ライフサイエンスコーパス: oxacillin

1 cell wall stability, such as ampicillin and oxacillin.

2 determined by using Mueller-Hinton agar with oxacillin.

3 The two VMEs were with oxacillin.

4 ree very major errors (VMEs; 1.7%) were with oxacillin.

5 ed with results obtained by CLSI methods for oxacillin.

6 sion septum was prevented after acylation by oxacillin.

7 d by their size and their susceptibility for oxacillin.

8 articularly sensitive to rifampin but not to oxacillin.

9 determine the susceptibility of S. aureus to oxacillin.

10 tional methods are functionally resistant to oxacillin.

11 olates) were evaluated for susceptibility to oxacillin.

12 aZ and for inoculum effects to cefazolin and oxacillin.

13 acillin, 25mug/kg dicloxacillin and 30mug/kg oxacillin.

14 llin and 946/993 (95.3%) were susceptible to oxacillin.

15 nitive therapy with cefazolin, nafcillin, or oxacillin.

16 our of six tested isolates were resistant to oxacillin.

17 ponse following incubation of S. aureus with oxacillin.

18 s less expensive for outpatient therapy than oxacillin.

19 ) received ceftriaxone and 50 (40%) received oxacillin.

20 r infections treated with ceftriaxone versus oxacillin.

21 llin (6 microg), methicillin (5 microg), and oxacillin (1 microg) disks.

22 or errors (one each with chloramphenicol and oxacillin), 1 major error (chloramphenicol), and 15 mino

23 3.6%), coagulase-negative staphylococci with oxacillin (2 of 74, 2.7%), gram-negative bacilli with ce

24 ntration (sub-MIC) levels, lowers the MIC of oxacillin (2) against a number of MRSA strains by up to

25 le/trimethoprim, 77.5%; levofloxacin, 58.5%; oxacillin, 54.7%; ciprofloxacin, 51.0%; gatifloxacin, 51

26 ing intermediate) for hVISA were as follows: oxacillin, 82%; erythromycin, 82%; clindamycin, 73%; lev

27 ceptible bacteria incubated with and without oxacillin after 120 min.

28 ared with patients who received nafcillin or oxacillin, after controlling for other factors.

29 ompared with patients receiving nafcillin or oxacillin, after controlling for other factors.

30 o as (-)-LZ-2112, is known to synergize with oxacillin against methicillin-resistant Staphylococcus a

31 ion with 4% salt (the conditions used in the oxacillin agar screen method), the oxacillin MICs of 16

32 Due to the poor sensitivity of the oxacillin agar screen plate for predicting resistance in

33 the 51 strains, 44 (86%) did not grow on the oxacillin agar screen plate, broth microdilution MICs we

34 eference broth microdilution method, and the oxacillin agar screen plate.

35 Another seven strains did grow on the oxacillin agar screen plate.

36 culated onto a pair of commercially prepared oxacillin agar screen plates containing 6 microg of oxac

37 Louis, Mo.), and the oxacillin agar screen test for detection of MRSA, with P

38 The oxacillin agar screen test, the VITEK-1 system, the VITE

39 n, 100/100; Velogene, 100/100; Vitek, 95/97; oxacillin agar screen, 90/92; disk diffusion, 100/89; Mi

40 ethods (broth microdilution, disk diffusion, oxacillin agar screen, MicroScan conventional panels, Mi

41 ant and should be verified as susceptible by oxacillin agar screening with incubation for 48 h.

42 itive therapy with cefazolin vs nafcillin or oxacillin among patients with MSSA infections complicate

43 incorporation also lowers resistance toward oxacillin, an antibiotic that targets penicillin-binding

44 Oxacillin and cefoxitin disk and MIC tests were evaluate

45 The goal of this study was to evaluate oxacillin and cefoxitin disk diffusion (DD) and broth mi

46 in screen agar (BD Diagnostics, Sparks, MD), oxacillin and cefoxitin Etests (AB Biodisk, Solna, Swede

47 The results for oxacillin and cefoxitin generated by the automated syste

48 found that the three tested systems, Vitek 2 oxacillin and cefoxitin testing and cefoxitin disk susce

49 The Vitek 2 oxacillin and cefoxitin tests had very major error rates

50 ted against oxacillin and the combination of oxacillin and clavulanic acid with the Vitek GPS-SA card

51 An additional PBP inducible by oxacillin and corresponding to S. aureus PBP2A was ident

52 correlated with increased susceptibility to oxacillin and DCS.

