ライフサイエンスコーパス: overexpression

1 or contributions from EPSPS gene duplication/overexpression.

2 lity of cells to maintain RNF168 and ub-H2AX overexpression.

3 g to cell polarity that is altered upon Rgd3 overexpression.

4 ells to restore myelin in the context of PLP overexpression.

5 d lipotoxicity, which can be rescued by SCD1 overexpression.

6 ife cycle steps affected by changes in Mov10 overexpression.

7 uppression of COUP-TFII level, induce VEGF-C overexpression.

8 herapy, with similar findings made upon MYCL overexpression.

9 rine synthesis reversed the effects of UHMK1 overexpression.

10 longer by countering apoptosis through BCL2 overexpression.

11 ly abrogates the hepatomegaly induced by YAP overexpression.

12 resulting in miR-182 underexpression and QR2 overexpression.

13 orter complex (MCUC) inhibitory subunit MCUb overexpression.

14 oglycosides, which can be suppressed by eamA overexpression.

15 hat in l-DOPA-naive rats striatal rAAV-Nurr1 overexpression (1) increased cortically-evoked firing in

16 HE4 overexpression activated the NF-kappaB pathway through t

17 PHGDH overexpression activates serine synthesis to promote can

18 We further demonstrated that Msi1 overexpression affects IEC differentiation in a region-s

19 (EC-HIPP) network, we demonstrate that hAPP overexpression aggravates EC-Tau aggregation and acceler

20 Surprisingly, S-SCAM overexpression also attenuated GABAergic synapses, but t

21 GAPC overexpression also enhances the binding ability of NF-Y

22 enic wild-type mice, mice with neuronal Mfn2 overexpression also exhibited alleviated bodyweight loss

23 MYCN overexpression also suppressed response to cisplatin-eto

24 In addition, overexpression and depletion of dynamin 1 in MPCs increa

25 Cardiomyocyte-specific CatA overexpression and increased CatA activity in the LV of

26 Metabolic labeling assays, FADS3 overexpression and knockdown approaches, and plasma LCB

27 th-dating analysis, retrograde tracing, gene overexpression and knockdown, and axonal quantification

28 sion partially rescues the lam1 mutant, both overexpression and knockout of NsWOX9 in N. sylvestris r

29 to strong enhancer elements, leading to TERT overexpression and poor prognosis in neuroblastoma, but

30 C development via alleviating p21(WAF1/CIP1) overexpression and protumorigenic microenvironment.

31 This allows controlled overexpression and repression of all genes owing to satu

32 of strumpellin in cultured cells using both overexpression and RNA interference along with cell-spre

33 agroinfiltration system would be useful for overexpression and silencing studies of target genes to

34 in future validation studies involving RNAi/overexpression approaches.

35 decreased sphingolipid synthesis and ORMDL3 overexpression are linked to airway hyperreactivity.

36 find that PTBP1 knockdown and MSI1 and PCBP2 overexpression are sufficient to activate many photorece

37 ) using CRISPR site-directed mutagenesis and overexpression assays.

38 While TET3 overexpression augments HGP, knockdown of either TET3 or

39 d the functions of 3 new adipose IR genes by overexpression-based phenotypic rescue in the Simpson-Go

40 yc mRNA and protein were augmented upon Gfi1 overexpression, but reduced following Gfi1 knockdown or

41 o study gene function when early ablation or overexpression can cause developmental defects or embryo

42 lysis of transcriptome profiles in LINC00313 overexpression combined with HIV Tat treatment.

43 Hepatic SIRT1 overexpression corrects defective autophagy, restores th

44 e in cell survival, although a high level of overexpression could be toxic to DA neurons.

45 Whilst eIF4E overexpression could enhance the translation of both ERa

46 ls (GCs) or by prolonged brain-specific VEGF overexpression culminating in extensive, highly selectiv

47 Gal2 overexpression decreased the proliferation of human colo

48 ds to Purkinje cell degeneration, and Inpp5a overexpression decreases inositol 1,4,5-trisphosphate (I

49 the levels of successful SG4 parasitism and overexpression decreases parasitism by SG4z.

