ライフサイエンスコーパス: oxazole

1 ity to CGI-17341 (and a related nitroimidazo-oxazole).

2 ine group into an oxazolone or (substituted) oxazole.

3 ng the distinguishing role of the activating oxazole.

4 is detailed, targeting the 5-position of the oxazole.

5 dration of which gave the desired indole bis-oxazole.

6 ed in the elaboration of RRM1 containing the oxazole.

7 oxazole and gave the macrocyclic indole bis-oxazole.

8 e > thiazole > pyrrole > imidazole > furan > oxazole.

9 from novel aryl-substituted o-vinylstyryl-2-oxazoles.

10 n of enamides to afford 2,4,5-trisubstituted oxazoles.

11 to hydroperoxides bearing the heteroaromatic oxazoles.

12 des to 2-phenyl-5-(methylthio)-4-substituted oxazoles.

13 functionalities at 4-position of the product oxazoles.

14 C-5 monosubstituted and C-4,5 disubstituted oxazoles.

15 s also observed in the case of 2-arylbenzo[d]oxazoles.

16 and can also be applied to the synthesis of oxazoles.

17 transfers to ynamides to furnish 4-amino-1,3-oxazoles.

18 ethylene position thereby affording extended oxazoles.

19 eries of reversed amides and azoles, such as oxazole, 1,2,4-oxadiazole, and 1,3,4-oxadiazole, as well

20 ethylamine give 2-substituted condensed ring oxazoles 10, 16a-c, 18a-d, 20a-c, and 25 in a new genera

21 azines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2

22 uorene 7, 2-(4-cyanophenyl)-5-(4-aminophenyl)oxazoles 14 and 20, 1,3,5-hexatrienes 24a-d and 26a-c, 1

23 eries of alpha-ketoheterocycles based on the oxazole 2 (OL-135) incorporating systematic changes in t

24 Cell incubation in a medium containing oxazole 2 resulted in the elaboration of RRM1 containing

25 r each protein studied, the incorporation of oxazole 2 strongly increased oxazole fluorescence, sugge

26 Finally, oxazole 2 was incorporated into position 13 of MreB, a b

27 66, was also expressed in cellulo containing oxazole 2; the incorporation was verified by mass spectr

28 previously unknown benzo[5,6]chromeno[8,7-d]oxazole-2,7(3H)-diones was developed based on the invest

29 ent and DBU-assisted oxidation to form D-Ala-oxazole; (2) formation of D-Val-thiazole and D-Ala-thiaz

30 Intermolecular alkylation of the aziridinyl oxazole 20 using PhSO(2)CH(2)CH(2)OTf is possible despit

31 Cyclodehydration then gave the desired oxazole 24 and deprotection followed by mesylation and e

32 Oxazole 24 demonstrated high and selective 5-LO inhibito

33 The trifluoromethyl-substituted oxazole 24 was the best compound of the oxazole series i

34 Starting from oxazole 26, a sequence of N-methylation, cyanide additio

35 hange of the core heterocycle readily led to oxazoles 28 and 29, which were confirmed as highly poten

36 amide 8a and 2-oxo-5-phenyl-N-(4-phenylbutyl)oxazole-3-carboxamide 12a, which resulted in the identif

37 (1-methyl-4-piperidyl)phenyl]-2-oxo-N-pentyl-oxazole-3-carboxamide 32b as a potent AC inhibitor with

38 nitial hits, 2-oxo-4-phenyl-N-(4-phenylbutyl)oxazole-3-carboxamide 8a and 2-oxo-5-phenyl-N-(4-phenylb

39 Oxazole 39 had excellent solubility and good oral PK whe

40 the proposed binding mode, and comparison of oxazoles 39 and 46 revealed interesting differences in o

41 Sonogashira cross-coupling between trifloyl oxazole (4) and alkynylmetal species (5).

42 One compound, 4-(benzyl-(2-[(2, 5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl)-carbamoyl)-2-decanoyla

43 zol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxa mide (PF-04802367 or PF-367) has been

44 riazol-4-yl)-2-methyl-5-(3-methylphenyl)-1,3-oxazole-4-carboxamide (ACT-389949), adding further evide

45 ighly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synth

46 Similarly, three of the serine-derived oxazole-4-carboxamides were elaborated to novel trisubst

47 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates under the same reaction condition

48 dipolar cycloaddition to give acenaph[1,2-d]oxazoles (41 and 61a,b).

