ライフサイエンスコーパス: overall yield

1 o afford multifunctionalized molecules (>80% overall yield).

2 sis of the alkaloid in three steps and a 36% overall yield.

3 mercially available starting materials in 6% overall yield.

4 ute led to UT-39 in 19 steps with around 10% overall yield.

5 embled in 19 steps with a approximately 5.0% overall yield.

6 otent neurokinin 1 (NK1 ) antagonist in 60 % overall yield.

7 of (-)-bactobolin A trifluoroacetate in 10% overall yield.

8 emical transformations and resulted in a 44% overall yield.

9 5R)-1a was accomplished in nine steps in 18% overall yield.

10 s the chiral tetrahydroisoquinoline 1 in 54% overall yield.

11 from ethyl 4-fluorobenzoylacetate (3) in 46% overall yield.

12 g of a [2.2.1]dioxabicycloheptane core in 7% overall yield.

13 isobutyrylguanosine in nine steps with 10.2% overall yield.

14 rded a mixture of three stereoisomers in 61% overall yield.

15 ra has been synthesized in 12 steps and 28 % overall yield.

16 s single diastereoisomers (>99:1 dr) in good overall yield.

17 is of (-)-gephyrotoxin in nine steps and 14% overall yield.

18 e indole alkaloids in only four steps in 80% overall yield.

19 thiazino-, or thiazepino-2H-indazole in good overall yield.

20 accomplished in nine chemical steps and 13 % overall yield.

21 leted the synthesis of 3 in 12 steps and 13% overall yield.

22 dione alkaloids caulibugulones A-D in 24-57% overall yield.

23 catalytic, generating mycothiazole in 14.5% overall yield.

24 nt amino acid residues in nine steps and 42% overall yield.

25 nse element (ERE) were synthesized in 12-17% overall yield.

26 l synthesis of tatanan A in 13 steps and 13% overall yield.

27 MgCl.LiCl and hydrolysis furnished 5 in good overall yield.

28 as it is prepared in just five steps and 23% overall yield.

29 propylidene-D-myo-inositol in 16 steps in 3% overall yield.

30 en accomplished in nine linear steps and 55% overall yield.

31 and practical route involving 5 steps in 40% overall yield.

32 ve system was made in 21 steps and only 0.1% overall yield.

33 onogashira cross-coupling reactions with 62% overall yield.

34 nine steps from thiosalicylic acid in 14.5% overall yield.

35 s affords (+/-)-gamma-rubromycin (1) in 4.4% overall yield.

36 ge scale preparation, is accomplished in 23% overall yield.

37 ol required seven steps and proceeded in 18% overall yield.

38 drolysis gave beta-truxinic acid, 10, in 69% overall yield.

39 ized from seven to five steps, with a better overall yield.

40 ophenylboronic acid and 2-iodoaniline in 60% overall yield.

41 l in 13 linear steps from furfural with ~11% overall yield.

42 m commercially available isoprene in a 21.7% overall yield.

43 synthesis is completed in four steps and 41% overall yield.

44 ynthesis proceeds in eight stages with a 20% overall yield.

45 in 13 linear steps (longest sequence) in 8% overall yield.

46 was accomplished in 10 linear steps in 7.4% overall yield.

47 lide A has been achieved in 17 steps and 8 % overall yield.

48 ith high stereocontrol (>20:1 d.r.) and 11 % overall yield.

49 longest linear sequence and proceeds in 10% overall yield.

50 d pure (Z)-(2-bromovinyl)boronates in 57-60% overall yield.

51 lavine was accomplished in 8 steps and 7.1 % overall yield.

52 cins involves at least 17 steps, with a poor overall yield.

53 multiple catalytic reactions with excellent overall yield.

54 hybrubin A in three steps from 13 and 20.8% overall yield.

55 ced from the Bamford-Stevens reactant in 82% overall yield.

56 eps (14 chromatographic separations) and 11% overall yield.

57 btained expeditiously in five steps and 16 % overall yield.

58 ues (RX, NaHCO(3)/DMF/100 degrees C) in high overall yields.

59 o give bicyclic oxazolidine products in good overall yields.

