ライフサイエンスコーパス: overwhelm

1 ammatory when their regulatory functions are overwhelmed.

2 apacity of the endoplasmic reticulum (ER) is overwhelmed.

3 bei, China, the local health-care system was overwhelmed.

4 eriod to ensure the healthcare system is not overwhelmed.

5 the number of guidelines and updates can be overwhelming.

6 ories of individuals in need too emotionally overwhelming.

7 However, the resulting deluge of data can be overwhelming.

8 of deaths as local health facilities become overwhelmed(4).

9 This overwhelming abundance of cryptobenthic larvae fuels ree

10 proposed for addressing the challenge of the overwhelming abundance of genomic sequence and other bio

11 relative to the infecting bacterium and the overwhelming abundance of uninformative structural RNAs

12 ow that growth by dimers is preferred due to overwhelming accumulation of adsorbed dimers on the crys

13 viruses susceptible to error catastrophe, an overwhelming accumulation of mutations incompatible with

14 ocal regulatory macrophages (M2-like) become overwhelmed, activating an inflammatory response (M1-lik

15 However, overwhelming activation and accumulation of neutrophils

16 botic thrombocytopenic purpura (TTP) whereas overwhelming activation of complement via an alternative

17 r trace silver extraction in the presence of overwhelming activities of (137)Cs via the autodepostion

18 Owing to the overwhelming advantage in energy density, lithium-sulfur

19 andard in critically ill patients due to its overwhelming advantages, was the only tool able to speci

20 , the default IgG response at age 1 year was overwhelmed after age 2 years by an "pre-atopic" IgG res

21 ethylated CpGs at other gene regions, and by overwhelming age-related methylation in CpG islands and

22 pled algorithmic approaches to deal with the overwhelming amount of data generated by modern mass spe

23 high spatial-temporal resolution provides an overwhelming amount of data.

24 Sensory environments often contain an overwhelming amount of information, with both relevant a

25 ally expanded in recent years, leading to an overwhelming amount of patient variants with high variab

26 mponents of the immune system as well as the overwhelming amounts of data can make it difficult to in

27 in ultimately preventing ICUs from becoming overwhelmed and a subsequent second lockdown.

28 ice with HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response

29 edoxin-thioredoxin antioxidant chain becomes overwhelmed, and H2O2 degradation stalls or ceases.

30 synthetic methodology toward heterocycles is overwhelming, and catalysis, in particular, as one of th

31 ssively and express phenotypes indicative of overwhelming antigenic stimulus and tissue homing/cytoto

32 idly detoxified in regenerating species, but overwhelms antioxidant scavenging in cells from non-rege

33 ased susceptibility to frost damage that can overwhelm any benefit of flowering early.

34 nce of some calcifying herbivores, which can overwhelm any direct negative effects.

35 ond which internal resistance mechanisms are overwhelmed are uncommon.

36 Although we also confirmed overwhelming association at the LOXL1 locus, the key SNP

37 Pines use defensive resin to overwhelm attackers, creating an Allee effect requiring

38 extracting rare stochastic events out of an overwhelming background using the highly sensitive CEI m

39 ion and compromises host defense, leading to overwhelming bacterial infection.

40 Previous randomised trials have shown an overwhelming benefit of mechanical thrombectomy for trea

41 However, an overwhelming body of knowledge has accumulated in the fi

42 hich physical effects of habitat-formers can overwhelm broad-scale thermal trends, suggesting a need

43 in the B-site ordered samples are gradually overwhelmed by B-site disorder.

44 ecause existing software solutions are often overwhelmed by error correction tasks.

45 ate recognition and because authorities were overwhelmed by many patients and poor community involvem

46 r the last three decades, the field has been overwhelmed by nanotechnology, nanomedicine, and many na

47 conditions, estrogen effects were partially overwhelmed by pro-inflammatory cytokines.