53 is isolate was phenotypically susceptible to oxacillin and did not contain the mecA gene by Southern

54 ombined presence of erythromycin, linezolid, oxacillin and fusidic acid shows binding of fusidic acid

55 the discovery of synergistic action between oxacillin and manuka honey against methicillin-resistant

56 However, oxacillin and methicillin disk testing remain excellent

57 ompared to an antistaphylococcal penicillin (oxacillin and nafcillin) or first-generation cephalospor

58 iates by 16- to 4,096-fold the activities of oxacillin and of meropenem against methicillin-resistant

59 y, the efficacy of antibiotics (doxycycline, oxacillin and rifampicin) in preventing Staphylococcus a

60 tingly, a 957 mutant was less susceptible to oxacillin and showed increased peptidoglycan crosslinkin

61 bactericidal and bacteriostatic antibiotics (oxacillin and tetracycline, respectively) were tested to

62 ere 1 to 8 micrograms/ml were tested against oxacillin and the combination of oxacillin and clavulani

63 of - defense genes, as well as reductions in oxacillin and trimethoprim-sulfamethoxazole susceptibili

64 rA double mutants in the endocarditis model, oxacillin and vancomycin treatment of the mgrA/sarA doub

65 owed high and homogeneous resistance to both oxacillin and vancomycin.

66 ganism is typically resistant to penicillin, oxacillin, and erythromycin (the latter mediated by msrA

67 robials, including cefoxitin, ciprofloxacin, oxacillin, and methicillin.

68 nvolves the use of three disks (methicillin, oxacillin, and penicillin) or two disks (methicillin and

69 egrees C, and a higher relative affinity for oxacillin as compared with cefoxitin.

70 Clinical Laboratory Standards methods using oxacillin as the class drug.

71 Oxacillin bactericidal assays showed that mecA- and PBP

72 cci present in the specimen are resistant to oxacillin (based on amplification of the mecA gene).

73 Likewise, oxacillin BMD and cefoxitin DD tests using the coagulase

74 ts for S. pseudintermedius/S. schleiferi and oxacillin BMD and cefoxitin DD tests using the CoNS brea

75 ve CoNS strains but gave better results than oxacillin BMD or oxacillin DD for mecA-negative strains

76 Oxacillin BMD testing by current Clinical and Laboratory

77 Oxacillin BMD using S. aureus/S. lugdunensis breakpoints

78 rolyzed benzylpenicillin-, methicillin-, and oxacillin-bound NDM-1 have been solved to 1.8, 1.2, and

79 ee for Clinical Laboratory Standards (NCCLS) oxacillin breakpoints for broth microdilution and disk d

80 cefoxitin DD test performed equivalently to oxacillin broth microdilution (BMD) and to oxacillin DD

81 ccus warneri were evaluated by cefoxitin and oxacillin broth microdilution (BMD), disk diffusion (DD)

82 ally, a cefoxitin disk diffusion test and an oxacillin broth microdilution assay were examined.

83 The cefoxitin disk diffusion and oxacillin broth microdilution assays categorized 100% an

84 For four of the latter group of strains, oxacillin broth microdilution MICs were > 4 micrograms/m

85 flow cytometry (FCM) following incubation in oxacillin broth.

86 ne isolate was determined to be resistant to oxacillin by reference broth microdilution testing (MIC,

87 reus (MRSA) infections by demonstrating that oxacillin can be used to significantly attenuate the vir

88 First-line MSSA therapies (nafcillin, oxacillin, cefazolin) are generally avoided in the 10% o

89 with either a beta-lactam (n=24), including oxacillin, cefazolin, or ceftaroline, or a glyco-/lipope

90 ith either a beta-lactam (n = 24), including oxacillin, cefazolin, or ceftaroline, or a glyco-/lipope

91 he crystal structures of three beta-lactams (oxacillin, cefepime, ceftazidime) complexes with PBP2a-e

92 ty against beta-lactam antibiotics including oxacillin, cloxacillin, and dicloxacillin, but not abaca

93 iofur), ampicillin, cefazolin, penicillin G, oxacillin, cloxacillin, naficillin, and dicloxacillin.