60 rom aldehyde 4, was developed with excellent overall yields.

61 generates aminophthalazin-1(2H)-ones in good overall yields.

62 ,2-a]quinazolinones 4, respectively, in good overall yields.

63 methyl ketones, esters, and amides in 48-78% overall yields.

64 e by standard synthetic procedures with high overall yields.

65 ubstituted pyrroles in moderate to very good overall yields.

66 were synthesized in three steps with 86-91% overall yields.

67 olo-fused heterocycles were obtained in good overall yields.

68 te the desired fused 1,2,3-triazoles in good overall yields.

69 mmercially available (R)-Roche ester in >10% overall yields.

70 ely, could be achieved in few steps and good overall yields.

71 no-substituted indanes and tetralins in good overall yields.

72 veral polyfunctionalized derivatives in good overall yields.

73 dine systems as single diastereomers in good overall yields.

74 s were synthesized in four steps with 17-66% overall yields.

75 of 4-substituted chlorophthalazines in good overall yields.

76 TDs) with rare alicyclic scaffolding in high overall yields.

77 ocedure to give the target compounds in good overall yields.

78 in a regioselective manner and in excellent overall yields.

79 umn chromatography in very good to excellent overall yields.

80 es C to form substituted 2-indanones in good overall yields.

81 ducts were obtained in moderate to excellent overall yields.

82 ain the target peptides in good to excellent overall yields.

83 were synthesized in only 8 steps and 24-26% overall yields.

84 n 3-5 steps on a multigram scale with 10-72% overall yields.

85 s from simple building blocks with excellent overall yields.

86 were identified to be equally important for overall yields.

87 perature within minutes in good to excellent overall yields.

88 yn-1-ols, respectively, in one-pot with good overall yields.

89 ght halves of halichondrins A-C in excellent overall yields.

90 valent iodine reagents were prepared in good overall yields.

91 natural products were synthesized with high overall yields (13-20%).

92 ioselective syntheses of cladoacetals A (1a, overall yield: 16%) and B (1b, overall yield: 34%) from

93 cetals A (1a, overall yield: 16%) and B (1b, overall yield: 34%) from crotonaldehyde in nine and seve

94 itro esters and amides were obtained in good overall yields (53-84%).

95 sis of (+)-brevianamide A (seven steps, 7.2% overall yield, 750 mg scale), which involves a bioinspir

96 efficient six-step DTS that proceeded in 35% overall yield (83% average yield per step).

97 in 11 vessels and approximately 24% combined overall yield (A + C).

98 6)-carboxyfluorescein (JOE) is reported; the overall yield achieved starting from isovanillin is 10 t

99 The macrocycles were isolated in 13-45% overall yield after HPLC purification and lyophilization

100 sis of 1 was accomplished in 7 steps and 38% overall yield aided by the development of an innovative,

101 iene classes have been synthesized in 40-47% overall yield along four-step synthetic routes.

102 In an overall yield analysis, pathogen yield was 57% (871 of 1

103 ed from readily available d-arabinose in 11% overall yield and >99.5/0.5 dr (diastereomeric ratio).

104 ocedure and isolated in approximately 50-60% overall yield and <99% enantiopurity, after diastereosel

105 synthesis of stagonolide E (vs 11 steps, 4% overall yield and 91% Z, previously), and a five-step, 2

106 The route proceeds in ten steps with an 8% overall yield and 92% ee.

107 e structure of yuremamine is reported in 39% overall yield and 96% ee over five steps.

108 urnishing the desired products in up to 77 % overall yield and 99:1 enantiomeric ratio.

109 synthetic route proceeds in 7 steps with 47% overall yield and begins from the abundant and inexpensi

110 rahydroquinolines 18 or indolines 14 in high overall yield and diastereoselectivity (19 examples each

111 with complete exo stereoselectivity in good overall yield and enantioselectivity (up to 99% and 166:

112 to non-glucose sugars often results in lower overall yield and productivity of ethanol.