48 icial effect of high CO2 on Trichodesmium is overwhelmed by the deleterious effect of the concomitant

49 Ophthalmic surgeons have been overwhelmed by the influx of multifocal intraocular lens

50 olecule, but this minor enzyme inhibition is overwhelmed by the marked enhancement of membrane recrui

51 isting healthcare infrastructure was already overwhelmed by the outbreak.

52 limited information-processing resources are overwhelmed by the total concurrent processing demands i

53 drug-induced error-prone polymerase Pol IV, overwhelms cells with toxic DNA breaks.

54 appearance and propagation of bacteria cause overwhelming cellular stress responses that induce apopt

55 noniterative at the module level remains an overwhelming challenge, which may account for the seemin

56 Considering the overwhelming changes that occurred during primate evolut

57 ult as variations in root surface area would overwhelm citrate benefits.

58 protein in the CNS, which potentially could overwhelm clearance of cytotoxic alphaSN species.

59 hylmercury inputs to the estuary by 25-200%, overwhelming climate-driven changes over the next decade

60 sage in nitrogen reduction reaction (NRR) as overwhelming competition from hydrogen evolution reactio

61 y assuming a tame solution and inaction from overwhelming complexity.

62 rmance, people remember certain stimuli with overwhelming consistency.

63 The overwhelming contribution of diesel compared to gasoline

64 h late recovery from coma lacked evidence of overwhelming cortical injury but demonstrated prominent

65 Given the huge influence caused by the overwhelming COVID-19 pandemic affecting over three mill

66 Overwhelming data in both humans and mice reveal a clear

67 Overwhelming data suggest that oncogenic and neurodegene

68 However, mCRPC showed overwhelming de novo resistance to immune checkpoint blo

69 We identified an overwhelming decrease in the expression of anti-oxidant

70 le this may be thought of as secondary to an overwhelming desire for drugs, it could equally well ref

71 t cells showed that Bccip deletion caused an overwhelming down-regulation of genes involved in mitoti

72 ndation of this model is the theory that the overwhelming driver of cancer risk is mutations.

73 We also observe an overwhelming effect of the established TCF4 locus.

74 count after therapy initiation highlight the overwhelming effectiveness of antiretroviral therapy in

75 o acid mutations, hypoxia, or infection, can overwhelm ER protein quality control, leading to misfold

76 There is overwhelming evidence both in vivo and in vitro that tra

77 Importantly, overwhelming evidence gathered over recent years shows t

78 Overwhelming evidence has shown poor reproducibility and

79 Overwhelming evidence indicates that the pancreatic canc

80 In conclusion, there is overwhelming evidence linking the NLRP3 inflammasome and

81 While previously controversial, overwhelming evidence now suggests that increased reacti

82 Overwhelming evidence now supports the presence of a dee

83 ived comparatively little attention, despite overwhelming evidence of a pivotal role for the PAG in c

84 With overwhelming evidence of change in habitats, biologists

85 Recent genetic studies have provided overwhelming evidence of the involvement of microglia-re

86 Results showed overwhelming evidence of the paradox across lifetime and

87 Despite the overwhelming evidence showing the influence of sex or ob

88 Overwhelming evidence shows the critical role of glycoly

89 Overwhelming evidence supports the endosymbiosis theory

90 There is overwhelming evidence that leaf-internal isoprene increa

91 (13)C and (1)H NMR data provide overwhelming evidence that most UiO-66 organic linkers a

92 timulate the immune system, and there is now overwhelming evidence that this drives chronic immune ac

93 Despite overwhelming evidence that transcriptional activation by

94 There is now overwhelming evidence to support lowering LDL-c (low-den

95 lt twins suggest that replacement eventually overwhelms evolution over multi-decade timescales, hinti

96 dogenous Neanderthal DNA is present among an overwhelming excess of recent human DNA.

