ライフサイエンスコーパス: oxazoline

1 a key cyclopentenone harboring a spirocyclic oxazoline.

2 ollowed by a gradual transition toward the 2-oxazoline.

3 poly-2-methyl-2-oxazoline or poly-2-ethyl-2-oxazoline.

4 e to 4-(methoxycarbonyl)-5,5-disubstituted 2-oxazoline.

5 wer GB (321 kJ/mol less) than 2,4-dimethyl-3-oxazoline.

6 dative cyclization of N-alkenylamides into 2-oxazolines.

7 nsation of isocyanides and aldehydes to form oxazolines.

8 were prepared by cationic polymerization of oxazolines.

9 ivity between the t-Bu- and i-Pr-substituted oxazolines.

10 cNAc-Fc homodimer) with the synthetic glycan oxazolines.

11 rther reaction with an amine base provides 2-oxazolines.

12 cooperative effects in meta-substituted aryl oxazolines.

13 Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781),

14 tereospecifically and regiospecifically into oxazolines (+/-)-13 and (+/-)-14 and into cyclic carbama

15 ovel method for the preparation of 4-allenyl-oxazolines 2 is described via the reaction of 2-en-4-yn-

16 ycosides having a cis-1,2-fused pyranose-1,3-oxazoline-2-thione structure and bearing different subst

17 Non-C(2) symmetric oxazolines (20-25) have also been examined as ligands, a

18 ide 24b via electrocyclic ring opening of an oxazoline 23b.

19 1 (X = CH(2)), imidazoline 2 (X = NH), and 2-oxazoline 3 (X = O).

20 Novel intermediate oxazoline[3,2-a]pyridiniums were facilely prepared from

21 C2-sulfonium glycosyl imidate 39 as well as oxazoline 37 as key intermediates in this novel oxidativ

22 presence of SOCl(2) produced 2-substituted 2-oxazolines 3a-j in 84-98% yields and 2-substituted thiaz

23 Chiral and achiral 3-methoxynaphthalen-2-yl oxazolines 4a,b failed to undergo an aromatic nucleophil

24 e2)2 (M = Ti, Zr, Hf; Ox(R) = 4,4-dimethyl-2-oxazoline, 4S-isopropyl-5,5-dimethyl-2-oxazoline, 4S-ter

25 hyl-2-oxazoline, 4S-isopropyl-5,5-dimethyl-2-oxazoline, 4S-tert-butyl-2-oxazoline) at room temperatur

26 With use of this method chiral oxazoline 6, bisoxazoline 7, bisthiazoline 8, and 5,6-di

27 , the perchlorate salts of 2,4,4-trimethyl-2-oxazoline (6) and 2-amino-2-methylpropyl acetate (7).

28 forming the salt of 2,4,4,5,5-pentamethyl-2-oxazoline (8) with loss of thianthrene (Th).

29 reaction was employed to construct a chiral oxazoline 9 (99% yield, 98% ee) that served the dual pur

30 s diacylated product undergoes a second aryl oxazoline acylation on its remaining secondary amine, al

31 tivation of 3-amido oxetanes to synthesize 2-oxazoline amide ethers using a transient electrophilic a

32 drogenations mediated by the chiral, carbene-oxazoline analogue of Crabtree's catalyst "cat" in asymm

33 ns, together with the previously constructed oxazoline analogues 5d and 6d, were subjected to biologi

34 ansformation may be achieved by oxidation of oxazoline analogues of phenolic and indolic amides.

35 and instead proceeds through arabinose amino-oxazoline and anhydronucleoside intermediates.

36 ed by chemical synthesis of a large N-glycan oxazoline and its subsequent enzymatic ligation to GlcNA

37 olytic activity toward both the Man(9)GlcNAc oxazoline and the product as well as to its enhanced act

38 ment of an effective and practical method of oxazoline and thiazoline formation, which can facilitate

39 stereoselectivity and led, in most cases, to oxazolines and amides as single diastereomers.