50 LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes

51 Our findings show that MYCN overexpression drives SCLC chemoresistance and provide a

52 omoted prostate cancer metastasis, and HAI-2 overexpression efficiently blocked TMPRSS2-induced metas

53 eta cells inhibited proliferation, and SMAD7 overexpression enhanced cell proliferation.

54 Protrudin overexpression facilitated the accumulation of endoplasm

55 related lesions, rats with GEC-targeted HO-1 overexpression (GEC(HO-1) rats) were generated using a S

56 by preventing the known toxic effects of Zta overexpression.IMPORTANCE Epstein-Barr virus infects mos

57 Notably, Sox9 overexpression improves BD paucity and liver phenotypes

58 sistent with our clinical observations, BRF1 overexpression in a Pten-deficient mouse (Pten(Delta/Del

59 of a mouse model that allows inducible Msi1 overexpression in a temporal and tissue-specific manner.

60 KRAS G12V overexpression in an isogenic lung model reveals >50,600

61 Finally, PTPN14 overexpression in B16F10 cells reduced the ability of CA

62 However, the mechanisms of AXL overexpression in cancer remain unclear.

63 ion as a critical mechanism underlying PHGDH overexpression in cancer.

64 TRPV3 overexpression in HBECs conferred resistance to ERS and

65 the molecular mechanisms and function of HE4 overexpression in hypoxia-induced renal fibrosis will pr

66 and murine homologs, and we show that let-7g overexpression in mice limits CHD7 expression in the dev

67 etermine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells.

68 Overexpression in the epithelial sodium channel (ENaC) i

69 We cloned the full-length EB1 cDNA for its overexpression in the testis, which was found to block t

70 R regulon virulence activator aphB, and ompR overexpression in wild-type cells also repressed virulen

71 validated the notion that MYC, YAP1 or MMP13 overexpression increased the incidence of brain metastas

72 Here, we have demonstrated that Twist1 overexpression increases the expression of platelet-deri

73 fetoprotein, and SOX9, suggesting that DCLK1 overexpression induces clonogenicity and dedifferentiate

74 ether, the studies here showed that miR-200a overexpression inhibited Dicer expression, in turn, resu

75 Moreover, adipose OGT overexpression inhibits lipolysis and promotes diet-indu

76 The phenotype associated with CfrA overexpression is also observed in PII-deficient strains

77 in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease.

78 y cancers including colorectal cancer, where overexpression is associated with poor survival.

79 loop-helix transcription factor (MYC), whose overexpression is commonly associated with aggressive fo

80 By contrast, wakefulness induced by nlp-2 overexpression is diminished by deletion of either gnrr-

81 her, our results suggest that p21(WAF1/CIP1) overexpression is essential in the development of protum

82 In vivo, HMGN1 overexpression is linked to decreased quiescence and inc

83 of alpha-synuclein and especially when full overexpression is obtained, whereas the SSVEP facilitate

84 Hyperglycosylation of alpha-DG with LARGE overexpression is shown to inhibit cancer cell growth an

85 plication causes megakaryocyte-specific PLAU overexpression is unknown.

86 KV receptor and further validated it through overexpression, knockout, and inhibition of NCAM1 in Ver

87 etween this KI-LAMP1-APEX method and our two overexpression LAMP1-APEX probes, achieving complementar

88 s putative enhancers of Atf4 and Hsps, whose overexpression largely recapitulated the Myt-mutant phen

89 This overexpression leads to a >100-fold increase in platelet

90 AR2 overexpression leads to an accumulation of Arm with GM13

91 their location more proximally, while Arl8B overexpression leads to increased density and more dista

92 Likewise, Gas5 overexpression led to decreased cocaine intake, decrease

93 mal cell number and shape in e2fb mutant and overexpression lines during leaf development in Arabidop

94 of stalk and leaf midrib sections from SbF5H overexpression lines indicated that the lignin compositi

95 nd other categories of sRNAs in silenced and overexpression lines, in agreement with its likely compe

96 line-inducible adipose tissue-specific MMP14 overexpression model to study its regulatory function.