113 flow steps performed in succession in better overall yield and shorter reaction times relative to the

114 t eucapsitrione, has been synthesized in 43% overall yield and six steps, including a key Suzuki-Miya

115 , 23d, and 23e were prepared in good to high overall yield and were selective for beta-alanyl aminope

116 ed C-H activation/Cope rearrangement in good overall yield and with good diastereo- and enantiocontro

117 Overall yields and results likely vary between studies d

118 d-based derivatives were synthesized in good overall yields and screened for their inverse agonist ac

119 3, and 14, respectively) were made in 13-17% overall yields and six to seven steps from oxazolidine b

120 (-)-(R,R,R)-hoprominol (in 10 steps and 4.0% overall yield) and (-)-(4'S,4''R,2'''R)-hopromalinol (in

121 acid 12 were synthesized in eight steps (44% overall yield) and three steps (55% overall yield), resp

122 resentative applications: an eight-step, 15% overall yield, and completely Z-selective route leading

123 ,S)-homaline was achieved in 8 steps and 18% overall yield, and the asymmetric synthesis of (-)-(R,R)

124 ed photocatalyst 1a can be prepared in a 56% overall yield ( approximately 4.4 g).

125 photocatalyst 2a can be synthesized in a 78% overall yield ( approximately 8.1 g), and the iridium-ba

126 ly unstable but could be trapped in very low overall yield as the stable O(2)-benzyl derivative.

127 cedure afforded the target compound in a 68% overall yield based on the initial amount of the startin

128 atural products phidianidines A and B in 19% overall yield by a convergent route that will make analo

129 The oxidant was prepared in 87% overall yield by combining a fluorous amine with tosyl c

130 ative technique to produce nanosheets in 95% overall yield by cyclical monolayer compressions in a ro

131 ntiomer were prepared in seven steps and 22% overall yield by employing both enantiomers of a BINOL-d

132 i-A) systems have been synthesized in 58-66% overall yield, by a three-step synthesis sequence starti

133 total synthesis of (+)-scuteflorin A in 14% overall yield, employing a chiral iminium salt to effect

134 -d-ribose, the product is obtained in a 6.7% overall yield following an 11-step reaction sequence.

135 e the unstable hexacyclic parnafungin A (13% overall yield for 8 steps) and C (8% overall yield for 9

136 A (13% overall yield for 8 steps) and C (8% overall yield for 9 steps) models.

137 The overall yield for the 12-step synthesis is 34%.

138 rsor to dihydrocompactin (vs 13 steps and 5% overall yield, formerly).

139 doubly substituted (DS) configurations which overall yield four electrons in four singly occupied orb

140 been accomplished in 12 linear steps and 18% overall yield from (-)-ethyl lactate.

141 le-up challenges and was accomplished in 46% overall yield from 3,3-dimethyldicyclohexanone (6), more

142 hesis of (+)-petromyroxol in 9 steps and 20% overall yield from a readily accessible starting materia

143 of THL was accomplished in 10 steps and 31% overall yield from an achiral ynone.

144 (+/-)-actinophyllic acid is realized in 22% overall yield from commercially available di-tert-butyl

145 e synthesis proceeds in six steps and 59-70% overall yield from commercially available l-fucose, maki

146 lock 45 was synthesized in 11 steps and 6.5% overall yield from commercially available materials.

147 for the longest linear sequence and in 15.8% overall yield from commercially available methyl (R)-(+)

148 )-vincorine is achieved in nine steps and 9% overall yield from commercially available starting mater

149 indanone was prepared in three steps and 48% overall yield from cyclohex-2-en-1-one.

150 ine (-)-31 was obtained in 16 steps and 3.6% overall yield from cyclohexan-1,3-dione.

151 ps for the longest linear route, with a 1.7% overall yield from d-cellobiose and d-glucose.

152 inine is prepared in seven steps and ca. 55% overall yield from dimedone using an "open and shut" (ri

153 has been achieved in 14 linear steps and 11% overall yield from ethyl glyoxalate.

154 ctical synthetic sequence furnished 1 in 11% overall yield from hydrocortisone in 15 linear steps.

155 /-)-streptonigrin in 14 linear steps and 11% overall yield from inexpensive ethyl glyoxalate.

156 id (+)-gliocladin C (11) in 10 steps and 11% overall yield from isatin is reported.