94 arge detached clumps were highly tolerant to oxacillin compared with exponential-phase planktonic cul

95 ase and exhibit borderline susceptibility to oxacillin, comprised a greater percentage of the 120 wou

96 ntiated by FCM after 2 h of incubation in an oxacillin-containing liquid culture medium.

97 S. aureus isolates were incubated in oxacillin-containing Mueller-Hinton broth, stained using

98 ut gave better results than oxacillin BMD or oxacillin DD for mecA-negative strains of CoNS.

99 The cefoxitin DD test is preferred over the oxacillin DD test for predicting mecA-mediated oxacillin

100 o oxacillin broth microdilution (BMD) and to oxacillin DD tests among S. aureus and mecA-positive CoN

101 Oxacillin DD tests using the Clinical and Laboratory Sta

102 Our findings demonstrate that oxacillin DD tests using the CLSI M100-S28 breakpoints f

103 Oxacillin DD yielded high ME rates (20.7 to 21.7%) using

104 This effect is based primarily on the oxacillin-dependent repression of the accessory gene reg

105 reus strains to beta-lactam antibiotics (eg, oxacillin) depends on the production of penicillin-bindi

106 have shown a reasonable correlation between oxacillin disc and automated sensitivity testing, changi

107 e use of MSA containing lipovitellin with an oxacillin disk (MSAL(Ox)).

108 methods were compared with those obtained by oxacillin disk diffusion.

109 with those obtained by a PCR-based assay and oxacillin disk diffusion.

110 solates and that laboratories should perform oxacillin disk or MIC tests of these isolates when they

111 MRSA isolates were identified by the oxacillin disk-diffusion method.

112 d be used in conjunction with a 1-micrograms oxacillin disk.

113 e diameters for methicillin, penicillin, and oxacillin disks; (ii) the sum of the zone diameters for

114 methicillin-resistant S. aureus, addition of oxacillin does not result in delocalization of PBP2 indi

115 MSSA and five MRSA strains were subjected to oxacillin exposure for up to 2 h.

116 urrent infections compared with nafcillin or oxacillin for MSSA infections complicated by bacteremia.

117 In this comparison of ceftriaxone versus oxacillin for MSSA osteoarticular infections, there was

118 ylpenicillin, cloxacillin, dicloxacillin and oxacillin) from cows' milk, without prior protein precip

119 fepime, piperacillin-tazobactam, ampicillin, oxacillin, gentamicin, and a combination of gentamicin/p

120 , and the inhibitors restored sensitivity to oxacillin in a highly resistant S. aureus strain.

121 d significantly enhanced MRSA eradication by oxacillin in a mouse bacteremia model.

122 t also potentiated the anti-MRSA activity of oxacillin in a synergistic fashion, resulting in an 8-fo

123 uding some showing synergistic activity with oxacillin in clinically relevant (epidemic) methicillin-

124 The oxacillin-induced changes in the chemical composition of

125 ling of the spectral data, reflective of the oxacillin-induced chemical composition changes in MSSA a

126 Live pneumococci, oxacillin-killed pneumococci, and pneumococcal cell wall

127 64.7 murine macrophages with pneumococci and oxacillin led to significantly higher inducible nitric o

128 to 2 mug/mL compared to strains with MIC of oxacillin < 1 mug/mL.

129 bh variants display increased sensitivity to oxacillin (methicillin) as well as susceptibility to com

130 reus isolates were recovered; 208 (59%) were oxacillin (methicillin) susceptible and 146 (41%) were o

131 (Ox)), use of Mueller-Hinton agar containing oxacillin (MHA(Ox)), and the use of MSA containing lipov

132 n this study, including 226 isolates with an oxacillin MIC >= 1 mug/mL and 176 isolates with an MIC <

133 outcome occurrence between patients with an oxacillin MIC >= 1 mug/mL and an MIC < 1 mug/mL (16.4% v

134 our cohort of patients with MSSA bacteremia, oxacillin MIC (i.e., >= 1 versus < 1 mug/mL) was not ass