40 trans-glycosylation using well-defined sugar oxazolines and mutant forms of endo beta-N-acetylglucosa

41 ition states with t-Bu- and i-Pr-substituted oxazolines and suggested a possible explanation for the

42 In addition, it was shown that both oxazolines and their precursors could efficiently lead t

43 Oxazolines and thiazolines are important constituents of

44 f N-acylbenzotriazoles in the preparation of oxazolines and thiazolines under mild conditions and sho

45 ono(oxazolines), to bis(oxazolines), to tris(oxazolines) and tetra(oxazolines) and variations thereof

46 s(oxazolines), to tris(oxazolines) and tetra(oxazolines) and variations thereof can be more easily mo

47 tammetry (CV) analyses of bidentate pyridyl, oxazoline, and imidazoline nitrogen ligands, along with

48 catalyzed asymmetric conjugate addition of 2-oxazoline- and 2-thiazoline 4-carboxylate to a nitroalke

49 nylation of ferrocene derivatives bearing an oxazoline-aniline directing group.

50 However, oxazoline anion 30, a synthetic equivalent of ethyl phen

51 )(NAr)(hoz)2+] (hoz = 2-(2'-hydroxyphenyl)-2-oxazoline) (Ar = 2,4,6,-(Me)C(6)H(2); 4-(OMe)C(6)H(4); 4

52 Third, readily available bis(oxazolines) are shown for the first time to be effective

53 utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand.

54 , we introduce for the first time the use of oxazoline as a more versatile motif for this transformat

55 sing allylamine, acrylic acid and 2-methyl-2-oxazoline as precursor to produce amine, carboxyl and ox

56 rected] could not take more complex N-glycan oxazoline as substrate for transglycosylation, indicatin

57 esses transglycosylation activity with sugar oxazoline as the donor substrate, but the transglycosyla

58 ) core by use of azido-containing Man3GlcNAc oxazoline as the donor substrate.

59 ted substituents on the aromatic ring and an oxazoline as the heterocyclic moiety, demonstrated in vi

60 f the chemical synthesis of defined N-glycan oxazolines as donor substrates, the expression of the Fc

61 can still catalyse synthetic processes using oxazolines as donors, but which do not hydrolyse the rea

62 ynthesis of bespoke N-glycans using N-glycan oxazolines as glycosyl donors.

63 able to use both bi- and triantennary glycan oxazolines as substrates for transglycosylation, in cont

64 se-catalyzed transglycosylation, using sugar oxazolines as the donor substrates.

65 protophormiae (Endo-A) with synthetic sugar oxazolines as the donor substrates.

66 The studies performed with chiral oxazolines as vehicles for a number of C-C bond-forming

67 y diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to prov

68 yl-5,5-dimethyl-2-oxazoline, 4S-tert-butyl-2-oxazoline) at room temperature and below, affording five

69 nd their derivatives, including ortho ester, oxazoline, azido epoxide, as well as sulfonamide-, amide

70 ic side chains in one block, poly(2-methyl-2-oxazoline)-b-poly(2-N,N-dimethyl-1,3,5-triazine-2,4-diam

71 ccomplished with the use of chiral phosphine-oxazoline based ligand structures.

72 Here we report a novel poly(2-oxazoline)-based block copolymer with the aromatic heter

73 Reported here is the use of an oxazoline-based directing group capable of overriding th

74 oromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, o

75 general class of imino ethers that includes oxazolines, benzoxazoles and benzimidates are applicable

76 Bi-Oxazoline (biOx) has emerged as an effective ligand fram

77 r side chain in poly(2-methoxycarboxyethyl-2-oxazoline) block (PMestOx) of the PMeOx-PMestOx diblock

78 pha,omega-hydroxy-end-capped poly(2-methyl-2-oxazoline)-block-poly(dimethylsiloxane)-block-poly(2-met

79 By chemical modification of the oxazoline, both the gamma-lactone (28) and the delta-lac

80 The protocol was enabled by a new bis(oxazoline) (BOX) ligand designed via a rapid structure-a

81 did not recognize the complex-type N-glycan oxazoline but could efficiently use the high-mannose-typ

82 This enzyme-bound aryl oxazoline can be transferred by VibF to various amine ac

83 stical copolymerization of 2-oxazines with 2-oxazolines can lead to the formation of amphiphilic grad

84 etylase (HDAC) is described that contains an oxazoline capping group and a N-(2-aminophenyl)-benzamid

85 stablish that a readily available nickel/bis(oxazoline) catalyst accomplishes a wide array of enantio

86 zoic acid salts of the chiral copper(II) bis(oxazoline) catalyst deliver both diastereomers of the He

87 secondary benzyl chlorides with a Ni(II)/bis(oxazoline) catalyst in the presence of Mn(0) as a stoich

88 ass directly over the immobilized copper bis(oxazoline) catalyst without detrimentally impacting the

89 ylzinc reagent, LiI, and a chiral nickel/bis(oxazoline) catalyst, furnishes the Negishi cross-couplin

90 can be achieved with the aid of a nickel/bis(oxazoline) catalyst.

