ライフサイエンスコーパス: oxazolidinone

1 ne enolate equivalent of 4-benzyl-N-glycinyl oxazolidinone".

2 h the aromatic ring directly attached to the oxazolidinone.

3 i-conjugating substituent is proximal to the oxazolidinone.

4 ative fashion, releasing each monomer as a 2-oxazolidinone.

5 lowed by efficient resolution using a chiral oxazolidinone.

6 -to-U mutation, also conferred resistance to oxazolidinone.

7 r insertion reaction to produce 5,5-dimethyl oxazolidinone.

8 ce is not blocked by the substituents on the oxazolidinone.

9 boron enolates to enals using the same Evans oxazolidinones.

10 ing expansion to a mixture of cis- and trans-oxazolidinones.

11 of Rh2(OAc)4, providing mannosamine 2-N,3-O-oxazolidinones.

12 onventional acetamide functionality found in oxazolidinones.

13 icant role in the mechanism of action of the oxazolidinones.

14 acterial peptides and a new class of agents, oxazolidinones.

15 of the intermediate (R)-5-(hydroxymethyl)-2-oxazolidinones.

16 blocks: 4-oxazolin-2-ones and 4-methylene-2-oxazolidinones.

17 carbamates, thiocarbamates, hydantoins, and oxazolidinones.

18 ted together with isomerization rates of the oxazolidinones.

19 g pyridines, quinolines, pyrrolidinones, and oxazolidinones.

20 ty for 92 isolates tested) and linezolid, an oxazolidinone (100% susceptibility for 41 isolates teste

21 23 and 54, prepared from epoxy alcohol 9 via oxazolidinones 15 and 51, respectively, underwent ring-c

22 ,5-dibenzyloxy-2-fluorobenzaldehyde with the oxazolidinone 2, a chiral glycine equivalent.

23 n anti-selective aldol addition of propionyl oxazolidinone 28 to angelic aldehyde 27, followed by a H

24 oxy)phenylmagnesium bromide and CuCN to acyl oxazolidinone 50 was developed (85% yield, only the requ

25 old were synthesized starting from Seebach's oxazolidinone 6 and were subsequently employed in asymme

26 stereoselective ring contraction to provide oxazolidinone 6.

27 Oxazolidinones 6 and 8 exhibit MIC90 values of 0.50 micr

28 Oxazolidinones 7-10 undergo stereoselective lithiation-s

29 n of bioisosteric replacements for the usual oxazolidinone A-ring.

30 The oxazolidinones, a new chemical class of synthetic antimi

31 The mechanism of oxazolidinone action and the precise location of the dru

32 The exact site and mechanism of oxazolidinone action has not been elucidated.

33 To localize the site of oxazolidinone action in the living cell, we have cross-l

34 vitro have complicated the understanding of oxazolidinone action.

35 ructural basis for the discovery of improved oxazolidinones active against emerging drug-resistant cl

36 Further functionalization of 4-methylene-2-oxazolidinones afforded substituted indoles and heterocy

37 actory for reaction of the chiral N-acylated oxazolidinone, affording (2S,3S)-2-(3-((tert-butyldiphen

38 This annotation describes a novel oxazolidinone agent, (S)-5-((isoxazol-3-ylamino)methyl)-

39 tion of CuF(2)/DTBP-catalyzed N-arylation of oxazolidinones, amides, amines, and azoles has been expl

40 none (AOZ) and 3-amino-5-morpholino-methyl-2-oxazolidinone (AMOZ) side-chains of furazolidone and fur

41 lidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), 1-aminohydantoine (AHD), semicarba

42 Three oxazolidinone analogues (3e, 8d, and 8o) were identified

43 ith regard to the synthesis of antibacterial oxazolidinone analogues of the Zyvox antimicrobial famil

44 The salient structural feature of these oxazolidinone analogues, 6 (U-100480), 7 (U-101603), and

45 a potent survival advantage conferred by the oxazolidinone and called into question the use of glycop

46 ields from commercially available 4-benzyl-2-oxazolidinone and N-Boc-glycine.