49 ile ylide anti-4, which was transformed into oxazole 5.

50 ted dipeptide analogue (4) and a fluorescent oxazole (5) having amine and carboxyl groups approximate

51 A highly versatile route to oxazole-5-amides is presented.

52 4-(4-methylpiperazin-1-yl)phenyl]methyl]-1,2-oxazole-5-carboxamide} acts through a novel mechanism of

53 dramatic change of regioselectivity to give oxazole-5-carboxylates and 5-phosphonates.

54 e 4-position of alkyl 4-hydroxynaphtho[2,1-d]oxazole-5-carboxylates can be easily changed by converti

55 d transformation into 4-hydroxynaphtho[2,1-d]oxazole-5-carboxylic esters by formal insertion of the m

56 Conversion of readily accessible oxazole-5-trifluoroacetamides into their Boc-protected 5

57 Oxazole 50 was equally active in both the RPAR and guine

58 Oxazole 59 was the most active inhibitor in the human mo

59 Oxazole 9 was further characterized and exhibited improv

60 based on silver ion-assisted intramolecular oxazole alkylation and cyanide-induced ylide generation

61 tuents on the pyridine ring, implicating the oxazole alpha-hydroxy group as an active participant in

62 lulo incorporation of a strongly fluorescent oxazole amino acid (lacking an asymmetric center or alph

63 ly expressed in vitro with several different oxazole amino acids at position 66, was also expressed i

64 the heteroatom substitution position of the oxazole anchor in addition to the aryl substitution patt

65 port properties of conjugated oligomers with oxazole anchors, focusing on the role of the heteroatom

66 of pyridine at the C5 position of the 2-keto-oxazole and 2-keto-1,3,4-oxadiazole derivatives signific

67 It contains four oxazole and four thiazole rings and is representative of

68 and cyclodehydration incorporated the second oxazole and gave the macrocyclic indole bis-oxazole.

69 trategy focused on evaluating the effects of oxazole and phenyl ring replacements of the 2-(5-methyl-

70 iels-Alder reaction of an acetylene-tethered oxazole and the [4 + 3] cycloaddition of an oxyallyl.

71 Indeed, both the oxazole and the thiazole can be formed together in a one

72 Oxazole and thiazole rings are present in numerous nonri

73 iotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear arra

74 to convert serine and cysteine residues into oxazole and thiazole rings.

75 earing heterocycles of the different nature (oxazole and thiophene) as aromatic moieties have been de

76 A series of (imidazolylmethyl)oxazoles and -thiazoles were prepared and evaluated as a

77 d for the synthesis of highly functionalized oxazoles and benzofurans using an intramolecular Wittig

78 lopment of the nickel-catalyzed arylation of oxazoles and benzoxazoles with aryl halides.

79 A concise, one-pot route to oxazoles and furocoumarins has been reported.

80 -catalyzed conditions to yield imidazo[1,2-c]oxazoles and imidazo[2,1-c][1,4]oxazine heterocycles.

81 Substituted oxazoles and imidazoles are synthesized in one pot from

82 rbier coupling reactions of alpha-iodomethyl oxazoles and related thiazoles are described with samari

83 ring dicyclizations to form 2,4-concatenated oxazoles and the mild synthesis of thiazoles from natura

84 -4-(3',4',5'-trimethoxyphenyl)-5-substituted oxazoles and their related 4-substituted-5-(3',4',5'-tri

85 Oxazoles and thiazoles are commonly found moieties in no

86 ysteine residues of the precursor peptide to oxazoles and thiazoles by the McbBCD synthetase complex.