97 Pathway Analysis (IPA) showed that LINC00313 overexpression negatively regulates cell movement and mi

98 HOXA9 overexpression not only predicts poor diagnosis and outc

99 miR156 overexpression (OE) reduces below-ground tuber yield, bu

100 ple autoimmune and inflammatory diseases and overexpression of a C4 isoform has recently been linked

101 tibular sensory epithelia, while conditional overexpression of a constitutively active version of Yap

102 Pharmacological inhibition of Src or overexpression of a kinase-dead Src mutant prevented the

103 The resistant genotype had a constitutive overexpression of a large number of protein-coding genes

104 We report, for the first time, a significant overexpression of A(2A)R in hippocampal neurons of aged

105 We found that overexpression of ABHD5 induces cell cycle arrest at the

106 Overexpression of ABT promotes seed germination and seed

107 Overexpression of active Nek2A, but not kinase-dead Nek2

108 Overexpression of Ago2 rescues some of the defects of mi

109 Overexpression of alpha2delta3 increases the excitatory

110 Here, we report that overexpression of an operon encoding a highly conserved

111 infected hepatocytes and can be inhibited by overexpression of ATM from a clone lacking miR-181c bind

112 Overexpression of ATOH1 in variant MCC cell lines and fi

113 Because of the overexpression of Aurora kinases in a broad range of can

114 Constitutive overexpression of B1 in awned wheat produced an awnlette

115 The altered GSLs could be rescued through overexpression of B3GALT5.

116 Overexpression of beta-Arr2 in injured or beta-Arr2-defi

117 Here, we report that overexpression of BMP7, a member of the TGFB superfamily

118 oE expression and Abeta pathologies, whereas overexpression of C/EBPbeta accelerates AD pathologies,

119 Overexpression of C/EBPbeta in human wild-type alpha-Syn

120 atrial fibrillation, whereas atrial-specific overexpression of calcitonin prevents both atrial fibros

121 Furthermore, overexpression of CBFbeta counteracted the interference

122 Overexpression of CBFbeta neutralized the D/N phenotype

123 Our results suggest that overexpression of CD80 fully rescues LAT function in lat

124 Retroviral overexpression of Cdx2 induces AML in mice, however the

125 sed sugar content and total biomass, whereas overexpression of ClVST1(97) increases Suc content.

126 nclude downregulation of CD38 expression and overexpression of complement inhibitory proteins on MM t

127 evealed that the expression of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and APETALA1 (AP1) w

128 ous doses of nicotine was compared following overexpression of corticotropin-releasing factor (CRF) i

129 Overexpression of CRF in the NAc increased nicotine IVSA

130 ilar across all groups; however, in females, overexpression of CRF resulted in a larger increase in C

131 f plant immunity is dependent on CsACD2, and overexpression of CsACD2 in citrus suppresses plant immu

132 Hepatic overexpression of Cxcl1 and/or IL-8 promoted steatosis-t

133 Furthermore, we found that the overexpression of CXXC5, which correlates with mRNA and

134 Overexpression of D-type cyclins in human cancer frequen

135 ss mDAP inhibited growth of this strain, but overexpression of dapF(Ct) allowed the mutant to overcom

136 Here, we show that overexpression of dcap-1 in neurons of worms is sufficie

137 In a second approach, we found overexpression of DeltaN-Dbf4 and Cdc7 increased DDK act

138 eudomonas aeruginosa, it has been shown that overexpression of different efflux pumps is linked to th

139 Overexpression of Doc2b variants in triple-knock-out neu

140 Overexpression of DOCK4 increased CTB invasiveness, cons

141 Overexpression of dominant negative mutants of GRAF1/2,

142 imary cultures of rat cortical neurons using overexpression of dominant-negative forms of several tra

143 Overexpression of Drp1 K38A or S637A mutant phenocopies

144 sociated with aboveground N content and that overexpression of DWF1 significantly improves plant grow

145 m2 further impaired DNA replication, and the overexpression of each partially compensated for the oth

146 Ectopic overexpression of EDN1 in cells with mutated EGFR result

147 cally, inactivation of p120ctn combined with overexpression of EGFR induces a signaling cascade that

148 Remarkably, although overexpression of either Tgfb1b or Tgfb3 can stimulate p

149 Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN2

150 on of epidermal PIF4 or auxin signaling, and overexpression of epidermal phyB suppresses thermorespon

151 Conversely, overexpression of EPT1 results in a hypervirulent phenot

152 t a conserved sequence motif-via the ectopic overexpression of eukaryotic acetyltransferase complexes