47 of sialyl phosphates suggest that the 4O,5N-oxazolidinone and the 4,5-O-carbonate systems influence

48 in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the

49 iscrepancy between the Evans' boron-mediated oxazolidinone and the Crimmins' titanium-mediated oxazol

50 nyls in 0.5 mol % loading and N-arylation of oxazolidinones and amides with aryl iodides in 8 mol % l

51 Apart from the oxazolidinones and cationic peptides, the remainder of t

52 in revealed partial cross-resistance between oxazolidinones and chloramphenicol; no cross-resistance

53 excellent regioselectivity and converted to oxazolidinones and dihydrofurans.

54 ends of the enamine formation rates from exo-oxazolidinones and endo-oxazolidinones upon variation of

55 ic glycopeptides, quinupristin-dalfopristin, oxazolidinones and everninomycins.

56 ibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766,

57 f the pharmacologically important 4-benzyl-2-oxazolidinones and in the case of penicillamine.

58 ABSSSI) and represent the next generation of oxazolidinones and lipoglycopeptides.

59 fluences only the isomerization rates of the oxazolidinones and not the enamine formation rates, whic

60 The corresponding oxazolidinones and thiazolidine-2-thiones were obtained

61 aracter of titanium(IV) enolates from N-acyl oxazolidinones and thiazolidinethiones.

62 Ring closure gave the oxazolidinone, and successive deprotection concluded an

63 and tertiary lactams, 2-imidazolidinones, 2-oxazolidinones, and succinimides) to the cumyloxyl radic

64 other heterocycles such as delta-lactams, 2-oxazolidinones, and tetrahydrofurans.

65 Additionally, the arylation of sulfonamides, oxazolidinones, and ureas is reported.

66 ring the course of our investigations in the oxazolidinone antibacterial agent area, we have identifi

67 of new nitrogen-carbon-linked (azolylphenyl)oxazolidinone antibacterial agents has been prepared in

68 Tedizolid is a novel oxazolidinone antibacterial drug designed to provide enh

69 Tedizolid, a novel oxazolidinone antibacterial with potent activity against

70 The oxazolidinone antibacterials target the 50S subunit of p

71 Here we have identified the oxazolidinone antibiotic linezolid as a Nlrp3 agonist th

72 Recent data suggest that the oxazolidinone antibiotic linezolid decreases IFN-gamma a

73 osphate is the second commercially available oxazolidinone antibiotic, although the first one in clas

74 raocular injection of linezolid, a synthetic oxazolidinone antibiotic, was performed in rabbits to as

75 Oxazolidinone antibiotics inhibit bacterial protein synt

76 Oxazolidinone antibiotics, an important new class of syn

77 A new representative of oxazolidinone antibiotics, linezolid, was found to be ac

78 Kits were available for 3-amino-2-oxazolidinone (AOZ) and 3-amino-5-morpholino-methyl-2-ox

79 ites investigated were as follows: 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazol

80 several mechanisms involving iminium and/or oxazolidinone are proposed.

81 The oxazolidinones are a new chemical class of synthetic ant

82 The oxazolidinones are a new class of synthetic antibacteria

83 Oxazolidinones are a novel class of synthetic antibacter

84 The 3-aryl-2-oxazolidinones are a relatively new class of synthetic a

85 antibacterial agents such as rifamycins and oxazolidinones are designed to overcome both quinolone-s

86 A range of oxazolidinones are furnished in good yields (avg 63%) an

87 The oxazolidinones are one of the newest classes of antibiot

88 Oxazolidinones are potent inhibitors of bacterial protei

89 Cephalosporins and oxazolidinones are potential candidates for expanding th

90 N-Acyl-2-oxazolidinones are ring-opened by lithium iodide and dec

91 ly defined methyl-2-pyrrolidinone and methyl oxazolidinone as the P1'-ligands.

92 s a nucleophile-assisted anti elimination of oxazolidinones as a major enamine formation pathway.

