconial agenesis.
44 agy and showed defects in the development of otoconia, organic particles that contain calcium carbona
45 cloned the major protein component of murine otoconia, otoconin-90 (OC90).
46                         To date, a number of otoconia-related proteins have been identified mostly in
47         We propose that normal generation of otoconia requires a complex temporal and spatial control
48 monstrate the critical roles of otoconins in otoconia seeding, growth and anchoring and suggest mecha
49  contain thousands of small particles called otoconia that serve a similar function.
50 d that these magnetic crystals form a bed of otoconia that stimulate hair cells transducing magnetic
51 -het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vest
52  to gravity requires dense particles, called otoconia, which are localized in the vestibular macular