153 activating transcription factor 4 (ATF4) and overexpression of exogenous ATF4 cDNA indicated that ATF

154 Overexpression of FENDRR in PMA-activated THP-1 cells in

155 Overexpression of gamma-glutamyl transpeptidase (GGT1) h

156 We then performed viral-mediated overexpression of Gas5 in NAc neurons to determine its r

157 Overexpression of Gfat1 (glutamine:fructose-6-phosphate

158 e Tregs, and ex vivo data reveal that forced overexpression of GILZ in mature Tregs inhibits their su

159 A similar response was obtained by overexpression of GLS2 in T98G glioma cells, including d

160 ic activation is important for infection, as overexpression of GLUT4, the high capacity glucose trans

161 Here we showed that overexpression of GRP78 and PDI protein expression corre

162 ls, increased hepatic CD8+ and F4/80+ cells, overexpression of hepatic mRNA associated with inflammat

163 Amplification of HER2 gene (ERBB2) and overexpression of HER2 protein on cancer cells are found

164 ession limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness.

165 marked global hypomethylation and selective overexpression of histone genes.

166 Overexpression of HRP3-II, but not of HRP3-I, increased

167 In vivo overexpression of human miR-298 resulted in nonsignifica

168 Overexpression of human TET catalytic domains (hTETCDs)

169 However, overexpression of IKZF3 was unable to upregulate IL-10 a

170 e 1 differentiation status, characterized by overexpression of ILC1/NK cell-related genes and downreg

171 Overexpression of KCS1 in akr2a mutants rescued akr2a mu

172 Overexpression of LCN2 increased HIF1A that in turn medi

173 es to alter seed oil composition involve the overexpression of lipid biosynthetic enzymes, but how th

174 was transferable between grass species, and overexpression of LNJ in barley and rice caused similar

175 We show that SST interneuron-selective overexpression of Lypd6, an endogenous nicotinic signali

176 Overexpression of maize PTPN (ZmPTPN) promoted, while kn

177 LMP1 signalling leads to overexpression of many cellular antigens previously show

178 Importantly, also in human CLL, we found overexpression of many phosphatases including SHIP2.

179 Overexpression of mcp-1 in neurons enhances survival und

180 n important role in tumour survival and that overexpression of MEGF11 induces both a cytokine and a c

181 Endothelium-specific overexpression of miR-1 was achieved through lentiviral

182 Furthermore, viral vector-mediated overexpression of miR-124 in the irradiated brain amelio

183 decreased mGluR5 function, while astroglial overexpression of miR-128-3p strongly and selectively di

184 n, arresting cell cycle progression, whereas overexpression of miR-181c promoted apoptosis of HCV-inf

185 ion in the TCGA glioma dataset revealed that overexpression of miR-21 was a potential independent pro

186 dentified as a direct target of miR-210, and overexpression of miR-210 inhibited MLL4 and, subsequent

187 In vitro, both overexpression of mutant COPA and silencing of COPA indu

188 Furthermore, overexpression of MYB125 in transgenic poplar resulted i

189 Deregulated overexpression of MYC is implicated in the development a

190 Overexpression of MYC2 in a phyB background partially su

191 Finally, overexpression of myeloid KLF2 protects mice from HFD-in

192 ns in the cellular metabolome resulting from overexpression of N-Myc.

193 Transgenic overexpression of NbP3IP conferred resistance to RSV inf

194 We demonstrate that both overexpression of netrin-1 and brain administration of r

195 Overexpression of neuropeptide precursor VGF in 5xFAD mi

196 Knockout and overexpression of NPC6 decreased and increased, respecti

197 tes to the initiation of cancer by mediating overexpression of oncogenes(1-3), and to the development

198 Overexpression of OsWAKL21.2 in rice induces immune resp

199 e used mice with conditional tubule-specific overexpression of periostin or knockout mice lacking per

200 Overexpression of Pfn1 successfully rescued the migratio

201 (Phb1(iDeltaIEC)) and mice with IEC-specific overexpression of Phb1 (Phb1Tg), we demonstrate that IEC