87 ine residues in a polypeptide precursor into oxazoles and thiazoles during the maturation of the Esch

88 Oxazoles and thiazoles react initially by a Criegee-type

89 ing, and cyclization to N-difluoromethylated oxazoles and thiazoles.

90 sphonium trifluoromethanesulfonate to afford oxazoles and thiazolines (oxidized to thiazoles) with hi

91 2,6-diethyl-4,8-diarylbenzo[1,2-d:4,5-d']bis(oxazoles) and four different 2,4,6,8-tetraarylbenzobisox

92 nd in P2'-cyclopropylaminobenzothiazole (or -oxazole), and/or P1-benzene ring with fluorine scan of m

93 Thiophene, oxazole, and imidazole derivatives were used as aryl moi

94 Quantum chemical analysis on the imidazole, oxazole, and thiazole derivatives of thiazole-2-amine in

95 taining two different heteroatoms isoxazole, oxazole, and thiazole on Si(111)-7 x 7 was studied.

96 aining two different heteroatoms (isoxazole, oxazole, and thiazole) and of the aromatic molecules con

97 thods for the synthesis of analogues of this oxazole- and thiazole-containing cyclic peptide have bee

98 therefore, we designed and synthesized model oxazole- and thiazole-peptides and measured their (1)O(2

99 Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic aci

100 The oxazole antagonists exhibited significant reductions in

101 Thiazole and oxazole are particularly common constituents of naturall

102 the ester moiety with a 5-ethyl-substituted oxazole as in compound 14.

103 such as pyrroles, pyridines, thiazoles, and oxazoles, as well as other relevant organic derivatives,

104 Metalation of oxazoles at the 4 and 5 position was achieved after regi

105 lation is enabled under gold catalysis by an oxazole-based directing group optimally tethered to a le

106 rphyrinoid generates three pyrrole-modified, oxazole-based porphyrins: the known porpholactol (2-oxa-

107 ions with benzene and related substrates, an oxazole-based superelectrophile is found to be significa

108 When the oxazole-based superelectrophile is reacted with ferrocen

109 and electronic properties of these benzobis(oxazole) (BBO) compounds was evaluated.

110 Various 2,5-disubstituted oxazoles bearing aryl, vinyl, alkyl, and heteroaryl subs

111 BODIPY fluorophore has been conjugated to an oxazole-benzamide FtsZ inhibitor.

112 A cascade oxazole-benzannulation for the synthesis of naphtho[2,3-

113 bute the activity boost upon substitution of oxazole by oxadiazole to reduced steric interactions in

114 lize the high potency and selectivity of the oxazoles by molecular modeling and docking.

115 s are converted into four thiazoles and four oxazoles by the three subunit Microcin B17 synthetase.

116 side chain of 2 (OL-135) and representative oxazole C5 substituents were prepared and examined as in

117 NRP heterocyclizations to thiazoles and oxazoles can occur on the elongating framework of acyl-S

118 Oxazole chemisorbs on Si(111)-7 x 7 through both dative-

119 polymer in the synthesis of a small array of oxazole compounds has been demonstrated.

120 rocycles, a class of molecules that includes oxazoles, constitute one of the most common building blo

121 ansfer approach allows the generation of 1,3-oxazoles containing a variety of sulfonyl-protected alky

122 ed method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is desc

123 Featured in this set are the oxazole-containing hamigeran M (4) and eight compounds (

124 Oxazole-containing macrocycles represent a promising cla

125 general feature of the interactions between oxazole-containing macrocyclic ligands (including telome

126 An efficient assembly and union of the oxazole-containing side chain 4 with macrolide 3 was car

127 ide analogues that contain variations in the oxazole-containing side chain and in the macrolide core

128 hich directly converts isoxazoles into their oxazole counterparts via a photochemical transposition r

129 pyrimidin-5-yl)methyl)piperazin-1-yl)benzo[d]oxazole, demonstrated a correlation between compound per

130 analysis of crystals of 4 and an acetylated oxazole derivative of 5 (6) confirm the proposed structu

131 ation of which produced a macrocyclic indole-oxazole derivative.