97 There is now overwhelming experimental and clinical evidence that ath

98 IT may be less effective when a tumor lacks "overwhelming" expression of a single target such as EGFR

99 Finally, the complex nature of plasma was overwhelming for HD1, but we define conditions for the t

100 ions based on molecular profiling results is overwhelming for many oncology clinicians and researcher

101 Designing mechanical metamaterials is overwhelming for most computational approaches because o

102 exacerbating socioeconomic inequalities and overwhelming fragmented health systems.

103 The present findings indicate that the overwhelming GABAergic drive present at the DMV is prima

104 promising medical technology to address the overwhelming global aging, which requires advanced micro

105 onsumption of adulterated alcohol frequently overwhelm health care facilities in developing countries

106 us disease 2019 pandemic has or threatens to overwhelm health care systems.

107 and other obesity-associated diseases could overwhelm health-care systems in the future.

108 Widespread use of these medications forced overwhelmed health care systems to search for ways to ef

109 ill still lead to COVID-19 epidemics rapidly overwhelming health systems, with substantial excess dea

110 emergency departments (EDs) and potentially overwhelming health systems.

111 ts exciting scientific challenges as well as overwhelming health, equity, and economic benefits.

112 th rate of COVID-19 continues to threaten to overwhelm healthcare systems in multiple countries.

113 The epidemic threatens to overwhelm healthcare systems, and identifying those regi

114 mental to the ability to detect and respond, overwhelmed healthcare systems are already experiencing

115 rus, has spread rapidly throughout the world overwhelming healthcare systems.

116 s such as transcription and replication that overwhelm high-fidelity DNA repair.

117 The pace and extent to which GCM projections overwhelm historical trends will play a key role in defi

118 , but in the clinical setting are limited by overwhelming host material and ultra-low target frequenc

119 elopmental upregulation in I (KL) appears to overwhelm I (H) These results counter previous hypothese

120 es a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative

121 This overwhelming immune response is regulated by damage-asso

122 D-19, but this antiinflammatory response was overwhelmed in severe illness, with the IL-6:AAT ratio m

123 a, this intensification is likely to involve overwhelming increases in wet spell intensity.

124 ighly susceptible to fatal ehrlichiosis, had overwhelming infection, and developed extensive tissue i

125 cent deaths of several migrant children from overwhelming infections in United States detainment cent

126 nia, a condition linked to increased risk of overwhelming infections, remain largely unknown.

127 ls at lesional sites was concomitant with an overwhelming infiltration of CD8(+) T-cells that demonst

128 vation syndrome (MAS) is an acute episode of overwhelming inflammation characterized by activation an

129 ntributes to tissue healing and recovery but overwhelming inflammation is associated with postoperati

130 a novel macrophage population that controls overwhelming inflammation on one hand but is also necess

131 Here, we show that VML injury incites an overwhelming inflammatory and fibrotic response that lea

132 yte and macrophage lineage cells, leading to overwhelming inflammatory responses.

133 sly overlooked annual CO(2) sinks due to the overwhelming influence of these weathering reactions.

134 Continued ingestion (for >=12 h) overwhelmed initial killing, and a second, late-phase mi

135 and attractive target for modulation of the overwhelming innate immune response.

136 Although an overwhelming insecticidal effect against Anopheles steph

137 Proteomics revealed overwhelming interactions of endogenous VCP with ribosom

138 red to simulate cellular crowding, introduce overwhelming interferences to mass spectrometry (MS) ana

139 h is predominantly focused on healthcare, an overwhelming investment in developing drugs and treatmen

140 groups rather than one is clearly unable to overwhelm it.