135 point, the CLSI VET01-S2 S. pseudintermedius oxacillin MIC and disk breakpoints, and the European Com

136 No correlation was found between oxacillin MIC and vancomycin or daptomycin MIC.

137 S25 coagulase-negative Staphylococcus (CoNS) oxacillin MIC breakpoint and cefoxitin disk breakpoint,

138 presence of resistance mediated by mecA, the oxacillin MIC breakpoint for defining resistance in CoNS

139 hylococcus aureus/Staphylococcus lugdunensis oxacillin MIC breakpoints and cefoxitin disk and MIC bre

140 The rationale behind revised oxacillin MIC breakpoints for select staphylococci is di

141 This study led CLSI to adjust the oxacillin MIC breakpoints for SOSA.

142 specificity, respectively, were as follows: oxacillin MIC by broth microdilution, 94.4% and 96.7%; o

143 the primary outcome between high versus low oxacillin MIC groups among those who received ASP (22.9%

144 Phoenix system, 7 on the Vitek 2 system), an oxacillin MIC in the susceptible range was correctly cha

145 Thus, an oxacillin MIC of > or = 2 micrograms/ml indicated resist

146 eporting isolates that test resistant by the oxacillin MIC or cefoxitin disk test as oxacillin resist

147 AT demonstrated 99% agreement with MicroScan oxacillin MIC results for 388 isolates of S. aureus.

148 mmercial automated susceptibility test panel oxacillin MIC results were also evaluated and demonstrat

149 For a different four isolates, the oxacillin MIC was < or =0.25 microg/ml on the Vitek GPS

150 /ml), one isolate was inducibly resistant to oxacillin (MIC of 16 microg/ml after overnight induction

151 lococcus aureus that developed resistance to oxacillin (MIC up to 16 mug/ml).

152 ty at the stationary phase and resistance to oxacillin microaerobically; (4) YneJ, re-named here as P

153 Borderline oxacillin resistance (i.e., oxacillin MICs 1-8 mug/mL) is observed in strains hyperp

154 ed in the oxacillin agar screen method), the oxacillin MICs of 16 of the mecA-negative strains increa

155 ns of expression class 1 or 2 (demonstrating oxacillin MICs of 4 to >16 microg/ml) and 36 mecA-negati

156 The oxacillin MICs of the latter strains were 0.25 to 4 micr

157 l 61 challenge strains of CoNS for which the oxacillin MICs were 0.5 to 2 microg/ml were tested in a

158 ococcus aureus strains lacking mec for which oxacillin MICs were 1 to 8 micrograms/ml were tested aga

159 and 41 non-mecA-producing strains for which oxacillin MICs were near the susceptible breakpoint.

160 0 mug/ml) and a somewhat lower resistance to oxacillin (minimal inhibitory concentration = 200 mug/ml

161 use, each containing 4% NaCl and 6 microg of oxacillin/ml (0.6-microg/ml oxacillin was also studied w

162 en plates prepared in house with 6 microg of oxacillin/ml and 4% NaCl using the four different inocul

163 ented with 4% NaCl and containing 0.6 microg oxacillin/ml and incubation at 35 degrees C for 48 h (on

164 nitol-salt agar (MSA), use of MSA containing oxacillin (MSA(Ox)), use of Mueller-Hinton agar containi

165 susceptible strains that demonstrate MICs of oxacillin of 1 to 2 mug/mL compared to strains with MIC

166 bactam and tazobactam, the reactions between oxacillin or 6alpha-hydroxyisopropylpenicillinate (both

167 nts can be predicted from the penicillin and oxacillin or cefoxitin results.

168 Routine testing of penicillin and oxacillin or cefoxitin should be used to infer susceptib

169 lococcal beta-lactams except for penicillin, oxacillin or cefoxitin, and ceftaroline.