91 Dinickel naphthyridine-bis(oxazoline) catalysts promote enantioselective intermolec

92 the stereochemical outcome of the copper-bis(oxazoline)-catalyzed C-H insertion reaction between meth

93 son, a 1:1 mixture of the palladium pyridine-oxazoline complex (N-N)Pd(Me)Cl inverted question markN-

94 An iridium carbene oxazoline complex was used to catalyze hydrogenations of

95 A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in p

96 ridines is catalyzed by a novel iron(II) bis(oxazoline) complex.

97 genation mixtures formed using these iridium-oxazoline complexes.

98 A family of bis(oxazoline) complexes of coordinatively unsaturated monom

99 tituent onto the cyclopentadienyl ring of an oxazoline-conjugated ferrocene with the stereochemical s

100 simple catalytic hydrogenation at C-1 of an oxazoline constructed from the corresponding 2-aminopyra

101 , the ethylpiperazine-functionalized aza-bis(oxazoline) copper catalyst resulted in rate acceleration

102 This strategy is based on chiral bis(oxazoline) copper(II) complex-catalyzed enantioselective

103 the outer mannose residues of the Man3GlcNAc-oxazoline core, thus allowing introduction of large olig

104 The oligosaccharide oxazoline corresponding to the biantennary complex-type

105 exo-Diels-Alder reaction catalyzed by a bis-oxazoline Cu(II) catalyst enabled rapid assembly of the

106 do selectivity enhancements delivered by bis(oxazoline)-Cu(II) Lewis acid catalysts in the Diels-Alde

107 t, specifically, an optically active carbene oxazoline derivative, were found to be mostly catalyst c

108 ation to furnish thiocyanated thiazoline and oxazoline derivatives in high yields (up to 97%).

109 strate its applicability in the synthesis of oxazoline derivatives through a convenient two-step proc

110 formation of the corresponding 4-substituted oxazoline derivatives.

111 Here, we employ cleavable poly(2-oxazoline) diblock copolymer surfactants to form perfluo

112 We report herein a ruthenium-catalyzed, oxazoline-directed strategy for C-H allylation of aryl o

113 stereoselectivity (>99:1 dr) observed in the oxazoline-directed, Pd(II)-catalyzed sp(3) C-H bond iodi

114 e peptide precursor from the oligosaccharide oxazoline donor substrates.

115 lipid A region-was synthesized using an 1,3-oxazoline donor, which was followed by coupling with an

116 thesis by transglycosylation using activated oxazoline donors.

117 the remaining groups and manipulation of the oxazoline eventually led to pactamycin, pactamycate, and

118 ne-oxazoline (HetPHOX) ligands and ferrocene-oxazoline (FcPHOX) ligands and their application in the

119 nes and oxazolines, which provides the trans-oxazolines following in situ Heine-type aziridine ring e

120 efficiently use the high-mannose-type glycan oxazoline for transglycosylation.

121 rolytic activity but are able to take glycan oxazolines for transglycosylation.

122 the epoxides were converted directly to the oxazoline form of the target molecules using a Ritter re

123 results show that controlling the balance of oxazoline formation and glycosylation is key to achievin

124 4-carboxy-VibF in the first demonstration of oxazoline formation by an NRPS cyclization domain.

125 Highly selective cis-oxazoline formation is achieved starting from anti-E-bis

126 no impact on the diastereoselectivity of the oxazoline formation, and chiral triazolylidenes did not

127 A powerful method for the synthesis of 2-oxazolines from silyl-protected beta-hydroxyamides is re

128 The formation of chiral oxazolines from these materials provided interesting and

129 as precursor to produce amine, carboxyl and oxazoline functional group rich surfaces.