132 es of furanone series containing benzene and oxazole derivatives as aryl residues has been carried ou

133 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculo

134 have been developed for selective generating oxazole derivatives which are privileged building blocks

135 The oxazole-directed C-H borylation-oxidation was unpreceden

136 -H metalation-Negishi coupling, a late-stage oxazole-directed C-H borylation-oxidation, and one elect

137 ithiane-epoxide union in conjunction with an oxazole-directed stereoselective reduction.

138 cessing structurally unique ionic pyridinium-oxazole dyads (PODs) with tunable emission wavelengths.

139 5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (ezutromid, 1) is a first-in-class utrophin modu

140 ncorporation of oxazole 2 strongly increased oxazole fluorescence, suggesting its potential utility a

141 Introduction of the oxazole fluorophore 5 into dihydrofolate reductase or gr

142 chanistic considerations rationalize kinetic oxazole formation over the more customary triazine or py

143 r rhodium carbene N-H insertion, followed by oxazole formation to give (S)-2-[1-tert-(butoxycarbonyla

144 ng three contiguous stereocenters, a modular oxazole formation, a flexible cross-metathesis approach

145 ymmetric ortholithiation strategy, a modular oxazole formation, and a late-stage Z,Z-selective Suzuki

146 and (2) a chemoselectivity for thiazole over oxazole formation.

147 Various approaches to the indole bis-oxazole fragment of the marine secondary metabolite diaz

148 ve, densely functionalized 2,4-disubstituted oxazole fragment was constructed using an efficient Negi

149 a series of functionalized 2,5-disubstituted oxazoles from propargylic amides is reported.

150 ated for the synthesis of highly substituted oxazoles from readily accessible ynamides in the presenc

151 acile preparation of mono- and disubstituted oxazoles from these TosMIC reagents and aldehydes is des

152 hydrocyanation of terminal olefins in which oxazoles function as nitrile equivalents.

153 substituted phenyl rings containing terminal oxazole groups with the same chemical constitution on bo

154 heteroatom substitution position in terminal oxazole groups.

155 The first practical C-2 protecting group of oxazoles has been demonstrated.

156 ethod for the synthesis of 4,5-disubstituted oxazoles has been developed directly from carboxylic aci

157 nnulation for the synthesis of naphtho[2,3-d]oxazoles has been developed employing ortho-alkynylamido

158 igo(ethylene glycol) chain, and a switchable oxazole heterocycle in the same covalent skeleton.

159 a coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone.

160 ne cluster for the synthesis of thiazole and oxazole heterocycles on ribosomally produced peptides.

161 From the best performing oxazoles, HUP-55 was selected for in vivo studies.

162 For example, an oxazole hydroxamate inhibits HDAC6 with an IC50 of 59 nM

163 A new set of end-cap heterocycle dimers, oxazole-hydroxybenzimidazole (No-Hz) and chlorothiophene

164 ibutions in the regions of space surrounding oxazole, imidazole, and thiazole are used to investigate

165 sting of para-linked phenylenes connected to oxazole, imidazole, or nitro-substituted pyrrole.

166 ntage over reported procedures includes that oxazoles, imidazoles, benz(ox/othi/imid)azoles, and indo

167 s delivered 2-substituted naphtho[1,2-d][1,3]oxazoles in a single synthetic operation.

168 nucleophiles provided the highly substituted oxazoles in good yields.

169 ses the regioselectivity to give 5-amino-1,3-oxazoles, in comparison with the previously reported syn

170 ecreases in the order thiazole > imidazole > oxazole; in combination with previous results on furan,

171 c 1,2,4-oxadiazoles 10, 1,3,4-thiadiazoles > oxazoles including 2 > 1,2-diazines > thiazoles > 1,3,4-

172 A second approach to an indole bis-oxazole involved an intermolecular rhodium carbene N-H i

173 o-step synthesis of 2-phenyl-4,5-substituted oxazoles involving intramolecular copper-catalyzed cycli

174 2,4-Oxazole is an important structural motif in various natu

175 The formation of the oxazole is believed to result from an intramolecular cyc

176 l, and 5-heterosubstituted 2-(1-normon-2-yl) oxazoles is described.