170 The combination of 4 with oxacillin or meropenem shows efficacy in infected mice,

171 ane domain-binding site can also accommodate oxacillin or novobiocin but not erythromycin or linezoli

172 comycin and a beta-lactam (either nafcillin, oxacillin, or cefazolin) for staphylococcal bacteremia m

173 s to identify the chemical changes caused by oxacillin over time and to determine the feasibility of

174 FP), cloxacillin (CLO), dicloxacillin (DCL), oxacillin (OXA) and phenoxymethylpenicillin (PEV), in Ma

175 (AMP), penicillin G (PG), penicillin V (PV), oxacillin (OXA), cloxacillin (CLO), dicloxacillin (DICLO

176 arried the mecA gene but were susceptible to oxacillin (oxacillin-susceptible methicillin-resistant S

177 0.04), erythromycin (P<0.0001), methicillin/oxacillin (P<0.0001), ampicillin (P = 0.01), and ceftria

178 31 of 74 [42%] ceftriaxone vs 25 of 50 [50%] oxacillin; P = .4).

179 43 of 56 [77%] ceftriaxone vs 26 of 32 [81%] oxacillin; P = .6).

180 50 of 60 [83%] ceftriaxone vs 32 of 37 [86%] oxacillin; P = .7) and >6 months (43 of 56 [77%] ceftria

181 elated beta-lactam antibiotics (amoxicillin, oxacillin, penicillin G).

182 in agar screen plates containing 6 microg of oxacillin per ml and 4% NaCl.

183 decreased 10-fold (from 6.0 to 0.6 microg of oxacillin per ml) for the agar swab screen method, fully

184 e media containing either 0.625 microgram of oxacillin per ml, 40 microgram of cephalexin per ml, or

185 reen containing 4% NaCl plus-6 micrograms of oxacillin per ml, the sensitivities in detecting the 44

186 esistance and biofilm formation in vitro and oxacillin persistence in an experimental endocarditis mo

187 fashion, resulting in an 8-fold increase in oxacillin potency, for a MIC of 16 mug mL(-1).

188 nce methods: mecA gene detection and MICs of oxacillin previously determined by broth microdilution a

189 susceptibility of Staphylococcus species to oxacillin reduced significantly (P = .002) and there was

190 Borderline oxacillin resistance (i.e., oxacillin MICs 1-8 mug/mL) i

191 ontrols) displayed significant reductions in oxacillin resistance and biofilm formation in vitro and

192 LAT provided rapid and reliable detection of oxacillin resistance and proved a useful adjunct to the

193 phenotypic and genotypic characteristics of oxacillin resistance both in vitro and in an experimenta

194 ncreasing vancomycin MICs and the changes in oxacillin resistance could be reproduced by appropriate

195 Oxacillin resistance depended on the overtranscribed S.

196 tection was reported but was correlated with oxacillin resistance in a species other than S. aureus o

197 tination test for detection of mecA-mediated oxacillin resistance in canine staphylococci.

198 were evaluated for their abilities to detect oxacillin resistance in coagulase-negative staphylococci

199 software version VTK-R07.01 for detection of oxacillin resistance in coagulase-negative staphylococci

200 d a sensitivity and specificity at detecting oxacillin resistance in CoNS at a level that was accepta

201 These results suggested that sarA regulates oxacillin resistance in mecA-positive MRSA.

202 s spp., had low sensitivity for detection of oxacillin resistance in members of the Staphylococcus in

203 acillin DD test for predicting mecA-mediated oxacillin resistance in S. aureus and CoNS.

204 foxitin DD test for predicting mecA-mediated oxacillin resistance in staphylococci and revised Table

205 usion (DD) test for predicting mecA-mediated oxacillin resistance in staphylococci was assessed durin

206 transcription of mecA, the gene required for oxacillin resistance in staphylococci, was quantified in

207 hring, West Sacramento, CA) for detection of oxacillin resistance in Staphylococcus aureus.

208 and mecA real-time PCR for the detection of oxacillin resistance in Staphylococcus aureus.

209 ) were evaluated for their ability to detect oxacillin resistance in Staphylococcus aureus.

210 n the rise along with an increasing trend of oxacillin resistance in Staphylococcus species.

211 ve and specific for detecting staphylococcal oxacillin resistance in the clinical microbiology labora

212 Major changes were observed in the oxacillin resistance phenotype of several of the isolate

213 ar dilution methods, more CoNS isolates with oxacillin resistance related to the mecA gene were detec

214 ens were also cultured on CHROMagar MRSA and oxacillin resistance screening agar base (ORSAB) and in

215 Oxacillin resistance was induced in 6 of the 10 MecA+ is

216 attributed to the Vitek 2 system overcalling oxacillin resistance.