141 spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective ph

142 tive correlated response in the humerus that overwhelmed its own trait-specific response to selection

143 zed mutants, the capacity of this network is overwhelmed, leading to the observed increase in phenoty

144 ment has to be tightly controlled to prevent overwhelming leukocyte infiltration, activation, and, co

145 olving hundreds of introns and genes with an overwhelming loss of IR in erythroid cells and MKs compa

146 multiple extreme high PPT pulse events could overwhelm LST influences, suggesting a divergence in how

147 Rationale: In addition to the overwhelming lung inflammation that prevails in COVID-19

148 zero positive end-expiratory pressure caused overwhelming lung injury, subsequently shown by others t

149 The overwhelming majority (97%) of alpha-satellite DNA is fo

150 ase I-hypersensitive sites and show that the overwhelming majority are populated by well-spaced sites

151 ch incorrect candidate locations consumes an overwhelming majority of a modern read mapper's executio

152 An acceptable formation model for the overwhelming majority of chondrules, however, has not be

153 The overwhelming majority of clustered CTCF sites colocalize

154 y of EBP1 in human (Homo sapiens) cells, the overwhelming majority of EBP1 interactors are part of ri

155 a subset of these frequencies that drive the overwhelming majority of gas transport in fractured rock

156 oss-comparison of assemblies showed that the overwhelming majority of HGT candidates in the Boothby e

157 hed active variants up to 2,800-fold from an overwhelming majority of inactive ones at approximately

158 o Mycobacterium tuberculosis (MTB), with the overwhelming majority of infected individuals not develo

159 nto the human genome, we discovered that the overwhelming majority of intronic and exonic RE are expr

160 The overwhelming majority of Msp2 variants expressed during

161 However, Ral, and the overwhelming majority of mutant oncogenic K-Ras, are dev

162 Though the overwhelming majority of natural processes occur far fro

163 The overwhelming majority of nonphysicians adopted the "good

164 tes, and can be readily implemented when the overwhelming majority of nucleic acids in a specimen der

165 The overwhelming majority of participants in current genetic

166 al-regulated kinase inhibitor treatment, the overwhelming majority of patients eventually acquire res

167 conclusion, COL7A1 harbored mutations in the overwhelming majority of patients with dystrophic epider

168 rvention within 6 months of insertion in the overwhelming majority of patients.

169 g and MNase HS regions) may give rise to the overwhelming majority of phenotypic variation, greatly n

170 Small-scale farmers - the overwhelming majority of poultry producers in low-income

171 e acetylation marks have been described, the overwhelming majority of regulatory genomics studies foc

172 To date, the overwhelming majority of researches have focused on chem

173 The overwhelming majority of scientific knowledge is publish

174 y the male population, which constitutes the overwhelming majority of smokers in China.

175 The overwhelming majority of sports-related sudden deaths oc

176 However, the overwhelming majority of studies demonstrate the presenc

177 the active sites of oxidoreductases, yet the overwhelming majority of studies on small-molecule mimic

178 II PI3K in PI(3,4)P(2)-driven function, the overwhelming majority of the lipid accumulates through d

179 preservation solution after NMP removes the overwhelming majority of third-party allogeneic pRBCs, b

180 The overwhelming majority of UTIs are caused by uropathogeni

181 Because the overwhelming majority of variants are present in only a

182 Moreover, the overwhelming majority of variants, both somatic and germ

183 In dogs, an overwhelming majority of visually-responsive cortex exhi

184 s and assemble into homomeric complexes, the overwhelming majority of which (>96%) are symmetric.

185 ng variants identified per individual can be overwhelming, making it prudent to focus on noncoding re

186 Although Cannabis contains an overwhelming milieu of terpenoids, only a limited number

187 In order to make sense of the overwhelming mutational data and capitalize on this clin

188 Alternatively, land-use change might overwhelm natural buffering and amplify latent climate s

189 e development of new technologies, which now overwhelm natural REE anomalies.

190 Anthropogenic emissions completely overwhelmed natural marine lead (Pb) sources during the

191 Furthermore, these communities have an overwhelming need and desire for point-of-use water trea

192 e disease, misfolded proteins accumulate and overwhelm normal systems of homeostasis and quality cont

193 The 2020 COVID-19 pandemic has abruptly overwhelmed normal life.

194 pment with an immense cytoplasm and a single overwhelmed nucleus.