157 ne has been accomplished in 15 steps and 30% overall yield from known compounds.

158 icient and practical route with satisfactory overall yield from low-cost starting materials.

159 Previously, compound 1 was prepared in low overall yield from piperidinone 2 via the Strecker react

160 dalin was accomplished in five steps and 39% overall yield from readily available 4-bromo-2-triisopro

161 false positive hits and as such improve the overall yield from screening campaigns.

162 the drug substance (99.9 LC area %) in 49.8% overall yield from starting material DLAC (1).

163 a multigram scale in three steps and in 44% overall yield from the corresponding benzylamines.

164 gion with a total of three HPLC events in 8% overall yield from the fragments.

165 e corresponding galactose analogue in 66-78% overall yields from free sugars.

166 In only three steps and in 21-67% overall yields from the natural trioxane artemisinin, a

167 atch synthesis, including improvement of the overall yield (from 34% to 64%), reduction of reaction t

168 The overall yields (from phenylacetaldehyde) were 19% for 3-

169 in C has been established in four steps (31% overall yield) from a readily available compound without

170 Dinemasone C was prepared in three steps (8% overall yield) from cis-tetrahydro-4-hydroxy-6-methyl-2-

171 C acid was synthesized in eight steps (14.5% overall yield) from commercially available starting mate

172 as been synthesized in only three steps (76% overall yield) from easily accessible 1-bromo-2-vinylnap

173 aureol has been achieved in eight steps (14% overall yield) from epoxyfarnesol.

174 'R,2'''R)-hopromalinol (in 10 steps and 9.3% overall yield), from commercially available starting mat

175 R)-hopromine was achieved in 9 steps and 23% overall yield, from commercially available starting mate

176 = Ni, Pd, and Pt, respectively) in excellent overall yield (>95%) after three steps from commercially

177 ), which was synthesized in six steps in 52% overall yield, had low micromolar EC(50) for DeltaPhe508

178 +/-)-7-hydroxylycopodine that proceeds in 5% overall yield has been achieved.

179 )-C(sp(3)) Sonogashira coupling with a 36.5% overall yield has been described.

180 h minimum intermediate purification and good overall yield in nine linear steps.

181 s (PIN-acac complexes) were prepared in good overall yield in three steps from 2-iodo-1-naphthoic aci

182 dyads are designed and synthesized in 67-73% overall yields in 3 steps from commercially available st

183 ed products are obtained in moderate to good overall yields irrespective of the strategy followed, in

184 N-acetylneuraminic acid in 15 steps and 17% overall yield is described.

185 n swabs without evidence of pigment, but the overall yield is significantly greater when they are not

186 The target tetrasaccharide, obtained in high overall yield, is amenable for conjugation to proteins.

187 from (R)-(+)-pulegone (3), proceeding in 44% overall yield, is described.

188 ccessible in essentially three steps and 34% overall yield, is stable as a solid when heated to 44 de

189 ural analogues) in only four steps and 5-15% overall yields; moreover, the stereochemistry of hinduch

190 of lipoprotein(a) levels >/=80th percentile overall yielded net reclassification indices of +16% (95

191 realized in four to six linear steps with an overall yield of <=22%.

192 produced 48.24 +/- 0.01 g/L ethanol with an overall yield of 0.329 g/g available sugars.

193 henolide was accomplished in 13 steps and an overall yield of 1.75% starting from commercially availa

194 product was obtained isomerically pure in an overall yield of 12%, which compares favorably with all

195 without the use of phenolic protection in an overall yield of 13.4%.

196 phimedine in 8 steps from tryptamine with an overall yield of 14%.

197 ebrachidine (2), was then accomplished in an overall yield of 14.1% in 13 reaction vessels from d-(+)

198 atographic purification, which results in an overall yield of 16-23% depending on the identity of the

199 2-methoxynaphthalene in 11 steps and with an overall yield of 2%.

200 ased on the starting purified A chain and an overall yield of 24 % based on the substitution of the r

201 selective synthesis of 1 in 10 steps with an overall yield of 24% from readily available benzyloxyace

202 d recrystallization significantly raises the overall yield of 2S.