93 of enamine formation and clarify the role of oxazolidinones as nonparasitic intermediates in proline

94 and asymmetric aldol reactions using chiral oxazolidinones as the key steps.

95 Chiral oxazolidinone auxilaries are effective in controlling th

96 Most applications of chiral oxazolidinone auxiliaries in asymmetric synthesis operat

97 Chiral oxazolidinone auxiliaries provide essentially complete c

98 Chiral oxazolidinones auxiliaries were found to be effective fo

99 sing an oxyallyl containing a (R)-4-phenyl-2-oxazolidinone auxiliary (2(Ph)), under either thermal or

100 on of an alpha-side chain, and the use of an oxazolidinone auxiliary provided excellent diastereocont

101 azones bearing different substituents on the oxazolidinone auxiliary were compared; consistently high

102 istribution depended on the structure of the oxazolidinone auxiliary, substituent on the enolate, and

103 R spectroscopic and computational studies of oxazolidinone-based lithium enolates-Evans enolates-in t

104 gy has also been applied to the synthesis of oxazolidinone-based marketed drugs, including Rivaroxaba

105 Oxazolidinone-based sodiated enolates (Evans enolates) w

106 the discovery of an alternative mechanism of oxazolidinone-based stereocontrol that does not require

107 Oxazolidinones bearing a (pyridin-3-yl)phenyl moiety (e.

108 of N-acyl-imides, N-acyl-lactams, and N-acyl-oxazolidinones bearing five- and six-membered rings usin

109 The model suggests that oxazolidinones bind between the P- and A-loops, partiall

110 CHL and oxazolidinones bind to the ribosomal peptidyl transfer c

111 The evidence suggests that a specific oxazolidinone binding site is formed in the translating

112 The structure and exact location of the oxazolidinone binding site remain obscure, as does the m

113 A mutants G2032A and G2447A are resistant to oxazolidinones both in vitro and in vivo with the latter

114 rgies (BDE) of the complexed and uncomplexed oxazolidinone bromide suggest that complexation lowers t

115 pi-conjugating substituent is distal to the oxazolidinone but decreased steric interaction when the

116 Complexation of the acylated oxazolidinone by n-Bu2BOTf was too rapid to monitor, as

117 m the E isomer of the oxyallyl (in which the oxazolidinone C horizontal lineO and oxyallyl oxygen are

118 catalyzed radical chloroalkylation of N-acyl oxazolidinones capitalizing on valence tautomerism of ti

119 functional groups--ester, epoxide, sulfone, oxazolidinone, carbamate, and sulfamate--are found to en

120 the erythronolide core provided a series of oxazolidinone carbamates that were equally as active as

121 pha-alkoxy group rather than the more distal oxazolidinone carbonyl in the complex and enolate.

122 y orientation such that in one conformer the oxazolidinone carbonyl is oriented toward the OH of the

123 substituted and terminal alkenes using Shi's oxazolidinone catalyst, the asynchronicity of the epoxid

124 ts of the type 2 IMDA reaction incorporating oxazolidinone chiral auxiliaries have been evaluated.

125 symmetric Diels-Alder reactions using Evans' oxazolidinone chiral auxiliary furnished a high level of

126 Comparison of the Ki values for oxazolidinones, chloramphenicol, and sparsomycin reveale

127 Linezolid, the first antimicrobial of the oxazolidinone class, has met with more widespread use an

128 Oxazolidinones comprise an important class of antibacter

129 dation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated.

130 f various olefins with an N-aryl-substituted oxazolidinone-containing ketone as catalyst and hydrogen

131 utyrolactones, using the N-tolyl-substituted oxazolidinone-containing ketone as catalyst and Oxone as

132 The chiral auxiliary, 4-diphenylmethyl-2-oxazolidinone, controlled the stereoselectivity in both

133 terial agents but, with the exception of the oxazolidinone core, no new scaffolds have emerged in the

134 and aryl amides (as well as a lactam and a 2-oxazolidinone) couple with unactivated secondary (and hi

135 The oxazolidinone cross-linked specifically to 23 S rRNA, tR

136 clusive synthesis of either N-Boc, O-Boc, or oxazolidinone derivatives.