177 ne-catalyzed synthesis of highly substituted oxazoles is presented.

178 convergent access to densely functionalized oxazoles is realized in a functional-group tolerant mann

179 idazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole) is most commonly mediated by loss of a specific

180 such as thiophene, furan, pyridine, indole, oxazole, isoxazole, and benzoxazole, are effective in th

181 A 1,3-oxazole KRM-II-81 (9) was discovered from a series of si

182 Instead, binding of the cyclic oxazole L2H2-6M(2)OTD was accompanied by the uptake of o

183 -2-yl)pyridine (L5), 2-(pyridin-2-yl)benzo[d]oxazole (L6), or 2,2'-dibenzo[d]thiazole (L7) are report

184 s for the synthesis of gamma-butenolides and oxazoles, leveraging Tf(2)O's promoted reactivity of nit

185 sis, and application of a novel bifunctional oxazole linchpin; and Stille coupling of a C(28) trimeth

186 w that conjugated molecules with homogeneous oxazole linkages obey a quantum circuit rule such that G

187 rein we report the repurposing of a thiazole/oxazole-modified microcin (TOMM) cyclodehydratase to sit

188 Listeriolysin S (LLS) is a thiazole/oxazole-modified microcin (TOMM) produced by hypervirule

189 of orthologous enzymes involved in thiazole/oxazole-modified microcin biosynthesis, a rapidly growin

190 Thiazole/oxazole-modified microcins (TOMMs) are a class of post-t

191 The thiazole/oxazole-modified microcins (TOMMs) represent a burgeonin

192 first compound discovered from the thiazole/oxazole-modified microcins family and the linear azole-c

193 ery of new related compounds in the thiazole/oxazole-modified microcins/linear azole-containing pepti

194 rrole groups in meso-tetraphenylporphyrin by oxazole moieties is described, generating inter alia the

195 porphyrin-like chromophore) or (substituted) oxazole moiety (chlorin-like chromophore with, for the p

196 ty (IC(50) > 10 muM), implying that both the oxazole moiety and the phosphate group are necessary for

197 Photooxidation of the oxazole moiety in 1 gave enigmimide B (4), thus establis

198 le moiety of meso-tetraarylporphyrin 1 by an oxazole moiety is described.

199 dification of the series revolved around the oxazole moiety to increase the hydrophilicity of the com

200 ure that involves the annelation of the [1,2]oxazole moiety to the isoindole ring, producing derivati

201 nd an acyclic portion that spans an embedded oxazole moiety.

202 prises a 23-membered macrocycle, an embedded oxazole motif, and a macrolactone with a unique ene-thio

203 Bioassay-guided fractionation identified two oxazole natural products with selective activity against

204 Upon methylation of the oxazole nitrogen atom, the substrates underwent rapid in

205 n of an additional heteroatom at position 4 (oxazole numbering, N > O > CH) substantially increases a

206 arts: (1) Synthesis of functionalized alkyne oxazoles of type 5; (2) intramolecular Diels-Alder/retro

207 repared by the base-promoted ring-opening of oxazoles, offering an alternative to the conventional fo

208 Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly genera

209 oselectivity can be controlled toward either oxazole or benzofuran derivatives.

210 Depending on the substitution pattern on the oxazole or oxazoline moieties, mono- and dioxabacterioch

211 y efficient, and affords C4-C5 disubstituted oxazoles or imidazoles in a single operation.

212 ues, containing the heme-ligating imidazole, oxazole, or pyridine group instead of the thiazole moiet

213 iumboranes and 2-aminopyridines, imidazoles, oxazoles, or isoxazoles leads to the incorporation of th

214 roducts decorated with thiazoles and (methyl)oxazoles originating from cysteines, serines, and threon

215 rst time as an intermediate in the isoxazole-oxazole photoisomerization.