130 lyzed by [Cu{(S,S)-tBu-box}](SbF6)2 [box=bis(oxazoline)] generate chiral alpha-functionalized alpha-h

131 stituted and electronically varied thiophene-oxazoline (HetPHOX) ligands and ferrocene-oxazoline (FcP

132 The use of N-glycan oxazolines, high energy intermediates on the hydrolytic

133 cks such as primary and secondary amines and oxazolines, highlighting its synthetic utility.

134 Using our method, oxazoline hydroxamates with diverse 2-substituents were

135 hydes, imines, and activated olefins to form oxazolines, imidazolines, and pyrrolines, respectively.

136 ene ortho C-H bonds with pyridine, pyrazole, oxazoline, imine, urea, amide...

137 c hydrogenation of substituted benzenes with oxazoline imino(pyridine) (OIP) molybdenum precatalysts

138 e converted into 2-(9'-fluorenylmethyloxy)-2-oxazoline in high yield, thereby providing a new pathway

139 oxy-3-phenylurea 2 using CuCl2 and 2-ethyl-2-oxazoline in methanol gave acyl nitroso species in situ,

140 in situ deprotected and dehydrated to give 2-oxazolines in good yields.

141 lysis allows the regioselective synthesis of oxazolines in high yields.

142 tiated cascade provides highly substituted 2-oxazolines in high yields.

143 cient to take various modified N-glycan core oxazolines, including the bisecting sugar-containing der

144 Known inhibitors of this enzyme are oxazolines incorporating a hydroxamic acid at the 4-posi

145 Oxazolines incorporating a hydroxamic acid, which is bel

146 yanide-induced ylide generation via a labile oxazoline intermediate (62 to 66).

147 ition, and electrocyclic ring opening of a 4-oxazoline intermediate affords the indoloquinone 31 in a

148 structural and electronic properties of the oxazoline intermediate are similar to the known chitinas

149 s double displacement mechanism involving an oxazoline intermediate distinguishes the family 18 chiti

150 tly observe both a Michaelis complex and the oxazoline intermediate.

151 the catalytic acid/base for reaction via an oxazoline intermediate.

152 midins act as transition state analogs of an oxazoline intermediate.

153 d two potential hydrolysis intermediates (an oxazoline ion and an oxocarbenium ion) to a family 19 ba

154 hevamine (a family 18 chitinase) involves an oxazoline ion intermediate stabilized by the neighboring

155 sugar D, thus preventing the formation of an oxazoline ion intermediate.

156 Structural and electronic features of the oxazoline ion likely to be important in the design of ne

157 omers (2-vinylpridine (2VP), 2-isopropenyl-2-oxazoline (IPOx)).

158 ral 2,2'-(2,6-pyridinediyl)bis(4-isopropyl-2-oxazoline) (iPr-Pybox) to a self-assembled Co(II)-[W(V)(

159 mistry of the stereogenic carbon next to the oxazoline is not necessarily the dominant chiral center

160 cular rearrangement of 3-amido oxetanes to 2-oxazolines is the hallmark of this transformation and is

161 led that C(4)-phenyl substitution on the bis(oxazoline) is optimal for high asymmetric induction.

162 eed upon to be caused by an intermediate 1,2-oxazoline, is often bypassed by introducing extra synthe

163 f the substituents on the aryl moiety of the oxazoline lead to a surprising modulation of reactivity.

164 pper triflate (CuOTf) and a C2-symmetric bis-oxazoline ligand (5a-c).

165 ew, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee's and good yield

166 the electronically asymmetric quinoline and oxazoline ligand modules.

167 ontrast, complex of a finely tuned phosphino-oxazoline ligand promotes unique [2+2]-cycloaddition bet

168 Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is ach

169 nyne in the presence of a bidentate pyridine-oxazoline ligand.

170 reocenters is disclosed using a new pyridine oxazoline ligand.

171 reocenters was developed using a new pyridyl-oxazoline ligand.