217 tance as elsewhere in the country, including oxacillin resistance; however, the rate of fluoroquinolo

218 aboratories were able to detect methicillin (oxacillin) resistance in Staphylococcus aureus, high-lev

219 (methicillin) susceptible and 146 (41%) were oxacillin resistant (MRSA).

220 ulase-negative staphylococci tested, 81 were oxacillin resistant and 37 oxacillin susceptible by the

221 the oxacillin MIC or cefoxitin disk test as oxacillin resistant, following such guidelines produces

222 S were falsely classified as methicillin and oxacillin resistant.

223 cillin sensitive and 1 isolate was MecA- but oxacillin resistant.

224 rocedural infections from which methicillin (oxacillin)-resistant Staphylococcus aureus (MRSA) strain

225 ureus PBP2A, and was greatly overproduced in oxacillin-resistant clinical isolate S. sciuri SS37 and

226 to S. aureus PBP2A was identified in another oxacillin-resistant clinical isolate, S. sciuri K3, whic

227 3 oxacillin-sensitive S. aureus isolates, 17 oxacillin-resistant CNS, and 7 oxacillin-sensitive CNS).

228 All 249 oxacillin-resistant isolates gave strong positive reacti

229 vate dehydrogenase gene were detected in the oxacillin-resistant isolates.

230 In the St Louis area, oxacillin-resistant organisms, Pseudomonas aeruginosa, a

231 Oxacillin-resistant rates of Staphylococcus aureus and c

232 tant S. aureus (MRSA) and 27 were borderline oxacillin-resistant S. aureus (BORSA).

233 Both methods provided reliable detection of oxacillin-resistant S. aureus and facilitated the discov

234 from each of 60 staphylococcal isolates (13 oxacillin-resistant S. aureus isolates, 23 oxacillin-sen

235 for 48 h) of the methods tested revealed all oxacillin-resistant S. aureus isolates, and no growth fa

236 mmended for the detection of vancomycin- and oxacillin-resistant S. aureus.

237 Locally generated data showed that oxacillin-resistant staphylococci (57.0% overall) had sl

238 lin-susceptible staphylococci, and 97.4% for oxacillin-resistant staphylococci.

239 n-susceptible Staphylococcus aureus (14.3%), oxacillin-resistant Staphylococcus aureus (4.4%), coagul

240 Nosocomial oxacillin-resistant Staphylococcus aureus (ORSA) bloodst

241 Oxacillin-resistant Staphylococcus aureus (ORSA) is a vi

242 In the present study, 21 oxacillin-resistant Staphylococcus aureus (ORSA) isolate

243 Oxacillin-resistant Staphylococcus aureus (ORSA) was fou

244 Pure cultures were noted for 20% of oxacillin-resistant Staphylococcus aureus cultures, 9.2%

245 methods for the detection of vancomycin- and oxacillin-resistant Staphylococcus aureus in </=6 h: (i)

246 with lower susceptibility rates seen for the oxacillin-resistant strains.

247 s of antibiotics; 46.6% of CNS isolates were oxacillin-resistant, and they were more resistant to ant

248 Staphylococcus aureus breakpoints to report oxacillin results for Staphylococcus saprophyticus.

249 The oxacillin results interpreted by the VET01-S2 (disk and

250 The oxacillin-salt agar screen (OS) test, the reference brot

251 cillin resistance was confirmed by growth on oxacillin-salt screening agar.

252 s with discrepant results was done using BBL oxacillin screen agar (BD Diagnostics, Sparks, MD), oxac

253 g a blood culture pellet was compared to the oxacillin screen agar method using isolated colonies.

254 MIC by broth microdilution, 94.4% and 96.7%; oxacillin screen agar, 94.3% and 96.7%; PBP2' latex aggl

255 Those lots of oxacillin screen medium that fail to grow heteroresistan

256 ly the inoculation methods to be used in the oxacillin screen test for Staphylococcus aureus, we test

257 biology system (BD Diagnostics, Sparks, MD), oxacillin screening agar (BD Diagnostics), BBL CHROMagar

258 wo isolates that were mecA positive but were oxacillin sensitive according to conventional methods.