137 xcellent torquoselectivities obtained in the oxazolidinone-directed Nazarov cyclization suggest that

138 Steady-state kinetic analysis shows that oxazolidinones display a competitive inhibition pattern

139 onent of the ribosomal peptidyl transferase, oxazolidinones do not inhibit peptide bond formation, an

140 id tests during the clinical-trial phases of oxazolidinone drug development in order to ensure test a

141 ents (Wittig rearrangements) of alpha-alkoxy oxazolidinone enolates are described.

142 with lithium enolates derived from acylated oxazolidinones (Evans enolates) are described.

143 or allylation of a silylenolate of an N-acyl oxazolidinone; excellent enantioselectivities and yields

144 ne derivatives that are incapable of forming oxazolidinones exhibit no rate enhancement in the presen

145 The oxazolidinone family is a new class of synthetic antibio

146 xycarbonylaryl isocyanates formed a bicyclic oxazolidinone, followed by a sequence of intramolecular

147 verted in a one pot manner to functionalized oxazolidinones following a regio- and stereoselective ox

148 TBI-223, a novel oxazolidinone for tuberculosis, is designed to provide i

149 eagents with nonracemic N-enoyl-4-phenyl-1,3-oxazolidinones for the preparation of 1,3-syn-dimethyl a

150 luoromethyl groups at the phenyl ring of the oxazolidinone fragment are the most potent in each serie

151 xploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substit

152 e-scale syntheses of 3-(cycloprop-2-en-1-oyl)oxazolidinones from acetylene and ethyl diazoacetate are

153 pecific synthesis of vicinally substituted 2-oxazolidinones from alpha,beta-unsaturated lactams using

154 C-H oxidation reaction for the synthesis of oxazolidinones from simple N-Boc amines is reported.

155 Ester and oxazolidinone functions direct the addition of a variety

156 cular cross-coupling of N-aryl-4-methylene-2-oxazolidinones furnished a series of oxazolo[3,4-a]indol

157 thers via the acid-catalyzed ring-opening of oxazolidinone-fused aziridines with alcohols.

158 f allyl azidoformates to construct aziridine/oxazolidinone-fused bicyclic structures.

159 It is found that a trans-fused 4O,5N-oxazolidinone group stabilizes the equatorial glycoside,

160 renine substrate led to the discovery of the oxazolidinone GSK180 as a potent and specific inhibitor

161 metric synthesis of (5S)-(acetamidomethyl)-2-oxazolidinones has been developed and is employed for th

162 the structure-activity relationships of the oxazolidinones have been conducted at Pharmacia.

163 stly, a method for the preparation of chiral oxazolidinone heterocycles from chiral epoxy alcohols is

164 razic acid 9 moieties were obtained by Evans oxazolidinone imide enolate alkylation and hydrazination

165 e free radical atom transfer reactions of an oxazolidinone imide substrate, 1, derived from alpha-bro

166 or clinical use include linezolid, the first oxazolidinone in clinical use, daptomycin, the first lip

167 Tedizolid phosphate is a novel oxazolidinone in development for the treatment of ABSSSI

168 ed enolization of (+)-4-benzyl-3-propionyl-2-oxazolidinone in THF-hydrocarbon mixtures shows unusual

169 se latter compounds undergo cyclization to 2-oxazolidinones in MeOH.