172 Here, we describe the development of a bis(oxazoline) ligand that enables the desymmetrization of m

173 The effect of varying the bis(oxazoline) ligand, copper salt, and site of C-H insertio

174 By using a bis(oxazoline) ligand, good yields and enantioselectivities

175 opper(I) catalyst equipped with a chiral bis(oxazoline) ligand, high yields and enantioselectivities

176 tioselection was achieved using a chiral bis(oxazoline) ligand, in many cases with high enantioselect

177 el complex that bears a bidentate chiral bis(oxazoline) ligand.

178 dium complexes of the N-heterocyclic carbene oxazoline ligands 1 in asymmetric hydrogenations of aryl

179 e have identified 2-(2-diarylphosphinophenyl)oxazoline ligands and mild reaction conditions for effic

180 a range of novel gem-disubstituted ferrocene-oxazoline ligands and their application in both the asym

181 A series of phosphine-oxazoline ligands based on proline are reported.

182 llylation under NHK conditions using modular oxazoline ligands developed in our laboratory.

183 ear to differ from the traditional phosphine-oxazoline ligands in that the stereochemistry of the ste

184 -disubstitution of i-Pr-containing ferrocene oxazoline ligands results in increased enantioselectivit

185 design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of isopro

186 Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized.

187 es, in contrast to other chelating imine and oxazoline ligands.

188 on a set of newly developed chiral quinolyl oxazoline ligands.

189 me using chiral acetyl-protected aminomethyl oxazoline ligands.

190 A series of eight novel bis(oxazoline) ligands incorporating gem-disubstitution on o

191 A screening study of bis(oxazoline) ligands reveals that aryl stereodirecting gro

192 mmercially available or readily prepared bis(oxazoline) ligands such as (4R,5S)-Ph(2)BoxH, (4S,5R)-Ar

193 Base-functionalized aza-bis(oxazoline) ligands were prepared to explore the concept

194 o acids, bioactive molecules, and chiral bis(oxazoline) ligands.

195 mpounds is disclosed using a chiral pyridine oxazoline-ligated palladium catalyst under mild conditio

196 nce by the sugar acetamido moiety to form an oxazoline-like intermediate.

197 , and finally obtaining poly[oligo(2-ethyl-2-oxazoline) methacrylate]s (POEOXMAs) by reversible addit

198 hieved by first synthesizing oligo(2-ethyl-2-oxazoline) methacrylates (OEOXMAs) by cationic ring-open

199 -Me(2)Box]La[N(TMS)(2)](2) (Box = 2,2'-bis(2-oxazoline)methylenyl; Ar = 4-tert-butylphenyl, 1-naphthy

200 Employing just 4 mol % bis(oxazoline)-Mg(OTf)(2) complex with an amine cocatalyst,

201 in the stereochemistry of their butyrate or oxazoline moieties were not recognized by human T cells.

202 n the substitution pattern on the oxazole or oxazoline moieties, mono- and dioxabacteriochlorins may

203 The S(c) configured oxazoline moiety (R = Me, i-Pr) was used to control the

204 tral chirality, (ii) imidazoline moiety over oxazoline moiety, and (iii) phosphine unit is investigat

205 ique mode of stereoinduction from the chiral oxazoline moiety, where the stereogenic center alpha to

206 s route guided by the point chirality at the oxazoline moiety.

207 The chiral oxazoline motif is present in many ligands that have bee

208 The use of a copper-bis(oxazoline)-NaBARF catalyst complex system leads to forma

209 nd synthesized by cationic polymerization of oxazolines on mesoporous silica.

210 eptides capped with an N-terminal 2-alkoxy-2-oxazoline or 2-oxazolidinone unit.

211 particles coated with either poly-2-methyl-2-oxazoline or poly-2-ethyl-2-oxazoline.

212 ckbone carbonyl carbon to form a thiazoline, oxazoline, or methyloxazoline ring.

213 er both in substrate and the [Cu(R,R)-Ph-bis(oxazoline)]OTf(2) catalyst and zero order in TEMPO.

214 y, where the stereogenic center alpha to the oxazoline oxygen atom is significant.