259 0 coagulase-negative isolates were MecA+ but oxacillin sensitive and 1 isolate was MecA- but oxacilli

260 e 10 MecA+ isolates previously classified as oxacillin sensitive.

261 isolates, 17 oxacillin-resistant CNS, and 7 oxacillin-sensitive CNS).

262 ere more resistant to antibiotics than their oxacillin-sensitive counterparts (P < .001), including f

263 3 oxacillin-resistant S. aureus isolates, 23 oxacillin-sensitive S. aureus isolates, 17 oxacillin-res

264 hylococcus aureus isolates and found that an oxacillin-sensitive/cefoxitin-resistant profile had a se

265 2 for expression of high level resistance to oxacillin, suggesting that the PBP2A homolog may prefere

266 haracterized strains of CoNS were tested for oxacillin susceptibility by the NCCLS broth microdilutio

267 rrent disk diffusion breakpoint criteria for oxacillin susceptibility for S. aureus showed a very-maj

268 Positive correlation between methicillin and oxacillin susceptibility test results and the detection

269 After screening for oxacillin susceptibility, MRSA and selected methicillin-

270 ved by AST devices was "cefoxitin resistance/oxacillin susceptibility," ranging from 54.1% (Phoenix)

271 rror rate when cefoxitin was used to predict oxacillin susceptibility.

272 change in the function of PBP2a resulting in oxacillin susceptibility.

273 i tested, 81 were oxacillin resistant and 37 oxacillin susceptible by the Vitek II assay compared wit

274 tested by agar dilution, 24 of 28 (86%) were oxacillin susceptible.

275 The GPS-SA card classified 86% of strains as oxacillin susceptible.

276 ycin resistance rates of 26.0% and 55.0% for oxacillin-susceptible and -resistant Staphylococcus aure

277 Three of the 139 oxacillin-susceptible isolates were also strongly positi

278 Ninety-two oxacillin-susceptible isolates were selected to assess t

279 The three oxacillin-susceptible isolates with strongly positive re

280 mecA gene but were susceptible to oxacillin (oxacillin-susceptible methicillin-resistant S. aureus [O

281 SA800, seven of which included both ORSA and oxacillin-susceptible S. aureus isolates.

282 amicin, and tetracycline were active against oxacillin-susceptible staphylococci (82 to 99% susceptib

283 method was 91.5% for enterococci, 99.8% for oxacillin-susceptible staphylococci, and 97.4% for oxaci

284 The predominant aerobic organisms were oxacillin-susceptible Staphylococcus aureus (14.3%), oxa

285 avancin MIC(90) values (0.19 microg/ml) than oxacillin-susceptible strains (0.125 microg/ml).

286 Oxacillin-susceptible, mecA-positive Staphylococcus aure

287 tes in AST systems based on cefoxitin and/or oxacillin testing yielded overall positive agreements wi

288 d between the response of the hemB mutant to oxacillin therapy and that of the parent strain in any t

289 In contrast, oxacillin therapy did not significantly reduce bacterial

290 invasive pneumonia and sepsis, we show that oxacillin-treated MRSA strains are significantly attenua

291 discontinued due to toxicity (9 of 50 [18%] oxacillin vs 3 of 74 [4%] ceftriaxone; P = .01).

292 and 6 microg of oxacillin/ml (0.6-microg/ml oxacillin was also studied with MH agar prepared in-hous

293 Oxacillin was ineffective for MSSA colonization in appro

294 Oxacillin was more often discontinued due to toxicity (9

295 itivity and specificity compared to those of oxacillin were 97.3% and 100%, respectively.

296 ubated for 2 h in the presence or absence of oxacillin were analyzed by flow cytometry after labeling

297 Patients receiving oxacillin were more likely to have it discontinued due t

298 Inoculum volume and induction with oxacillin were PBP 2a testing variables.

299 ratories generate disk diffusion results for oxacillin when testing S. aureus ATCC 25923 and S. pneum

300 was inhibited by the beta-lactam antibiotic oxacillin, which slowed inactivation of daptomycin and e