216 al synthesis of galmic, the synthesis of its oxazole precursors, the coupling of the building blocks

217 A series of various di- and trisubstituted oxazole products bearing different appendages including

218 Weinreb amides to provide exclusively 2-acyl oxazole products.

219 ttached CF(3)-group for the formation of the oxazole products.

220 iophene, furan, indole, imidazole, thiazole, oxazole, pyrazole) have been involved into this process,

221 In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of n

222 12 model compounds were determined at pH 7: oxazoles react 2 orders of magnitude faster (k(O(3)) = 9

223 The oxazole reactions are especially efficient and are used

224 l)carbodiimide hydrochloride (EDCI)-mediated oxazole rearrangement that affords quaternary 5,5-(aryl,

225 d of the expected substituted 2-aminobenzo[d]oxazoles, relatively stable ring-opened oxyphosphonium b

226 ysteine and serine residues to thiazoles and oxazoles, respectively, within the 69 aa McbA structural

227 cysteines and four serines to thiazoles and oxazoles, respectively.

228 four Ser residues to four thiazoles and four oxazoles, respectively.

229 kylamino groups in the fifth position of the oxazole ring (29 examples; up to 88% yields).

230 Opening of the oxazole ring and deoximation reaction give a facile acce

231 moothly with the carboxamide en route to the oxazole ring by a P,N- or P,S-bidentate ligand such as M

232 ised that allows for the introduction of the oxazole ring either late in the synthetic sequence via a

233 que functional groups including a conjugated oxazole ring, a bromine substituent, and an alpha-hydrox

234 titution pattern at positions 4 and 5 of the oxazole ring, where the aryl group in position 5 deactiv

235 mbered phosphomacrolides, while 4 and 5 were oxazole ring-opened congeners.

236 e biphenylsulfonamide is substituted with an oxazole ring.

237 s followed by sequential construction of two oxazole rings in the presence of copper catalyst.

238 compounds to generate up to six of the seven oxazole rings of the antibiotic.

239 cy of occurrence is because the thiazole and oxazole rings originate from cysteine, serine, and threo

240 diazocarbonyl compounds to generate the four oxazole rings, which demonstrates the power of rhodium c

241 drated amino acids, and multiple thiazole or oxazole rings.

242 ent in preMccB17 into four thiazole and four oxazole rings.

243 d biological evaluation of a novel series of oxazole RTAs with high potency, excellent oral bioavaila

244 The indole-oxazole scaffold is found in a range of biologically act

245 e a highly divergent synthesis of the indole-oxazole scaffold via a one-pot Friedel-Crafts/Robinson-G

246 uted oxazole 24 was the best compound of the oxazole series in both the ex vivo (6 h pretreated rats)

247 Our results show that oxazole serves as an efficient anchor group to form stab

248 of each other, neither the macrolide nor the oxazole side chain substituents of neopeltolide can inhi

249 A convergent route to the oxazole side chain was developed using a Sonogashira cro

250 Multiple oxazole skeletons in the aryl periphery are constructed

251 with the formation of the 2,4-disubstituted oxazole, so this was synthesized via a modified approach

252 d C(1-28) macrocyclic iodide with a C(29-46) oxazole stannane side chain to establish the complete ph

253 onging to three different chemical families, oxazoles, strobilurins and triazoles, in water and fruit

254 Just as significantly, the nature of the C5 oxazole substituent substantially impacts the selectivit

255 nt effect in which electron-withdrawing meta-oxazole substituents increased inhibitor potency.

256 With simple and small C5 oxazole substituents, each series bearing a biphenylethy

257 S data analyses, which established 1-3 to be oxazole-substituted 18-membered phosphomacrolides, while

258 After an initial hydroarylation process, the oxazole substructure was deconstructed using a [4 + 2]/r

259 and subsequent introduction of the terminal oxazole subunit.