215 Cobalt oxazoline palladacycles (COP) containing acetylacetonate

216 Cobalt oxazoline palladacyclic (COP) complex 4 containing aceta

217 ly(vinylpyrrolidone)), PMOX (poly(2-methyl-2-oxazoline)), PDMA (poly(N,N-dimethyl acrylamide)), and P

218 N-Palmitoylethanolamine-oxazoline (PEA-OXA) possesses anti-inflammatory and pote

219 rther neutral polymer, namely poly(2-ethyl-2-oxazoline) (PEOz) can be successfully used as a dipole l

220 indirectly attributed to interaction of the oxazoline-phenyl substituent with the palladium and with

221 r and demonstrate that the threonine-derived oxazoline plays a critical role in determining the kinet

222 imethyl-1,3,5-triazine-2,4-diamine-6-ethyl-2-oxazoline) (PMeOx-PcBOx), and demonstrate its potential

223 c poly[(2-methyl-2-oxazine)- grad-(2-butyl-2-oxazoline)] (PMeOzi- grad-PBuOx) as well as the thermore

224 poly[(2-methyl-2-oxazine)- grad-(2-propyl-2-oxazoline)] (PMeOzi- grad-PPrOx) confirmed their potenti

225 m and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter w

226 Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules

227 arises from spontaneous rearrangement of an oxazoline precursor.

228 tarting from anti-E-bis-imidates while trans-oxazoline predominantly forms from anti-Z-bis-imidates.

229 Furthermore, the rapid generation of oxazoline products is demonstrated in the expeditious as

230 C-H activation of t-Bu- and i-Pr-substituted oxazolines provided good agreement with the experimental

231 The pyridine bis-oxazoline (PyBox) core provides the chiral Ln(3+) enviro

232 ently introduced simple chiral ruthenium bis(oxazoline) (pybox) complex ( Angew.

233 Here, we report chiral bifunctional oxazoline-pyridone ligands that enable enantioselective

234 yrrole-2-carbaldehydes with formation of 1,2-oxazoline-pyrrole ensembles.

235 The use of a bidentate ligand, quinoline-2-oxazoline (Quinox), and TBHP((aq)) as the terminal oxida

236 kN-N = (R)-(+)-4-isopropyl-2-(2-pyridinyl)-2-oxazoline (R-5b) and NaBAr(4) (5 mol %) catalyzed the as

237 [N-N = (R)-(+)-4-isopropyl-2-(2-pyridinyl)-2-oxazoline] [(R)-2] and NaBAr(4) [Ar = 3,5-C(6)H(3)(CF(3)

238 ric Negishi cross-couplings (a bidentate bis(oxazoline), rather than a tridentate pybox); in the case

239 Chiral oxazolines, readily available from the corresponding ami

240 nd 13 steps, respectively, and feature a key oxazoline reduction that sets the stage for piperazine c

241 eals that aryl stereodirecting groups at the oxazoline ring 4 position and additional substitution (g

242 ition of indoles in combination with unusual oxazoline ring cleavage and subsequent 1,2-alkyl shift a

243 d with proton transfer from the intermediate oxazoline ring formed in the phosphopeptide to the metal

244 The stereochemical configuration of the oxazoline ring is shown to be the major structural facto

245 he nitro group followed by hydrolysis of the oxazoline ring yielded an optically active gamma-lactam

246 lexes [(G-PHOX)CoX(2)] (G = 4-substituent on oxazoline ring) effect selective 1,2-, 1,4-, or 4,3-addi

247 Ligand modification (substitution at the oxazoline ring) significantly enhanced the reactivity, c

248 corporating gem-disubstitution on one of the oxazoline rings were prepared from (S)-valine.

249 amide is heterocyclized to form thiazole and oxazoline rings, and the peptide is cleaved to yield the

250 se produces MBT derivatives with beta-methyl oxazoline rings.

251 ng interactions to the nitrogen atoms of the oxazoline rings.

252 ce mechanisms with doubly amphiphilic poly(2-oxazoline)s (POx), a safe and highly efficient polymer f

253 nd-group diversification approach for poly(2-oxazoline)s (POx), enabling quick and reliable productio

254 Poly(2-oxazoline)s (POxs) are a versatile class of biocompatibl

255 based on multifunctional amphiphilic poly(2-oxazoline)s and covalently cross-linked with spiropyran

256 olymerization modification of poly(2-alkyl-2-oxazoline)s and poly(2-alkyl-2-oxazine)s using Ind*Rh(II

257 cturally similar amphiphiles based on poly(2-oxazoline)s and poly(2-oxazine)s with respect to their s