170 erivatives to identify the site of action of oxazolidinones in the ribosomes of bacterial and human c

171 terial properties of a series of piperazinyl oxazolidinones in which the distal nitrogen of the piper

172 The antibiotics chloramphenicol (CHL) and oxazolidinones, including linezolid (LZD), are known to

173 Many oxazolidinones, including linezolid (marketed as Zyvox),

174 We propose that oxazolidinones inhibit bacterial protein biosynthesis by

175 Here we show that various oxazolidinones inhibit ribosomal peptidyltransferase act

176 We found that oxazolidinones inhibit translation of natural mRNA templ

177 Oxazolidinones interact with the A site of the bacterial

178 utagenesis, and structural data suggest that oxazolidinones interfere with initiator fMet-tRNA bindin

179 orms an N-protonated enamine species from an oxazolidinone intermediate accounts for the experimental

180 raction between the bifunctional urea and an oxazolidinone intermediate to increase the rate of enami

181 S ribosomal subunit allows for docking of an oxazolidinone into a proposed binding pocket.

182 ally pure biaryl atropisomers using a benzyl oxazolidinone is disclosed.

183 That is, the oxazolidinone is made to adopt a specific, coplanar conf

184 ibenzothiphene sulfilimine confirms that the oxazolidinone is the major product with an estimated yie

185 This paper describes a new class of chiral oxazolidinone ketone catalyst for asymmetric epoxidation

186 chem has been used to optimize new azole and oxazolidinone leads.

187 N-acylation of the sugar oxazolidinones led to alpha-selective glycosyl donors fo

188 tion, the crystal structure of the canonical oxazolidinone, linezolid, has been determined bound to t

189 deformylase inhibitors, and new lincosamide, oxazolidinone, lipopeptide and cephalosporin derivatives

190 re was established using two (4R)-4-benzyl-2-oxazolidinone-mediated boron aldol reactions.

191 etamide, pyrrolidinone, imidazolidinone, and oxazolidinone moieties at P2 are the most potent with K(

192 form a new chemotype by virtue of an unusual oxazolidinone moiety and exhibit specific antibiosis aga

193 The majority of the ligands incorporate the oxazolidinone moiety as a novel polar head, and the natu

194 s between the substituents on enynes and the oxazolidinone moiety of the ketone catalyst are importan

195 en the alkyne group of the substrate and the oxazolidinone moiety of the ketone catalyst as well as t

196 data were used to model the position of the oxazolidinone molecule within its binding site in the pe

197 prepared to explore the potential of these 4-oxazolidinone natural products as antimicrobial agents.

198 Neither the oxazolidinones nor chloramphenicol stimulated misincorpo

199 noglycosides, vancomycin, lipoglycopeptides, oxazolidinones, novel tetracycline-derivatives, and dapt

200 could arise from further modification of the oxazolidinone nucleus.

201 The oxazolidinone of the N-acetyl-5-N,4-O-carbonyl protected

202 ed diastereotopic faces (by virtue of chiral oxazolidinone) of the enecarbamates exhibit distinct dif

203 Incorporating an oxazolidinone on the scaffold mitigated toxicological is

204 oxazolidinones were converted separately to oxazolidinone-opened derivatives 28alpha and 28beta.

205 a-(N-carbamoyl) allenes can be cyclized to 2-oxazolidinones or deprotected to afford the free amines

206 e Evans syn aldol products using N-propionyl oxazolidinones, oxazolidinethiones, and thiazolidinethio

207 tionic species, weak nucleophiles such as NH-oxazolidinone participated efficiently in the hydroamina

208 namely macrolides, lincosamides, phenicols, oxazolidinones, pleuromutilins and streptogramins.

209 The oxazolidinone PNU-100480 is superior to linezolid agains

210 e research in this area, the discovery of an oxazolidinone possessing improved myelotoxicity compared

211 Oxazolidinones possessing a C-5 carboxamide functionalit

212 silver nitrate in acetone provided the trans-oxazolidinones predominantly.

213 aerobic oxidative amination of styrene with oxazolidinone proceeds with catalyst-controlled regiosel

214 tivity approaching that of the corresponding oxazolidinone progenitor.