260 d (1)O(2)) were observed during ozonation of oxazoles, suggesting that all oxygen atoms from ozone ar

261 group in five-position of the benzothiazole/oxazole system could achieve such a gain in selectivity

262 substituents on the 2-phenyl portion of the oxazole tail increased the ex vivo potency of these inhi

263 trate that a synthetic G4 ligand, Y2H2-6M(4)-oxazole telomestatin derivative (6OTD), limits the growt

264 Three prominent SM ligands (an oxazole telomestatin derivative, pyridostatin, and PhenD

265 Telomestatin and oxazole telomestatin derivatives (OTD) are some of the m

266 nt methods that provide access to the indole-oxazole template are relatively scarce, which impedes th

267 nonequivalent constitutions (i.e., O(4)O(5) oxazole terminal linkages) show unexpectedly higher cond

268 ese results suggest that charge transport in oxazole-terminated molecules is determined by the hetero

269 observe quantum interference (QI) effects in oxazole-terminated phenylene molecular junctions, includ

270 ), also binds and activates another cyanine, oxazole thiazole blue (OTB), giving two well-resolved em

271 he design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I

272 eterocycles including pyridines, imidazoles, oxazoles, thiazoles, isoxazoles, and pyrazoles.

273 key steps, a diverse set of trifluoromethyl-oxazoles, -thiazoles, -imidazoles, -1,2,4-triazines, and

274 A facile synthesis of 2,4,5-trisubstituted oxazoles through an oxidative, copper-catalyzed, and sol

275 was coupled to another diazocarbonyl-derived oxazole to give the corresponding biaryl, deprotection a

276 n studies showed the ability of the new [1,2]oxazoles to arrest cells in the G2/M phase in a concentr

277 lecular photocyclization in 2-(2-vinylstyryl)oxazoles to form benzo[f]quinoline derivatives proceeds

278 at C2 is viable from the most acidic (benzo)oxazoles to moderately acidic (benzo)thiazoles, as well

279 ion of propargylic stannanes with 5-iodo-1,3-oxazoles to produce 1,1-disubstituted allenes (11).

280 lized the binding site of the benzothiazoles/oxazoles to the CaM-BD/CaM interface and then used compu

281 g of a C(28) trimethyl stannane with a C(29) oxazole triflate.

282 modeling, we suggest that all benzothiazole/oxazole-type KCa activators bind relatively "deep" in th

283 conditions (dioxane, 105 degrees C) or into oxazoles under noncatalytic thermolysis (o-dichlorobenze

284 eral approach toward 2-thiophenylsubstituted oxazoles using aziridination of a double bond of (acyl)a

285 a one-pot synthesis of 2,4,5-trisubstituted oxazoles via a Friedel-Crafts/Robinson-Gabriel synthesis

286 talyzed oxidative cyclization of enamides to oxazoles via vinylic C-H bond functionalization at room

287 e exclusive formation of trifluoromethylated oxazoles (vide infra).

288 thyl-1,3-oxazolidin-2-yl]phenoxy]heptyl]-1,2-oxazole (W84) and gallamine.

289 bstrates the formation of naphtho[1,2-d][1,3]oxazoles was also observed.

290 s of pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles was synthesized for the treatment of hyperproli

291 d 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology.

292 expected tripeptide product, 2,5-substituted oxazoles were isolated when O-tert-butyl protected N-hyd

293 he corresponding 2-alkyl-5-aryl- substituted oxazoles were obtained in up to 80% yield via a decarbox

294 All of the o-vinylstyryl-2-oxazoles were synthesized by a multicomponent Wittig rea

295 t on its aromaticity, which is very minor in oxazole, when compared to furan, and small but noticeabl

296 oice of strategy to synthesize naphtho[2,3-d]oxazoles with a great variety of substituents.

297 lly efficient synthesis of 2,5-disubstituted oxazoles with broad substrate scope.

298 tion generating cyclopenta[2,3]pyrrolo[2,1-b]oxazoles with good yields and excellent diastereoselecti

299 Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the correspond

300 ing block by regiocontrolled "click-unclick" oxazole-ynone Diels-Alder cycloaddition/cycloreversion a