195 Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, b

196 The overwhelming number of genetic alterations identified th

197 Despite the overwhelming number of human long non-coding RNAs (lncRN

198 Although there is an overwhelming number of research articles and reviews foc

199 This financial burden is an overwhelming obstacle for Haiti's poorest citizens, and

200 clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at

201 Sometimes, cancer researchers can feel overwhelmed or confused when faced with such a corpus of

202 We propose that overwhelming or disrupting the chaperone function of PZP

203 gainst chronic infections from progressively overwhelming other antibody specificities.

204 Their complexity overwhelms our intuitive notions of how molecular regula

205 s opioids works to close this gate, reducing overwhelming pain generated by parallel pathways.

206 erior population survival during a simulated overwhelming pandemic.

207 e essential, but the scale of the task risks overwhelming parliament and the civil service.

208 Here, based on overwhelming patterns of genetic, morphological, and eco

209 ddicted tumors in vitro and in vivo leads to overwhelming phospho-STAT1 activation, turning on its tu

210 s and clinical presentation of patients with overwhelming postsplenectomy infection (OPSI).

211 k were IgA isotype, in stark contrast to the overwhelming predominance of IgG isotype Env-specific B

212 ents with upper GI tumors was thwarted by an overwhelming predominance of low ERCC1 mRNA expression.

213 standing feature of these assemblages is the overwhelming predominance of monothalamids, a group ofte

214 Fish from another population showed an overwhelming preference for red irrespective of what was

215 markers onto the tree of Bacteria shows the overwhelming presence of diderm phyla and the non-monoph

216 f prokaryotic type were characterized by the overwhelming presence of omega-3 C18 polyunsaturated fat

217 the search for novel approaches to blunt the overwhelming pro-allergic Th2 response, we evaluated the

218 evidence that complement activation provokes overwhelming pro-inflammatory responses, whether or not

219 The overwhelming proportion of false positives results in re

220 Aggregation does not arise because of overwhelming proteasome-mediated degradation but because

221 tory disease causing thousands of deaths and overwhelming public health systems.

222 Overwhelming pulmonary inflammation and endothelium disr

223 Given the overwhelming quantity of information available from the

224 O2 and water availability are likely to have overwhelmed reduced nitrogen availability.

225 Also notable was the overwhelming reduction in mast cell transcripts, potenti

226 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es

227 ttempts at repair by continued proliferation overwhelm reparative capacity, causing loss of specialis

228 suspension is dried, capillary pressure may overwhelm repulsive electrostatic forces, assembling agg

229 l system, antimicrobial use does not lead to overwhelming resistance, as is typical in clinical setti

230 c lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic

231 This coding scheme emphasizes the overwhelming role of the inferior olive in generating sa

232 Although the results revealed overwhelming satisfaction with the IACUC administrative

233 portunities associated with translating this overwhelming scientific progress into real clinical bene

234 idity with which the virus struck was indeed overwhelming, scientists throughout the world have been

235 The overwhelming size and rapid growth of the biomedical lit

236 s 2 and prevent health systems from becoming overwhelmed; some have instituted full or partial lockdo

237 Overwhelming spectroscopic and chemical evidence support

238 Despite overwhelming structural similarity between the periplasm

239 The overwhelming success of exome- and genome-wide associati

240 s an intriguing feature and critical for the overwhelming success of higher plants.

241 Despite the overwhelming success of vaccines in preventing infectiou

242 ecently, 5 major randomized trials showed an overwhelming superior benefit of combining endovascular

243 ns introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides

244 We find overwhelming support for a long-term decline across all

245 We find overwhelming support for agriculture being introduced to

246 ral snakes in both space and time, providing overwhelming support for Batesian mimicry.

247 among the three distinct analyses, providing overwhelming support for the monophyletic status of subf

248 isrupt traditional health care operations by overwhelming system resource capacity but also create op

249 In severe trauma, overwhelming systemic inflammation can result in additio

250 Sepsis is typically triggered by an overwhelming systemic inflammatory response to pathogens

251 Overwhelming systemic inflammatory responses may suppres

252 s at both local and regional scales that may overwhelm temporal signals.