215 With the N-acetyl-5-N,4-O-oxazolidinone-protected 1-adamantanylthio sialyl donor h

216 It is demonstrated that a ring-fused 2,3-oxazolidinone-protected derivative of 1-tolylthio-N-acet

217 Two N-acetyl 4O,5N-oxazolidinone-protected sialyl thioglycosides epimeric a

218 Variations in the oxazolidinone, protecting group, and imine components sh

219 y installed enantioselectively via the Evans oxazolidinone protocol.

220 rived from commercially available 4-benzyl-2-oxazolidinone provide a rigid, conformationally restrict

221 Oxazolidinones represent a new and promising class of an

222 Oxazolidinones represent a novel class of antibiotics th

223 The oxazolidinones represent the first truly new class of an

224 tes with what is presently the most frequent oxazolidinone resistance mutation may aid surveillance a

225 sis in the wild-type rRNA operon produced an oxazolidinone resistance phenotype, establishing that th

226 me interaction, we selected Escherichia coli oxazolidinone-resistant mutants, which contained a rando

227 ydrazones with different substituents on the oxazolidinone revealed that benzyl and diphenylmethyl we

228 ammonia equivalents in the N-amination of 2-oxazolidinones revealed that O-(p-nitrobenzoyl)hydroxyla

229 state of 4pi electrocyclic ring closure, the oxazolidinone ring and the cyclizing pentadienyl cation

230 es and the N-acetyl substituent of the 2N,3O-oxazolidinone ring in stereochemical control is presente

231 enzyme complexes, the carbonyl group of the oxazolidinone ring makes hydrogenbond interactions with

232 e leverage the tunability of oxazolidine and oxazolidinone rings to systematically characterize struc

233 es of N-acetylglucosamine, protected with an oxazolidinone spanning the nitrogen and O-3, and bearing

234 A chiral oxazolidinone stereocontrol element in the N-acylhydrazo

235 higher levels of allylic strain between the oxazolidinone substituent and adjacent groups on the pen

236 Here, we describe a series of N-linked oxazolidinone substituents on the benzisoxazole that imp

237 ns between unsymmetrical furans and a chiral oxazolidinone-substituted oxyallyl is presented.

238 An oxazolidinone-substituted oxyallyl undergoes chemoselect

239 The favorable affect of the oxazolidinone substructure for alpha-sialylation is illu

240 microbial susceptibility testing showed that oxazolidinones such as linezolid (mean MIC 3.13 mug/mL)

241 powerful electron-withdrawing nature of the oxazolidinone system, which in turn is a function of its

242 can be extended to include the synthesis of oxazolidinone systems through use of dimethyl carbonate.

243 d that the peptidyltransferase itself is the oxazolidinone target.

244 exposure to amikacin and the next-generation oxazolidinone tedizolid (both target ribosomes) or cefox

245 The novel oxazolidinone tedizolid demonstrates antimicrobial activ

246 The novel oxazolidinone tedizolid phosphate is in late-stage clini

247 The novel oxazolidinone tedizolid phosphate is in late-stage devel

248 macrolides (cethromycin and solithromycin), oxazolidinones (tedizolid phosphate and radezolid), and

249 the PPARalpha receptor, thus validating the oxazolidinone template for PPAR activity.

250 r an ene product when (1)O(2) reacts with an oxazolidinone tethered 2-phenyl-1-propenyl system.

251 The proposed isomeric dipeptide ion is an oxazolidinone that takes fully covalent and ion-neutral

252 Oxazolidinones that are connected to a quinolone moiety

253 ked to clinical side effects associated with oxazolidinone therapy.

254 ith an overall yield of 23% from the 4-O,5-N oxazolidinone thiosialoside donor.

255 here X is a suitable chiral auxiliary (e.g., oxazolidinone) this strategy affords access to homochira

256 For lactams and oxazolidinones, this last method is much better.

257 Linezolid, the first oxazolidinone to be approved for clinical use, displays

258 study of a strategically designed library of oxazolidinones to determine the effects of molecular str

259 ddition of titanium(IV) enolates from N-acyl oxazolidinones to TEMPO has permitted us to suggest an e

260 of a new class of antimicrobial agents, the oxazolidinones, to be approved for clinical use in the U

261 Oxazolidinones, totally synthetic class of novel antibac

262 ide, a dihydrofolate reductase inhibitor, an oxazolidinone, two peptide antibiotics, a glycylcycline,

263 We have prepared two potent, synthetic oxazolidinones, U-100592 and U-100766, which are current

264 atom-economic transformation of epoxides to oxazolidinones under microwave irradiation.