202 Overexpression of PKI and its subsequent repression of P

203 This suggests that overexpression of PMP22 under CMT1A conditions overwhelm

204 Furthermore, overexpression of PYCR1 in PINCH-1 KO cells restores pro

205 Herein, we find that overexpression of Rac1 is associated with multi-drug res

206 In T-ALL cell lines overexpression of RASGRP1 increases flux through the RAS

207 Overexpression of Rig-G led to significantly reduced cel

208 Finally, overexpression of ROBO2 in cultured mouse podocytes comp

209 ckdown caused loss of lipoprotein secretion, overexpression of SAR1B but not of SAR1A could restore s

210 Overall, these results indicated that overexpression of SbF5H did not compensate for the loss

211 nd promotes Las multiplication, phenocopying overexpression of SDE15.

212 injury models of neutrophilic inflammation, overexpression of SEMA3F delayed inflammation resolution

213 We demonstrate that overexpression of SEMA4C promotes properties of cellular

214 Overexpression of Sig-1Rs rescues, whereas the Sig-1R kn

215 plants with thermosensitive phenotype, while overexpression of SLG1 enhances the tolerance of plants

216 Here we show that overexpression of SNAI1, a key modulator of EMT, is a pa

217 Knockdown or overexpression of SNORD26 or SNORD96A resulted in change

218 tworks than parental Suit2 cells, and forced overexpression of ST6Gal-I in the Suit2 line was suffici

219 rsisted at 14 months and correlated with the overexpression of Star.

220 Here, we show that overexpression of the C terminus of Spc110 is toxic to c

221 ntrinsic and could be rescued by conditional overexpression of the constitutively active NOTCH intrac

222 The development of NAFLD was associated with overexpression of the critical fatty acid uptake and de

223 This is driven by the overexpression of the fusion kinase NPM1-ALK, but the me

224 tochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron i

225 r without tetraploidization due to transient overexpression of the kinase PLK4, human cells return to

226 Overexpression of the Klp64D cargo domain also results i

227 2 enhancer (3q21) to MECOM (3q26) results in overexpression of the MECOM isoform EVI1 and monoallelic

228 this study, we examined whether the loss or overexpression of the membrane-bound ephrin-B1 in astroc

229 erved 3' UTR miR-290-binding site of Pfn2 or overexpression of the Pfn2 open reading frame alone in o

230 leterious immune signaling caused by chronic overexpression of the pro-inflammatory cytokine IL-6.

231 Overexpression of the RNA:DNA endonuclease RNAse H1 resc

232 Our data suggest that overexpression of the Spc110 C terminus acts as a domina

233 We found that overexpression of the transcription factor MITF was suff

234 model, in which dissemination is induced by overexpression of the transcription factor Twist1.

235 d loss of the expression of miR-15a/-15b and overexpression of their direct/indirect targets.

236 Overexpression of this gene in A. thaliana promotes andr

237 Importantly, transgenic overexpression of TMPRSS13 in CRC cell lines increased t

238 ngineered cells lacking all four TMTC genes, overexpression of TMTC3 rescued O-linked glycosylation o

239 Overexpression of transferrin receptor 1 (TFR1) is commo

240 Here we employ conditional overexpression of translation initiation factor eIF4E to

241 Overexpression of Trop2 induces tumor growth and metasta

242 sence of ERbeta was associated with aberrant overexpression of Tsc22d3 (GILZ), a glucocorticoid-respo

243 We also show that overexpression of two definitive endoderm transcription

244 of transgenic mice with macrophage-specific overexpression of urokinase (SR-uPA(+/0) mice) and of SR

245 Finally, overexpression of VAMP8 reduced the intracellular accumu

246 of the lung lymphatic network by transgenic overexpression of Vegfc in club cell secretory protein (

247 relation among BKPyV integration, persistent overexpression of viral large T antigen (TAg), and malig

248 Conversely, overexpression of VZVsncRNA13 using adeno-associated vir

249 Overexpression of wild-type EHD1 accelerated internaliza

250 We also observed that overexpression of WT MAP3K19 activates both the ERK and

251 We found that overexpression of WT SLC20A2 increased phosphate uptake,

252 Cardiac-specific overexpression of YAP rescues cardiac defects in Xinbeta

253 targets in cancer therapy due to their high overexpression on cancer cells and their ability to inte

254 STAT5, or AKT reversed the effects of TC-PTP overexpression on epidermal survival and proliferation.

255 dy, we examined the impact of ectopic RNF168 overexpression on hydroxyurea (HU)-induced stalled repli

256 tegy to treat genetic diseases caused by the overexpression or aberrant splicing of a specific protei

257 membrane permeabilization blockage via BCL2 overexpression or BAX deletion.