258 Poly(2-oxazoline)s and, more recently, also poly(2-oxazine)s re

259 on amphiphilic triblock copolymers of poly(2-oxazoline)s with orthogonal functional groups on the sid

260 ine the high structural modularity of poly(2-oxazoline)s with the excellent biological properties of

261 Chiral bis(oxazoline)-scandium Lewis acids serve as chiral counteri

262 imple transformation: conversion to a chiral oxazoline, SeO2-promoted oxidative rearrangement to the

263 Zn(PO4)](+), [LZn2(PO4)], and 2,4-dimethyl-3-oxazoline showing that [LGa2(PO4)](2+) is the only compo

264 to suppress the formation of trichloromethyl oxazoline side product and enable high glycosylation yie

265 we report a palladium(II) [Pd(II)]/sulfoxide-oxazoline(SOX)/phosphoric acid-mediated C(sp(3))H/N(sp(2

266 ters were determined for both thiazoline and oxazoline substrates, with k(cat) values ranging between

267 A diastereoselective synthesis of 4-vinyl oxazolines syn-2 was developed based on an acid-catalyze

268 Oxazolines syn-2 were transformed to C-quaternary threon

269 Two conventional methods for oxazoline synthesis were also applied to generate more t

270 Three different syntheses of the phosphine oxazoline systems 1 are presented.

271 hreonine side chains as well as an efficient oxazoline-thiazoline interconversion on the macrocyclic

272 (Cy) domains generate biologically important oxazoline/thiazoline groups found in natural products, i

273 efficiently transfer the complex-type glycan oxazoline to a GlcNAc peptide and GlcNAc-containing ribo

274 a revision of the reported structure from an oxazoline to an isoxazolidinone.

275 ng-opening polymerization of a 2-alkylthio-2-oxazoline to furnish a polythiocarbamate.

276 edefined N-glycans from corresponding glycan oxazolines to the Fc-deglycosylated intact IgGs without

277 catalyzing the oxidation of thiazolines and oxazolines to yield fully aromatic heterocycles.

278 ent of ligand architectural design from mono(oxazolines), to bis(oxazolines), to tris(oxazolines) and

279 ectural design from mono(oxazolines), to bis(oxazolines), to tris(oxazolines) and tetra(oxazolines) a

280 cores were prepared from amphiphilic poly(2-oxazoline) triblock copolymers.

281 uccessfully converted into the corresponding oxazolines, under milder and less wasteful conditions th

282 backbone and two stereochemically identical oxazoline units, leads to the formation of four stereois

283 first reported oligomer of [2,4']-coupled 2-oxazoline units.

284 directed strategy for C-H allylation of aryl oxazolines using allylic alcohols as the coupling partne

285 ntly developed a method for the synthesis of oxazolines using resin capture and ring-forming release

286 n of the Corey-Chaykovsky reaction to access oxazolines using sulfur ylides and stable precursors of

287 es and aminoalcohols to access 2-substituted oxazolines was investigated.

288 of IgG1-Fc when an excess of oligosaccharide oxazolines was used as the donor substrates.

289 bstitution on the arenes adjacent to the bis(oxazolines) was found to be particularly impactful, due

290 l trifluoromethyl ketones, and the resulting oxazolines were obtained with good to excellent diastere

291 Overall, eight different phosphine oxazolines were prepared.

292 First, an array of large oligosaccharide oxazolines were synthesized and evaluated as substrates

293 acid catalyzed or spontaneous cyclization to oxazolines, which are precursors of unsaturated amino al

294 proceeds through a mixture of aziridines and oxazolines, which provides the trans-oxazolines followin

295 ld leverages the intermolecular formation of oxazolines with a wide functional group tolerance on bot

296 to convert aryl olefins to the corresponding oxazolines with high chemo- and diastereoselectivity.

297 amate-, and carbonate-substituted 2-phenyl-2-oxazolines with mixed lithium-magnesium amides followed

298 ions through ring-opening of 4-benzylidene-2-oxazolines with Sc(OTf)3.

299 od includes the chemical synthesis of glycan oxazolines with varied number and location of the M6P mo

300 acid-catalyzed hydrolysis of poly(2-ethyl-2-oxazoline), yielding the pure polycations.