203 olesterol was accomplished with an excellent overall yield of 3.5%.

204 as few as 15 linear steps (21 total) with an overall yield of 4.6%.

205 ble starting materials in five steps with an overall yield of 40% and without any column chromatograp

206 followed by oxidative photocyclization in an overall yield of 41% of 6 and 76% of 15.

207 lidine-3,4-diol], prepared in 11 steps in an overall yield of 45% from d-lyxonolactone, is a potent s

208 ncisely achieved in four or five steps in an overall yield of 45, 33 and 44%, respectively, from a co

209 The overall yield of 46% in five steps was a significant imp

210 The overall yield of 50 % is a large improvement over the si

211 vatized with sialic acid were prepared in an overall yield of 50-60%.

212 g group in 18 allowed preparation of 1 in an overall yield of 53% from 4 and eliminated the necessity

213 ng/whole-genome sequencing (n=143) giving an overall yield of 53.7%.

214 wing the synthesis of (R)-pantolactone in an overall yield of 55% (three steps) and high enantiomeric

215 ORS278, has been achieved in 25 steps in an overall yield of 6% using myo-inositol and ethyl propiol

216 ease-associated variants in 12 cases, for an overall yield of 6.3%.

217 With an overall yield of 6.4%, this pentacyclic compound has bee

218 stereoselective synthesis of morphine in an overall yield of 6.6 %.

219 15 linear steps from 4-bromotryptophol in an overall yield of 6.7%.

220 rs more than 99%; esters were isolated in an overall yield of 68% +/- 5% with radiochemical purity of

221 nvergent approach provides telmisartan in an overall yield of 72% while circumventing many issues ass

222 mol) from starting sugar 1 in 15 steps in an overall yield of 73%, with only 5 purification steps.

223 lt (1, Bobbitt's salt) in 88% yield, with an overall yield of 75%.

224 dispegatrine (1) has been accomplished in an overall yield of 8.3% (12 reaction vessels) from 5-metho

225 imidazole as elution buffer, which gave the overall yield of 80.3% and purity of 97.5%.

226 eylactone A is described in 10 steps with an overall yield of 9.5%.

227 lethylamine at 65 degrees C for 1 h, with an overall yield of 96%.

228 bserved folding rates, resulting in a higher overall yield of active protein.

229 and IPr are isolated in four steps, with an overall yield of approximately 50%.

230 d three-step procedure and is isolated in an overall yield of approximately 55%.

231 ost deleterious stresses, affects growth and overall yield of crop plants.

232 progenitor cells enhanced the maturation and overall yield of in-vitro-derived RBCs.

233 U-34 and TT-35 in 18 steps with an excellent overall yield of more than 10% from d-xylose, while the

234 The overall yield of mutations among ARVC cases was 58% vers

235 The overall yield of our synthesis is 3.2% from 2-methylcycl

236 The overall yield of pathogenic mutations was higher among d

237 The overall yield of SL was 23.2% (95/409).

238 The overall yield of the eight-step sequence was 60 %.

239 f this two-step strategy offers a comparable overall yield of the final product.

240 ldicyclohexanone (6), more than doubling the overall yield of the first generation route.

241 e determine speed, product distribution, and overall yield of the photochemical process.

242 The overall yield of the product is among the highest report

243 The overall yield of the target intermediate obtained in nin

244 The overall yield of TRDN mutations was significantly greate

245 18 are obtained in nine and five steps with overall yields of 15% and 33%, respectively.

246 essible from the Inhoffen-Lythgoe diol) with overall yields of 15%, 6%, and 3% for 5a, 5b, and 5c, re

247 of three heptasaccharides in seven steps and overall yields of 24-36% from the corresponding monosacc

248 -dihydroxybenzoic acid with the satisfactory overall yields of 31% and 34%.

249 ieno[3,2-b][1]benzothiophenes were formed in overall yields of 5-32%.

250 p procedure afforded the desired products in overall yields of 5-36%, and it tolerates structural div

251 11 steps from 4-methoxypyridines 6 and 7 in overall yields of 8 and 8%, respectively.