265 Chirality transfer of the Evans (S)-oxazolidinone unit via a Zimmerman-Traxler-like transiti

266 with an N-terminal 2-alkoxy-2-oxazoline or 2-oxazolidinone unit.

267 The transformation is general for oxazolidinones unsubstituted in the 5 position and occur

268 ation rates from exo-oxazolidinones and endo-oxazolidinones upon variation of the proline and water c

269 yst efficiently transforms amino alcohols to oxazolidinones (upon reaction with CO(2) ) and then to m

270 lly 5 mol % catalyst loading, cyclic amides, oxazolidinones, ureas, unsaturated cyclic amines, and al

271 The soft enolization of an acylated oxazolidinone using di-n-butylboron triflate (n-Bu2BOTf)

272 ent method for intermolecular N-arylation of oxazolidinones using catalytic copper in the presence of

273 o-1-phenyl-1,3-dienes from a range of chiral oxazolidinones using palladium-catalysis is reported.

274 as allowed to react with N-triphenylmethyl-5-oxazolidinone via the corresponding azomethine ylide.

275 , which excludes the direct deprotonation of oxazolidinones via E2 mechanism.

276 ymmetric alkylation using N-(N-Boc-glycinyl) oxazolidinone was standardized to ensure the stereoselec

277 Basic hydrolysis of each of these oxazolidinones was accompanied by transannular attack at

278 An efficient one-pot synthesis of oxazolidinones was developed through CuI/DBU/MS joint sy

279 d (Z)-enolate of (4S/4R)-4-benzyl-N-glycinyl oxazolidinones was extended following other subsequent r

280 tivity relationships of structurally related oxazolidinones, we have prepared and evaluated the antib

281 chiral reference, and the analyte 4-benzyl-2-oxazolidinone were generated by electrospray ionization

282 n-pentenyl glycosides of N-Cbz 2-mannosamine oxazolidinones were converted separately to oxazolidinon

283 In human cells, oxazolidinones were crosslinked to rRNA in the PTC of mi

284 tion of bacterial ribosomes predicts that if oxazolidinones were engineered to accumulate in Gram-neg

285 Several highly substituted 2-oxazolidinones were obtained in 19-46% yields in a one-p

286 3-(2-Haloacyl)-2-oxazolidinones were shown to react with enals in an asym

287 Two new oxazolidinones were tested to determine interpretive sus

288 Several polar side chains (alcohols, oxazolidinone) were well-tolerated for CB(2) receptor ac

289 ads to increased steric interaction with the oxazolidinone when a pi-conjugating substituent is dista

290 ting adduct underwent cyclization to give an oxazolidinone, which could be readily hydrolyzed to an o

291 buted in part to the tied back nature of the oxazolidinone, which reduces hindrance around the nucleo

292 amine formation is zero-order in proline and oxazolidinones, which excludes the direct deprotonation

293 Tedizolid is a new oxazolidinone with improved in vitro and intracellular p

294 especially promising for the development of oxazolidinones with an improved safety profile.

295 duced by the photochemical reaction of vinyl oxazolidinones with chromium carbene complexes.

296 In the search for novel oxazolidinones with improved potency and spectrum, we ha

297 Amination of 4-alkyl-2-oxazolidinones with O-(mesitylenesulfonyl)hydroxylamine

298 Interaction of oxazolidinones with the mitochondrial ribosomes provides

299 olone, nitroimidazole, diarylquinolines, and oxazolidinones), with 2965 relapse and 1544 colony-formi

300 computations, suggesting that valine-derived oxazolidinones would be superior to the phenylalanine-de