253 ent and community sample testing can quickly overwhelm testing capability globally.

254 educed Treg recruitment to the kidney and an overwhelming TH1 immune response, with an aggravated cou

255 The evidence is now overwhelming that partially assembled nucleosome states

256 The evidence is now overwhelming that psychiatric disorders are "polygenic"-

257 icularly at axon terminals, ultimately might overwhelm the capacity of intracellular disposal mechani

258 m (ER) stress occurs when misfolded proteins overwhelm the capacity of the ER, resulting in activatio

259 However, nonnative invasion may overwhelm the effect of immigration timing on community

260 Interhost dispersal was strong enough to overwhelm the effects of host factors, largely eliminati

261 ally to microbiome variation, and is able to overwhelm the effects of individual host factors, in an

262 CST is <+/-2 bars, so the latter will rarely overwhelm the former, explaining why historical earthqua

263 a common surgery to repair a broken limb can overwhelm the immune system and become the driver of fur

264 Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose.

265 aFXII in human plasma and in mice appears to overwhelm the normal inhibitory function of C1 inhibitor

266 assembly/disassembly will potentially act to overwhelm the spatial information that controls microtub

267 ated sediment-water diffusive fluxes greatly overwhelmed the atmospheric depositional flux to the riv

268 or numbers of patients with EVD that quickly overwhelmed the capacity for safe management.

269 increase in blood culture utilization, which overwhelmed the capacity of automated blood culture inst

270 In the tropics, fast currents overwhelmed the effect of short planktonic durations.

271 %DO overwhelmed the influence of atmospheric CO(2), temperat

272 ific variation in these responses was large, overwhelming the average community response.

273 ting condensation level (LCL) with elevation overwhelming the effects of decreasing total column wate

274 ce 2009, the economic recovery increased TF, overwhelming the influence of improved emissions intensi

275 Thus, increasing MYH14 assembly overwhelms the ability of cells to polarize and invade,

276 xt] to a regime where the surface conduction overwhelms the bulk.

277 me (d < ~2 nm) the effect of the yellow band overwhelms the effect of quantum confinement with distin

278 erexpression of PMP22 under CMT1A conditions overwhelms the endoplasmic reticulum quality control sys

279 olved oxalate and the mineral surface for Ni overwhelms the enhancement in adsorption associated with

280 isfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the

281 lux of HOCs bioaccumulated from natural prey overwhelms the flux from ingested microplastic for most

282 dden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myoc

283 ind that the size of the pro-tobacco network overwhelms the others, which suggests a huge number of u

284 Depletion of PTF1A causes an imbalance that overwhelms the UPR, induces cellular injury, and provoke

285 access to in the larger populations may have overwhelmed their working memory and weakened their abil

286 een sometimes described as "compelling" and "overwhelming", there are limitations that existing studi

287 obial community structure, but that diet can overwhelm these genetic effects.

288 ors in response to challenging situations or overwhelming threats can become activated pathologically

289 thus have the potential to contribute to the overwhelming thrombo-inflammation in COVID-19, and the i

290 continuously released novel packages can be overwhelming to the immunologist with limited computatio

291 However, the barriers to mutagenesis can be overwhelmed under two sets of circumstances.

292 ls initiate the ER stress response and, when overwhelmed, undergo apoptosis.

293 scovery of new phages and help interpret the overwhelming unknown sequences in the viral metagenomics

294 the tumor promoting activity of AID when it overwhelms uracil excision repair.

295 e energy and environmental issues due to the overwhelming use of fossil fuels.

296 There is an overwhelming variety of LAMP indicators in the literatur

297 Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading

298 However, even an attenuated epidemic may overwhelm weak health systems, emphasizing the importanc

299 because reference-induced biases can become overwhelming when dealing with divergent strains.

300 ourth, 'Missing the big picture', identifies overwhelming workload and fixation on specific parameter