252 moted iodination (-40 to -60 degrees C) with overall yields of 80-90% and > 95% para selectivity foll

253 much higher asymmetric inductions and higher overall yields of aziridines.

254 oted dehydration and reduction provides good overall yields of the title compounds in three steps and

255 ide inhibitor BMS-986094 was achieved in 23% overall yield on a gram scale.

256 3'-phosphitylation give targets 1-4 in ~1-3% overall yield over 11 steps from 5.

257 Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U

258 steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially

259 (20 mol %) to give cyclopenta[b]indoles with overall yields ranging from 8 to 73% (for 2 steps).

260 e intermediates in half the steps and higher overall yield relative to previous routes.

261 readily accessible precursors in the highest overall yields reported to date (6, six steps, 82%; 7, s

262 eps (44% overall yield) and three steps (55% overall yield), respectively.

263 a total of 13 linear steps, and 7 % and 8 % overall yield, respectively (see scheme; (-)-sp= (-)-spa

264 c group differentiation (12 steps, 4% and 8% overall yield, respectively).

265 arins (MW = 1778.5 and 1816.5) in 45 and 37% overall yield, respectively, starting from a simple disa

266 nucleosides in seven steps with 24% and 12% overall yield, respectively.

267 ording these natural products in 29% and 27% overall yield, respectively.

268 s(4'-anilino)naphthalene, 21, in 65% and 90% overall yield, respectively.

269 ercial d-galactal in 13.4%, 21.1%, and 16.7% overall yield, respectively.

270 NJ as single diastereoisomers in 16% and 24% overall yield, respectively.

271 of uracil (U) and thymine (T) in 37 and 45% overall yields, respectively.

272 ccomplished in four steps and 25.6 and 37.4% overall yields, respectively.

273 hyl ether could be synthesized in 29 and 18% overall yields, respectively.

274 Overall, yield-scaled GWP was minimized at optimal N rat

275 and 91% Z, previously), and a five-step, 25% overall yield sequence to access a precursor to dihydroc

276 The latter methods gave overall yields similar to that of the deprotonation appr

277 none has been achieved in eight steps and 9% overall yield starting from (+)-valencene, leading to a

278 gin A has been achieved in six steps and 14% overall yield starting from commercially available tyros

279 ter afforded the target compounds in 16-21 % overall yield starting from D-glucose.

280 en accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chl

281 to a concise (13 steps) and efficient (14 % overall yield) synthesis of the macrolide (-)-clavosolid

282 Moreover, they are formed with speeds and overall yields that are significantly greater than those

283 b]indoles with great structural diversity in overall yields up to 37%.

284 obtained with high enantioselectivity and in overall yields up to 68%.

285 nooxy amines have been synthesized in 60-95% overall yield using a common synthetic strategy from rea

286 phane was synthesized in three steps in good overall yield using mild conditions.

287 ion of F-BODIPYs to O- and C-BODIPYs in high overall yields using a mild one-pot procedure.

288 synthesized in 4 steps from d-ribose in 41% overall yield via an efficient intramolecular Baylis-Hil

289 ree-step route that provides ketone 5 in 75% overall yield was developed.

290 aration of GSH bioconjugates in a satisfying overall yield was exemplified by the case of trypanothio

291 nitial contact and among pregnant women, the overall yield was lower than anticipated.

292 lichondrin B; 150 mg of halichondrin B (68 % overall yield) were obtained from 200 mg of the right-ha

293 ions, inexpensive reagents, step-counts, and overall yield when compared with previous synthetic atte

294 ch at least one pathogen was identified) and overall yield (which calculated the proportion of study

295 hese monomers is challenging (~20 steps, <3% overall yield), which has precluded full characterizatio

296 ygrolines and pseudohygrolines in 30% to 56% overall yields with dr's > 95:5.

297 rcially available starting materials (61-75% overall yield) with minimal chromatographic purification

298 ced Winterfeldt spirocyclic precursor in 47% overall yield, with a longest linear sequence of five st

299 as achieved in 5 steps from galactose in 81% overall yield without any chromatographic separation ste

300 nthesis of the enantioenriched API in higher overall yield without the need for a resolution.