258 Accordingly, upon overexpression or depletion of USP22, enrichment of cell

259 MYO18B mRNA irrespective of CEBPB, miR-520G overexpression or IFN-gamma treatment.

260 d Add3 and in genetically modified rats with overexpression or knockout of ADD3.

261 gating LAIR1 immunosuppression through LAIR2 overexpression or SHP-1 inhibition sensitizes resistant

262 e regenerated diabetic wound bed with TWIST1 overexpression or silencing (piLenti-TWIST1-shRNA-GFP),

263 JMJD1A and MDFIC, but not by MDFI, and HIC1 overexpression phenocopied the growth suppressive effect

264 ertaken using antisense oligonucleotides and overexpression plasmids.

265 tly created knockin models that overcome the overexpression problem, and have generated high depth RN

266 IL-6 overexpression promoted activation of CD4(+) T cells whi

267 n orthotopic xenograft animal model, TMPRSS2 overexpression promoted prostate cancer metastasis, and

268 llular sensitivity to cisplatin, whereas its overexpression promotes drug resistance.

269 he digestive and excretory organs, where its overexpression promotes the aggregation of polyQ protein

270 surgically induced joint instability, TIMP3 overexpression proved to be less protective in cartilage

271 PARK2 overexpression reduces melanoma cell growth in vitro and

272 sing centromeric Cse4(CENP-A) levels by YTA7 overexpression requires the activity of Scm3(HJURP), the

273 o2, dependent on its phospho state, and Rgd3 overexpression rescues aberrant Rho3 localization and ce

274 Interestingly, the SULF2 overexpression resulted in GLI1 enrichment at select STA

275 nic mouse line (TG50), markedly higher PDE4B overexpression, resulting in a ~50-fold increase in card

276 es mortality of the mosquitoes, whereas SAP2 overexpression results in increased resistance, probably

277 HIF-1alpha overexpression significantly increased CSC survival in h

278 GBP2 overexpression significantly promotes GBM cell migration

279 We also observed that ATP6V0C overexpression stabilizes tetherin expression.

280 Developmental, overexpression, structure-function, and genetic epistasi

281 owth and metastasis, largely on the basis of overexpression studies and the application of exogenous

282 Overexpression studies have implicated BC200 and the rod

283 l recipients, the pattern of coordinate gene overexpression subsided by 28 to 30 days.

284 of mutant CHMP2B in the fly eye and that Ik2 overexpression suppressed the effect of mutant CHMP2B in

285 ver-enriched activator protein (LAP) isoform overexpression suppresses MYO18B transcription but promo

286 helicase activity in UAP56 and show that its overexpression suppresses R loops and genome instability

287 However, with Ag overexpression, this defect is overcome, and low-avidity

288 e in designing target therapies such as PlGF overexpression, to cure placental disorders during pregn

289 Acetylation of Pif1 exacerbated its overexpression toxicity phenotype, which was alleviated

290 of SERPING1, CFH, and CD74 in the KCNH2-3.1 overexpression transgenic mice.

291 a freezing-sensitive phenotype, whereas phyB-overexpression transgenic plants displayed enhanced free

292 lectively eliminates cancer cells with GRP78 overexpression via activating unfolded protein response-

293 onferring tolerance to aromatic acids, ESBP6 overexpression was also shown to significantly improve t

294 By contrast, p16 overexpression was associated with triglyceride accumula

295 We showed that ICAM-1 overexpression was primarily caused by MPs derived from

296 Using inducible cMYC overexpression, we demonstrate that post-pregnancy MECs

297 Using mutant GluN2A overexpression, we show that Tyr-1292 and Tyr-1387 but n

298 SNORD26 and SNORD96A knockdown and overexpression were undertaken using antisense oligonucl

299 ts both AURKA and AURKB showed a significant overexpression, when compared to health controls.

300 al characterization was accomplished by gene overexpression while haplotype analyses assessed B1 poly